1) Mice were given either an ASEA beverage or placebo beverage for one week before undergoing endurance treadmill tests or remaining sedentary.
2) Mice that received ASEA ran 29% longer on treadmill tests compared to those that received placebo, suggesting increased endurance capacity.
3) Mice that received ASEA and ran showed 30% slower depletion of muscle glycogen and increased phosphorylation of acetyl-CoA carboxylase, a marker of increased fatty acid oxidation, compared to placebo runners.
International Journal of Pharmaceutical Science Invention (IJPSI) inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
ISSN 2347-2251
It appears that you're describing the scope of a scientific journal. This journal covers a wide range of topics related to both Pharmaceutical Sciences and Biological Sciences of the journalism journals.
The Indo-American Journal of Pharma and Bio Sciences is an online international journal that publishes articles quarterly.It's important to note that the specific policies, guidelines, and the editorial board of IAJPB may change over time, so it's advisable to visit the journal's official website or contact the journal of the research on journaling.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
The Protective Role Of High Dietary Protein On Arsenic Induced Hepatotoxicity...IOSR Journals
The objective of the present investigation was to study the protective role of High dietary protein on arsenic induced hepatotoxicity model in adult male albino rats. Hepatotoxicity in rats was caused by arsenic tri oxide at a dose of 3mg- /ml/kg body weight. Hepamerz, a drug used as standard hepatoprotective agent, was administered orally as standard hepatoprotective agent for 14 consecutive days prior to arsenic treatment at a dose of 10mg- /ml/kg body weight. This drug has many side effects. These side effects have prompted the scientific world for the search of alternative natural remedies of liver damage. The High dietary protein was administered orally to rats along with arsenic. The biochemical parameters were investigated. The results indicated that biochemical changes produced by arsenic were restored to almost normal by High protein diet. The High protein diet produced hepatoprotective effect through the modulation of antioxidant - mediated mechanism by altering serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), superoxide dismutase (SOD) and catalase (CAT) activities and reduced glutathione (GSH) and lipid peroxidation (LPO) levels - against arsenic induced hepatotoxicity model in rats.
Interaction between anxiolytic effects of magnesium oxide nanoparticles and e...Nanomedicine Journal (NMJ)
This study examined the anxiolytic (anxiety-reducing) effects of magnesium oxide nanoparticles (MgO NPs) and exercise in rats. The results showed that both 6 weeks of exercise and chronic administration of MgO NPs individually reduced anxiety in rats. However, when MgO NPs were administered during exercise, there was no additional reduction in anxiety beyond the effects of exercise alone. The study suggests that exercise and MgO NPs may reduce anxiety through common mechanisms in the central nervous system.
1) Mice were given either an ASEA beverage or placebo beverage for one week before undergoing endurance treadmill tests or remaining sedentary.
2) Mice that received ASEA ran 29% longer on treadmill tests compared to those that received placebo, suggesting increased endurance capacity.
3) Mice that received ASEA and ran showed 30% slower depletion of muscle glycogen and increased phosphorylation of acetyl-CoA carboxylase, a marker of increased fatty acid oxidation, compared to placebo runners.
International Journal of Pharmaceutical Science Invention (IJPSI) inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
ISSN 2347-2251
It appears that you're describing the scope of a scientific journal. This journal covers a wide range of topics related to both Pharmaceutical Sciences and Biological Sciences of the journalism journals.
The Indo-American Journal of Pharma and Bio Sciences is an online international journal that publishes articles quarterly.It's important to note that the specific policies, guidelines, and the editorial board of IAJPB may change over time, so it's advisable to visit the journal's official website or contact the journal of the research on journaling.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
The Protective Role Of High Dietary Protein On Arsenic Induced Hepatotoxicity...IOSR Journals
The objective of the present investigation was to study the protective role of High dietary protein on arsenic induced hepatotoxicity model in adult male albino rats. Hepatotoxicity in rats was caused by arsenic tri oxide at a dose of 3mg- /ml/kg body weight. Hepamerz, a drug used as standard hepatoprotective agent, was administered orally as standard hepatoprotective agent for 14 consecutive days prior to arsenic treatment at a dose of 10mg- /ml/kg body weight. This drug has many side effects. These side effects have prompted the scientific world for the search of alternative natural remedies of liver damage. The High dietary protein was administered orally to rats along with arsenic. The biochemical parameters were investigated. The results indicated that biochemical changes produced by arsenic were restored to almost normal by High protein diet. The High protein diet produced hepatoprotective effect through the modulation of antioxidant - mediated mechanism by altering serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), superoxide dismutase (SOD) and catalase (CAT) activities and reduced glutathione (GSH) and lipid peroxidation (LPO) levels - against arsenic induced hepatotoxicity model in rats.
Interaction between anxiolytic effects of magnesium oxide nanoparticles and e...Nanomedicine Journal (NMJ)
This study examined the anxiolytic (anxiety-reducing) effects of magnesium oxide nanoparticles (MgO NPs) and exercise in rats. The results showed that both 6 weeks of exercise and chronic administration of MgO NPs individually reduced anxiety in rats. However, when MgO NPs were administered during exercise, there was no additional reduction in anxiety beyond the effects of exercise alone. The study suggests that exercise and MgO NPs may reduce anxiety through common mechanisms in the central nervous system.
