This book provides an overview of emerging technologies for drug efficacy, safety, and biologics discovery. It is divided into three parts that discuss drug efficacy and safety technologies, biologics technologies, and future perspectives. The 14 chapters cover topics such as systems pharmacology, biomarkers, zebrafish models, toxicity pathways, stem cells, nanotechnology, and biological engineering. The book advocates an interdisciplinary approach and applying the four modalities of manipulate, measure, mine, and model to drug research. It presents technological advances that can improve predictions of drug properties and foster collaboration across small and large molecule discovery.

1. NEW FROM WILEY
Drug Efficacy, Safety, and Biologics Discovery:
Emerging Technologies and Tools
Sean Ekins and Jinghai J. Xu (Ed.)
PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY
1. Focus on Fundamentals: Towards Better Therapeutic Index Prediction
Jinghai J. Xu and Li J. Yu (Merck and Takeda-Millenium, USA)
2. High Throughput Protein-Based Technologies and Computational Models for Drug
Development, Efficacy and Toxicity
Leonidas G. Alexopoulos, Julio Saez Rodriguez and Christopher W. Espelin (Harvard Medical School
and Pfizer Inc, USA)
This book provides an up to date
analysis of emerging technologies and 3. Cellular Systems Biology Applied to Pre-Clinical Safety Testing: A Case Study of CellCiphr™
tools for drug efficacy, safety, and Cytotoxicity Profiling
biologics discovery and advocates the Lawrence Vernetti, William Irwin, Kenneth A. Giuliano, Albert Gough, Kate Johnston and D. Lansing
breakdown of disciplinary silos and Taylor (Cellumen, USA)
systematic application of the 4 modalities
(manipulate, measure, mine, and model) 4. Systems Pharmacology, Biomarkers and Biomolecular Networks
which are the central theme of this book. Aram Adourian, Thomas N. Plasterer, Raji Balasubramanian, Ezra Jennings, Shunguang Wang, Jan van
Systems biology, stem cells, RNAi, and der Greef, Robert McBurney, Pieter Muntendam, Noubar Afeyan (BG Medicine, USA)
biomarker discovery, are already
influencing our predictions of drug 5. Zebrafish Models for Human Diseases and Drug Discovery
efficacy. Automated data mining, Hanbing Zhong, Ning-Ai Liu and Shuo Lin (Peking University, China, Cedars-Sinai Medical Center and
computational (in silico) approaches, high UCLA, USA)
throughput screening and high content
screening, continue to impact our 6. Toxicity Pathways and Models: Mining for Potential Side Effects
predictions of drug safety. Several key Sean Ekins and Josef Scheiber (Collaborations in Chemistry and Novartis, USA)
technological advances in biologics and
complex drug discovery will be 7. Computational Systems Biology Modeling of Dosimetry and Cellular Response Pathways
presented to foster the cross-fertilization Qiang Zhang, Yu-Mei Tan, Sudin Bhattacharya and Melvin E. Andersen (The Hamner Institutes for
of ideas between the fields of small Health Sciences, USA)
molecule and larger molecule discovery.
This book cuts across multiple areas of 8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity and Hepatotoxicity Evaluation
drug discovery, each presented by Julio C. Davila, Donald B. Stedman, Sandra J. Engle, Howard I. Pryor II and Joseph P. Vacanti
(Pfizer Inc, USA)
pioneers in the field, and should have a
broad appeal to many biological
9. Telemetry Technology for Preclinical Drug Discovery and Development
scientists and interdisciplinary
Yi Yang (Novartis, USA)
technologists interested in drug research.
II. BIOLOGICS TECHNOLOGY
ISBN: 978-0-470-22555-4• $115.00 •
408 pages • Cloth • Jan 2008 10. Nanotechnology to Improve Drug Delivery
Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji (Northeastern University, USA)
T O O R D E R :
US, MEXICO & SOUTH AMERICA 11. Functional Glycomics and the Future of Glycomic Drugs
Tel: 1-800-225-5945 • Outside the US: Ram Sasisekharan (MIT, USA)
(732) 469-4400
Fax: (732) 302-2300 12. Modeling Efficacy and Safety of Engineered Biologics
E-mail: custserv@wiley.com • URL: Jeff Chabot and Bruce Gomes (Pfizer, USA)
www.catalog.wiley.com
13. Regulation of Gene Expression by Small, Non-Coding RNAs: Practical Applications
CANADA
Roman Herrara and Eric Tien (Pfizer, USA)
Tel: 1-800-567-4797 • Fax: 1-800-565-
6802 • Please add GST.
III. FUTURE PERSPECTIVE
GERMANY
Tel: (49) 6201 6061 52 • Fax: (49) 6201 14. Future Perspectives of Biological Engineering in Pharmaceutical Research:
6061 84 The Paradigm of Modeling, Mining, Manipulation and Measurements
E-mail: sales-books@wiley-vch.de Jinghai J. Xu, Sean Ekins, Michael McGlashen and Douglas Lauffenburger (Merck, Collaborations in
ALL OTHERS Chemistry, and MIT, USA)
Tel: +44 1243 779777 • Fax: +44 1243
843296