This document discusses how to evaluate clinical and scientific studies on non-caloric sweeteners. It outlines several key points to consider when assessing different types of studies, such as whether they were published in peer-reviewed literature, who authored them, and potential flaws in study design. The document concludes that well-conducted clinical studies have shown non-caloric sweeteners do not promote weight gain and can aid in weight loss. It also determines aspartame does not cause cancer based on the majority of preclinical studies and large epidemiological studies finding no association.
Simple Weight Loss Recipes
How You Can Safely and Naturally END Your Weight Issues WITHOUT Expensive Trips to the Doctor, Potentially Toxic Prescriptions, or Dangerous Side Effects.
http://rapbank.com/go/5254/75255/simple-weight-loss-recipes.html
Globally 165 million children under-five
years of age are stunted. Hence development of local
therapeutic nutritional intervention is recommended by WHO.
Present study was designed to find the efficacy of the
nutritional intervention for the recovery of impaired lipid
metabolism and correlation of weight for height% with
cholesterol, triglyceride in malnourished children. 105 test and
100 control SAM children without infection, of 1 to 5 years of
age and either sex were enrolled. Test group was given
treatment of nutritional intervention therapy, providing 2.5 to
3gm Protein and 90-100 kcal /kg body Weight/day, for the
three months. Their Anthropometric, and Biochemical
parameters were measured before and after the nutritional
therapy. Before the nutritional intervention treatment P values
for Serum Total cholesterol, Triglyceride, Weight for height
%, were insignificant suggestive of similar baseline
characteristics at enrollment. After nutritional intervention
treatment P values for Serum Total cholesterol, Triglyceride,
Weight for height % were highly significant. The r value of
Pearson correlation coefficient for triglycerides in the study
group and its ANOVA model was very significant, showing
poor positive correlation with weight for height % while for
total cholesterol it was found to be insignificant. Depending on
results we conclude that it is the most effective food supplement
for the speedy recovery of the impaired lipid metabolism in
SAM children and the use of weight for height % as a
anthropometric marker for the pre-indication of fatty liver in
malnourished children
Adequacy of Enteral Nutritional Therapy Offered to Patients in an Intensive C...asclepiuspdfs
Introduction: Malnutrition is a common framework in hospitalized patients. Enteral nutritional therapy (ENT) is the most commonly used strategy to treat malnutrition. However, complications related to ENT can make it impossible to reach the nutritional requirements of the patient. Objectives: The objectives of the study are to evaluate the nutritional status of patients receiving exclusive ENT and to assess the adequacy of ENT in an intensive care unit (ICU). Materials and Methods: Retrospective study conducted in an ICU of a private hospital in Cuiabá/MT/Brazil between 2015 and 2016. The sample consisted of 115 patients >18 years of age in exclusive ENT. The nutritional status was evaluated using anthropometric, clinical, dietary, and biochemical measurements, and it was categorized by the subjective global assessment. The calorie and protein requirements were calculated according to the hospital protocol
Simple Weight Loss Recipes
How You Can Safely and Naturally END Your Weight Issues WITHOUT Expensive Trips to the Doctor, Potentially Toxic Prescriptions, or Dangerous Side Effects.
http://rapbank.com/go/5254/75255/simple-weight-loss-recipes.html
Globally 165 million children under-five
years of age are stunted. Hence development of local
therapeutic nutritional intervention is recommended by WHO.
