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Ischaemic heart disease
Coronary
Heart Disease
{CAD}
The reduction of blood flow to the heart
[Atherosclerosis] in the arteries of heart.
It is the most common of the cardiovascular disease.
Types includes stable angina, unstable angina,
myocardial infraction and sudden cardiac death.
Occasionally it may feel like heartburn.
StableAngina
 Characterised by central chest pain, discomfort or
breathlessness that is precipitated by exertion or other
forms of stress and is promptly relieved by rest.
 Activities precipitating angina
Physical exertion
Cold exposure
Heavy meals
Intense emotion
Pathophysiology
 Limitation of blood flow to the heart causes ischemia
(shortage of oxygen) and is called as myocardial infraction
(commonly referred to as a heart attack).
 It leads to damage, death, and eventual scarring of the heart
muscle without regrowth of heart muscle cells.
 The artery’s lining becomes hardened, stiffened and
accumulates deposits of calcium, fatty lipids, and abnormal
inflammatory cells – to form a plaque.
 A more severe form is chronic total occlusion (CTO) when a
coronary artery is completely obstructed for more than 3
months.
Diagrammatic
representation
The other terms for
this condition is
hardening of the
arteries and
narrowing of the
arteries.
Symptoms
 Pain in the cardinal
 Prolonged cardiac pain: chest, throat, arms,
epigastrium
 Anxiety and fear of impending death
 Nausea and vomiting
 Pale skin
 Leg swelling
Risk factors
 High blood pressure
 Smoking
 Diabetes
 Lack of exercise
 Obesity
 High blood cholesterol
 Poor diet
 Depression
 Excessive alcohol
In 2015,CAD
affected 110
million people
andresulted in 8.9
million deaths.
 The risk of CAD death decreased between 1980 and
2010, especially in developed countries.
 In the United States in 2010, about 20% are above 65
have been affected by CAD while it was present in 7%
of those 45 to 64 age groups, and 1.3% of those 18 to
45.
 Rates were higher among men than women of a given
age.
It makes up 15.6%
of all deaths,
making it the most
common cause of
death globally.
Prevention
 Up to 90% of cardiovascular disease be preventable if
established risk factors are avoided.
 Prevention involves adequate physical exercise,
decreasing obesity, treating high blood pressure,
eating a healthy diet, decreasing cholesterol levels, and
stop smoking.
 Medications and exercise are roughly equally effective.
 High levels of physical activity reduce the risk of
coronary artery disease by about 25%.
Secondary
prevention
 Weight control
 Avoiding the consumption of trans fats
 Decreasing psychosocial stress
 Exercise
 Aerobic exercise like walking, jogging, or swimming
can reduce the risk of mortality from coronary artery
disease.
 Aerobic exercise can help decrease (LDL) and increases
(HDL).
Treatment
 There are a number of treatment options for coronary
artery disease;
Lifestyle changes
Medical treatment- drugs (example.., cholesterol
lowering medications, beta-blockers, nitro-glycerine,
calcium channel blockers, etc)
Coronary interventions as angioplasty and coronary
tent.
Coronary artery bypass grafting (CABG).
Antiplatelet drugs such as aspirin.
Research
 Research efforts are focused on new angiogenic
treatment and various adult stem cell therapies.
 A region on chromosome 17 was confined to families
with multiple cases of myocardial infraction.
 Numerous clinical trials were performed, either
applying protein therapies or cell therapies using
different kinds of adult stem cell populations. Research
is still going on…..
 Myeloperoxidase has been proposed as a biomarker.
Thank you

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Ischaemic heart disease

  • 2. Coronary Heart Disease {CAD} The reduction of blood flow to the heart [Atherosclerosis] in the arteries of heart. It is the most common of the cardiovascular disease. Types includes stable angina, unstable angina, myocardial infraction and sudden cardiac death. Occasionally it may feel like heartburn.
  • 3. StableAngina  Characterised by central chest pain, discomfort or breathlessness that is precipitated by exertion or other forms of stress and is promptly relieved by rest.  Activities precipitating angina Physical exertion Cold exposure Heavy meals Intense emotion
  • 4. Pathophysiology  Limitation of blood flow to the heart causes ischemia (shortage of oxygen) and is called as myocardial infraction (commonly referred to as a heart attack).  It leads to damage, death, and eventual scarring of the heart muscle without regrowth of heart muscle cells.  The artery’s lining becomes hardened, stiffened and accumulates deposits of calcium, fatty lipids, and abnormal inflammatory cells – to form a plaque.  A more severe form is chronic total occlusion (CTO) when a coronary artery is completely obstructed for more than 3 months.
  • 5. Diagrammatic representation The other terms for this condition is hardening of the arteries and narrowing of the arteries.
  • 6. Symptoms  Pain in the cardinal  Prolonged cardiac pain: chest, throat, arms, epigastrium  Anxiety and fear of impending death  Nausea and vomiting  Pale skin  Leg swelling
  • 7. Risk factors  High blood pressure  Smoking  Diabetes  Lack of exercise  Obesity  High blood cholesterol  Poor diet  Depression  Excessive alcohol
  • 8. In 2015,CAD affected 110 million people andresulted in 8.9 million deaths.  The risk of CAD death decreased between 1980 and 2010, especially in developed countries.  In the United States in 2010, about 20% are above 65 have been affected by CAD while it was present in 7% of those 45 to 64 age groups, and 1.3% of those 18 to 45.  Rates were higher among men than women of a given age. It makes up 15.6% of all deaths, making it the most common cause of death globally.
  • 9. Prevention  Up to 90% of cardiovascular disease be preventable if established risk factors are avoided.  Prevention involves adequate physical exercise, decreasing obesity, treating high blood pressure, eating a healthy diet, decreasing cholesterol levels, and stop smoking.  Medications and exercise are roughly equally effective.  High levels of physical activity reduce the risk of coronary artery disease by about 25%.
  • 10. Secondary prevention  Weight control  Avoiding the consumption of trans fats  Decreasing psychosocial stress  Exercise  Aerobic exercise like walking, jogging, or swimming can reduce the risk of mortality from coronary artery disease.  Aerobic exercise can help decrease (LDL) and increases (HDL).
  • 11. Treatment  There are a number of treatment options for coronary artery disease; Lifestyle changes Medical treatment- drugs (example.., cholesterol lowering medications, beta-blockers, nitro-glycerine, calcium channel blockers, etc) Coronary interventions as angioplasty and coronary tent. Coronary artery bypass grafting (CABG). Antiplatelet drugs such as aspirin.
  • 12. Research  Research efforts are focused on new angiogenic treatment and various adult stem cell therapies.  A region on chromosome 17 was confined to families with multiple cases of myocardial infraction.  Numerous clinical trials were performed, either applying protein therapies or cell therapies using different kinds of adult stem cell populations. Research is still going on…..  Myeloperoxidase has been proposed as a biomarker.