The document summarizes GVK BIO Informatics, which provides complete informatics solutions from knowledge management to predictive analytics. It highlights key databases and tools developed by GVK including CTOD (Clinical Trial Outcome Database) and a biomarker database. It also describes GVK's knowledge base development through custom data curation for leading database providers and key publications utilizing GVK's GOSTAR database.
The Role of Bioinformatics in The Drug Discovery ProcessAdebowale Qazeem
The Role of Bioinformatics in The Drug Discovery Process, is an undergraduate seminar presentation in the department of Biochemistry, Faculty of life Sciences, University of Ilorin, Ilorin.
Our second webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at developing the assay cascade for complex medicines.
Tilly Bingham, Concept Life Sciences
Our fifth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at how you can determine efficacy in vivo.
Jenny Worthington (Axis Bio)
In vivo protein target identification / target deconvolution via chemical proteomics as a facilitating tool for phenotype based drug discovery.
www.j-vomacka.com
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
The Role of Bioinformatics in The Drug Discovery ProcessAdebowale Qazeem
The Role of Bioinformatics in The Drug Discovery Process, is an undergraduate seminar presentation in the department of Biochemistry, Faculty of life Sciences, University of Ilorin, Ilorin.
Our second webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at developing the assay cascade for complex medicines.
Tilly Bingham, Concept Life Sciences
Our fifth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at how you can determine efficacy in vivo.
Jenny Worthington (Axis Bio)
In vivo protein target identification / target deconvolution via chemical proteomics as a facilitating tool for phenotype based drug discovery.
www.j-vomacka.com
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
INTRODUCTION
A PERFECT THERAPEUTIC DRUG
DRUG DISCOVERY- HISTORY
MODERN DRUG DISCOVERY
BIOINFORATICS IN DRUG DISCOVERY
DRUG DISCOVERY BASED ON BIOINFORMATIC TOOLS
BIOINFORMATICS IN COMPUTER-AIDED DRUG DISCOVERY
ECONOMICS OF DRUG DISCOVERY
CONCLUSION
REFERENCES
Bioinformatics: Introduction, Objective of Bioinformatics, Bioinformatics Databases, Concept of Bioinformatics, Impact of Bioinformatics in Vaccine Discovery
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the state of play for Complex Medicine and highlights the potential opportunity for the UK.
Prof Peter Simpson, Medicines Discovery Catapult
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the target landscape for Complex Medicine.
Dr Duygu Yilmaz, Medicines Discovery Catapult
Part of the MaRS Best Practices Series - Pre-Clinical development workshop
http://www.marsdd.com/bestpractices
Speaker: Jack Jiang, VP Medicinal and Analytical Chemistry, Ricerca BioSciences
INTRODUCTION
A PERFECT THERAPEUTIC DRUG
DRUG DISCOVERY- HISTORY
MODERN DRUG DISCOVERY
BIOINFORATICS IN DRUG DISCOVERY
DRUG DISCOVERY BASED ON BIOINFORMATIC TOOLS
BIOINFORMATICS IN COMPUTER-AIDED DRUG DISCOVERY
ECONOMICS OF DRUG DISCOVERY
CONCLUSION
REFERENCES
Bioinformatics: Introduction, Objective of Bioinformatics, Bioinformatics Databases, Concept of Bioinformatics, Impact of Bioinformatics in Vaccine Discovery
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the state of play for Complex Medicine and highlights the potential opportunity for the UK.
Prof Peter Simpson, Medicines Discovery Catapult
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the target landscape for Complex Medicine.
