The document outlines different stages of start-up funding for digital health companies, including idea stage with the founder's own money, co-founder stage with two owners, family and friends investing, seed rounds with business angels, Series A rounds with venture capitalists, and successful IPOs. It notes that most start-ups fail due to running out of money and not engaging with potential investors, experts, regulators, payers, users, and patients who could help. The presentation encourages understanding these stakeholders and what can be done to succeed in obtaining funding.
Presentation by Jos Berkemeijer for Facet Actuaries. From an ethical, practical en professional (actuarial) viewpoint, negative interest rates, zero risk attitude consequences and long term prediction methods are questioned discussed.
Smarter Tools for Modern Investment ManagementAppFolio
AppFolio Industry Principal Michael Sebastian will discusses how to use AppFolio Investment Management to increase productivity, impress investors, and grow your business
Can Lean help improve the Architecture Maturity of an entire Organization?Institut Lean France
Architecture is more often recognized as an art than as a science. At the Lean Digital Summit, Pierre Marchand and Christian Phan-Trong from Swiss Life will discuss how taking a fresh look at Architectural activities through a process and a “Lean” lens can yield unexpected benefits for the Architects as individuals and as a team. They also explained how this approach can greatly improve the architectural quality of the deliverables and the architectural maturity of an Organization.
More Lean Digital stories on www.lean-digital-summit.com
Presentation by Jos Berkemeijer for Facet Actuaries. From an ethical, practical en professional (actuarial) viewpoint, negative interest rates, zero risk attitude consequences and long term prediction methods are questioned discussed.
Smarter Tools for Modern Investment ManagementAppFolio
AppFolio Industry Principal Michael Sebastian will discusses how to use AppFolio Investment Management to increase productivity, impress investors, and grow your business
Can Lean help improve the Architecture Maturity of an entire Organization?Institut Lean France
Architecture is more often recognized as an art than as a science. At the Lean Digital Summit, Pierre Marchand and Christian Phan-Trong from Swiss Life will discuss how taking a fresh look at Architectural activities through a process and a “Lean” lens can yield unexpected benefits for the Architects as individuals and as a team. They also explained how this approach can greatly improve the architectural quality of the deliverables and the architectural maturity of an Organization.
More Lean Digital stories on www.lean-digital-summit.com
Bridging the Gap: Thriving in the Real Estate Revolution with Stand-Out Exper...AppFolio
The 4th Industrial Revolution is here, and renters, homeowners, and even employees have come to expect instant, mobile, and modern experiences. In such a competitive market, providing these experiences makes you stand out, and leads to a great brand reputation. Yet, a gap remains between the experience today's customers expect, and the experience most property managers actually provide. In this webinar, we'll highlight key services that your customers have come to expect-in today's on
The KPI - Cash Flow Modeling and Projections (Series: MBA Shortcut) Financial Poise
You can chase a lot of financial measures of your business, but nothing stacks up to cash flow. Like a boat captain on a rough sea, being able to see what is coming at you financially is absolutely invaluable.
Cash flow models are the absolute go-to tool for reviewing companies in distress, yet they are also invaluable to venture capitalist who must manage long range investments as well as fast growth. This webinar discusses the basic components of a cash flow model, why it is weekly and not monthly and why 13 weeks is the usual length. This webinar also discusses what type of data is best for making an efficient and practical cash flow model, as well as best practices for reporting and pitfalls associated with modeling and balance roll forwards.
To view the accompanying webinar, go to: https://www.financialpoise.com/financial-poise-webinars/cash-flow-modeling-2019/
The 6-18 months following launch of an enterprise or start-up are critical. Once a prototype has been launched and is in the market, a key priority is to achieve growth. Known as scaling up, this growth process typically requires achievement in three core areas:
Achieving product / market fit: Continually developing your product and business model to ensure the widest and deepest possible growth in terms of users;
Growing the human resources and decision-making capacity of your firm: Ensuring that your talent and governance structures are continually evolving to meet growth requirements;
Securing finance: Making sure you have the financial resources to grow, either using organic cash flow or external financing.