1) The study examined changes in plasma beta-endorphin (β-EP) concentrations in response to different heavy resistance exercise protocols.
2) Only the high total work protocol (1 min rest, 10 repetition maximum load) demonstrated significant increases in plasma β-EP and serum cortisol during and after exercise.
3) Increases in blood lactate were observed after all protocols, but were highest after the high total work protocol, and lactate concentrations correlated with β-EP concentrations.
This study examined the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure on the uterus of adult female rats. Rats were orally administered DEHP at doses of 0, 1, 10, and 100 mg/kg body weight daily for 30 days. Key findings include:
1) Serum estradiol levels were unchanged in the 1 and 10 mg groups but marginally increased in the 100 mg group. Progesterone levels increased in the 1 and 10 mg groups.
2) Histological examination found structural abnormalities in the uterus such as decreased diameter and thinning of layers in the 10 and 100 mg groups.
3) mRNA expression of estrogen receptor alpha decreased in the 100 mg
This study investigated the effects of N-acetylcysteine (NAC) on asprosin and meteorin-like protein (METRNL) levels in a rat model of lower extremity ischemia-reperfusion injury. Rats were divided into five groups: a control group, sham surgery group, NAC treatment group, ischemia-reperfusion injury group, and ischemia-reperfusion injury plus NAC treatment group. Serum and tissue levels of asprosin and METRNL were measured after 120 minutes of reperfusion. The results showed that asprosin and METRNL levels were lower in the ischemia-reperfusion injury group compared to controls, but higher in the ischemia-reperfusion injury plus NAC treatment group compared
Je ponline april2012kaminagakura_zagattoPaulo Redkva
The document examines whether the running-based anaerobic sprint test (RAST) can predict anaerobic capacity as measured by maximum accumulated oxygen deficit (MAOD). Eleven trained runners completed a RAST and tests to determine MAOD. No significant correlations were found between any RAST variables (peak power, mean power, fatigue index, maximal velocity, mean velocity) and MAOD. The study concludes that RAST does not predict anaerobic capacity in runners as measured by MAOD.
Prolonged paradoxical sleep deprivation (PSD) in rats results in increased food intake, activation of the hypothalamic-pituitary-adrenal (HPA) axis, and loss of body weight despite hyperphagia. This study examined the effects of 96 hours of PSD on metabolism regulation, feeding behavior, and stress response by assessing corticotropin-releasing hormone (CRH) and orexin (ORX) immunoreactivity in the hypothalamus of rats. PSD increased diurnal food intake but not nocturnal intake, augmented CRH and ORX immunoreactivity, and increased plasma levels of adrenocorticotropic hormone and corticosterone,
1) Prolonged paradoxical sleep deprivation (PSD) in rats results in increased food intake, activation of the hypothalamic-pituitary-adrenal (HPA) axis, and loss of body weight despite hyperphagia.
2) The study found that 96 hours of PSD increased immunoreactivity for corticotropin releasing hormone (CRH) in the paraventricular nucleus and for orexin in the lateral hypothalamus of rats.
3) PSD also increased plasma levels of adrenocorticotropic hormone and corticosterone, and average corticosterone levels correlated negatively with body weight gain, indicating activation of the HPA axis
Effects of eugenol on resting tension of rat atriaRobson Olivoto
Artigo para analise do Eugenol, um óleo essencial, como uma possível ferramenta biológica para experimentos com células musculares. Os resultados indicaram ou sugerem que existe uma via de ativação da maquinaria contrátil que ativa as proteínas contrateis (promovendo a contração) mesmo na ausência de íons cálcio.
This document provides information about a PhD scholar named Haseeb Ahsan who is exploring the therapeutic potential of Naproxen derivatives in treating rheumatoid arthritis under the supervision of Dr. Alamgeer. It introduces rheumatoid arthritis and issues with current treatments. The scholar hypothesizes that newly synthesized Naproxen derivatives will have anti-arthritic effects and safety. The document outlines plans to evaluate the anti-inflammatory effects of compounds in vitro and in animal models of arthritis, and to assess toxicity.
1) The study evaluated the antidepressant activity of the ethanolic extract of Ocimum sanctum (tulsi) leaves in mice.
2) In the forced swim test, Ocimum sanctum showed significant antidepressant activity at a dose of 8.5 mg/kg compared to the control.
3) The study indicates the potential antidepressant-like effects of Ocimum sanctum, though the exact mechanism is still unknown. Further research is needed to elucidate the mechanism of action.
Effect of Antioxidant status on liver following Atrazine exposure and its pro...IOSR Journals
The efficacy of Andrographis paniculata (AP) extract was studied on atrazine induced hepatic damage in rats. Ethanolic extract of AP (150mg/kg body weight) was found to protect the male wistar rats from hepato toxic action of atrazine as evidence by significant reduction in the level of lipid peroxidation and increased the antioxidant defense system activity in the atrazine intoxicated rats. However, AP treatment ameliorated the effects of atrazine suggesting it as potential antioxidant against atrazine induced oxidative stress.