Present study was designed to find the efficacy of the
nutritional intervention for the recovery of impaired lipid
metabolism and correlation of weight for height% with
cholesterol, triglyceride in malnourished children. 105 test and
100 control SAM children without infection, of 1 to 5 years of
age and either sex were enrolled. Test group was given
treatment of nutritional intervention therapy, providing 2.5 to
3gm Protein and 90-100 kcal /kg body Weight/day, for the
three months. Their Anthropometric, and Biochemical
parameters were measured before and after the nutritional
therapy. Before the nutritional intervention treatment P values
for Serum Total cholesterol, Triglyceride, Weight for height
%, were insignificant suggestive of similar baseline
characteristics at enrollment. After nutritional intervention
treatment P values for Serum Total cholesterol, Triglyceride,
Weight for height % were highly significant. The r value of
Pearson correlation coefficient for triglycerides in the study
group and its ANOVA model was very significant, showing
poor positive correlation with weight for height % while for
total cholesterol it was found to be insignificant. Depending on
results we conclude that it is the most effective food supplement
for the speedy recovery of the impaired lipid metabolism in
SAM children and the use of weight for height % as a
anthropometric marker for the pre-indication of fatty liver in
malnourished children
Adequacy of Enteral Nutritional Therapy Offered to Patients in an Intensive C...asclepiuspdfs
Introduction: Malnutrition is a common framework in hospitalized patients. Enteral nutritional therapy (ENT) is the most commonly used strategy to treat malnutrition. However, complications related to ENT can make it impossible to reach the nutritional requirements of the patient. Objectives: The objectives of the study are to evaluate the nutritional status of patients receiving exclusive ENT and to assess the adequacy of ENT in an intensive care unit (ICU). Materials and Methods: Retrospective study conducted in an ICU of a private hospital in Cuiabá/MT/Brazil between 2015 and 2016. The sample consisted of 115 patients >18 years of age in exclusive ENT. The nutritional status was evaluated using anthropometric, clinical, dietary, and biochemical measurements, and it was categorized by the subjective global assessment. The calorie and protein requirements were calculated according to the hospital protocol
Association between-stress-and-dietary-behaviours-among-undergraduate-student...Annex Publishers
Background: Studies have shown that a significant proportion of university students globally suffer from stress. Although many studies have reported an association between psychological stress and dietary behaviour, findings remain inconclusive. To date, no research in Kuwait has assessed the prevalence of stress and its relationship with dietary pattern among university students.
Objectives: This study was designed to determine the extent of stress among undergraduate students in Kuwait University and to examine the relationship between dietary behaviours and stress.
Methods: A total of 407 (164 males and 243 females) undergraduate students, aged ≥ 18 years, from 4 colleges of Kuwait University participated in this cross sectional study. Data were collected using a self-administered questionnaire consisting of three sections: socio demographic information, stress measures and a 7-day food frequency questionnaire.
Results: Of the total participants, 43% were found to suffer from some level of stress, with slightly more females (44%) than males (40.9%). When examined the severity of stress level, 28.4% of the females and 22% of the males had moderate to severe form of stress. Stressed female students were more likely to eat fast foods (OR 1.75; 95% CI: 1.02-3:00), snacks (OR 2.0; 95% CI: 1.16-3:43) and beverages (OR 2.28; 95% CI: 1.30-3.98) than unstressed female students. For male students, none of the food consumption groups were associated with stress.
Conclusions: These results show a clear difference in food selection patterns between stressed male and female students with stress being strongly associated with unhealthy food selection among female students than male students. These findings emphasize the importance for the development of specific intervention programs to decrease stress and improve healthy behaviour especially among female university students and thus reduce the potential negative implications of stress on health.
Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
Does physical-activity-and-sport-practice-lead-to-a-healthier-lifestyle-and-e...Annex Publishers
The prevalence of childhood obesity has been increasing rapidly and there is general consensus that good nutritional practices and physical activity should be encouraged as early as possible in life. The aim of this study was to describe and to compare the current lifestyle and dietary pattern of normal weight (NW) and overweight + obese (OW+OB) male adolescents who are physically active.
Methods: This observational and retrospective study was based on clinical records analysis of male adolescents aged 11-18 years who had undergone a medical evaluation at a Medical Sport Centre (Pavia, Italy) during 2009, and had filled in a self-administered life style questionnaire.