This presentation will offer a brief roadmap to prepare for your scaling up journey. It will include practical tools, methods and advice for different aspects of scaling, and outline some common pitfalls seen along the way.
It's important for business owners to know easy way to steer their growth. The Founder & CEO of STROTA ConsulTech sharing his knowledge and experience with 100 SMB businesses and sharing 5 Golden ways to grow the business ... Simple, but powerful back-of-the-envelop calculations could lead you to create and steer your own path for business growth.
Summary:
* The B2B Selling process has changed: B2B Buyers are now firmly in control.
* Investment Goods Manufacturers need to re-design their B2B Buyer Experience.
* Innovators and First Movers will gain Customer credibility and market share.
***
Ansaco helps CMOs of mid-size manufacturing organisations apply agile techniques to integrated marketing and achieve faster time-to-market.
Ansaco is your sparring and implementation partner for agile marketing in complex B2B environments:
• innovation strategy,
• dynamic planning,
• the digitalisation of processes,
• RoI reporting.
Unlike digital Agencies which only address technology issues, the proprietary Ansaco consulting frameworks encompass all marketing resources: people, processes, budgets and data as well as MarTech systems.
In the year 2020, just five years after its launch, has been INDUSTRY 5.0 named one of the TOP TEN INDUSTRIAL TRENDS OF THE NEXT DECADE.
In the same year INDUSTRY 5.0 KEYNOTE started on August 21, 2020, the INDUSTRY 5.0 AGE in INDIA was just 2 months later was the world's first INDUSTRY 5.0 AMBASSADOR ESTABLISHED.
On January 7, 2021, was INDUSTRY 5.0 officially listed by the EUROPEAN UNION into the EUROPEAN SUSTAINABLE DEVELOPMENT FRAMEWORK
On October 19, 2021, firstly sound the name of INDUSTRY 5.0 on the UNITED NATIONS event (7th WORLD INVESTMENT FORUM)
It is the decision of every company, corporation, and organization, if it becomes part of the FIRST INDUSTRIAL EVOLUTION EVER LED BY MAN (HUMAN) and becomes the LEADER or if it remains in the role of a FOLLOWER.
INDUSTRY 5.0 PARTNERSHIP offer the first choice
Michael Rada, HUMAN & INDUSTRY 5.0 Founder
As part of the regional leadership team, Peter leads the Commercial Marketing team in EMEA. In this master class, he talks about how Marketo uses marketing automation itself. With more than 25 years of experience in marketing, Peter has contributed to the success of multiple brands in the software and digital media industry, including Marketo, Microsoft Surface, Skype, Xbox and MSN.
Trends in B2B Marketing: The 7 Keys to Creating Successful B2B Marketing CopyAggregage
Marketers may use the same copy for their B2B and B2C clientele, but these customers should never be treated the same. In this webinar, you will get a clear overview of the 7 key differences between B2B and B2C, so your marketing is more relevant and engaging to business buyers. Join Robert Bly, independent copywriter and consultant, who will walk you through key details of your marketing copy strategy that will make a real difference to your buyers.
Taking entrepreneurs to a whole new level, new thinking and execution at the speed of light. Vision development, disruptive business models, zero budget go to market strategy, exceptional traction and consecutive funding.
How Property Managers Can Pivot to Compete in an On-Demand EconomyAppFolio
The way companies interact with consumers has changed for good. We’re now living in an on-demand economy where customers aren’t only expecting great service, but they want outstanding experiences, and property management is no exception. With a combination of tech tools and thinking outside the box, you can stay ahead of the competition and set your business up for success now, and in the future.