1) The study investigated the effects of IRL-1620, an ETB receptor agonist, on beta amyloid (Aβ)-induced cognitive impairment and oxidative stress in non-diabetic and diabetic rats.
2) IRL-1620 treatment significantly reduced oxidative stress markers increased by Aβ and improved spatial memory impairment caused by Aβ in both non-diabetic and diabetic rats.
3) The results suggest that stimulation of ETB receptors by IRL-1620 provides neuroprotection against Aβ-induced cognitive impairment and oxidative stress.
ATP (adenosine triphosphate) is the molecular unit that stores and transports energy within cells. It fuels enzymes and is present in all cells, providing energy for physiological processes. ATP is continuously recycled in the body, turning over its own body weight equivalent daily. Several studies have found that ATP supplementation can help reduce muscle fatigue, improve force output during exercise, increase muscle mass, strength and power, and provide small ergogenic effects on muscular strength under some conditions. However, more research is needed before recommending ATP supplementation to athletes seeking ergogenic aids.
Behavioral and Biochemical Studies of Piperidine Related Adrenolytic Compound...IJRESJOURNAL
ABSTRACT: The present study concerns behavioral and biochemical effects of 4 amino methyl piperidine substituted 2-bromo ethyl benzene derivative compounds. With intraperitoneal injection in rats, locomotor activity was significantly decreased in open field experiment, anxiolytic effect observed in light and dark apparatus significantly increased while stimulatory activity of compound monitor in home cage apparatussignificantly decreased. Moreover, blood glucose and cholesterol level also examined. Presentsynthetic compound decreases blood glucose level and also decreases the total serum cholesterol, suggested that these 4 amino methyl piperidine substituted 2-bromo ethyl benzene compounds may be effective as a drug for treatment of anxiety, enhancement of locomotion. It is also beneficial for cardiac and diabetic patient.
Evaluation of Antidepressant Activity of Aqueous Extract of Withania Somnifer...iosrjce
Anti-depressants play a major role in today’s life style. There are evidences of the ayurvedic
formulation withania somnifera (roots) being effective in various neuro- psychiatric conditions. The antidepressant
activities of aqueous extract Withania somnifera roots (AEWS) were studied using - Forced swim
test (FST). Effect of different doses of AEWS (30,40,50 mg/kg), Imipramine (15mg/kg)were studied on
behavioural despair tests induced immobility time . WS produced dose dependent decrease in immobility
time in FST, maximum effect being observed with WS 50 mg/kg. The findings support the use of WS as potential
adjuvant in depressive disorders.
This document describes various in vivo and in vitro models used for screening potential antiparkinsonian drugs. Some key in vivo models mentioned include: antagonism of tremors induced by tremorine/oxotremorine in mice; use of the MPTP model in monkeys to induce Parkinson-like symptoms; antagonism of reserpine-induced sedation in mice; measurement of circling behavior in rats with unilateral nigrostriatal lesions; and tests of motor function in rats such as the elevated body swing test, skilled paw reaching test, and stepping test. In vitro models described involve use of rat striatal slices and measurement of dopamine-stimulated adenylyl cyclase activity.
This document describes various in vivo and in vitro models used for screening potential antiparkinsonian drugs. Some key in vivo models mentioned include: 1) antagonism of tremors induced by tremorine/oxotremorine in mice, 2) use of the MPTP model in monkeys to induce Parkinson's disease-like symptoms, and 3) antagonism of sedation induced by reserpine in mice. Important in vitro/ex vivo models include measuring dopamine-stimulated adenylyl cyclase activity and radioligand binding studies for dopamine receptors. The document provides details on the procedures, evaluations, and modifications of these various screening models.
Comparison of the Hypazotemic Effects of Erythropoietin and U-74389G on Urea ...asclepiuspdfs
Aim: This study calculated the hypazotemic capacities of two drugs as follows: The erythropoietin (Epo) and the antioxidant drug U-74389G. The calculation was based on the results of two preliminary studies, each one of which estimated the hypazotemic influence, after the respective drug usage in an induced hypoxia-reoxygenation animal experiment. Materials and Methods: The two main experimental endpoints at which the blood urea levels were evaluated the 60th reoxygenation min (for the groups A, C, and E) and the 120th reoxygenation min (for the groups B, D, and F). Especially, the groups A and B were processed without drugs, groups C and D after Epo administration whereas groups E and F after U-74389G administration. Results: The first preliminary study of Epo presented a nonsignificant hypazotemic effect by 1.25% ± 1.67% (P = 0.4430). The second preliminary study of U-74389G presented a significant hypazotemic effect by 5.81% ± 1.57% (P = 0.0005). These two studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has 4.632148-fold more hypazotemic potency than Epo (P = 0.0000). Conclusions: The antioxidant capacities of U-74389G enhance the acute hypazotemic properties presenting 4.632148-fold more intensive hypazotemia than Epo (P = 0.0000).