Results: The results showed that out of 1423 clinical records 23.0% of subjects were OW, 5.4% OB and 71.6% NW. We invited all the overweight and obese subjects to participate in the study, 308 of them (75.8%) agreed. Then we randomly enrolled an equivalent number of NW participants (n=308) in the medical evaluation at the sports center with similar characteristics as for socio-economic status, physical activity and age for a whole sample of 616 subjects. We handled them a validated lifestyle questionnaire. The questionnaire analysis was used to compare OW+OB and NW participants, as far as eating habits, sedentary activities and time spent in sports. All the subjects frequently skipped breakfast, did not consume fruit and vegetables daily and had a high soft drinks intake. Inverse correlations were found between weight and physical activity (p=0.01). Sedentary activities were preferred by about 25% and 66 % of the NW and OW+OB groups respectively. The percentage of smokers was similar within the two groups (14%).
Conclusions: Adolescents eating habits are incorrect, despite BMI and sports practice. Sports practice seems contributing to lower spare time physical inactivity, but does not improve eating habits. Public health interventions should focus on the reinforcement of leisure time physical activity, besides nutrition education and behavioral education programs in order to prevent obesity in the adulthood.
Dietary Strategies for Weight Loss MaintenanceMARKETDIGITALBN
Weight regain after a successful weight loss intervention is very common. Most studies
show that, on average, the weight loss attained during a weight loss intervention period is not
or is not fully maintained during follow-up. We review what is currently known about dietary
strategies for weight loss maintenance, focusing on nutrient composition by means of a systematic
review and meta-analysis of studies and discuss other potential strategies that have not been studied
so far. Twenty-one studies with 2875 participants who were overweight or obese are included in
this systematic review and meta-analysis
PATIENT-GENERATED SUBJECTIVE GLOBAL ASSESSMENT (PG-SGA): A REVIEW Neeleshkumar Maurya
The present investigation, Subjective Global Assessment (SGA) and its different variants are being widely used as a nutritional status or risk assessment tool in clinical and hospital practice for myriads of disease including life-threatening one such as cancer, chronic kidney diseases. SGA is based on measurement and observation of several parameters such as weight change, dietary intake change, gastrointestinal symptoms, functional capacity, co morbidities related to nutritional condition and physical examination. However, the tool is not devoid of limitation and is being constantly improved for the optimization of its use in various other diseases. Therefore, clinicians need an easy to use and interpret, low cost, reliable tool to assess nutritional status. The PG-SGA is a more sensitive tool than other versions of SGA and is successfully being used as a screening tool in diseases like cancer, tuberculosis, HIV and chronic kidney disease (CKD) etc. According to the theory of “reverse epidemiology”, a patient with better nutritional status is supposed to have increased scope of survival. Therefore, it is increasingly being used patients who are at the pre-dialysis stage or being treated with dialysis. The review will summarize the basics of the nutritional assessment tool, its indications, and limitation of use in clinical practice etc. Moreover, the review will summarize the recommendations for use of PG-SGA in CKD and a brief review of existing literature to understand the scope of use and future perspective of the application of this tool for using in CKD patient population. Key Words: SGA, PG-SGA, Chronic kidney disease, Dialysis, nutrition
Highlights on the EFSA Opinion on the appropriate age range for introduction ...EFSA EU
FENS 2019 - Dublin
Highlights on the EFSA Scientific Opinion on the appropriate age range for introduction of complementary feeding into an infant's diet, Prof M Fewtrell
Association between-stress-and-dietary-behaviours-among-undergraduate-student...Annex Publishers
Background: Studies have shown that a significant proportion of university students globally suffer from stress. Although many studies have reported an association between psychological stress and dietary behaviour, findings remain inconclusive. To date, no research in Kuwait has assessed the prevalence of stress and its relationship with dietary pattern among university students.
Objectives: This study was designed to determine the extent of stress among undergraduate students in Kuwait University and to examine the relationship between dietary behaviours and stress.
Methods: A total of 407 (164 males and 243 females) undergraduate students, aged ≥ 18 years, from 4 colleges of Kuwait University participated in this cross sectional study. Data were collected using a self-administered questionnaire consisting of three sections: socio demographic information, stress measures and a 7-day food frequency questionnaire.
