Infant mortality in India has decreased significantly from 204 per 1000 live births in 1911-1915 to 41 per 1000 live births in 2012. However, rates still vary greatly between states, with Madhya Pradesh having an IMR of 56 and Kerala only 12. Biological factors like low birth weight, young or older maternal age, high fertility, and cultural factors like breastfeeding practices, maternal education, and access to healthcare impact infant mortality rates. Preventive measures include improving prenatal nutrition and sanitation, promoting breastfeeding and growth monitoring, increasing access to primary healthcare and education, and encouraging family planning.