Protective Effect of β-Carotene Extracted From the Cyanobacterium Oscillatori...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
1. The study investigated the role of the central dopaminergic system in the analgesic action of paracetamol using rodent pain models.
2. It found that paracetamol's analgesic activity increased when combined with drugs that increase dopamine levels and decreased when combined with a dopamine blocker.
3. Brain dopamine levels were higher in mice treated with paracetamol plus drugs increasing dopamine, and lower with a dopamine-decreasing drug. This suggests modulation of the dopaminergic system contributes to paracetamol's analgesic effects.
This study examined the effects of prolonged simvastatin (SIM) treatment on ischemia-reperfusion (I/R) induced acute kidney injury in rats. Rats were divided into four groups: sham, ischemia, I/R, and I/R+SIM treated. The I/R group showed intense inflammation, necrosis, and apoptosis in kidney tissue. The I/R+SIM group showed reduced inflammation and tissue damage. Biochemical analysis found increased oxidative stress and inflammation markers in the ischemia and I/R groups compared to control, but levels in the I/R+SIM group were similar to control. Histological analysis also showed more damage in ischemia and I/R groups versus control, while the I/R+
A brochure describing the remarkable benefits of ASEA, the "world's only" cellular supplement which is scientifically-founded, multi-patented, and totally native to the body.
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Similar to ASEA: Redox Cell Signaling Endurance Study.pdf
1) The study examined changes in plasma beta-endorphin (β-EP) concentrations in response to different heavy resistance exercise protocols.
2) Only the high total work protocol (1 min rest, 10 repetition maximum load) demonstrated significant increases in plasma β-EP and serum cortisol during and after exercise.
3) Increases in blood lactate were observed after all protocols, but were highest after the high total work protocol, and lactate concentrations correlated with β-EP concentrations.
This study examined the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure on the uterus of adult female rats. Rats were orally administered DEHP at doses of 0, 1, 10, and 100 mg/kg body weight daily for 30 days. Key findings include:
1) Serum estradiol levels were unchanged in the 1 and 10 mg groups but marginally increased in the 100 mg group. Progesterone levels increased in the 1 and 10 mg groups.
2) Histological examination found structural abnormalities in the uterus such as decreased diameter and thinning of layers in the 10 and 100 mg groups.
3) mRNA expression of estrogen receptor alpha decreased in the 100 mg
This study investigated the effects of N-acetylcysteine (NAC) on asprosin and meteorin-like protein (METRNL) levels in a rat model of lower extremity ischemia-reperfusion injury. Rats were divided into five groups: a control group, sham surgery group, NAC treatment group, ischemia-reperfusion injury group, and ischemia-reperfusion injury plus NAC treatment group. Serum and tissue levels of asprosin and METRNL were measured after 120 minutes of reperfusion. The results showed that asprosin and METRNL levels were lower in the ischemia-reperfusion injury group compared to controls, but higher in the ischemia-reperfusion injury plus NAC treatment group compared
Je ponline april2012kaminagakura_zagattoPaulo Redkva
The document examines whether the running-based anaerobic sprint test (RAST) can predict anaerobic capacity as measured by maximum accumulated oxygen deficit (MAOD). Eleven trained runners completed a RAST and tests to determine MAOD. No significant correlations were found between any RAST variables (peak power, mean power, fatigue index, maximal velocity, mean velocity) and MAOD. The study concludes that RAST does not predict anaerobic capacity in runners as measured by MAOD.
Prolonged paradoxical sleep deprivation (PSD) in rats results in increased food intake, activation of the hypothalamic-pituitary-adrenal (HPA) axis, and loss of body weight despite hyperphagia. This study examined the effects of 96 hours of PSD on metabolism regulation, feeding behavior, and stress response by assessing corticotropin-releasing hormone (CRH) and orexin (ORX) immunoreactivity in the hypothalamus of rats. PSD increased diurnal food intake but not nocturnal intake, augmented CRH and ORX immunoreactivity, and increased plasma levels of adrenocorticotropic hormone and corticosterone,
1) Prolonged paradoxical sleep deprivation (PSD) in rats results in increased food intake, activation of the hypothalamic-pituitary-adrenal (HPA) axis, and loss of body weight despite hyperphagia.
2) The study found that 96 hours of PSD increased immunoreactivity for corticotropin releasing hormone (CRH) in the paraventricular nucleus and for orexin in the lateral hypothalamus of rats.
3) PSD also increased plasma levels of adrenocorticotropic hormone and corticosterone, and average corticosterone levels correlated negatively with body weight gain, indicating activation of the HPA axis
Effects of eugenol on resting tension of rat atriaRobson Olivoto
Artigo para analise do Eugenol, um óleo essencial, como uma possível ferramenta biológica para experimentos com células musculares. Os resultados indicaram ou sugerem que existe uma via de ativação da maquinaria contrátil que ativa as proteínas contrateis (promovendo a contração) mesmo na ausência de íons cálcio.