Results: Of the total participants, 43% were found to suffer from some level of stress, with slightly more females (44%) than males (40.9%). When examined the severity of stress level, 28.4% of the females and 22% of the males had moderate to severe form of stress. Stressed female students were more likely to eat fast foods (OR 1.75; 95% CI: 1.02-3:00), snacks (OR 2.0; 95% CI: 1.16-3:43) and beverages (OR 2.28; 95% CI: 1.30-3.98) than unstressed female students. For male students, none of the food consumption groups were associated with stress.
Conclusions: These results show a clear difference in food selection patterns between stressed male and female students with stress being strongly associated with unhealthy food selection among female students than male students. These findings emphasize the importance for the development of specific intervention programs to decrease stress and improve healthy behaviour especially among female university students and thus reduce the potential negative implications of stress on health.
Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
Does physical-activity-and-sport-practice-lead-to-a-healthier-lifestyle-and-e...Annex Publishers
The prevalence of childhood obesity has been increasing rapidly and there is general consensus that good nutritional practices and physical activity should be encouraged as early as possible in life. The aim of this study was to describe and to compare the current lifestyle and dietary pattern of normal weight (NW) and overweight + obese (OW+OB) male adolescents who are physically active.
Methods: This observational and retrospective study was based on clinical records analysis of male adolescents aged 11-18 years who had undergone a medical evaluation at a Medical Sport Centre (Pavia, Italy) during 2009, and had filled in a self-administered life style questionnaire.
Results: The results showed that out of 1423 clinical records 23.0% of subjects were OW, 5.4% OB and 71.6% NW. We invited all the overweight and obese subjects to participate in the study, 308 of them (75.8%) agreed. Then we randomly enrolled an equivalent number of NW participants (n=308) in the medical evaluation at the sports center with similar characteristics as for socio-economic status, physical activity and age for a whole sample of 616 subjects. We handled them a validated lifestyle questionnaire. The questionnaire analysis was used to compare OW+OB and NW participants, as far as eating habits, sedentary activities and time spent in sports. All the subjects frequently skipped breakfast, did not consume fruit and vegetables daily and had a high soft drinks intake. Inverse correlations were found between weight and physical activity (p=0.01). Sedentary activities were preferred by about 25% and 66 % of the NW and OW+OB groups respectively. The percentage of smokers was similar within the two groups (14%).
Conclusions: Adolescents eating habits are incorrect, despite BMI and sports practice. Sports practice seems contributing to lower spare time physical inactivity, but does not improve eating habits. Public health interventions should focus on the reinforcement of leisure time physical activity, besides nutrition education and behavioral education programs in order to prevent obesity in the adulthood.
Dietary Strategies for Weight Loss MaintenanceMARKETDIGITALBN
Weight regain after a successful weight loss intervention is very common. Most studies
show that, on average, the weight loss attained during a weight loss intervention period is not
or is not fully maintained during follow-up. We review what is currently known about dietary
strategies for weight loss maintenance, focusing on nutrient composition by means of a systematic
review and meta-analysis of studies and discuss other potential strategies that have not been studied
so far. Twenty-one studies with 2875 participants who were overweight or obese are included in
this systematic review and meta-analysis
PATIENT-GENERATED SUBJECTIVE GLOBAL ASSESSMENT (PG-SGA): A REVIEW Neeleshkumar Maurya
The present investigation, Subjective Global Assessment (SGA) and its different variants are being widely used as a nutritional status or risk assessment tool in clinical and hospital practice for myriads of disease including life-threatening one such as cancer, chronic kidney diseases. SGA is based on measurement and observation of several parameters such as weight change, dietary intake change, gastrointestinal symptoms, functional capacity, co morbidities related to nutritional condition and physical examination. However, the tool is not devoid of limitation and is being constantly improved for the optimization of its use in various other diseases. Therefore, clinicians need an easy to use and interpret, low cost, reliable tool to assess nutritional status. The PG-SGA is a more sensitive tool than other versions of SGA and is successfully being used as a screening tool in diseases like cancer, tuberculosis, HIV and chronic kidney disease (CKD) etc. According to the theory of “reverse epidemiology”, a patient with better nutritional status is supposed to have increased scope of survival. Therefore, it is increasingly being used patients who are at the pre-dialysis stage or being treated with dialysis. The review will summarize the basics of the nutritional assessment tool, its indications, and limitation of use in clinical practice etc. Moreover, the review will summarize the recommendations for use of PG-SGA in CKD and a brief review of existing literature to understand the scope of use and future perspective of the application of this tool for using in CKD patient population. Key Words: SGA, PG-SGA, Chronic kidney disease, Dialysis, nutrition
