Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the state of play for Complex Medicine and highlights the potential opportunity for the UK.
Prof Peter Simpson, Medicines Discovery Catapult
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the state of play for Complex Medicine and highlights the potential opportunity for the UK.
Prof Peter Simpson, Medicines Discovery Catapult
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
Our second webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at developing the assay cascade for complex medicines.
Tilly Bingham, Concept Life Sciences
Our fifth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at how you can determine efficacy in vivo.
Jenny Worthington (Axis Bio)
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the target landscape for Complex Medicine.
Dr Duygu Yilmaz, Medicines Discovery Catapult
Clinical trial data wants to be free: Lessons from the ImmPort Immunology Dat...Barry Smith
Presentation to the Clinical and Research Ethics Seminar, Clinical and Translational Science Center, Buffalo, January 21, 2014
https://immport.niaid.nih.gov/
http://youtu.be/booqxkpvJMg
Our fourth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at alternative delivery for mRNA vaccines.
Helen McCarthy, pHion Therapeutics
Our fifth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at physicochemical characterisation new and novel approaches to understand the pharmacokinetics of complex drugs.
Juliana Maynard (MDC)
Global gene therapy market & pipeline insightKuicK Research
“Global Gene Therapy Market & Pipeline Insight” Market Highlight:
Gene Therapy Market Overview
Significance of Gene Therapy in Cancer Therapeutics
Current Applications of Gene Therapy to Cancer Treatment
Gene Therapy Market Dynamics: Drivers, Challenges & Future Outlook
FDA & AMA Guidelines for Gene Therapy
Gene Therapy Pipeline by Phase, Indications, Country & Company
Gene Therapy Pipeline: 246 Drugs
Marketed Gene Therapy: 2 (Gendicine & Rexin-G)
Cancer Gene Therapy Pipeline: 69 Drugs
Join us in Boston this coming Fall to attend Cambridge Healthtech Institute's (CHI) 2nd Annual FAST: Functional Analysis & Screening Technologies Congress on November 17-19, 2014 and meet with a community of 250+ biologists, screening managers, assay developers, engineers and pharmacologists dedicated to improving in vitro cell models and phenotypic screening to advance drug discovery and development at 6 conferences: Phenotypic Drug Discovery (Part I & II), Engineering Functional 3D Models, Screening and Functional Analysis of 3D Models, Organotypic Culture Models for Toxicology and Physiologically-Relevant Cellular Tumor Models for Drug Discovery. Delegates have the opportunity to share insights in interactive panel discussions and connect during networking breaks. View innovative technologies and scientific research revolutionizing early-stage drug discovery in the exhibit/poster hall.
Our second webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at developing the assay cascade for complex medicines.
Tilly Bingham, Concept Life Sciences
Our fifth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at how you can determine efficacy in vivo.
Jenny Worthington (Axis Bio)
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the target landscape for Complex Medicine.
Dr Duygu Yilmaz, Medicines Discovery Catapult
Clinical trial data wants to be free: Lessons from the ImmPort Immunology Dat...Barry Smith
Presentation to the Clinical and Research Ethics Seminar, Clinical and Translational Science Center, Buffalo, January 21, 2014
https://immport.niaid.nih.gov/
http://youtu.be/booqxkpvJMg
Our fourth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at alternative delivery for mRNA vaccines.
Helen McCarthy, pHion Therapeutics
Our fifth webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at physicochemical characterisation new and novel approaches to understand the pharmacokinetics of complex drugs.
Juliana Maynard (MDC)
Global gene therapy market & pipeline insightKuicK Research
“Global Gene Therapy Market & Pipeline Insight” Market Highlight:
Gene Therapy Market Overview
Significance of Gene Therapy in Cancer Therapeutics
Current Applications of Gene Therapy to Cancer Treatment
Gene Therapy Market Dynamics: Drivers, Challenges & Future Outlook
FDA & AMA Guidelines for Gene Therapy
Gene Therapy Pipeline by Phase, Indications, Country & Company
Gene Therapy Pipeline: 246 Drugs
Marketed Gene Therapy: 2 (Gendicine & Rexin-G)
Cancer Gene Therapy Pipeline: 69 Drugs
Join us in Boston this coming Fall to attend Cambridge Healthtech Institute's (CHI) 2nd Annual FAST: Functional Analysis & Screening Technologies Congress on November 17-19, 2014 and meet with a community of 250+ biologists, screening managers, assay developers, engineers and pharmacologists dedicated to improving in vitro cell models and phenotypic screening to advance drug discovery and development at 6 conferences: Phenotypic Drug Discovery (Part I & II), Engineering Functional 3D Models, Screening and Functional Analysis of 3D Models, Organotypic Culture Models for Toxicology and Physiologically-Relevant Cellular Tumor Models for Drug Discovery. Delegates have the opportunity to share insights in interactive panel discussions and connect during networking breaks. View innovative technologies and scientific research revolutionizing early-stage drug discovery in the exhibit/poster hall.