This document provides information about a PhD scholar named Haseeb Ahsan who is exploring the therapeutic potential of Naproxen derivatives in treating rheumatoid arthritis under the supervision of Dr. Alamgeer. It introduces rheumatoid arthritis and issues with current treatments. The scholar hypothesizes that newly synthesized Naproxen derivatives will have anti-arthritic effects and safety. The document outlines plans to evaluate the anti-inflammatory effects of compounds in vitro and in animal models of arthritis, and to assess toxicity.
1) The study evaluated the antidepressant activity of the ethanolic extract of Ocimum sanctum (tulsi) leaves in mice.
2) In the forced swim test, Ocimum sanctum showed significant antidepressant activity at a dose of 8.5 mg/kg compared to the control.
3) The study indicates the potential antidepressant-like effects of Ocimum sanctum, though the exact mechanism is still unknown. Further research is needed to elucidate the mechanism of action.
Effect of Antioxidant status on liver following Atrazine exposure and its pro...IOSR Journals
The efficacy of Andrographis paniculata (AP) extract was studied on atrazine induced hepatic damage in rats. Ethanolic extract of AP (150mg/kg body weight) was found to protect the male wistar rats from hepato toxic action of atrazine as evidence by significant reduction in the level of lipid peroxidation and increased the antioxidant defense system activity in the atrazine intoxicated rats. However, AP treatment ameliorated the effects of atrazine suggesting it as potential antioxidant against atrazine induced oxidative stress.
1) The study investigated the effects of IRL-1620, an ETB receptor agonist, on beta amyloid (Aβ)-induced cognitive impairment and oxidative stress in non-diabetic and diabetic rats.
2) IRL-1620 treatment significantly reduced oxidative stress markers increased by Aβ and improved spatial memory impairment caused by Aβ in both non-diabetic and diabetic rats.
3) The results suggest that stimulation of ETB receptors by IRL-1620 provides neuroprotection against Aβ-induced cognitive impairment and oxidative stress.
ATP (adenosine triphosphate) is the molecular unit that stores and transports energy within cells. It fuels enzymes and is present in all cells, providing energy for physiological processes. ATP is continuously recycled in the body, turning over its own body weight equivalent daily. Several studies have found that ATP supplementation can help reduce muscle fatigue, improve force output during exercise, increase muscle mass, strength and power, and provide small ergogenic effects on muscular strength under some conditions. However, more research is needed before recommending ATP supplementation to athletes seeking ergogenic aids.
Behavioral and Biochemical Studies of Piperidine Related Adrenolytic Compound...IJRESJOURNAL
ABSTRACT: The present study concerns behavioral and biochemical effects of 4 amino methyl piperidine substituted 2-bromo ethyl benzene derivative compounds. With intraperitoneal injection in rats, locomotor activity was significantly decreased in open field experiment, anxiolytic effect observed in light and dark apparatus significantly increased while stimulatory activity of compound monitor in home cage apparatussignificantly decreased. Moreover, blood glucose and cholesterol level also examined. Presentsynthetic compound decreases blood glucose level and also decreases the total serum cholesterol, suggested that these 4 amino methyl piperidine substituted 2-bromo ethyl benzene compounds may be effective as a drug for treatment of anxiety, enhancement of locomotion. It is also beneficial for cardiac and diabetic patient.
Evaluation of Antidepressant Activity of Aqueous Extract of Withania Somnifer...iosrjce
Anti-depressants play a major role in today’s life style. There are evidences of the ayurvedic
formulation withania somnifera (roots) being effective in various neuro- psychiatric conditions. The antidepressant
activities of aqueous extract Withania somnifera roots (AEWS) were studied using - Forced swim
test (FST). Effect of different doses of AEWS (30,40,50 mg/kg), Imipramine (15mg/kg)were studied on
behavioural despair tests induced immobility time . WS produced dose dependent decrease in immobility
time in FST, maximum effect being observed with WS 50 mg/kg. The findings support the use of WS as potential
adjuvant in depressive disorders.
This document describes various in vivo and in vitro models used for screening potential antiparkinsonian drugs. Some key in vivo models mentioned include: antagonism of tremors induced by tremorine/oxotremorine in mice; use of the MPTP model in monkeys to induce Parkinson-like symptoms; antagonism of reserpine-induced sedation in mice; measurement of circling behavior in rats with unilateral nigrostriatal lesions; and tests of motor function in rats such as the elevated body swing test, skilled paw reaching test, and stepping test. In vitro models described involve use of rat striatal slices and measurement of dopamine-stimulated adenylyl cyclase activity.
This document describes various in vivo and in vitro models used for screening potential antiparkinsonian drugs. Some key in vivo models mentioned include: 1) antagonism of tremors induced by tremorine/oxotremorine in mice, 2) use of the MPTP model in monkeys to induce Parkinson's disease-like symptoms, and 3) antagonism of sedation induced by reserpine in mice. Important in vitro/ex vivo models include measuring dopamine-stimulated adenylyl cyclase activity and radioligand binding studies for dopamine receptors. The document provides details on the procedures, evaluations, and modifications of these various screening models.