Highlights on the EFSA Opinion on the appropriate age range for introduction ...EFSA EU
FENS 2019 - Dublin
Highlights on the EFSA Scientific Opinion on the appropriate age range for introduction of complementary feeding into an infant's diet, Prof M Fewtrell
Under nutrition is often an invisible and silent
emergency.2 It recognizes that hunger and malnutrition are rooted
in poverty, deprivation, and under development, and that they are
the result of inadequate access to the basic requirements for
nutritional well-being, including safe and adequate food, care,
health, education and a clean environment.1 Present study was
designed to find the efficacy of the nutritional intervention for the
recovery of impaired carbohydrate metabolism and correlation of
weight and height with PP-Sugar and BMI after nutritional
rehabilitation.105 test and 100 control SAM children without
infection, of 1 to 5 years of age and either sex were enrolled. Test
group was given treatment of nutritional intervention therapy,
providing 2.5 to 3gm Protein and 90-100 kcal / kg body
Weight/day, for the three months.
Their blood sugar, BMI, weight and height were measured before
and after the nutritional therapy. Before the nutritional
intervention treatment P values for F and PP blood glucose, BMI,
Weight and height were insignificant suggestive of similar baseline
characteristics at enrollment. After nutritional intervention
treatment P values for F and PP blood glucose, BMI, Weight and
height were significant suggestive.
The r value of Pearson correlation coefficient for Sugar PP in the
study group was, showing poor positive correlation with height and
r value for BMI in the study group was showing poor negative
correlation with height.
The r value of Pearson correlation coefficient for Sugar PP in the
study group was, showing poor negative correlation with weight
and r value for BMI in the study group was showing poor positive
correlation with weight.
Depending on results the investigators conclude that for the speedy
recovery of the impaired carbohydrate metabolism in SAM
children it is the most effective food supplement.
Works Cited Milne, Anne C., Alison Avenell, and Jan Potter. Meta-.docxkeilenettie
Works Cited
Milne, Anne C., Alison Avenell, and Jan Potter. "Meta-Analysis: Protein and Energy Supplementation in Older People."
Annals of Internal Medicine
144.1 (2006): 37-48.
ProQuest.
Web. 1 Oct. 2014.
Meta-Analysis: Protein and Energy Supplementation in Older People Anne C. Milne, MSc; Alison Avenell, MD; and Jan Potter, MBChB Background: Protein and energy undernutrition is common in older people, and further deterioration may occur during illness. Purpose: To assess whether oral protein and energy supplementa tion improves clinical and
nutritional outcomes for older people in the hospital, in an institution, or in the community. Data Sources: Cochrane Central Register of Controlled Trials (CEN TRAL), MEDLINE, EMBASE,
HealthStar, CINAHL, BIOSIS, and CAB abstracts. The authors included English- and non-English-language studies and hand-searched journals, contacted manufacturers, and sought information from trialists. The date of the most recent search of CENTRAL and MEDLINE is June 2005. Study Selection: Randomized and quasi-randomized controlled tri als of oral protein and energy
supplementation compared with placebo or control treatment in older people. Data Extraction: Two reviewers independently assessed trials for inclusion, extracted data, and assessed trial quality. Differences were resolved by consensus. Data Synthesis: Fifty-five trials were included (n = 9187 randomly tions (Peto odds ratio, 0.72 [95% Cl, 0.53 to 0.97]) and reduced mortality (Peto odds ratio, 0.66 [CI, 0.49 to 0.90]) for those un dernourished at baseline. Few studies reported evidence that suggested any change in mortality, morbidity, or function for those given supplements at home. Ten trials reported gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, with oral supplements. Limitations: The quality of most studies, as reported, was poor, particularly for concealment of allocation and blinding of outcome assessors. Many studies were too small or the follow-up time was too short to detect a statistically significant change in clinical out come. The clinical results are dominated by 1 very large recent trial in patients with stroke. Although this was a high-quality trial, few participants were undernourished at baseline. Conclusions: Oral nutritional supplements can improve nutritional status and seem to reduce mortality and complications for under nourished elderly patients in the hospital. Current evidence does not support routine supplementation for older people at home or for well-nourished older patients in any setting. assigned participants). For patients in short-term care hospitals who were given oral supplements, evidence suggested fewer complica-Ann Intern Med. 2006:144:37-48. For author affiliations, see end of text.
