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IN SILICO DRUG
DISCOVERY AND
DEVELOPMENT
GROUP A:
Edwin J. Alvarado
José Antonio Cruz-Arzón
Crystal K. Colón
Carla Jeanine Figueroa-García
MENTOR:
Jessica Díaz
INTRODUCTION
Structure-based Drug Design
Pharmacophore Models
FTMap: Benzene Probes
OBJECTIVE
Identification of Optimal Targets for Drug Development: Benzene
Mapping
Target
Analysis
Primary
Sequence
Analysis
Optimal Targets
For
Drug Development
Chemical
Probe
Screening
Therapeutically
Relevant
Protein Targets
Biomedically Relevant Biological Problem
Drug Discovery Strategy
RECEPTOR /
TARGET
PREPARATION
Download RECEPTOR / TARGET file
CODE: 1BVE
NAME: HIV-1 Protease
RECEPTOR /
TARGET
PREPARATION
Analyze using PyMOL® software
Separate PROTEIN from
LIGAND
HIV-1 P.
DMP
CONFIGURATION
FILE GENERATION
GRID
BENZENE MAPPING
AND ANALYSIS
Benzene probe mapping
Loading results onto model
Benzene configuration analysis
Binding propensity comparison
BENZENE MAPPING
AND ANALYSIS
Benzene cluster selection
CLUSTER I: 001
CLUSTER II: 013
CLUSTER III: 022
CLUSTER IV: 028
BENZENE MAPPING
AND ANALYSIS
BENZENE MAPPING
AND ANALYSIS
CLUSTERS Benzene Map
HIV-1 P.
CONCLUSION
Pharmacophore model can be derived.
Then on, potential drugs can be developed.
In silico Drug Discovery and Development: Benzene Mapping

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Editor's Notes

  1. Crystal Edwin Jose Carla
  2. Carla
  3. Edwin