Dr Duygu Yilmaz, Medicines Discovery Catapult
Part of the MaRS Best Practices Series - Pre-Clinical development workshop
http://www.marsdd.com/bestpractices
Speaker: Jack Jiang, VP Medicinal and Analytical Chemistry, Ricerca BioSciences
This thesis presents the development of computational methods and tools using as input three-dimensional structures data of protein-ligand complexes. The tools are useful to mine, profile and predict data from protein-ligand complexes to improve the modeling and the understanding of the protein-ligand recognition. This thesis is divided into five sub-projects. In addition, unpublished results about positioning water molecules in binding pockets are also presented. I developed a statistical model, PockDrug, which combines three properties (hydrophobicity, geometry and aromaticity) to predict the druggability of protein pockets, with results that are not dependent on the pocket estimation methods. The performance of pockets estimated on apo or holo proteins is better than that previously reported in the literature (Publication I). PockDrug is made available through a web server, PockDrug-Server (http://pockdrug.rpbs.univ-paris-diderot.fr), which additionally includes many tools for protein pocket analysis and characterization (Publication II). I developed a customizable computational workflow based on the superimposition of homologous proteins to mine the structural replacements of functional groups in the Protein Data Bank (PDB). Applied to phosphate groups, we identified a surprisingly high number of phosphate non-polar replacements as well as some mechanisms allowing positively charged replacements. In addition, we observed that ligands adopted a U-shape conformation at nucleotide binding pockets across phylogenetically unrelated proteins (Publication III). I investigated the prevalence of salt bridges at protein-ligand complexes in the PDB for five basic functional groups. The prevalence ranges from around 70% for guanidinium to 16% for tertiary ammonium cations, in this latter case appearing to be connected to a smaller volume available for interacting groups. In the absence of strong carboxylate-mediated salt bridges, the environment around the basic functional groups studied appeared enriched in functional groups with acidic properties such as hydroxyl, phenol groups or water molecules (Publication IV). I developed a tool that allows the analysis of binding poses obtained by docking. The tool compares a set of docked ligands to a reference bound ligand (may be different molecule) and provides a graphic output that plots the shape overlap and a Jaccard score based on comparison of molecular interaction fingerprints. The tool was applied to analyse the docking poses of active ligands at the orexin-1 and orexin-2 receptors found as a result of a combined virtual and experimental screen (Publication V). The review of literature focusses on protein-ligand recognition, presenting different concepts and current challenges in drug discovery.
Looking Beyond Biosimilarity - Importance of Patient Safety: Presentation of...drsomduttprasad
Here is my presentation at FOCUS 2016, the XXIVth Annual Conference of the Bombay Ophthalmologists' Association held from August 19-21, 2016 at ITC Maratha, Hyatt Regency & Hilton, Sahar, Mumbai.
Requesting a complete biosensor system in phyto-sourced drug discovery and de...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Bioinformatics in the Clinical Pipeline: Contribution in Genomic Medicineiosrjce
In this review report we like to focus on the new challenges in methodology of modern biology be
used in medical science. Today human health is a primary issue to cure disease, undoubtedly the answer to this
is bioinformatics or (In-silco) tools has change the concept of treating patients to understand the need of
genomic medicine in use. Those with new modes of action in clinical treatment, is a major health concern in
medical science. On global prospective scientific role in constructing new ideas to remediate health care to
treat disease exciting in nature is challenging task. So awareness needs to accelerate store clinical datasets for
scientific represents to design genomic drugs. This new outline will drive the medical to discover public data
and create a cognitive approach to use technology cheaper at cost effective mode.
Research trends in different pharmaceutical areas: Natural product chemistry
Imtiaj Hossain Chowdhury
B’Pharm (Jahangirnagar University), M’Pharm (Jahangirnagar University)
Master’s in Public Health (American International University Bangladesh)
This is a presentation given at the Opal Events meeting ""Drug Discovery Partnerships: Filling the Pipeline". I was speaking in a session with Jean-Claude Bradley regarding "Pre-competitive Collaboration: Sharing Data to Increase Predictability". This presentation discussed some of the work we are doing on Open PHACTS. My thanks especially to Carole Goble, Lee Harland and Sean Ekins for their comments.
GVK BIO is one of the largest India-based Discovery, Development and Manufacturing solutions provider to the Biopharma industry. GVK BIO provides a continuum of Drug
Discovery solutions from pre-Hit to candidate
selection. Our expertise spans across
numerous therapeutic areas with a focus on
Oncology, Pain and Metabolic diseases. We
leverage our expertise in Chemistry, Biology,
CADD, ADMET/PK and Animal Disease models
to provide a customised and truly integrated
model for Drug Discovery leading to preclinical
candidates.