www.annals.OIJ
ndernutrition among older people is a continuing source of concern (1, 2). Older people have longer periods of illness and longer hospital stays (3), and data show tha.
This is about a review study which focused on nearly 2,215 articles pertaining to organic food and its health aspects.. This study was done only on Pubmed database. This study gives a consolidated knowledge about those 2,215 articles done in Pubmed database. Any number of queries & doubts are gladly welcomed. :)
WCRF International Continuous Update Project (CUP). Presentation given by Giota Mitrou PhD MSc, Head of Research Funding and Science Activities, World Cancer Research Fund International (WCRF International).
Examples of Nutrition ClaimsClaims about a popular diet BetseyCalderon89
Examples of Nutrition Claims
Claims about a popular diet that is supposed to change your body, reverse a disease, or dramatically improve your health or performance in some way.
Claims about a particular food, beverage or dietary supplement that is supposed to help you lose weight, gain muscle, boost immunity, improve mood or memory, lower blood cholesterol or blood sugar levels, fight inflammation, remove toxins, prevent or cure a disease, make your hair/nails/skin/digestion better, slow aging…
Claims about a particular ingredient in foods/beverages that’s supposed to be “bad,” “toxic,” or contribute to a particular health problem (acne, autism, ADHD, PCOS, diabetes, cancer, Alzheimer’s disease, aging, hormone disruption, infertility, obesity, digestive problems)…
Sources of Nutrition Claims
Google!
Magazines, Newspapers, Blogs
Books, Videos, Documentaries
Advertisements, Social Media Influencers
Product label, brochure, website
Scientific peer-reviewed journals
How to choose a claim…
Examples:
Magazine article or blog claiming Intermittent fasting or whole 30 or keto is the answer to weight loss. Vitamin D/C/zinc and COVID19.
LA Times article reporting on a new study that shows chocolate or red wine protects the heart (in time for Valentine’s Day)
Book or Youtube video that claims sugar or wheat or gluten is toxic
Documentary that claims plant-based diet best for performance (The Game Changers)
Advertisement about new dietary supplement or “cleanse” for brain health, skin health, digestive health (turmeric, collagen, probiotics, spirulina, apple cider vinegar)
Website bodybuilding.com claiming need certain amount/type of protein to get huge muscles. Or no soy/no dairy for PCOS or fertility.
2
Evaluating Nutrition Research & Claims
Is the source credible & unbiased?
Author/credentials
“Nutritionists” vs. “Registered Dietitians” – what’s the difference?
Self-proclaimed guru, fitness trainer, massage therapist, store clerk
MDs, DCs, PhDs – are they always reliable?
Is there any conflict of interest? Are they trying to sell you something?
Publication source
Internet site (.com or .org, .edu, .gov)
Magazine, newsletter, brochure, trade journal (paid advertising)
Peer-reviewed, professional/scientific journal
Most “nutritionists” have little to no formal education/degree (e.g. famous people, fitness trainer/massage therapist/GNC or health food store clerk). Some “nutritionists” do have a high level of education/degree, but they may or may not be highly educated in nutrition
Conflict of interest – Juice plus, herbal life, arbonne sales rep directly trying to sell you something or researcher/author/speaker could be employed/paid by the company trying to sell something (funded by beef/dairy council)
Example of ephedra article in fitness magazine, local SCV magazines
3
Evaluating Nutrition Research & Claims
How good is the research?
