The document presents a new model for capacitated lot sizing and scheduling in a permutation flow shop environment, addressing backlog and sequence-dependent setups. It proposes two metaheuristic algorithms, Genetic Algorithm (GA) and Imperialist Competitive Algorithm (ICA), which are calibrated and compared to a lower bound to demonstrate the superior performance of ICA. The study aims to advance current methods in handling lot sizing and scheduling challenges in manufacturing systems with multiple products and periods.