The document discusses how the immune system deteriorates with age, known as immunosenescence. Key points include: - Innate immune cells like neutrophils and monocytes/macrophages show functional declines with aging, including altered receptor expression and signaling. - The adaptive immune system also deteriorates with age. B cell and humoral immunity show reduced costimulatory molecule expression and defects in signaling. T cell immunity declines in naïve cell numbers, cytotoxic function, and proliferation ability. Memory CD8+ T cells lose co-stimulatory molecules like CD28 with age. - These immune changes contribute to the chronic low-grade inflammation, or "inflamm-aging", seen in older individuals