Study design
No systematic method at all
testimonials, anecdotal, before/after
Epidemiolo ...
The effects of reduce and eliminate appeals on individual meat consumptionNew Food Innovation Ltd
In this study its was shown that even simple reduce and eliminate meat appeals in the form of news articles can lead to a significant reduction in individuals meat consumption five week later
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. How to evaluate clinical and scientific studies on non-caloric sweeteners Bernadene Magnuson, PhD, FATS University of Toronto, Canada
3. Introduction Hundreds of studies and reports have been published on non-caloric sweeteners. Yet, is still controversial topic! Regulatory agencies approve safety-
4. Introduction Yet, many websites and articles claim that sweeteners are associated with a wide variety of potential adverse effects and should be avoided.
5. Introduction How can we determine what to believe? How can we explain the different opinions? What advice to give patients, family, friends?
6. Outline Overview of approaches to evaluation of studies Preclinical studies, clinical studies, reviews Examples Sweeteners and weight loss/gain? Aspartame and cancer? Conclusions
7. Critical points to consider What type of study and how conducted? Will discuss in detail in next slides Was the study/report published in peer-reviewed literature? Recent conference presentation on soft drinks and obesity widely publicized but never published reports on websites and media not reviewed by scientists What are the credentials of the author(s)?
9. Methods for assessing reliability of scientific reports Toxicology studies ToxRtool (Schneider et al., 2009, Toxicology Letters) Clinical studies Institute for Clinical Systems Improvement( ICSI) 2003 American Dietetic Association – Evidence Analysis
10. Assessing preclinical studies If using cells or cell material (enyzmes), consider: Are simplified, isolated systems Effect of digestion and absorption? I.e. Aspartame is completely digested to amino acids and methanol, which is rapidly metabolized to CO2; Direct addition of aspartame to cells? – never occurs in human Concentration – how compares to amount from diet? Response of cells – is effect within the normal range? What is the control treatment?
11. Assessing preclinical studies If using animals, consider: Dose given orally? added to diet? Number of doses? Diet defined composition? nutritionally adequate? stability and consistency? Animals background historical incidence of disease health of animals Methods Appropriate protocols?
12. Interpretation of results Evidence of dose response? If at high dose only, due to inflammation or metabolic overload? Is dose relevant to human exposures? Increase over historical controls? Is tumor type relevant to humans? i.e. forestomach tumors Is mechanism relevant to humans? i.e. formaldehyde and nasal tumors in rats ToxRTool - to assess the reliability of toxicological data. Schneider et al., 2009, available online
19. Primary Study Considerations Were inclusion/exclusion criteria clearly stated? Adhered to? Any question of bias introduced in the study ? Does report show statistically significant but clinically insignificant effect? Or lack power? Too small sample size? Are the results generalizable to other populations? Any traits of a poorly-designed study? Examples: treatment and control groups different at baseline, low compliance with the intervention, important outcomes not measured, inappropriate statistics for study design. (www.icsi.com)
20. Secondary Report Considerations Was search for primary studies comprehensive and current? Were clear criteria given for inclusion/exclusion of studies? Was quality of the articles assessed and reported? If a meta-analysis was done, was homogeneity assessed? If no meta-analysis was done, did the authors state why not? Was there at least a narrative synthesis of primary studies? Are studies in review generalizable to target population? Are conclusions valid (i.e., based on primary evidence)? (www.icsi.com)
22. Body weight changes in rats fed non-caloric sweeteners Aspartame-either have no difference or reduced body weight (and reduced food intake) compared to controls. Saccharin –increased weight gain (Switherset al., 2009); due to increased food intake. Effect on appetite or section of gastrointestinal peptides No effect of sweetener (aspartame, acesulfame K or sucralose) on appetite or section of gastrointestinal peptides that regulate appetite in rats or humans (Steinertet al., 2011) ; in contrast to studies with isolated cells in culture. Preclinical studies
23. Critical review of Clinical Studies American Dietetic Association, January 2009 Does aspartame affect appetite or food intake? Evidence Analysis method used to evaluate each study, based on ICSI guidelines. 19 studies in adults ; 14 randomized controlled; 4 nonrandomized; 1 short term. Conclusion: “There is good evidence that aspartame does not affect appetite or food intake in adults.” Grade 1 = good evidence to support conclusion.
