A layman's guide to ASEA and the science and power behind Redox Signaling Molecules, by Gary Samuelson Phd

1. Base Camp Presentation
How to talk about Redox Signaling
Gary Samuelson, Ph.D.

2. Redox Signaling is an Exploding
Field of Science
Books
•Redox Biochem
•Ruma Banerjee
•Antioxidant and Redox
Regulation of Genes
•Chandan K Sen
•Redox Signaling in Biology and
Medicine
•Claus Jacob
•Redox‐Mediated Signal
Transduction: Methods and
Protocols
•John T Hancock
•Redox Protemics
•Nick Lane
•And More
Journals
•Antiox & Redox Signaling
•Physiol Genomics
•Am. J. of Physiology
•The J. of Immunology
•PNAS
•Arteriosclerosis, Thromb.
Vasc.
•Hundreds More
Conferences
•The Gordon Research
Conference on Thiol‐based
Redox Regulation and Signaling
•4th International Conference
on Oxidative/Nitrosative Stress
and Disease
•International Symposium on
the Pathophysiology of
Reactive Oxygen and Nitrogen
Species
•Many more

3. Signaling Molecules in ASEA Come From
Salt and Water
Na Cl+ -
H
O
H
H
O
H
N N
Salt
Nitrogen
Water
H
O O
H
O O
H
N O
H
O
Cl
Hydrogen
Peroxide
Nitric
Oxide
Super
Oxides
Hypo
chlorites
More
than 20
Molecule
s …
REDuction OXidation
… …

4. Do we need to become experts in
Redox Biochemistry? Answer: No
Dr. Ruma Banerjee

5. What are Redox Signaling
Molecules?
• They are produced inside our cells
• They help cells communicate with each other
• They help tissues heal themselves
• The redox signaling molecules in ASEA are
actual molecules made from salt and water

6. How Do Redox Signaling Molecules
Work?
• They help cells communicate with each other
• They increase the “bars” on our “cell phones”
• When our cells have a problem, they need to
talk to each other
• If they cannot talk the problems become worse
• If they can talk, the problems can be solved

7. Cells Need to Communicate!!!
Cell
C
e
ll
Mail
box
Cell
C
e
ll
Mail
box

8. Cells are Like Houses that Shelter Life‐
Sustaining Activity
Fireplace, Furnace, Stove, Heaters ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Mitochondria
Mail Slots and Sorting ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Receptors, Vesicles, Golgi
Appliances, Tools, etc. ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Micromachines
Walls, Floors, Plumbing, Wires ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Membranes, tubules

9. We can think of Cells as
Houses Along Streets
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Blood
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10. Cells live in Communities Where
They Must Communicate to Survive

11. M
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When Cells Have a Problem
They Need Emergency Response
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12. Redox Signaling Helps Cells Detect the
Extent of the Damage
Normal
Healthy Cells
Have Fires
and Smoke
(Controlled
Oxidation )
When the
Fire and
Smoke Get
out of
Controll,
Cells need
Help

13. What Happens When Cells Need
Help?
• They must be able to send a “redox” signal
• Redox Signaling Molecules carry the signals
• Fire Marshalls see these “smoke” signals and
call in the fire crew
• Fire Crews put out the fires (with antioxidants)
and help repair the damage or destroy and
rebuild the house

14. Why Do I Need Redox Signaling
Molecules?
• Your body has tens of billions of cells that
need repair or replacement every day, even
more if you are sick or sore
• As you age and especially if you are sick you
do not have enough redox signaling molecules
to handle the demand
• If your cells are not able to call for help, they
will continue to “burn” (oxidize) and will not
be repaired or replaced fast enough

15. Does Your Brain and Nervous System
Need to Be Protected and Repaired?

16. Does Your Heart and Veins Need to be
Repaired?

17. Do Your Muscles Need to Be Repaired?

18. If You Answered “Yes” to Any of
These, You Need Redox Signaling
Molecules!

19. Redox Imbalance (Oxidative Stress)
Signals Protect‐Repair‐Replace Response

20. Innovation: Infuse Balanced Redox Signaling
Molecules (Lost by Aging or Stress) back into Tissues

21. Redox Signaling Technology is Destined
to Fuel the Greatest Advances in Medical
Science This Century
• Redox Signaling is fundamental to all
biological multi‐cellular processes
• It is non‐specific, non‐toxic and applicable
to a broad range of processes and pathways
• It is at the very core of mediating and
regulating the mechanisms that restore
functionality and health

22. Increasing Proper Redox Signaling in Your
Body is the Single Most Important Thing
You Can Do For Your Health
• Redox Signaling is absolutely necessary for all
living things on earth with more than one cell
• Redox Signaling Molecules in proper balance
cannot hurt you, they are in all of your cells
already, you just need more of them to keep
the cells healthy
• You need Redox Signaling Molecules so that
your body can restore and maintain its health

23. Stable Balanced Redox Signaling
Molecules in ASEA Confirmed
• ASEA contains a balance of ROS and RS
• Fluorescent Indicators Detect ROS
Components in ASEA
• ESR and EPR methods were used to verify
existence of stable ROS components
• Low Temperature Mass Spectroscopy used
find several ionic components of ASEA

24. ASEA Generates and Enhances
Antioxidants with Zero Toxic Effects
• ASEA causes no signs of toxicity on human
cells, even on a genetic level
• ASEA causes a significant increase (500%) in
the effectiveness of Antioxidants
• ASEA causes enhanced detection of damaged
cells
• ASEA causes increased messenger sensitivity
• ASEA causes old (senescent) cells to revive

25. Scientists Have Proven that There Are
Redox Signaling Molecules in ASEA
• ASEA contains the same balance of Redox
Signaling Molecules that already exist in the fluids
inside your body, cells and tissues
• Complex analysis has been done to prove that
ASEA has Redox Signaling Molecules and that
they are safe
• ASEA helps put out the fires in your body, helps
the body restore the cells proper function and
causes damaged cells to revitalize

26. Groundwork Toward Redox Signaling
Development
• Can stable complexes of Redox Signaling
Molecules be manufactured? YES.
• Can the bioactivity of such be
characterized? YES.
• Can such complexes be non‐toxic and
readily absorbed? YES.
• Can such a technology be commercialized?
It is up to you!

27. The Most Effective Way to Take ASEA
• Pour into a clean glass measuring cup
• 2 oz. twice a day – maintenance dose
• 4 oz. twice daily – mild challenges
• 8 oz. twice daily – severe challenges
• ½ oz twice daily or spray in mouth – reduce
detox symptoms
• Do not eat 5 min. before or after taking ASEA

28. Can We Tell the Story of the
Science of ASEA So That Everyone
Can Understand It and Repeat it?
If we can ASEA will make it into
more of the hands that need it