Understanding the health data future - Deloitte Healthconnect, co-hosted by D...DayOne
In collaboration with Deloitte, we launched in 2020 the DayOne Health Data Scenario Project. Some 50 Experts coming together in three workshops for a total of more than 18 hours have identified 10 potential scenarios that will lead the way in creating a much-needed efficient and rewarding healthcare data ecosystem. We presented our results in an online joint event: “Understanding the health data future – Deloitte Healthconnect, co-hosted by DayOne”
“It’s cheaper to clean up a mess than to avoid a mess.” This mantra, coined by Alan Greenspan explaining why financial bubbles happen, stands very much at the core of how we as a society typically seem to deal with health: rather than nudging and rewarding people to conduct a healthier life and increase their immunity, the primary focus of efforts and resources is often on treating sickness.
How can this change? What role do health data, nutrition and immunity play in this? And what difference would it make? Find out at our next DayOne Experts Event, co-hosted by DSM Nutritional Products.
There are a couple of reasons why it is not an easy thing to successfully implement preventive measures. First of all, behavioral change is hard to accomplish. Secondly, in most cases it is challenging to show the scientific evidence that a certain measure works and is worth the effort. One key focus area is the importance of an optimal nutrient intake to support our health – with a focus on immunity and beyond. Last but not least, we need to consider a business and policy model that makes prevention less of a moral burden but a worthwhile experience that we are willing to apply in a smart way.
These are the big questions we will address at the DayOne Experts Event:
Will the rise of digital and data availability change the landscape – and if so to what extent?
What can we learn from the current pandemic?
Does nutrition play a role in supporting your immunity?
Which data should we take into consideration to shape the future?
This was our conversation. Read the conclusions here: https://www.dayone.swiss/as-shown-by-covid-19-making-prevention-smart-requires-a-mind-shift/
Our partner: DSM Nutritional Products
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Bridging the Gap: Thriving in the Real Estate Revolution with Stand-Out Exper...AppFolio
The 4th Industrial Revolution is here, and renters, homeowners, and even employees have come to expect instant, mobile, and modern experiences. In such a competitive market, providing these experiences makes you stand out, and leads to a great brand reputation. Yet, a gap remains between the experience today's customers expect, and the experience most property managers actually provide. In this webinar, we'll highlight key services that your customers have come to expect-in today's on
The KPI - Cash Flow Modeling and Projections (Series: MBA Shortcut) Financial Poise
You can chase a lot of financial measures of your business, but nothing stacks up to cash flow. Like a boat captain on a rough sea, being able to see what is coming at you financially is absolutely invaluable.
Cash flow models are the absolute go-to tool for reviewing companies in distress, yet they are also invaluable to venture capitalist who must manage long range investments as well as fast growth. This webinar discusses the basic components of a cash flow model, why it is weekly and not monthly and why 13 weeks is the usual length. This webinar also discusses what type of data is best for making an efficient and practical cash flow model, as well as best practices for reporting and pitfalls associated with modeling and balance roll forwards.
To view the accompanying webinar, go to: https://www.financialpoise.com/financial-poise-webinars/cash-flow-modeling-2019/
The 6-18 months following launch of an enterprise or start-up are critical. Once a prototype has been launched and is in the market, a key priority is to achieve growth. Known as scaling up, this growth process typically requires achievement in three core areas:
Achieving product / market fit: Continually developing your product and business model to ensure the widest and deepest possible growth in terms of users;
Growing the human resources and decision-making capacity of your firm: Ensuring that your talent and governance structures are continually evolving to meet growth requirements;
Securing finance: Making sure you have the financial resources to grow, either using organic cash flow or external financing.
This presentation will offer a brief roadmap to prepare for your scaling up journey. It will include practical tools, methods and advice for different aspects of scaling, and outline some common pitfalls seen along the way.
It's important for business owners to know easy way to steer their growth. The Founder & CEO of STROTA ConsulTech sharing his knowledge and experience with 100 SMB businesses and sharing 5 Golden ways to grow the business ... Simple, but powerful back-of-the-envelop calculations could lead you to create and steer your own path for business growth.
Summary:
* The B2B Selling process has changed: B2B Buyers are now firmly in control.
* Investment Goods Manufacturers need to re-design their B2B Buyer Experience.