Lung Fibrosis Model Representative Studies by Aragen BioscienceGVK Biosciences
This is a presentation on the Lung Fibrosis Model Representative Studies by Aragen Bioscience, a GVK BIO entreprise. For further informtion visit:
www.gvkbio.com
www.aragenbio.com
GVK Biosciences (GVK BIO) Clinical Research division has an independent Quality Assurance (QA) unit which conducts audits of services of all business lines within the division on a routine basis to ensure delivery of quality services. The Clinical Research QA staff report
to the Director-QA, GVK BIO who in turn reports to the CEO of GVK BIO
Project Management at GVK BIO is led by skilled and highly motivated executives with experience averaging 6-7 years. Our Project Managers (PMs) employ proven planning, time management, problem solving and communication skills to ensure timely project delivery,
determined to exceed customer expectations.
GVK BIO vivarium is AAALAC certified and registered with CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals), Government of India.
The Medical Affairs team at GVK Biosciences (GVK BIO) comprises of well trained medical professionals with cumulative Clinical Research experience of about 28 years.
At GVK BIO, seamless integration of life sciences expertise with information technology helps bring database products and services to accelerate your research from discovery to development.
GVK Biosciences (GVK BIO) offers screening services for drug discovery to determine biological activity and properties customized to meet the research needs of the Pharma and Biotech industries. Our range of assays include Biochemical, Cellular, ADME assays & Animal models for profiling of NCEs for Potency, Selectivity, Efficacy, Drugability and Toxicity.
BioIT converts information to knowledge for usage in Discovery & Development. It integrates data from multidisciplinary areas using Science and Information Technology
At GVK BIO, we provide a full range of analytical services from Discovery to Commercial Phase III. The Analytical Service portfolio includes method development and validation, stability studies, analytical testing and release, structure elucidation, GMP separation and CMC Support
GVK BIO In vitro ADME screening service offers a portfolio of automated High throughput assays for investigating metabolism, distribution and toxicity, permeability, solubility & physicochemical properties. We deliver consistent, accurate compound data with cost-efficiency.
Search Engine Optimization Strategies for Local Businesses.pdfseodigitalbraino
Maximize your online presence and drive growth with Digital Braino, your go-to for digital marketing services in Indore. Our expert team specializes in a wide range of services including SEO, social media marketing, content creation, and online advertising. With our innovative strategies and client-focused approach, we help businesses enhance their online presence and achieve their marketing objectives. Let Digital Braino propel your business to new heights.
janani Digital Marketer|Digital Marketing consultant|Marketing Promotion|Coim...janudm24
Myself Janani Digital marketing consultant located in coimbatore I offer all kinds of digital marketing services for your business requirements such as SEO SMO SMM SMO CAMPAIGNS content writing web design for all your business needs with affordable cost
Digital Marketing Services | Techvolt Software :
Digital Marketing is a latest method of Marketing techniques widely used across the Globe. Digital Marketing is an online marketing technique and methods used for all products and services through Search Engine and Social media advertisements. Previously the marketing techniques were used without using the internet via direct and indirect marketing strategies such as advertising through Telemarketing,Newspapers,Televisions,Posters etc.
List of Services offered in Digital Marketing |Techvolt Software :
Techvolt Software offers best Digital Marketing services for promoting your products and services through online platform on the below methods of Digital marketing
1. Search Engine Optimization (SEO)
2. Search Engine Marketing (SEM)
3. Social Media Optimization (SMO)
4. Social Media Marketing (SMM)
5. Campaigns
Importance | Need of Digital Marketing (Online Promotions) :
1. Quick Promotions through Online
2. Generation of More leads and Business Enquiries via Search Engine and Social Media Platform
3. Latest Technology development vs Business promotions
4. Creation of Social Branding
5. Promotion with less investment
Benefits Digital Marketing Services at Techvolt software :
1. Services offered with Affordable cost
2. Free Content writing
3. Free Dynamic Website design*
4. Best combo offers on website Hosting,design along with digital marketing services
5. Assured Lead Generation through Search Engine and Social Media
6. Online Maintenance Support
Free Website + Digital Marketing Services
Techvolt Software offers Free website design for all customer and clients who is availing the digital marketing services for a minimum period of 6 months.