Comparison of the Hypazotemic Effects of Erythropoietin and U-74389G on Urea ...asclepiuspdfs
Aim: This study calculated the hypazotemic capacities of two drugs as follows: The erythropoietin (Epo) and the antioxidant drug U-74389G. The calculation was based on the results of two preliminary studies, each one of which estimated the hypazotemic influence, after the respective drug usage in an induced hypoxia-reoxygenation animal experiment. Materials and Methods: The two main experimental endpoints at which the blood urea levels were evaluated the 60th reoxygenation min (for the groups A, C, and E) and the 120th reoxygenation min (for the groups B, D, and F). Especially, the groups A and B were processed without drugs, groups C and D after Epo administration whereas groups E and F after U-74389G administration. Results: The first preliminary study of Epo presented a nonsignificant hypazotemic effect by 1.25% ± 1.67% (P = 0.4430). The second preliminary study of U-74389G presented a significant hypazotemic effect by 5.81% ± 1.57% (P = 0.0005). These two studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has 4.632148-fold more hypazotemic potency than Epo (P = 0.0000). Conclusions: The antioxidant capacities of U-74389G enhance the acute hypazotemic properties presenting 4.632148-fold more intensive hypazotemia than Epo (P = 0.0000).
Protective Effect of β-Carotene Extracted From the Cyanobacterium Oscillatori...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
1. The study investigated the role of the central dopaminergic system in the analgesic action of paracetamol using rodent pain models.
2. It found that paracetamol's analgesic activity increased when combined with drugs that increase dopamine levels and decreased when combined with a dopamine blocker.
3. Brain dopamine levels were higher in mice treated with paracetamol plus drugs increasing dopamine, and lower with a dopamine-decreasing drug. This suggests modulation of the dopaminergic system contributes to paracetamol's analgesic effects.
This study examined the effects of prolonged simvastatin (SIM) treatment on ischemia-reperfusion (I/R) induced acute kidney injury in rats. Rats were divided into four groups: sham, ischemia, I/R, and I/R+SIM treated. The I/R group showed intense inflammation, necrosis, and apoptosis in kidney tissue. The I/R+SIM group showed reduced inflammation and tissue damage. Biochemical analysis found increased oxidative stress and inflammation markers in the ischemia and I/R groups compared to control, but levels in the I/R+SIM group were similar to control. Histological analysis also showed more damage in ischemia and I/R groups versus control, while the I/R+
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ASEA: A World ClassTriathlete"s Product ReviewASEA
Rich Roll reviews the ASEA product after being skeptical at first. He summarizes the science behind redox signaling molecules and how ASEA claims to provide a stable formula of these molecules to enhance the body's natural antioxidant defenses and cellular repair. After using ASEA himself, Rich Roll believes he has realized tangible performance gains in his endurance training and recovery. He met with the scientific founder of ASEA and was impressed by the research, leading him to endorse ASEA as a product he feels he can stand behind.
The study found that after drinking ASEA for one week, athletes experienced increased mobilization of free fatty acids in their blood prior to exercise. This mobilization of fatty acids from fat stores helps spare glycogen and provides more fuel for later stages of exercise. The study observed shifts in 43 metabolites in the athletes' blood after drinking ASEA, indicating mobilization of fuel stores from abdominal fat. This glycogen sparing effect of ASEA was found to help increase athletes' endurance and power output. Further research is still being done to understand the implications of increases in blood vitamin C levels after exercise for athletes drinking ASEA.
Discover and experience the unique natural healing benefits contain in ASEA, the world's only wellness supplement which contains "multi-patented" Redox Cell Signaling Molecules, totally native to our bodies and the secret to health, vitality and anti-aging.
Discover the remarkable cellular health benefits of ASEA, the world's only, multi-patented health and wellness supplement which contains "native to the body" Redox Cell Signaling Molecules.
ASEATM is a supplement that claims to greatly improve cycling performance and recovery through redox signaling. It contains only water and sodium chloride but in trials increased VO2 max and reduced lactic acid buildup. The author found that after taking ASEATM, they were able to recover faster during races, increase power output while lowering heart rate, and set a new personal record on a weekly hill climb. They also experienced better overnight and digestive recovery. The only downside was the slight chlorine smell and taste from the sodium chloride.
This document discusses ASEATM, a supplement containing reactive molecules that are naturally produced by mitochondria to activate antioxidants and support the immune system and healing process. It explains that antioxidants alone cannot fight free radicals without these reactive molecules, and that maintaining the proper balance is important for health. The document claims that ASEATM is the first stable product containing these important reactive molecules, and research shows it increases antioxidant effectiveness, supports the immune system, and allows the body to produce its own antioxidants.
ASEA is a supplement that provides redox signaling molecules to fuel athletic performance and accelerate recovery. Redox signaling molecules are produced by cells and help cells work efficiently. ASEA is the only external source of perfectly balanced redox signaling molecules and fuels cells to perform at peak efficiency, push harder for longer, and recover faster. It allows athletes to build strength through more frequent, intense workouts and recover quickly during endurance events.
