Brief Intro to the ENCODE project          Joe Betts-LaCroix
History1953          Watson & Crick discover structure of DNA1977          Sanger Sequencing1990 – 2001   Human Genome Pro...
$185 Million3 orders of magnitude < Apollo
Bad News: only 10% finished(81 years left?)
Good News: “imputation”
Bad News: So Much to do•   variations among people•   cell types within the body•   more experiment types•   distant inter...
More Good News:2003vs. 2012 (now)vs. 2021_
ENCODEcoding region, aka genes:1% of genomenon-coding ”Junk DNA”: 99% of genomeENCODE:• functions for 80% of genome• 70,00...
Consortia vs. ExperimentsGood:• 24 Standard experiment types• Standards for types of DNA and methods• results public• resu...
1961 – 1969$100 Billion (in 2010 dollars)
$185 Million3 orders of magnitude < Apollo
Joe Betts-LaCroix at Health Extension Salon #1
Joe Betts-LaCroix at Health Extension Salon #1
Joe Betts-LaCroix at Health Extension Salon #1
Upcoming SlideShare
Loading in …5
×

Joe Betts-LaCroix at Health Extension Salon #1

2,421 views

Published on

Joe briefly summarizes what the recently announced ENCODE Project is, and the meaning of its preliminary results.

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
2,421
On SlideShare
0
From Embeds
0
Number of Embeds
2,081
Actions
Shares
0
Downloads
0
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Joe Betts-LaCroix at Health Extension Salon #1

  1. 1. Brief Intro to the ENCODE project Joe Betts-LaCroix
  2. 2. History1953 Watson & Crick discover structure of DNA1977 Sanger Sequencing1990 – 2001 Human Genome Project2003 – 2012 ENCODE PROJECT
  3. 3. $185 Million3 orders of magnitude < Apollo
  4. 4. Bad News: only 10% finished(81 years left?)
  5. 5. Good News: “imputation”
  6. 6. Bad News: So Much to do• variations among people• cell types within the body• more experiment types• distant interactions
  7. 7. More Good News:2003vs. 2012 (now)vs. 2021_
  8. 8. ENCODEcoding region, aka genes:1% of genomenon-coding ”Junk DNA”: 99% of genomeENCODE:• functions for 80% of genome• 70,000 promoter regions• 400,000 enhancer regions
  9. 9. Consortia vs. ExperimentsGood:• 24 Standard experiment types• Standards for types of DNA and methods• results public• results organizedBad:• do wrong stuff (cell lines, HeLa 1960’s frankenstein)• delayed incorporation of new tech & discoveries
  10. 10. 1961 – 1969$100 Billion (in 2010 dollars)
  11. 11. $185 Million3 orders of magnitude < Apollo

×