With Regards
Janani Digital Marketer
Coimbatore,Tamilnadu.
In the digital age, businesses are inundated with tools promising to streamline operations, enhance creativity, and boost productivity. Yet, the true key to digital transformation lies not in the accumulation of tools but in strategically integrating the right AI solutions to revolutionize workflows. Join Jordache, an experienced entrepreneur, tech strategist and AI consultant, as he explores essential AI tools across three critical categories—Ideation, Creation, and Operations—that can reshape the way your business creates, operates, and scales.This talk will guide you through the practicalities of selecting and effectively using AI tools that go beyond the basics of today’s popular tools like ChatGPT, Claude, Gemini, Midjourney, or Dall-E. For each category of tools, Jordache will address three crucial questions: What is each tool? Why is each one valuable to you as a business leader? How can you start using it in your workflow? This approach will not only clarify the role of these tools but also highlight their strategic value, making it perfect for business leaders ready to make informed decisions about integrating AI into their workflows.
Key Takeaways:
>> Strategic Selection and Integration: Understand how to select AI tools that align with your business goals and how to conceptually integrate them into your workflows to enhance efficiency and innovation.
>> Understanding AI Tool Categories: Gain a deeper understanding of how AI tools can be leveraged in the areas of ideation, creation, and operation—transforming each aspect of your business.
>> Practical Starting Points: Learn how you can start using these tools in your business with practical tips on initial steps and integration ideas.
>> Future-Proofing Your Business: Discover how staying informed about and utilizing the latest AI tools and strategies can keep your business competitive in a rapidly evolving digital landscape.
In today's digital world, customers are just a click away. "Grow Your Business Online: Introduction to Digital Marketing" dives into the exciting world of digital marketing, equipping you with the tools and strategies to reach new audiences, expand your reach, and ultimately grow your business.
website = https://digitaldiscovery.institute/
address = C 210 A Industrial Area, Phase 8B, Sahibzada Ajit Singh Nagar, Punjab 140308
Exploring the Top Digital Marketing Company in CanadaSolomo Media
Choosing Solomo Media as your digital marketing company in Canada can propel your business to new heights. With their expertise, innovative solutions, and client-centric approach, they are well-equipped to help you achieve your digital marketing goals. By focusing on strategic planning, leveraging cutting-edge tools, and delivering measurable results, Solomo Media proves to be a valuable partner in navigating the complex world of digital marketing.
Short video marketing has sweeped the nation and is the fastest way to build an online brand on social media in 2024. In this session you will learn:- What is short video marketing- Which platforms work best for your business- Content strategies that are on brand for your business- How to sell organically without paying for ads.
The Secret to Engaging Modern Consumers: Journey Mapping and Personalization
In today's digital landscape, understanding the customer's journey and delivering personalized experiences are paramount. This masterclass delves into the art of consumer journey mapping, a powerful technique that visualizes the entire customer experience across touchpoints. Attendees will learn how to create detailed journey maps, identify pain points, and uncover opportunities for optimization. The presentation also explores personalization strategies that leverage data and technology to tailor content, products, and experiences to individual customers. From real-time personalization to predictive analytics, attendees will gain insights into cutting-edge approaches that drive engagement and loyalty.
Key Takeaways:
Current consumer landscape; Steps to mapping an effective consumer journey; Understanding the value of personalization; Integrating mapping and personalization for success; Brands that are getting It right!; Best Practices; Future Trends
Google Ads Vs Social Media Ads-A comparative analysisakashrawdot
Explore the differences, advantages, and strategies of using Google Ads vs Social Media Ads for online advertising. This presentation will provide insights into how each platform operates, their unique features, and how they can be leveraged to achieve marketing goals.
In this presentation, Danny Leibrandt explains the impact of AI on SEO and what Google has been doing about it. Learn how to take your SEO game to the next level and win over Google with his new strategy anyone can use. Get actionable steps to rank your name, your business, and your clients on Google - the right way.
