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HIV/AIDS
WHAT WE NEED
TO KNOW
What is HIV?
• Human Immunodeficiency Virus
• Responsible for causing AIDS
What is AIDS?
• Acquired Immunodeficiency Syndrome
• Characterized by signs and symptoms of severe immune deficiency
-weight loss of more than 10% of body weight
-diarrhea lasting longer than 1 month
-fever lasting longer than 1 month
-other signs
source: WHO
Relevance to Public Health
•First recognized in 1981
•One of the largest epidemics of the 20th century
•Approximately 33 million people living with HIV by the end
of 2007
•2.7 million people infected with HIV in 2007
Effects of the Virus
•Attacks white blood cells that fight infection in healthy
people
•Changes the composition of white blood cells and enables
HIV to replicate itself
•Weakens the immune system
•Increases vulnerability to life-threatening illnesses
Phases of HIV Infection
Acute
•HIV replicates quickly
•Energy requirements increase
Asymptomatic
•No symptoms
Symptomatic
•Onset of opportunistic infections
•Further increase in nutritional requirements
Late symptomatic (full-blown AIDS)
•Heightened viral load
•Intense weight loss and wasting
•Opportunistic infections taking control
TYPES OF HIV TESTS
Blood tests for antibodies against HIV
•Most common: Enzyme immune assay/enzyme-linked
immunosorbent assay (ELISA)
•Gold standard: Western blot (more specific than ELISA and used as a
confirmatory test)
•Radio-immunobinding assay (expensive, used as a confirmatory test
when antibodies low)
•Dot-blot immunobinding assay (cost-effective rapid screening blood
test)
•Polymerase chain reaction (PCR) (measures HIV genetic information)
Continuation…
Urine tests
•Test for antibodies in urine
•Not as sensitive as blood tests
•Enzyme immune assay (EIA)
•Western blot
Oral fluid tests
•Test for antibodies in oral fluids
•EIA
•Western blot
TREATMENT OF HIV/AIDS
•No cure
•Treatment can help slow progression to AIDS, reduce
OIs, and minimize malnutrition.
•The most effective treatment is antiretroviral therapy
(ART) using antiretroviral drugs (ARVs)
Antiretroviral Therapy (ART)
•Combination of ARVs
•Proven to limit replication of HIV in the body, delay onset of
AIDS, and prevent additional OIs
•Challenges
−Expensive
−Must be taken for the rest of the person’s life
−Uncomfortable side effects
Comprehensive Package of
HIV and AIDS Program
• Prevention
• Health and sex education
• Expansion of behavior change and harm reduction strategies
• Increased access to VCT
• PMTCT
• Treatment
• Secure access to ARVs for PLHIV
• Treatment of OIs
• Proper nutrition
Continuation…
•Care and support
• Synergy with prevention interventions
• Health services
• Psychosocial support
• Management of ARV side effects
•Mitigation of social and economic impact
• Care of OVC
• Access to basic needs, rights, and general well-being
•Reduction of vulnerability
• Services for women, girls, PLHIV, and people in war and
conflict
• Economic empowerment and life skills training
•Cross-cutting issues
• Participation and acceptance of PLHIV
• Strong leadership from community to national level
CHALLENGES
•Political commitment
•Funding
•Human resources in health system
•Discrimination against PLHIV
•Scale and quality of interventions
•Lack of vaccine
CONCLUSIONS
• HIV attacks and weakens the immune system, reducing its ability to
fight infection.
• Main transmission routes are sexual, parenteral, vertical.
• The four phases of HIV disease are acute, asymptomatic,
symptomatic, and full-blown AIDS.
• HIV is recognized mainly by testing antibodies formed to fight the
virus.
• ART can prevent OIs and slow progression of AIDS.
• A comprehensive package of HIV and AIDS interventions should
include infection prevention, ART, care and support, and mitigation
of the impacts of HIV on food security, health, and education.

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HIV-AIDS.pptx

  • 2. What is HIV? • Human Immunodeficiency Virus • Responsible for causing AIDS What is AIDS? • Acquired Immunodeficiency Syndrome • Characterized by signs and symptoms of severe immune deficiency -weight loss of more than 10% of body weight -diarrhea lasting longer than 1 month -fever lasting longer than 1 month -other signs source: WHO
  • 3.
  • 4.
  • 5.
  • 6. Relevance to Public Health •First recognized in 1981 •One of the largest epidemics of the 20th century •Approximately 33 million people living with HIV by the end of 2007 •2.7 million people infected with HIV in 2007
  • 7. Effects of the Virus •Attacks white blood cells that fight infection in healthy people •Changes the composition of white blood cells and enables HIV to replicate itself •Weakens the immune system •Increases vulnerability to life-threatening illnesses
  • 8. Phases of HIV Infection Acute •HIV replicates quickly •Energy requirements increase Asymptomatic •No symptoms Symptomatic •Onset of opportunistic infections •Further increase in nutritional requirements Late symptomatic (full-blown AIDS) •Heightened viral load •Intense weight loss and wasting •Opportunistic infections taking control
  • 9. TYPES OF HIV TESTS Blood tests for antibodies against HIV •Most common: Enzyme immune assay/enzyme-linked immunosorbent assay (ELISA) •Gold standard: Western blot (more specific than ELISA and used as a confirmatory test) •Radio-immunobinding assay (expensive, used as a confirmatory test when antibodies low) •Dot-blot immunobinding assay (cost-effective rapid screening blood test) •Polymerase chain reaction (PCR) (measures HIV genetic information)
  • 10. Continuation… Urine tests •Test for antibodies in urine •Not as sensitive as blood tests •Enzyme immune assay (EIA) •Western blot Oral fluid tests •Test for antibodies in oral fluids •EIA •Western blot
  • 11. TREATMENT OF HIV/AIDS •No cure •Treatment can help slow progression to AIDS, reduce OIs, and minimize malnutrition. •The most effective treatment is antiretroviral therapy (ART) using antiretroviral drugs (ARVs)
  • 12. Antiretroviral Therapy (ART) •Combination of ARVs •Proven to limit replication of HIV in the body, delay onset of AIDS, and prevent additional OIs •Challenges −Expensive −Must be taken for the rest of the person’s life −Uncomfortable side effects
  • 13. Comprehensive Package of HIV and AIDS Program • Prevention • Health and sex education • Expansion of behavior change and harm reduction strategies • Increased access to VCT • PMTCT • Treatment • Secure access to ARVs for PLHIV • Treatment of OIs • Proper nutrition
  • 14. Continuation… •Care and support • Synergy with prevention interventions • Health services • Psychosocial support • Management of ARV side effects •Mitigation of social and economic impact • Care of OVC • Access to basic needs, rights, and general well-being
  • 15. •Reduction of vulnerability • Services for women, girls, PLHIV, and people in war and conflict • Economic empowerment and life skills training •Cross-cutting issues • Participation and acceptance of PLHIV • Strong leadership from community to national level
  • 16. CHALLENGES •Political commitment •Funding •Human resources in health system •Discrimination against PLHIV •Scale and quality of interventions •Lack of vaccine
  • 17. CONCLUSIONS • HIV attacks and weakens the immune system, reducing its ability to fight infection. • Main transmission routes are sexual, parenteral, vertical. • The four phases of HIV disease are acute, asymptomatic, symptomatic, and full-blown AIDS. • HIV is recognized mainly by testing antibodies formed to fight the virus. • ART can prevent OIs and slow progression of AIDS. • A comprehensive package of HIV and AIDS interventions should include infection prevention, ART, care and support, and mitigation of the impacts of HIV on food security, health, and education.