Ion c .ppt
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This presentation is on ion channels..I've used GIF formats to illustrate the working...plus i've related ion channels to that of a capacitor..!
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Bio 189 cell_membranes_and_signaling_spr
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brush border on luminal (apical) side.
Brush border contains protein carrier molecules to transport Na+ by co-transport mechanism with other substances (a.acids, glucose etc).
Additional sodium is transported by COUNTER-TRANSPORT that reabsorb sodium while secreting hydrogen.
About 65 % of filtered load of Na+ & water is reabsorbed in PCT.
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In 1st half of PC tubules, Na+ is re-absorbed by co-transport along with glucose, a.acids and other solutes.
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Ion channels.ppt
Ion channels are transmembrane proteins that regulate the voltage gradient across the plasma membrane by allowing ions to diffuse through pores down their electrochemical gradients. There are four main types of gating that control ion channels: ligand gating, phosphorylation, voltage gating, and mechanical gating. The sodium-potassium pump actively transports ions against their gradients in order to maintain the ion concentrations inside and outside the cell. Ion channels are crucial for electrical signaling in the nervous system, controlling the release of neurotransmitters and hormones, and transferring small molecules between cells through gap junctions.
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Ion c .ppt
- 1. ION CHANNELS Presented By- Ashutosh Tambare Ashwin kolhatkar Jayti saparia Kriti Katyayan Raghuramreddy Rajan Pandey
- 2. OUTLINE • Whatareionchannels? • Channelstructure • TypesofGatinginIonChannels • Thesodium-potassiumpump • Workingofionchannels • Importanceofionchannels
- 4. WHY DO WE NEED THEM??? IonsCannotDiffuseAcrosstheHydrophobic BarrieroftheLipidBilayer.
- 5. Structure???
- 6. Types of Gating in Ion Channels There are Four Types of Gating Controls - 1. Ligand Gating 2. Phosphorylation
- 8. TheSodium-PotassiumPump Extracellular fluidwithhigh concentration ofNa+ Cytoplasm withhigh concentration ofK+ 1 ThreeNa+ bind tothe cytoplasmicside of theprotein. 2 Phosphateis transferredfrom ATPtotheprotein. 3 Phosphorylation changesthe shapeofthe protein,moving Na+ acrossthe membrane. 4 K+ bindsto theprotein,causing phosphate release. 5 Releaseof phosphate changesthe shapeofthe protein, movingK+ to thecytoplasm. Na+ ATP ADP P Na+ P K+ P K+
- 10. + + + + - - - - Vm = Q/C ∆Vm = ∆Q/C THELIPIDBILAYERACTSLIKEACAPACITOR ∆Qmustchangebefore ∆Vm canchange
- 12. IMPORTANCEOFIONCHANNELS • Mediatethegeneration,conductionandtransmissionofelectrical signalsinthenervoussystem • Controlthereleaseofneurotransmittersandhormones • Transfersmallmoleculesbetweencells(gapjunctions)
- 13. THANK YOU
Editor's Notes
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