Key Takeaways:
1. Real content is king
2. Find ways to show EEAT
3. Repurpose across all platforms
How to Use AI to Write a High-Quality Article that Ranksminatamang0021
In the world of content creation, many AI bloggers have drifted away from their original vision, resulting in low-quality articles that search engines overlook. Don't let that happen to you! Join us to discover how to leverage AI tools effectively to craft high-quality content that not only captures your audience's attention but also ranks well on search engines.
Disclaimer: Some of the prompts mentioned here are the examples of Matt Diggity. Please use it as reference and make your own custom prompts.
Mastering Dynamic Web Designing A Comprehensive Guide.pdfIbrandizer
Dynamic Web Designing involves creating interactive and adaptable web pages that respond to user input and change dynamically, enhancing user experience with real-time data, animations, and personalized content tailored to individual preferences.
When most people in the industry talk about online or digital reputation management, what they're really saying is Google search and PPC. And it's usually reactive, left dealing with the aftermath of negative information published somewhere online. That's outdated. It leaves executives, organizations and other high-profile individuals at a high risk of a digital reputation attack that spans channels and tactics. But the tools needed to safeguard against an attack are more cybersecurity-oriented than most marketing and communications professionals can manage. Business leaders Leaders grasp the importance; 83% of executives place reputation in their top five areas of risk, yet only 23% are confident in their ability to address it. To succeed in 2024 and beyond, you need to turn online reputation on its axis and think like an attacker.\
Key Takeaways:
- New framework for examining and safeguarding an online reputation
- Tools and techniques to keep you a step ahead
- Practical examples that demonstrate when to act, how to act and how to recover
The Forgotten Secret Weapon of Digital Marketing: Email
Digital marketing is a rapidly changing, ever evolving industry--Influencers, Threads, X, AI, etc. But one of the most effective digital marketing tools is also one of the oldest: Email. Find out from two Houston-based digital experts how to maximize your results from email.
Key Takeaways:
Email has the best ROI of any digital tactic
It can be used at any stage of the customer journey
It is increasingly important as the cookie-less future gets closer and closer
What’s “In” and “Out” for ABM in 2024: Plays That Help You Grow and Ones to L...Demandbase
Delve into essential ABM ‘plays' that propel success while identifying and leaving behind tactics that no longer yield results. Led by ABM Experts, Jon Barcellos, Head of Solutions at Postal and Tom Keefe, Principal GTM Expert at Demandbase.
Come learn how YOU can Animate and Illuminate the World with Generative AI's Explosive Power. Come sit in the driver's seat and learn to harness this great technology.
Monthly Social Media News Update May 2024Andy Lambert
TL;DR. These are the three themes that stood out to us over the course of last month.
1️⃣ Social media is becoming increasingly significant for brand discovery. Marketers are now understanding the impact of social and budgets are shifting accordingly.
2️⃣ Instagram’s new algorithm and latest guidance will help us maintain organic growth. Instagram continues to evolve, but Reels remains the most crucial tool for growth.
3️⃣ Collaboration will help us unlock growth. Who we work with will define how fast we grow. Meta continues to evolve their Creator Marketplace and now TikTok are beginning to push ‘collabs’ more too.