24. Epidemiological studies Examine relationship between reported use of sweeteners and weight gain. Need to control for confounding variables. Example - Fowler et al. (2008) - Reported use of sweeteners associate with obesity. Number of methodological concerns – main issue is that data collection taken over 2 phases (1979-1982) and (1984-1988). Aspartame was not approved for food until (1981) and beverages in 1983! Thus inferences made against Aspartame are invalid!
25. Do non-caloric sweeteners promote weight loss? Or gain? Conclusion: Well-conducted clinical studies have shown that weight loss and weight maintenance is more successful with use of non-caloric sweeteners.
26. Does aspartame cause cancer? Preclinical studies Cells and bacteria studies have shown aspartame does NOT cause mutations 16 chronic animal studies: multiple species 14 found no evidence of carcinogenic or promoting effects of aspartame Only studies reporting positive results by Soffrittiet al. Detailed review of protocol and data of Soffrittiby numerous experts: EFSA; FDA; Health Canada; US National Toxicology Program; International expert panel (Crit Rev Toxicology, 2007) All conclude that: Are serious flaws in methodology and interpretation in Soffrittistudy “there is no credible evidence that aspartame is carcinogenic” “no need to revise previously established ADI”
28. Does aspartame cause cancer? Most preclinical studies aspartame does NOT cause cancer. few positive studies - serious flaws. Epidemiological studies if measured consumption – all find no association Conclusion: Aspartame does not cause cancer.
29. EFSA review of Aspartame At the request of the European Commission, EFSA has reviewed the safety of aspartame 4 times since first approved. Most recent – Feb 2011. Each time concluded - no need to conduct further studies, or to alter Acceptable Daily Intake (ADI). May 2011 – announced will review again in 2012 as part of the systematic re-evaluation of all authorized food additives in the European Union.
30. Conclusions Critical review of primary studies is required to identify weaknesses or limitations. Several published guidelines for conducting reviews are available. The overall weight of evidence from well-conducted studies supports the use of approved non-caloric sweeteners.
34. Clinical study - Appetite Anton et al., 2010. tested effect of preloads containing stevia, aspartame, or sucrose on food intake, satiety, and postprandial glucose and insulin levels. Design: 19 healthy lean and 12 obese individuals Preload, given before lunch and dinner; food intake measured. Hunger and satiety levels reported before and after meals, and every hour. Results: Despite caloric difference in preloads , did not compensate by eating more at meals Self- reported hunger and satiety levels did not differ.
42. Secondary review of literature American Dietetic Association, January 2009 Does aspartame affect appetite or food intake? Evidence Analysis method used to evaluate each study Only 2 studies in children ; 1 randomized controlled; 1 nonrandomized. Conclusion: “Limited evidence indicates that aspartame consumption does not affect appetite or food intake in children. Grade III = limited evidence to support conclusion
Editor's Notes
cohort prospective study two groups (cohorts) of subjects are identified, one of which is exposed to a clinical intervention, an environmental condition, or health risk factor, and the other group is not. The major disadvantage of the cohort study, compared to the randomized study, is that the groups may not be equivalent on other factors such as diet or smoking history. case-control study a group of patients who already have a disease or other outcome (the cases) is compared to another group of controls who do not. Thus, such studies are conducted retrospectively, not prospectively.
cohort prospective study two groups (cohorts) of subjects are identified, one of which is exposed to a clinical intervention, an environmental condition, or health risk factor, and the other group is not. The major disadvantage of the cohort study, compared to the randomized study, is that the groups may not be equivalent on other factors such as diet or smoking history. case-control study a group of patients who already have a disease or other outcome (the cases) is compared to another group of controls who do not. Thus, such studies are conducted retrospectively, not prospectively.