* Innovators and First Movers will gain Customer credibility and market share.
***
Ansaco helps CMOs of mid-size manufacturing organisations apply agile techniques to integrated marketing and achieve faster time-to-market.
Ansaco is your sparring and implementation partner for agile marketing in complex B2B environments:
• innovation strategy,
• dynamic planning,
• the digitalisation of processes,
• RoI reporting.
Unlike digital Agencies which only address technology issues, the proprietary Ansaco consulting frameworks encompass all marketing resources: people, processes, budgets and data as well as MarTech systems.
In the year 2020, just five years after its launch, has been INDUSTRY 5.0 named one of the TOP TEN INDUSTRIAL TRENDS OF THE NEXT DECADE.
In the same year INDUSTRY 5.0 KEYNOTE started on August 21, 2020, the INDUSTRY 5.0 AGE in INDIA was just 2 months later was the world's first INDUSTRY 5.0 AMBASSADOR ESTABLISHED.
On January 7, 2021, was INDUSTRY 5.0 officially listed by the EUROPEAN UNION into the EUROPEAN SUSTAINABLE DEVELOPMENT FRAMEWORK
On October 19, 2021, firstly sound the name of INDUSTRY 5.0 on the UNITED NATIONS event (7th WORLD INVESTMENT FORUM)
It is the decision of every company, corporation, and organization, if it becomes part of the FIRST INDUSTRIAL EVOLUTION EVER LED BY MAN (HUMAN) and becomes the LEADER or if it remains in the role of a FOLLOWER.
INDUSTRY 5.0 PARTNERSHIP offer the first choice
Michael Rada, HUMAN & INDUSTRY 5.0 Founder
As part of the regional leadership team, Peter leads the Commercial Marketing team in EMEA. In this master class, he talks about how Marketo uses marketing automation itself. With more than 25 years of experience in marketing, Peter has contributed to the success of multiple brands in the software and digital media industry, including Marketo, Microsoft Surface, Skype, Xbox and MSN.
Trends in B2B Marketing: The 7 Keys to Creating Successful B2B Marketing CopyAggregage
Marketers may use the same copy for their B2B and B2C clientele, but these customers should never be treated the same. In this webinar, you will get a clear overview of the 7 key differences between B2B and B2C, so your marketing is more relevant and engaging to business buyers. Join Robert Bly, independent copywriter and consultant, who will walk you through key details of your marketing copy strategy that will make a real difference to your buyers.
Taking entrepreneurs to a whole new level, new thinking and execution at the speed of light. Vision development, disruptive business models, zero budget go to market strategy, exceptional traction and consecutive funding.
How Property Managers Can Pivot to Compete in an On-Demand EconomyAppFolio
The way companies interact with consumers has changed for good. We’re now living in an on-demand economy where customers aren’t only expecting great service, but they want outstanding experiences, and property management is no exception. With a combination of tech tools and thinking outside the box, you can stay ahead of the competition and set your business up for success now, and in the future.
Similar to How start-up funding in digital health can work (20)
Understanding the health data future - Deloitte Healthconnect, co-hosted by D...DayOne
In collaboration with Deloitte, we launched in 2020 the DayOne Health Data Scenario Project. Some 50 Experts coming together in three workshops for a total of more than 18 hours have identified 10 potential scenarios that will lead the way in creating a much-needed efficient and rewarding healthcare data ecosystem. We presented our results in an online joint event: “Understanding the health data future – Deloitte Healthconnect, co-hosted by DayOne”
“It’s cheaper to clean up a mess than to avoid a mess.” This mantra, coined by Alan Greenspan explaining why financial bubbles happen, stands very much at the core of how we as a society typically seem to deal with health: rather than nudging and rewarding people to conduct a healthier life and increase their immunity, the primary focus of efforts and resources is often on treating sickness.
How can this change? What role do health data, nutrition and immunity play in this? And what difference would it make? Find out at our next DayOne Experts Event, co-hosted by DSM Nutritional Products.