3. GVK BIO INFORMATICS
COMPLETE SOLUTION FROM KNOWLEDGE MANAGEMENT TO PREDICTIVE ANALYTICS
- Patents, Journals
- Public Domain Information
- Client’s Proprietary data
Annotation &
Scientific
Data
Management
- Predictive Biology
- Drug Repurposing
- Clinical Pharmacology
- Application Development
- Application Integration
- Application Management
Knowledge
Base
Predictive
Analytics
BIO IT
- Small Molecules SAR
- Biomarker
- Clinical Trial Outcome
Environmental
Modelling and
Eco-Tox Risk
Assessment
IPR
- Prior Art search
- FTO search
- Novelty search
- PEC Assessment Reports
- Environmental Fate Registration Report
- Eco toxicological Risk Assessment
4. KNOWLEDGE BASE
CTOD
Clinical Trial Outcome Database
A web-based application
A web based biomarker
database
Key Differentiators
6.3 million small
26,000 biomarkers
~ 1 Mn patients
molecules
17 therapeutic
2,200 trials
areas
19 Indications
16 million SAR points
(2.9 million Patents,
840 indications
350,000 Journals)
(100,000
references)
(150,000 references)
•
•
•
•
•
Comprehensiveness
Current-ness
Usability
Comprehendability
Credibility
5. KNOWLEDGE BASE DEVELOPMENTCUSTOM DATA CURATION FOR FIVE LEADING DATABASE PROVIDERS
REACTIONS
CURATION FROM
JOURNAL ARTICLES
3 Million Reactions
throughput per year
Curation and Indexing
of Life Sciences and
Toxicology Journals
Developed Advanced
Curation Tools to
Improve Productivity
CLINICAL DATA
CURATION
Throughput of
600,000 Journals per
annum
Throughput of 50,000
Key Differentiators
Trials per annum
200,000 Journals per
annum
•
•
•
•
•
Comprehensiveness
Current-ness
Usability
Comprehendability
Credibility
7. Multi dimensional relational data
With One
Of
You Can Explore Data from
CLICK
Chemical
space
Pharmaco
logical
Space
Literature
Space
Chemical Structures
6.3 million
SAR Activities
~ 16 million
Literature Screened
3.5 million
Scaffolds
Pharmacokinetics/Metabo
lism
1.4 million
Patents
0.07 million
(3.2 M Screened)
Targets
6200+
Articles
0.3 million
~1.1 million
Frameworks or Cores
150,000
Clinical,
Marketed
& Toxic
Area
Clinical Compounds
~ 24,500
Drugs
~4750
Toxic Compounds
26,100
8. Data Sources
Pharmacological
Journals
Patents
(US, WO, EP, GB, JP)
Company web sites,
Conferences
Medicinal Chemistry
Journals
FDA/EMEA Docs
Scientific Reviews
Clinical Trail Registries
Manual curation with three levels of quality check
Standard Ontology for the data fields
Regular monthly data updates
9. DatabasesIntegrated in GOSTAR
Databases Integrated in GOSTAR
Records curated from
medicinal chemistry
journals
Contains data on the
toxicity, routes of
metabolism, organspecies-effects of toxicity
Med-Chem
Database
Natural Product
Database
Target
Databases
Mechanism
based
Toxicity
Database
Drug
Database
Clinical
Candidate
Database
Records curated from journals and
patents.
Popular target families like GPCR,
Kinase, NHR,
Peptidases etc
Contains information
on launched drugs
Compounds that have crossed
the IND phase and either ARE
or WERE in the Clinical Phase
10. Many publications using GOSTAR database
S.No
Title
1
Systematic exploration of dual-acting modulators
from a
combined medicinal chemistry and biology
perspective
2
Molecular clinical safety intelligence:
a system for bridging clinically focused
safety knowledge to early-stage drug
discovery – the GSK experience
Drug Discovery Today Volume 16,
Numbers 15/16 August 2011
3
What Do Medicinal Chemists Actually Make? A
50-Year Retrospective
Journal Of Medicinal Chemistry
April 25, 2011
4
Analysis of in vitro bioactivity data extracted from
drug discovery literature and patents: Ranking
1654 human protein targets by assayed
compounds and molecular scaffolds
Journal of Cheminformatics
2011, 3:14
5
Publication
Journal Of Medicinal Chemistry
Jan 3, 2013
Are There Differences between Launched Drugs,
Kazuki Ohno, Yuichi Nagahara,
Clinical Candidates, and Commercially Available
Kazuhisa Tsunoyama, and Masaya Orita
Compounds?
Company
11. GOSTAR database- list of publications
S.no
1
2
3
4
5
6
7
8
Title
Publication
Authors
Systematic exploration of dual-acting
Journal Of Medicinal Chemistry Aurelie Bornot, Udo Bauer, Alastair
modulators from a
Jan 3, 2013
Brown, Mike Firth, Caroline
combined medicinal chemistry and biology
Hellawell, and Ola Engkvist
perspective
Dana E. Vanderwall, Nancy Yuen,*,
Molecular clinical safety intelligence:
Mohammad Al-Ansari, James Bailey,
Drug Discovery Today Volume
a system for bridging clinically focused
David Fram,
16, Numbers 15/16 August
safety knowledge to early-stage drug
Darren V.S. Green, Stephen Pickett,
2011
discovery – the GSK experience
Giovanni Vitulli, Juan I. Luengo and
June S. Almenoff
W. Patrick Walters,* Jeremy Green,
What Do Medicinal Chemists Actually
Journal Of Medicinal Chemistry
Jonathan R. Weiss, and Mark A.