This is a slide show, with notes, about the CMTA's STAR initiative, created by Dana Schwertfeger and myself. It is to enhance your understanding of the CMTA's research STAR project and bring you up to date on recent news. Enjoy!
Growing Stronger Research Fund Overview Jan 2012 For DonorsAmer Haider
Website: http://www.growingstroner.org.
Overview of http://www.GrowingStronger.org, a non-profit focused on improving the quality of life of little people through supporting medical research.
mHealth Israel_Ryo Kosaka_AIST_National Institute of Advanced Industrial Scie...Levi Shapiro
Presentation by Ryo Kosaka, Senior Research Scientist, Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST). Includes an overview of priority strategies in Life Sciences and Biotech and description of the organization of the Life Sciences and Biotech department. Recent projects include a Portable System for High-Speed DNA Quantification, Application of a cell microarray chip for clinical diagnosis and single cell analysis, Safe and Secure Artificial Heart, New diagnosis for liver fibrosis utilizing glycans, AIST ventures from the department of Life Science & Biotech as well as International cooperation.
Δρ Χαράλαμπος Πιτσαλίδης, 3rd Health Innovation ConferenceStarttech Ventures
Ομιλία – Παρουσίαση: Δρ. Χαράλαμπος Πιτσαλίδης, Ερευνητής, Εργαστήριο Βιοηλεκτρονικών Συστημάτων & Βιοτεχνολογίας, Department of Chemical Engineering and Biotechnology, University of Cambridge, UK., Επιστημονικός Σύμβουλος σε Θέματα Βιοτεχνολογίας
Τίτλος παρουσίασης: «Ανθρώπινα Όργανα σε Chip». Καινοτόμες τεχνολογίες για την εύρεση νέων φαρμάκων και εξατομικευμένων θεραπειών»
From the Stem Cell workshop at the Bio-Link Summer Fellows Forum 2011
presenters: Edie Kaeuper, Carin Zimmerman, Golnar Afshar, Samantha Croft, & Bill Woodruff
Rahoitusinfo yrityksille 29.04.2021
Tervetuloa Turku Science Park Oy:n järjestämään rahoitusinfoon, jossa käydään läpi ajankohtaiset julkiset tukirahoitusmahdollisuudet yrityksille.
11.35 – 11.55 Ilmastorahaston tarjoamat rahoitusmahdollisuudet, Paula Laine, Ilmastorahasto
Rahoitusinfo yrityksille 29.04.2021
Tervetuloa Turku Science Park Oy:n järjestämään rahoitusinfoon, jossa käydään läpi ajankohtaiset julkiset tukirahoitusmahdollisuudet yrityksille.
10.45 – 11.15 EU – Horizon Europe, Cluster 5, Tom Warras, Business Finland
Rahoitusinfo yrityksille 29.04.2021
Tervetuloa Turku Science Park Oy:n järjestämään rahoitusinfoon, jossa käydään läpi ajankohtaiset julkiset tukirahoitusmahdollisuudet yrityksille.
10.05 – 10.25 ELY-keskuksen palvelut, rahoitus & elpymispaketin React EU-haku, Leevi Törmäkangas, ELY-keskus
Enterprise europe network rahoitusinfo 29.4.2021Business Turku
Rahoitusinfo yrityksille 29.04.2021
Tervetuloa Turku Science Park Oy:n järjestämään rahoitusinfoon, jossa käydään läpi ajankohtaiset julkiset tukirahoitusmahdollisuudet yrityksille.
11.15 – 11.35 Enterprise Europe Network (EEN), Olli Mankonen, Turku Science Park Oy
Kestävän ICT:n työpaja 12.3.2021 Tapio SalakoskiBusiness Turku
Työpajan teemana on ICT:n ympäristövaikutukset ja syyt, miksi digitaalisessa liiketoiminnassa kannattaa huomioida kestävän kehityksen tavoitteet.
Ohjelma:
Avaussanat - Timo Huttunen, Turku Science Park
"Digitalisaatio etenee, entä ymmärrys sen ympäristövaikutuksista?" - Lotta Toivonen, Sitra
"Kestävä ohjelmistokehitys alkaa EI:stä" - Johanna Andersen, Anders Innovations Oy
"Uudet liiketoimintamallit" - Sami Etula, Suomen vaikuttavuussijoitus Oy
"Isot jalat mutta lämmin käsi — kestävä ICT" - Tapio Salakoski, Turun yliopisto
Tilaisuuden päätössanat, Timo Huttunen
Kestävän ICT:n työpaja 12.3.2021 Lotta ToivonenBusiness Turku
Työpajan teemana on ICT:n ympäristövaikutukset ja syyt, miksi digitaalisessa liiketoiminnassa kannattaa huomioida kestävän kehityksen tavoitteet.