The document discusses redox signaling molecules, which are byproducts produced when mitochondria generate ATP through oxidative phosphorylation. Specifically, it notes that two types of redox signaling molecules - RS and ROS molecules - are produced. Redox signaling molecules play a key role in cellular functions and are important for processes like aging, healing, and repair. The document provides background on mitochondria and their role in producing ATP, the main energy source for cells.
ASEA is a supplement containing redox molecules that are sensed through smell rather than taste. Some people detect flavors like chlorine or hydrogen peroxide, indicating an imbalance. Over time, as the body's redox molecules are replenished, the flavor shifts to a bland water quality. ASEA is made by processing purified salt water through oxidation and reduction to transform it into a balanced mixture of redox molecules rather than a saline solution. It contains sodium but in a lower amount than many foods. ASEA is safely assimilated through diffusion like water and does not interact with other supplements or medications.
Asea > April 2012 Human Performance Study: Questions and Answers ASEA
The research was conducted at North Carolina Research Institute by Appalachian State University's Human Performance Laboratory led by Dr. David Nieman. 20 cyclists were randomized into groups drinking ASEA or a salt water placebo for 7 days. Blood tests before and after a 75km cycling trial found ASEA caused a significant shift in 43 metabolites prior to exercise, compared to 10-20 shifts typically found for supplements. This indicated ASEA primes the body for exercise by mobilizing fatty acids from fat stores to be used as fuel, both at rest and during exercise, sparing muscle glycogen. The results surprised researchers as most supplements only cause shifts after combined with exercise.
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1. ►ASEA™ is a saline-based beverage that undergoes a proprietary process and contains reactive
redox-signaling molecules.
►31P NMR and EPR experiments utilizing spin trap molecules (DIPPMPO) were used to explore the
ASEA beverage for free radicals. An additional experiment using 31P NMR DIPPMPO with and
without superoxide dismutase was conducted. Results supported the presence of stable peroxyl
and/or superoxide radicals in ASEA.
►The theory of hormesis involves repeated exposure to a mild physical, chemical, or biological stress
resulting in increased resistance to subsequent exposures to otherwise harmful doses of the same
stressors. The exposures to mild stressors are thought to induce beneficial cellular responses
leading to increased whole organism resistance to the stress. Common examples of this beneficial
response include, exercise, ischemic preconditioning, and caloric restriction (Mattson, 2008). ASEA
may increase exercise performance through a hormesis effect, but this has not yet been established.
►PURPOSE: To determine if mice given ASEA™ have increased endurance treadmill run times
compared to placebo and investigate potential mechanisms.
Animals: Six-month old male specific pathogen-free C57BL/6 mice (n =60) were purchased from Jackson Laboratory. Mice
were randomly assigned to each of the four treatment groups (n = 15 each). Mice were group housed (3-4/cage) and provided standard
rodent chow and water ad libitum. All animal procedures were reviewed and approved by the North Carolina Research Campus
IACUC.
Treatment and Design: ASEA or placebo (same ingredients as ASEA beverage without undergoing the proprietary processing)
was administered via gavage once per day for 1-week. The average body mass of all the mice at the start of the study determined the
volume of ASEA used for the gavaging, but the volume did not exceed 0.3mL. Following the 1-week treatment period (7 days) mice
were euthanized and tissues harvested for further analysis of outcome measures. Mice from the endurance testing treatment groups
were oriented to the treadmill in the following fashion: During the three day period preceding the maximal endurance test, mice were
oriented (trained) to the treadmill for 15 min/day. Speeds for the training days were 10 m/min, 15 m/min, and 18 m/min respectively.
Then, on the final day of treatment mice underwent the maximal endurance capacity test on the treadmill (Table 1). For the treadmill
orientation and endurance protocols, mice were run on a multi- lane rodent treadmill (Columbus Instruments, Columbus OH) equipped
with a shock grid at the back. When the mouse could either no longer run (as assessed by sitting on the shock grid with all 4 paws off of
the belt for more than 5 seconds), the mouse was removed from the shock grid immediately and placed back into the home cage. The
mice were monitored for recovery for a period of at least 20 minutes following the orientation bouts. Mice were euthanized within 30
minutes of the final endurance test.
Glycogen: Post-exercise and end point liver and muscle glycogen levels were assayed using the Glycogen Assay Kit (700480,
Cayman Chemical Company, Ann Arbor MI). Rate of muscle glycogen usage was estimated for both ASEA Run and Placebo Run
groups. Example Calculation: Average muscle glycogen (Placebo Sedentary) – Average muscle glycogen (Placebo Run) / Average
Placebo Run Time.
Enzyme Assays: β-hydroxyacyl-CoA dehydrogenase (β-HAD) activities were determined in whole gastrocnemius homogenates
using methods previously described (Laye, 2009). Briefly, powdered frozen muscle was homogenized in buffer containing HEPES, Na
pyrophosphate, Na+, EDTA, Triton, and protease and phosphatase inhibitors. CS activity was measured in homogenate incubated in
buffer containing oxaloacetate and dithiobis(2-nitrobenzoic acid) (DTNB). Acetyl-CoA was added to the buffer and CS activity was
determined by the appearance of reduced DTNB at a wavelength of 405nm. β-HAD activity was measured in homogenate incubated in
buffer containing triethanolamine, EDTA, and nicotinamide adenine dinucleotide (NADH). Acetyl-CoA was added to the buffer and β-
HAD activity was determined by the disappearance of NADH at a wavelength of 340nm. All assays were performed at 37°C.
