1. IRCM: WHO ARE WE?

2. HISTORY
HISTORY
1952: Jacques Genest created the département de recherches cliniques
at the Hôtel-Dieu
1967: Jacques Genest founded the IRCM
2012: 36 research units

3. THE IRCM’S UNIQUENESS
THE IRCM’S UNIQUENESS
Multidisciplinary research approach
Training of the next generation of scientists
Performance-based job permanency
Affiliated to the Université de Montréal; Associated with McGill University
Clinic associated with CHUM

4. THE IRCM IN 2010
THE IRCM IN 2012
425 researchers, employees and students
Fundamental and clinical research
36 research units, grouped in 5 research programs
Board of Directors chaired by Louise Lambert-Lagacé
President and Scientific Director: Tarik Möröy

5. THE IRCM IN 2012

6. RESEARCH PROGRAMS
RESEARCH PROGRAMS
Systems biology and medicinal chemistry
Cancer
Immunity and viral infections
Cardiovascular and metabolic diseases
Neurobiology and development

7. SYSTEMS BIOLOGY AND MEDICINAL CHEMISTRY
SYSTEMS BIOLOGY AND MEDICINAL CHEMISTRY
Bioinformatics and Computational Genomics (Benjamin Haibe-Kains)
Ribonucleoprotein Biochemistry (Marlene Oeffinger)
Chemical Biology and Peptide Research (Peter W. Schiller)
RNA Biology (Éric Lécuyer)
Bio-organic Chemistry (Yvan Guindon)
Chromatin and Genomic Expression (François Robert)
Gene Transcription and Proteomics (Benoit Coulombe)
Molecular Virology (Jacques Archambault)

8. CANCER
CANCER
Endothelial Cell Biology (Jean-Philippe Gratton)
Mammary Cancer Biology (Katrina Podsypanina)
Cell Division and Centrosome Biology (William Y. Tsang)
Molecular Genetics and Development (Marie Trudel)
Hematopoiesis and Cancer (Tarik Möröy)
Cellular Interactions and Development (Jean Vacher)
Cytoskeletal Organization and Cell Migration (Jean-François Côté)

9. IMMUNITY AND VIRAL INFECTIONS
IMMUNITY AND VIRAL INFECTIONS
Molecular Biology (Paul Jolicœur)
Mechanisms of Genetic Diversity (Javier Marcelo Di Noia)
Molecular Oncology (André Veillette)
Molecular Immunology (Hua Gu)
Immune Regulation (Woong-Kyung Suh)
Human Retrovirology (Éric A. Cohen)

10. CARDIOVASCULAR AND METABOLIC DISEASES
CARDIOVASCULAR AND METABOLIC DISEASES (1/2)
Molecular Biochemistry of Hypertension (Timothy L. Reudelhuber)
Biochemical Neuroendocrinology (Nabil G. Seidah)
Experimental Cardiovascular Biology (Christian F. Deschepper)
Metabolic Diseases (Rémi Rabasa-Lhoret)
Cardiovascular Pharmacology (Pierre Larochelle)
Molecular Mechanisms of Diabetes (Jennifer Estall)

11. CARDIOVASCULAR AND METABOLIC DISEASES
CARDIOVASCULAR AND METABOLIC DISEASES (2/2)
Molecular Endocrinology (M. Ram Sairam)
Neuropeptide Structure and Metabolism (Claude Lazure)

12. NEUROBIOLOGY AND DEVELOPMENT
NEUROBIOLOGY AND DEVELOPMENT
Epithelial Cell Biology (David R. Hipfner)
Molecular Biology of Neural Development (Frédéric Charron)
Neural Circuit Development (Artur Kania)
Genetics and Development (Marie Kmita)
Molecular Genetics (Jacques Drouin)
Cellular Neurobiology (Michel Cayouette)
Neuroethics (Éric Racine)

13. CORE FACILITIES
CORE FACILITIES
Molecular Biology and Functional Genomics
DNA sequencing and genotyping
DNA chip reader (microarray)
Real-time PCR device
Alpha Imager 2000

14. ANIMAL FACILITIES
ANIMAL FACILITIES
38 employees (PSA, TSA and administration)
Animal Facility 1 - Conventional: 830 m2 in renovation – summer 2011
2,700 mouse cages
500 rats
48 rabbits
Animal Facility 2 - SPF: 1,100 m2
7,000 mouse cages
160 rat and Guinea pig cages
Animal Facility 3 – SPF+: 1,030 m2
5,000 mouse cages

15. TECHNOLOGY TRANSFER
TECHNOLOGY TRANSFER (since 1986)
80 technologies:
Chemical compounds
Chemical compound screening tools
Diagnostic tools
Biomedical devices
Animal models of human diseases
62 technologies were the subject of patent applications, and 30 were
issued patents
58 technologies are still active and/or under marketing analysis
38 technologies were part, at varying degrees, of a technology transfer
process

16. CANADA RESEARCH CHAIRHOLDERS
CANADA RESEARCH CHAIRHOLDERS
Éric A. Cohen : Chair in human retrovirology
Javier Marcelo Di Noia : Chair in genetic diversity
Jean-Philippe Gratton : Chair in endothelial cell functional signalling
Paul Jolioeur : Chair in studies of pathogenesis of retrovirus-induced
diseases
Marie Kmita : Chair in molecular embryology and genetics
Tarik Möröy : Chair in hematopoiesis and immune cell differentiation
Nabil G. Seidah : Chair in precursor proteolysis
André Veillette : Chair in immune system signalling

17. SCIENTIFIC PUBLICATIONS
SCIENTIFIC PUBLICATIONS (1967-2011)
6,728 scientific publications
An average of 198 publications per year since 1977
Articles in Cell, Circulation, Genes and Development, Nature, Nature
Immunology, Science, Neuron
83 books published since 1967