Ohjelma:
Avaussanat - Timo Huttunen, Turku Science Park
"Digitalisaatio etenee, entä ymmärrys sen ympäristövaikutuksista?" - Lotta Toivonen, Sitra
"Kestävä ohjelmistokehitys alkaa EI:stä" - Johanna Andersen, Anders Innovations Oy
"Uudet liiketoimintamallit" - Sami Etula, Suomen vaikuttavuussijoitus Oy
"Isot jalat mutta lämmin käsi — kestävä ICT" - Tapio Salakoski, Turun yliopisto
Tilaisuuden päätössanat, Timo Huttunen
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. High cost and inefficient drug
development
Total cost: $2.6 billion
5k – 10 k
compounds
100 – 500
compounds
50 – 250
compounds
3-5
compounds
1
compound
HUMAN
5+ years 10+ years 12+ years
Prateek Singh, CEO
science@finnadvance.com
3. In-development Drugs Fail
in Clinical Trials
HUMAN
Drugs have different effects on 2D cell cultures and animals vs humans
→90 % of drugs validated on animals fail during human clinical trials
→Cell models and animal models do not adequately represent the human biology
→A large part of the total pharma R&D budget is spent on the failing drugs
Prateek Singh, CEO
science@finnadvance.com
Organ-on-Chip models allow significant saving in dollars (HUNDREDS OF MILLIONS) and
major timelines (YEARS)
Lancet. 2011 Jun
4;377(9781):1915
4. Impact of Finnadvance’s technology
In 5 years drug discovery costs are estimated to decrease 10-26% as a result
of this technology.
“If organ on chip was capable of identifying appropriate biomarkers, it would be
the “Holy Grail” of biotechnology”
Prateek Singh, CEO
science@finnadvance.com
6. Organ-on-chip Market Forecast
2015 2020
Timescale (year)
2025
100B
10B
1B
100M
10M
MarketSize,Log.Scale
(USD)
Animal Research
In Vitro
3D In Vitro
Organ on a Chip
Prateek Singh, CEO
science@finnadvance.com
Ref : https://www.alliedmarketresearch.com/organ-on-chip-market
Ref : Organs on Chips 2017 report, March 2017, Yole Developpement
7. -M.Sc. Protein Tech and
Biochemistry, University of Oulu.
-B.Tech Biotechnology, National
institute of technology, India.
-5 peer reviewed publications.
-22 international presentations.
Prateek was born in India, and
after living in several countries
found a home in the scientific community of Oulu,
Northern Finland.
Prateek’s multi-disciplinary know-how was needed for
an EU Project aiming to uncover core mechanisms of
initiation and maintenance of Vascular Anomalies. The
study would be done on the Organ-on-Chip platforms
he would build. He founded Finnadvance to
commercialize this innovation and make drug discovery
faster and cheaper, while eliminating the use of
laboratory animals.
Prateek is a huge fan of science. He is extremely proud
of having worked on projects funded by NASA, ESA,
the Academy of Finland and TEKES.
Prateek Singh
CEO & Founder
Jari Moilanen
COOMinna Kihlström
CSO
Tuan Nguyen
CTO
Tuomas Nurmi
CMO
Highly Skilled & Diverse Team
Prateek Singh, CEO
science@finnadvance.com
-Ph.D. Vascular Biology, Uni. of Oulu
-M.Sc. Biochemistry and Cell Biology,
Oulu University.
-M.Sc. Thesis: Institute for Cancer
Research, University of Oslo, Norway.
-3 High-impact peer reviewed
publications. 3 Supervised Thesises.
Minna brings 8+ years cell culture and in
vitro research, 6+ years in vivo mouse
modelling and 7+ years microscopy
experience to the team.
-B.Eng & M.Sc in Biomedical Engineering
International University, Vietnam.
-Microtechnology research trainee,
University of Sheffield, UK.
-Ph.D. Studies in Biochemistry and
Molecular medicine, University of Oulu.
-2 Peer reviewed publications, 4
international presentations.
Tuan is a Biochemical Engineer who raised 2
research funding before finishing his M.Sc.
He has also won 2 young entrepreneur
competitions.
-M.Sc. Marketing,
Helsinki University.
-Lean Six Sigma Green Belt.
-MBA Studies.
10+ years Customer Operation
Manager of large accounts in
B2B Sales and 12+ years of
team management. Jari brings a
lot of seniority to the team.
-M.Sc. Biochemistry, University
of Oulu.
-1 Peer reviewed pulication, 1
international presentation.
Intellectual property rights
course and first patent filed in
2020.
Experience in teaching dance,
English and elementary school.