Insulin has three characteristics:
Onset: is the length of time before insulin reaches the bloodstream and begins lowering blood glucose.
Peak time: is the time during which insulin is at maximum strength in terms of lowering blood glucose.
Duration: is how long insulin continues to lower blood glucose.
biological Insulin, synthesis, factors affecting synthesis, primary structure of insulin, different insulin preparations, mechanism of action of Insulin and pathway, physiological & biochemical effect of Insulin, Disorders related with insulin production, treatment strategy, Drugs Used to treat Diabetes Mellitus
Glibenclamide or glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM)
It was discovered in 1969 and approved for medical use in the united states in 1984.
Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release.
Drug Class : Hypoglycemics ;Sulfonylureas
Indications : Diabetes mellitus, type 2
SIDE EFFECTS : Hypoglycemia, Angioedema, Weight gain etc.
it contains info about infant and young child feeding guidelines ,breast feeding, complementary feeding, supplementary feeding, feeding in hiv aids, ims act etc
Insulin has three characteristics:
Onset: is the length of time before insulin reaches the bloodstream and begins lowering blood glucose.
Peak time: is the time during which insulin is at maximum strength in terms of lowering blood glucose.
Duration: is how long insulin continues to lower blood glucose.
biological Insulin, synthesis, factors affecting synthesis, primary structure of insulin, different insulin preparations, mechanism of action of Insulin and pathway, physiological & biochemical effect of Insulin, Disorders related with insulin production, treatment strategy, Drugs Used to treat Diabetes Mellitus
Glibenclamide or glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM)
It was discovered in 1969 and approved for medical use in the united states in 1984.
Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release.
Drug Class : Hypoglycemics ;Sulfonylureas
Indications : Diabetes mellitus, type 2
SIDE EFFECTS : Hypoglycemia, Angioedema, Weight gain etc.
it contains info about infant and young child feeding guidelines ,breast feeding, complementary feeding, supplementary feeding, feeding in hiv aids, ims act etc
Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in fat cells (adipocytes) it is stored as triglycerides.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. Definition:
Is a peptide hormone produced by beta cells in
the pancreas. it regulate the metabolism of the
carbohydrate and fats by promoting the
absorption of glucose from the blood to skeletal
muscle and fat tissue and by causing fat to be
stored rather than used for energy .insulin also
inhibit the production of glucose by liver
3. Structure:
Insulin consist of two polypeptide chain A & B chains
linked by disulfide bonds .
A chain consist of 21 Amino acids and B chain consist
of 30 amino acids(active form)
4. INSULIN SECRETION SOURCE (B-CELL)
B- Cell
Hormones
Description
Insulin Proinsulin (insulin+ c-peptide ) and active form
(insulin)
Amylin -Released with insulin in ratio of 1:100
-Amylin play a role in glycemic regulation by
slowing gastric emptying and promoting satiety
C-peptide - Secreted in bloodstream in equimolar quantities to
insulin
- C-peptide helps to prevent neuropathy and other
complication deterioration related to diabetes mellitus
(delay complication)
- C-peptide levels measured to diagnosis diabetes
(newly diagnosis)
6. Receptor type Tissue distribution
Glut -1 Is widely distributed in fetal tissues, In
the adult most cells (more in RBC &brain)
Glut-2 Liver .beta cells .hypothalamus .retina
.kidney .intestine.
Glut-3 Brain . placenta
Glut-4 Heart ,muscle ,fat
Glut-5 Intestine ,kidney, testis ,RBC
7. INSULIN THERAPY
Typeof insulin
A- Insulin short acting
1-INSULIN RAPID
Active
constituent
GLULISINE (ultra short) LISPRO ASPART
Onset time 10min to 20min 15min to 30min 15min to 30min
Peak time 30-90min 30-90min 30-90min
Duration 3-5 hours 3-5 hours 3-5 hours
Trade name APIDRA(SANOFI) HUMALOG (lilly) NOVORAPID PEN
NOVOLOG BOTT
(Novonordisck)
Notes Can be mixed(NPH)
Given (s/c , IV)
Can be
mixed(NPL,NPH)
Given (s/c , IV)
Can be
mixed(NPH,NPA)
Given (s/c ,Infusion
pump )
8.
9.
10. Active
constituent
REGULAR (rDNA) E.COLI
Onset time 30 min to 1 hour
Peak time 2 hours to 5 hours
duration 6 hours to 12 hours
Trade name HUMALIN R (LILLY)
ACTRAPID
NOVOLIN R
Notes Can be mixed
Given (s/c,IV)
2-INSULIN REGULAR
11. B-INSULIIN INTERMEDIATE ACTING
Active constituent NPH:NEUTRAL PROTAMINE HAGEDORN
NPL: NEUTRAL PROTAMINE LISPRO
NPA: NEUTRAL PROTAMINE ASPART
Onset time 3 HRS TO 8 HRS
Peak time 8 – 10 HRS
Duration 12-16 HRS
Trade name HUMILIN N (LIILY)
INSULRETARD (NOVO)
Notes - Given only S/C
- Can be mixed (NPH)
- Cloudy milky color
12. C -LONG ACTING INSULIN
Active
constituent
DETEMIR GLARGINE
(ultra long)
DEGLUDEC
(ultra long basal)
Onset time 3-8HRS 1-2 HRS 1-2 HRS
Peak time PEAKLESS PEAKLESS PEAKLESS
Duration 16-18HRS 24+ 42+
Trade name LEVEMIR PEN
(novonordisck)
LANTUS PEN
(SANOFI)
TRESIBA
(novonordisck)
Note - Can not be
mixed
- Given only s/c
- Can not be mixed
- Given only s/c
- Can not be
mixed
- Given only s/c
15. How to Switch Between Insulin Products
Insulin detemir (Levemir) to NPH • Convert unit-per-unit.
• NPH at bedtime (for type 2 patients
when combined with oral anti diabetes
meds). OR
• NPH twice daily (e.g., 50:50 or 2/3 in
AM and 1/3 before dinner or at
bedtime).
Insulin glargine (Lantus) to NPH • Convert unit-per-unit.
• NPH at bedtime (for type 2 patients
when combined with oral anti diabetes
meds). OR
• NPH twice daily (e.g., 50:50 or 2/3 in
AM and 1/3 before dinner or at
bedtime).
16. Regular human insulin (Humulin R,
Novolin R) to rapid-acting insulin
analog (insulin aspart [Novolog],
insulin glulisine [Apidra], insulin
lispro [Humalog])
• Convert unit-per-unit.
• Rapid-acting insulin analogs have
a faster onset of action and a
shorter duration of action than
human regular insulin.
Give rapid acting insulin analogs
about 10 minutes before meals or
with meals.