Make? A 50-Year Retrospective
April 25, 2011
Murcko
Analysis of in vitro bioactivity data
extracted from drug discovery literature
Christopher Southan, Kiran
Journal of Cheminformatics
and patents: Ranking 1654 human protein
Boppana, Sarma A.R.P. Jagarlapudi,
2011, 3:14
targets by assayed compounds and
Sorel Muresan
molecular scaffolds
Physicochemical property profiles of
Christian Tyrchan, Niklas Blomberg,
Bioorg. Med. Chem. Lett. 2009,
marketed drugs, clinical candidates and
Ola Engkvist, Thierry Kogej, Sorel
19 (24), 6943-6947
bioactive compounds
Muresan
Escape from Flatland: Increasing Saturation
J. Med. Chem., 2009, 52, 6752Frank Lovering, Jack Bikker,
as an Approach to Improving Clinical
6756
Christine Humblet
Success
Quantitative assessment of the expanding
complementarity between public and
Journal of Cheminformatics,
Christopher Southan, Peter
commercial databases of bioactive
2009, 1:10, 1-17
Varkonyi, Sorel Muresan
compounds
Josefin Rosen, Johan Gottfries, Sorel
Novel Chemical Space Exploration via
J. Med. Chem., 2009, 52 (7),
Muresan, Anders Backlund, Tudor I.
Natural Products
1953-1962
Oprea
Company
12. Contd..
9
10
11
12
13
14
15
16
17
Hongming Chen, Ulf Borjesson,
Ola Engkvist, Thierry Kogej, Mats
ProSAR: A New Methodology for
J. Chem. Inf. Model., 2009, 49
A. Svensson, Niklas Blomberg, Dirk
Combinatorial Library Design
(3), 603-614
Weigelt, Jeremy N. Burrows, Tim
Lange
Josef Scheiber, Bin Chen, Mariusz
Milik, Sai Chetan K. Sukuru,
Gaining insight into off-target mediated
Andreas Bender, Dmitri Mikhailov,
effects of drug candidates with a
J. Chem. Inf. Model., 2009, 49,
Steven Whitebread, Jacques
comprehensive systems chemical biology
308-317
Hamon, Kamal Azzaoui, Laszlo
analysis
Urban, Meir Glick, John W. Davies,
Jeremy L. Jenkins
Visual exploration of structure-activity
J Comput Aided Mol Des., 2008,
relationship using maximum common
Sung Jin Cho, Yaxiong Sun
22, 571-578
framework
Kinase-likeness and Kinase-Privileged
Alex M. Aronov, Brian McClain,
J. Med. Chem., 2008, 51, 1214Fragments: Toward Virtual
Cameron Stuver Moody, Mark A.
1222
Polypharmacology
Murcko
The influence of drug-like concepts on
Nature Reviews: Drug
Paul D. Leeson, Brian
decision-making in medicinal chemistry
Discovery, 2007, 6, 881-890
Springthorpe
Complementarity Between Public and
Current Topics in Medicinal
Christopher Southan, Peter
Commercial Databases: New Opportunities
Chemistry, 2007, 7, 1502-1508
Varkonyi, Sorel Muresan
in Medicinal Chemistry Informatics
Drug Discovery Today, Vol. 12,
Outsourcing lead optimization: constant
No. 1/2, 2007, 62-70
David E. Clark
change is here to stay
Shape Signatures: speeding up computer Drug Discovery Today, Vol. 11,
aided drug discovery
No. 19/20, 2006, 895-904
Peter J. Meek, ZhiWei Liu, LiFeng
Tian, Ching Y. Wang, William J.
Welsh, Randy J. Zauhar
Dependence of Molecular Properties on J. Med. Chem., 2006, 49, 3451Michal Vieth, Jeffrey J. Sutherland
Proteomic Family for Marketed Oral Drugs
3453