Hortonworks DataFlow (HDF) 3.3 is a scalable, real-time streaming data platform designed to collect, curate, and analyze data for actionable insights. The update includes enhancements such as support for Kafka 2.0, improved integrations, and new streaming analytics features aimed at optimizing data movement and analysis in various industries. Key applications of HDF include healthcare improvements through real-time data access and enhanced decision-making capabilities for transportation and logistics sectors.