There are a couple of reasons why it is not an easy thing to successfully implement preventive measures. First of all, behavioral change is hard to accomplish. Secondly, in most cases it is challenging to show the scientific evidence that a certain measure works and is worth the effort. One key focus area is the importance of an optimal nutrient intake to support our health – with a focus on immunity and beyond. Last but not least, we need to consider a business and policy model that makes prevention less of a moral burden but a worthwhile experience that we are willing to apply in a smart way.
These are the big questions we will address at the DayOne Experts Event:
Will the rise of digital and data availability change the landscape – and if so to what extent?
What can we learn from the current pandemic?
Does nutrition play a role in supporting your immunity?
Which data should we take into consideration to shape the future?
This was our conversation. Read the conclusions here: https://www.dayone.swiss/as-shown-by-covid-19-making-prevention-smart-requires-a-mind-shift/
Our partner: DSM Nutritional Products
For the 5th year, we culminated the best of the DayOne Healthcare Innovation initiative: hot topics, open debates, smart insights, bright ideas, high energy personalities and tangible expertise. This will include the Open Innovation Session that brings together the Health Hack and is a springboard for the Accelerator. The panel sessions included: The patient centric approach + four bright ideas; How to make it happen; + The healthcare innovation journey.
This year’s conference joined forces with BioData Congress 2020 in a virtual format. Thank you to the partners Arcondis and Innosuisse, as well as all the mentors, coaches and behind the scenes work to pull this all together in a great event wtih over 800 participants.
Breathe - Empowering parents of children with asthmaDayOne
Presentation by Moritz Dietsche (Haako) at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
it is essential to address the legal aspects early on and make them part of the solution. This was shown by this start-up showcase:
Pioneering value & data driven healthcare for PatientsDayOne
Presentation by Michel Mohler (Lyfegen) at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
it is essential to address the legal aspects early on and make them part of the solution. This was shown by this start-up showcase:
Legal Framework for Digital Health Innovation - Data Protection and SecurityDayOne
Presentation by Monika Menz, Vossius & Partner at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
Data - GDPR still governs the data protection landscape and is here to stay. But GDPR is more than an implementation issue – innovators need to embrace its principles already when designing their products, not only to be compliant but also to gain the trust of customers and patients. As healthcare innovations are IT dependent and data driven, data and IT security are often neglected. But they are key to convincing investors and customers of the innovator’s business model, because the stakes are high, not only in terms of a start-up’s reputation and liability, but ultimately and most of all in terms of the patient’s interests as well.
EU regulatory frameworks - Legal challenges and opportunities for digital hea...DayOne
Presentation by Karin Schulze, Head of Medical Devices at SFL at the DayOne Expert Event Legal challenges and opportunities for digital health innovation
Regulation
Regarding the new MDR, the big question that arises is not only whether a piece of software falls under the definition of a medical device, but also who decides whether it does. At least in this regard the new regulation is clear: it is the regulator. Which means, according to Karin Shulze from SFL, that If a company offers an app which they do not consider a medical device themselves, but the regulator does, the distribution of this app will be stopped.
Legal framework for digital health innvoation - Protection through patents, d...DayOne
Presentation by Philipp Marchand and Birgitte Bieler, Vossius & Partner at the DayOne Expert Event Legal challenges and opportunities for digital health innovation
Philipp Marchand from Vossius & Partner and co-host of the event said: “Technological developments, especially in the digital space, brought up completely new issues which lack clear definition. So, as lawyers and regulatory advisers, we have to be innovative and also come up with new solutions. This is a learning curve we have to go through together with entrepreneurs, industry and regulatory bodies“.
In other words, instead of being a French garden à la Versaille, the legal landscape has become a rather rough terrain to navigate. The uncertainty can be seen as a threat and show killer. A more entrepreneurial attitude, however, would be to see it as an opportunity, if not an invitation, to pursue more of a greenfield approach. But in order to make this happen, it is essential to address the legal aspects early on and make them part of the solution.
