Knowledge about the faradic current and its physiological effects,indications and its contraindication and the methods of the application of the faradic current,motor point stimulation and its benefit used in physiotherapy
Iontophoresis is a process of transdermal drug delivery by use of a voltage gradient on the skin. Molecules are transported across the stratum corneum by electrophoresis and electroosmosis and the electric field can also increase the permeability of the skin.
The History of SWD
Production, Generation, Method of Application, Patient Preparation, Physiologcal and therapeutic effects, Indications, Contraindications daners of SWD, and Evidence Based Practice.
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This lecture intends to provide general outline about the uses, parameters, precautions and contraindications of interferential current for undergraduate physiotherapy students at Kathmandu University School of Medical Sciences, Nepal. After the lecture, students will explore the evidences about current practices on the uses of IFT in various musculoskeletal pain conditions, critically appraise them and present the evidences to the class.
Knowledge about the faradic current and its physiological effects,indications and its contraindication and the methods of the application of the faradic current,motor point stimulation and its benefit used in physiotherapy
Iontophoresis is a process of transdermal drug delivery by use of a voltage gradient on the skin. Molecules are transported across the stratum corneum by electrophoresis and electroosmosis and the electric field can also increase the permeability of the skin.
The History of SWD
Production, Generation, Method of Application, Patient Preparation, Physiologcal and therapeutic effects, Indications, Contraindications daners of SWD, and Evidence Based Practice.
Interferential Current or therapy for Physiotherapy studentsSaurab Sharma
This lecture intends to provide general outline about the uses, parameters, precautions and contraindications of interferential current for undergraduate physiotherapy students at Kathmandu University School of Medical Sciences, Nepal. After the lecture, students will explore the evidences about current practices on the uses of IFT in various musculoskeletal pain conditions, critically appraise them and present the evidences to the class.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
it is consist osmotic drug delivery system. and its new approaches. its advantage & disadvantage.. principle. etc
and basic camponents and osmotic pump......
IONTOPHORESIS
INTRODUCTION
• Iontophoresis is the introduction of ionized medications into the subcutaneous tissues using a low-voltage DC.
• The amount of medication entering the tissues is based on the current density and the duration of the treatment.
• The medication types most commonly used for iontophoresis include anesthetics, analgesics, and anti-inflammatory agents.
• Iontophoresis is based on the principle that like charges repel, and that therefore a fixed charge electrode on the skin can promote the movement of charged ions of a drug through the skin by “pushing” them away.
• Based on the ionic reaction between the positive and negative poles of the generator, ionized medication molecules travel along the lines of force created by the current.
• At the positive electrode, positive ions are driven through the skin; negative ions are introduced through the skin using the negative pole.
• Iontophoresis has been shown to deliver the medication to depths of 6 to 20 mm below the skin.
• Iontophoresis can provide advantages over oral delivery, nasal delivery and over injections.
• For an electrical current to facilitate transdermal drug penetration, the current must be at least sufficient to overcome the combined resistance of the skin and the electrode being used.
• Studies have shown effective drug delivery with 40 to 80 mA-min treatments.
• To promote continuous delivery of the ionized drug, a direct current must be used for iontophoresis.
PARAMETERS
• Electrode Placement and Size- For iontophoresis, the drug delivery electrode is placed over the area of pathology.
• Polarity- For iontophoresis, the drug delivery electrode should have the same polarity as the active ion of the drug to be delivered.
• Current Amplitude- For iontophoresis, the amplitude should be determined by patient comfort and should be no greater than 4 mA.
• Treatment Time- For iontophoresis, the treatment time is affected by the current amplitude and should be adjusted to produce a total treatment dose of 40 to 80 mA-min, which is achieved by setting the amplitude to patient comfort and then setting, or having the device select, the treatment time to achieve the desired treatment dose
PHYSIOLOGICAL EFFECTS
• Ion penetration
• Acid/ alkaline reaction
• Hyperaemia
• Dissociation
THERAPEUTIC EFFECTS
• Local analgesia
• Relief of idiopathic hyperhidrosis
• Application of antibiotics
• Application of anti inflammatory drugs
• Neurogenic pain
• Oedema relief
• Ischemic ulcer
• Scar mobilization
INDICATIONS
• Acute inflammation
• Chronic inflammation
• Arthritis
• Myositis ossificans
• Myofascial pain syndromes
• As a vehicle for delivering local anaesthetics before injection or other minor invasive procedures
• Hyperhidrosis
CONTRAINDICATIONS
• Artificial pacemaker
• Unconscious patient
• Area of venous thrombosis
• Pregnancy
• Malignancy
• Infected wound
• Hemorrhage
INTRODUCTION, DEFINATION OF ELECTROPHORESIS, ELECTROPHORESIS PRINCIPLE, TYPES OF ELECTROPHORESIS, FREE ELECTROPHORESIS, ZONE ELECTROPHORESIS,PAPER ELECTROPHORESIS, WORKING OF PAPER ELECTROPHORESIS, PROCEDURE FOR PAPER ELECTROPHORESIS, VISUALISATION, FACTORS AFFECTING SEPARATION OF MOLECULES, APPLICATIONS, working of paper electrophoresis ,procedure for paper electrophoresis ,visualisation ,factors affecting separation of molecules ,applications ,forensics ,dna fingerprinting ,molecular biology ,microbiology information about the organisms ,biochemistry mapping of cellular components ,paper electrophoresis is also used in study of sic ,hemoglobin abnormalities ,separation of blood clotting factors ,serum plasma proteins from blood sample ,used in separation and identification of alkaloids ,used for testing water samples ,toxicity of water ,drug industry to determine presence of illelgal drUGS
biosensor, modern, principles, technology, applications, working of sensor, types of sensor , nanomaterial, based biosensor(nanosensor) optical biosensor, flourescent biosensor, electrochemical and glucose biosensor, genetically encoded biosensor, microbial biosensor, cancer , references included, advantages and disadvantages also included.
It contains 2-3 acetyl groups per glucose unit and its adsorption capacity is less than that of paper.
It gives sharper bands.
Provides a good background for staining glycoproteins.
ADVANTAGE:
No tailing of proteins or hydrophilic materials.
Available in wide range of particle size and layer thickness.
Give sharp bands and offer good resolution.
High voltage can be applied which will enhance the resolution.
Electrophoresis is the movement of charged particles through an electrode when subjected to an electric Field
Cations move towards cathode
Anions move towards anode
By this technique solutes are separated by their different rates of travel through an electric field.
Commonly used in biological analysis, particularly in the separations of proteins, peptides and nucleic acids
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27. List of Drugs Investigated Recently for Iontophoretic Delivery
28. Applications Inflammation With Constant Pain (Red, Hot, and Swollen ) Dexamethasone Sodium Phosphate 0.4% (negative polarity) delivered from the cathode for 3 treatments per week for 2-4 weeks. Diclofenac 5% (negative polarity) delivered from the cathode for 3 treatments per week for 2-4 weeks. Ketoprofen 10% (negative polarity) delivered from the cathode for 3-5 treatments per week for 2-6 weeks. Lidocaine Hydrochloride 4% (positive polarity) delivered from the anode for 3-5 treatments per week for 2 weeks.