Western Blotting: Western blotting was performed as previously described (Laye et al. 2009). The following antibodies were
used: Carnitine Palmitoyltransferase-1 (CPT1) (Santa Cruz Biotechnology, Santa Cruz, CA), Acetyl-CoA Carboxylase (ACC), and
phospho-ACC (Ser79) (Cell Signaling, Danvers, MA). Whole gastrocnemius homogenates were separated by SDS-PAGE, transferred to
polyvinylidene fluoride membranes. Membranes were exposed to the appropriate primary and secondary antibodies and bands were
visualized by chemiluminescence (Pierce SuperSignal, Fisher Scientific, Rockford, IL). Band density was determined using a
ChemiDoc XRTS Molecular Imager and Image Lab Software (BioRad, Hercules, CA). Phosphorylated-ACC (Ser79) protein was
normalized to total ACC protein.
Statistical Analyses: Two-way ANOVA was performed. Following a significant F-ratio, Student ‘s t-test were performed to
determine differences between treatments. Significance was established at P < 0.05
Background
Conclusions
Amy M. Knab, David C. Nieman, R. Andrew Shanely, Jennifer J. Zwetsloot, Lynn Cialdella-Kam, Mary Pat Meaney.
Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC
Results
Methods
Effects of ASEA beverage intake on endurance performance in mice
►When adjusted to run time, the estimated rate of muscle glycogen depletion was different between ASEA Run and Placebo Run groups.
►Skeletal muscle phosphorylated acetyl-CoA carboxylase (p-ACC) was significantly increased in ASEA Run compared to ASEA Sedentary (p=0.020) and Placebo Run groups (p=0.045). Fatty
acyl CoA transport (CPT1), and beta-oxidation (beta-HAD) were not different between ASEA Run and Placebo Run groups.
►ASEA increased run time to exhaustion by 29% in mice, potentially through less inhibition of fatty acid oxidation via increased P-ACC, and muscle glycogen sparing (30%).
►The data support increased endurance capacity and altered substrate utilization in mice after one week of ASEA intake. Further research is warranted to determine if these findings are due to
hormesis influences from the ASEA beverage.
Mark P. Mattson. Hormesis Defined. Ageing Res Rev. 2008 January; 7(1): 1-7 Funding, Reoxcyn Discoveries Group
Table 1: Treadmill Endurance Protocol
Time
(min)
Speed
(m/min) Details
1 0 adjustment to treadmill
5 10 "warm up"
2 12
2 14
2 16
2 18
2 20
2 22
Speeds between 20-24 correspond to roughly 80%
VO2max for mice
2- end 24
Mice will stay at this speed until they reach
exhaustion (sit on shock grid for 5 full seconds)
Study Design
ASEA Treatment
(1-week)
Placebo Treatment
(1-week)
ASEA Run Group:
N=15
Treadmill
ASEA Sedentary
Group:
N=15
Sedentary (normal
cage activity only)
Placebo Run
Group:
N=15
Treadmill
Placebo Sedentary
Group:
N=15
Sedentary (normal
cage activity only)
Figure 1: NMR Spectra analysis of ASEA beverage
31P NMR spectrum of a mixture of DIPPMPO and ASEA beverage.
Green numbers are peak chemical shifts, red numbers are integral
values of corresponding peaks.
Placebo ASEA
0
20
40
60
80
100
*
Figure 2: Endurance Run Time
Endurance Run Time (minutes)
ASEA Run group significantly
different than Placebo Run group
(p<0.001).
Run
Time
(min)
Placebo ASEA
0.00
0.02
0.04
0.06
Figure 3: Rate of Muscle Glycogen Depletion
*
Estimated rate of muscle glycogen
depletion. ASEA Run group
significantly different than Placebo
Run group (p=0.017).
ug/mg
protein/run
time
(min)
P
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0.0
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1.0
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Figure 4: Carnitine Palmitoyltransferase I
CPT-I as measured by Western Blot
in muscle tissue. No significant
differences between groups (p>0.05).
CPT-1
Content
(arbitrary
units)
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10
15
Figure 5: -Hydroxyacyl-CoA Dehydrogenase
-HAD enzyme activity was measured
in muscle tissue. No significant
differences between sedentary groups
or run groups (p>0.05).
-Hydroxyacyl-CoA
Dehydrogenase
Activity
(arbitrary
units)
P
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b
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0.0
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1.0
1.5
Figure 6: Phospho/pan-ACC
*
*
#
Phosphorylated ACC was normalized to
ACC content. Both were measured via
Western Blot analysis in muscle tissue.
* - Significantly different from Sedentary
within same treatment (p=0.02)
# - Significantly different than Placebo
Run (p=0.045)
Phospho/pan-ACC
Content
(arbitrary
units)