Protection
Accustomaed as it is to a science and engineering-driven approach, the healthcare industry has to change its mindset when it comes to protecting its business. As it is reasonable to patent a digital solution and to protect medical devices as well as mobile app interfaces by means of design and trademark rights, the legal framework is becoming more important. So, developing a great technological solution and then having it beautified later on will not suffice. Those capabilities have to be built in from day one to ensure freedom to operate and to generate added value from the digital solutions.
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Introduction by Thomas Brenzikofer, DayOne, Basel Area Business & Innovation
Greenfield or jungle? Navigating the legal landscape for digital healthcare innovation
At first sight, it’s hard not to agree that dealing with the legal aspects of creating healthcare innovation is — although necessary — a rather unsexy topic. So it comes as no surprise that the DayOne Experts Event “Legal challenges and opportunities for healthcare innovation”, held online on September 30, attracted a slightly smaller audience than when the talks usually concern revolutionary new pieces of digital technology ready to disrupt healthcare as we know it — for the better.
Future of aging day one 20200630 zaynakhayatDayOne
What comes to mind when you think of an older person? Who are they? Where do they live? What does their day look like? How do they want to live their life, make money, spend money, experience services and leave a legacy?
These are just some among the many provocative questions that were researched in the new book “The Future of Aging” by Zayna Khayat. The book provides a much needed «reboot» of the perspective on how society needs to engage with the aging population. It is also a reminder of the limits to current approaches to aging. The vision Zayna Khayat proposes is intended to help individuals and organizations of all types and from all sectors position themselves as long-term partners on whom aging adults can depend as they navigate their experiences of aging.
Innovation for the future of aging will include new policies, services, products, technologies, living spaces, and even approaches to shaping inter-generational communities—all of which will be transformative for the lives of older adults. The potential societal and economic returns from innovation for the future of aging are immense, and therefore need to be prioritized.
It’s time to redefine what it means to age.
We are proud to host Zayna Khayat for the DayOne LabTalk to discuss innovation opportunities for the future of aging!
This event is part of our Aging Well Catalyst project by DayOne: a journey which will seek out innovative solutions that can help with both functional and psycho-social well-being. Learn more at Dayone.swiss
Value-based Healthcare - Towards a systems approach in chronic diseasesnDayOne
Role of patient journey in science, predictive modeling and high-risk patients in early stages of disease progression, in real world context. Presented by Michael Rebhan, Novartis at the DayOne Basel event in June 2020
Value-based Healthcare today and tomorrow by Deloitte.DayOne
There is an increasing need for a value-based Healthcare based on holistic patient and health system outcomes. Success can only be reached by a genuinely collaborative approach.
Presented at the DayOne Expert event in Basel
The slides in this deck are what were discussed in the first of five Aging Well workshops. This first workshop focused on mobility for aging adults. Take a look.
How can digital bridge the mental health gaps?
Mental health is a story of gaps. This was made clear by all the speakers and panelists at DayOne’s most recent Expert Meeting titled “Measuring the Unmeasurable - will digital pave the way for new treatments in mental health?” which took place in Basel. Check out the slides from the event here.
20191203 DOE Data Driven Healthcare- Expert EventDayOne
DayOne Experts - Data-driven healthcare – are we ready?
Data is transforming healthcare. Health data from multiple sources such as electronic health records, genomic testing, imaging and digital tools, combined with advanced analytics can be used to deliver more personalised care, improve outcomes, empower patients and make healthcare more sustainable and efficient. But is the industry ready for these new approaches? What is needed on the policy level and in the regulatory field to enable a new era of data driven health solutions? How will their business models look like?
This is what we discussed at this DayOne Expert Event, which was proudly presented in close collaboration with the Embassy of the Netherlands, fostering the exchange between two world leading healthcare innovation ecosystems.
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What does “patient centricity” really mean and how is it actually done? This was the driving question of the DayOne Experts Meeting in Basel, co-hosted by Arcondis.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874