The document is a comprehensive reference guide published by NASA detailing the assembly and utilization of the International Space Station (ISS) as of November 2010. It highlights the accomplishments in maintaining a continuous human presence in space since 2000, the transition from assembly to full research utilization, and the collaborative efforts among international space agencies focusing on scientific research across various fields. Furthermore, it emphasizes the potential benefits of ISS research for life on Earth and the importance of STEM education for future generations of space explorers.