A presentation from the 2008 HIV Health and Treatments Update forum held in Sydney on 25 Nov 2008. Part 4: a look at HIV drugs in development, presented by Bill Whittaker.

2. HIV Treatment and Health Update 25 November 2008 Part 4 New HIV treatment pipeline

6. “ The white ones help my immune system but raise my blood pressure. The red ones lower my blood pressure but screw up my stomach. The green ones help my stomach but fuck with my immune system. Then these yellow ones simply ensure an attractive colour combination.”

11. Nucleosides eg. 3TC Non-Nucleosides eg. Efavirenz Fusion eg. T20 Proteases eg. Kaletra CD4 T-Cell HIV antiviral drugs interrupt the making of new HIV virus Maturation Integrase eg. Raltegravir

12. HIV attaching & taking over CD4 T-cell

13. Newly made HIV going off to work

14. CD4 CCR5 HIV CD4 T cell surface

15. CCR5 blocker CD4 T cell surface CCR5

16. CCR5 blocker CCR5 CD4 T cell surface This HIV virus particle…….gives up and goes away…..

18. 2008 Experimental HIV Antiviral Drugs Clinical Trials in People RTV like booster Gilead Phase II Enhancer GS 93502 RTV like booster Sequoia Phase I Enhancer SPI-452 Genentech Phase II CD4 TNX-355 Progenics Phase II CCR5 PRO 140 Phase I Aust. Schering Phase I CCR5 SCH532706 Schering Phase III CCR5 Vicriviroc Tobira Phase I CCR5 TBR-652 Gilead Phase II Integrase Elvitegravir Panacos Phase I/II Maturation Beviramat (PA-457) Sequoia Phase I/II Protease I SPI-256 Ardea Phase I/II Non-NRTI RDEA806 Tibotec/JJ Phase III Non-NRTI Rilpivirine (TMC-278) Pfizer Phase I/II Non-NRTI UK-453,061 Idenix Phase I/II Non-NRTI IDX899 Achillion Phase II NRTI Elvucitabine RFS Phase II NRTI Amdoxovir Australian Avexa Phase III NRTI Apricitabine Comment Pharma Clinical Trial progress Target Drug

19. HIV TREATMENT PIPELINE - 2007 Bevirimat Panacos TNX 355 Genentech GS1937 Gilead AVX754 Apricitabine Avexa Reverset Pharmasset Racivir Pharmasset TMC-278 Rilpivirine Tibotec BILR-355 BMS INCB9471 Incyte Corp ? Timelines for First Access KP-1461 Koronis Protease Inhibitors NNRTIs (Non Nukes) NRTIs (Nukes) Maturation inhibitor Integrase inhibitors Entry inhibitors 2012 2011 2010 2009 2008 Amdoxovir RFS Pharma GW 385 GSK

20. HIV TREATMENT PIPELINE - 2007 Bevirimat Panacos TNX 355 Genentech AVX754 Apricitabine Avexa TMC-278 Rilpivirine Tibotec ? Timelines for First Access 5/12 remain today Protease Inhibitors NNRTIs (Non Nukes) NRTIs (Nukes) Maturation inhibitor Integrase inhibitors Entry inhibitors 2012 2011 2010 2009 2008 Amdoxovir RFS Pharma

21. NEW ARV PIPELINE: Timelines for First Access Beviramat Panacos TNX 355 Genentech NO NEW INFO for some years SO DROP GS1937 Gilead AVX754 Apricitabine Avexa DISCONTINUED Reverset Pharmasset STALLED Racivir Pharmasset TMC-278 Rilpivirine Tibotec APPEARS DISCONTINUED BILR-355 BMS DISCONTINUED INCB9471 Incyte Corp Recently put on hold KP-1461 Koronis Protease Inhibitors NNRTIs (Non Nukes) NRTIs (Nukes) Maturation inhibitor Integrase inhibitors Entry inhibitors 2012 2011 2010 2009 2008 DISCONTINUED GW 640385 Brecanavir GSK

22. HIV TREATMENT PIPELINE - Now Beviramat Panacos TNX 355 Genentech AVX754 Apricitabine Avexa TMC-278 Rilpivirine Tibotec ? Timelines for First Access Vicriviroc Schering ACH-126 Elvucitabine Achillion IDX899 Idenix UK 453,061 Pfizer RDEA806 Ardea SCH 532706 Schering PRO 140 Progenics Protease Inhibitors NNRTIs (Non Nukes) NRTIs (Nukes) Maturation inhibitor Integrase inhibitors Entry inhibitors 2012 2011 2010 2009 2008 SPI-256 Sequoia Amdoxovir RFS Pharma

28. Getting New Treatments to You Activism is still necessary!!

29. Many of the topics in tonight’s update are covered in this Guide….. Pick up a copy at Positive Life, ACON or download from http://treataware.info/