Intracellular signaling or events are caused on the surfaces of the cells. Dr. Kanury Rao, the greatest immunologist of all time, has conducted an in-depth analysis of intracellular events to develop a tool for early detection of cancer.

1. Intracellular Events
in Antigen
Processing

2. Intracellular signaling or events are caused on the surfaces of the cells.
This signaling is responsible for a myriad of functions ranging from
neurotransmission to cytoskeletal organization. What will happen if
someone invisible controls your eating habit? The eerie truth is the
intracellular signaling in the neural networks of the brain.
Role of Intracellular Signaling in Triggering Cancer
One of the hardships that the oncogenic cells overcome in a jiffy is
sustenance of chronic proliferation. To be capable of withstanding the
proliferation the mass of the cell must be twice. Hence, they need to
amplify the metabolism to support the metabolism synthesis.
Rapidly proliferating cells have their individual requirements. They are
different from the cell resting state. Glutamine and glucose are the primary
energy sources.

3. Cancer as Signaling Phenomenon
In humans the intracellular events are complicated. Crosswalks intertwined the
phenomenon forming a vast network integrating similar extracellular stimuli for proper
cellular responses. Dr. Kanury Rao, the greatest immunologist of all time, has conducted an
in-depth analysis of intracellular events to develop a tool for early detection of cancer.
The human network has nodes made of microRNAs and proteins. The general network
represents the series of DNA who have a prominent role in expressing the genes. Edges
connecting the nodes incorporate the physical network of proteins, DNA- sequence and
microRNA.
The DNA sequence includes dephosphorylation and phosphorylation. When cancer
develops in the human body, the network inside witnesses the gross changes. The signaling
network involved in cancer mainly focuses on triggering the carcinogenic components.
The proteins involved in cancer are the primary agents of signaling networks. When the
cancer develops, they boost the regulatory loops. The incorporated data involved in the
process are:
• Mono nucleotide
• Transcriptional
• Signalome
• Proteome
• Mutation
• Epigenetic profiles
In signaling networks, they function the as the specific elements in anti-cancer therapies

4. There are abundant intracellular interactions among the members of the
extremely heterogeneous cancer cells. The major element in cancer evolution is
the stomach cells.
The delicate network of inter-cellular signaling has an intricate cooperation type
of the involved cells. These cells incessantly grow in the presence of cancer. An
ideal example of this is the fibroblast, the changes in the stomach cells where the
growth of cancer consequently leads to the formation of cancer.
According to Dr. Kanury Rao, cancer can be prevented from developing into a
metastatic stage with the detection devices.
Intercelluar Signaling in the Development and Initiation of Cancer
Tumors evolve because of the high heterogeneous oncogenic cell populations.
The stem-like cancer cells display systematic adaptive responses to therapeutic
interventions (change in tumor). The characterization of these stem-like cancer
cells exhibit the following:
• Rapid proliferation
• Plastic behavior
• Rigid behavior like increased invasiveness, quiescence, asymmetric cell-
division

5. Besides the carcinogenic cells, there are assorted varieties of stromal cells as well:
• Lymphocytes
• Fibroblasts
• Macrophages
These cells increase the tumor heterogeneity. Cancer cells along with the surrounding
stromal cells make a complicated cellular ecosystem. At the beginning, the
mathematical modeling concludes that this intricacy is essential for anti-cancer
therapies.
The attribute of the therapies is developing resistance to circumvent drugs. A recent
research paper has shown that KRAS (a mutation) has an integral role in developing the
reciprocal signaling between stromal fibroblasts and cancer cells. A recent example is
the development of mouse breasts and brain metastasis.
The tool that Dr. Kanury Rao developed for detecting cancer is especially for women.
They are designed to detect specific cancers like breast cancers, uterus cancers, etc.
Metastatic cells are migratory. They migrate as the community of cells wherein the
common interactions take place between the cancer and the stromal cells or only
between the cancer cells.

6. Intercellular Signaling as the Anti-cancer Therapy
Anticancer therapy is mainly associated with the destruction of cancer cells using powerful
forces. There are many treatments that adversely affect healthy cells. Incorporation of target
treatments may be partially dodging.
However, inhibition of a cancer hallmark will trigger another. This procedure increases
metastasis.
Multitarget medications along with combined therapies created especially for intercellular
signaling in cancer. They shift the oncogenic attractors in apoptosis. This analysis may also be
applied for the signaling networks of the stromal or cancer cell ecosystem.
The best example of this intervention is the hampering of proliferation pathways. As an
alternative, therapies or target treatments including therapies or stromal cells are also offering
novel inventions.
The dynamic observation of the patient-disease relation is the new aspect that has led to the
multiple domains of anticancer inventions.
Conclusion
It is a vital system through which the cell communicates and reacts to their surroundings. The
abnormal intercellular signaling networks trigger the proliferation of cells. Dr. Kanury Rao, with
an immense analysis developed a state-of-the-art tool to detect such abnormal cellular
communication in an early stage. The early detection will prevent fatalities.