Our profound expertise in neuroscience and more than a decade of experience in contract research results in a sustainable advantage for our customers. We offer you a sophisticated range of validated transgenic and non-transgenic in vivo and in vitro models in order to make sure that your new chemical or biological entities get profiled in depth using both novel and established drug targets that may play a role in the complex etiology of neuro-degenerative disease.

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NEUROPHARMACOLOGY
Alzheimer - Parkinson - Hun ngton - ALS - Psychiatric Disorders

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3. QPS AUSTRIA
THE COMPANY
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QPS helps you navigate
Our profound expertise in
neuroscience and more than a
decade of experience in contract
research results in a sustainable
advantage for our customers.
We offer you a sophisticated range
of validated transgenic and non-
transgenic in vivo and in vitro
models in order to make sure
that your new chemical or biological
entities get profiled in depth using
both novel and established drug
targets that may play a role in the
complex etiology of neuro-
degenerative disease

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5. QPS AUSTRIA
MISSION STATEMENT
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QPS helps you navigate 5
We are committed to combine
scientific experience, state of the art
techniques and excellent
communication to deliver superior
support in drug development.
Our mission is to accelerate the
development of medicines
worldwide by enabling cost effective
breakthroughs in pharmaceutical
innovation.
QPS is a global leader in contract
research.
We are known for our quality,
technical expertise, efficiency and
customer focus.
Our passionate and productive work
creates value for patients and
customers while creating
opportunities for employees to grow
and thrive.

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7. EXPERIENCED PARTNER
IN DRUG DEVELOPMENTT
QPS Austria has developed
multiple methods for testing and
evaluating new potential treatment
approaches for neurological and
psychiatric indications.
The close link to state of the art
science enables us to reliably
assess the potential of new
compounds.
The wide range of assays and
evaluation methods allows our
customers to gain the most
comprehensive information about
their drug candidates.
Outstanding quality and reliable
timelines are our dedication.
QPS Austria can help to
significantly reduce the time to
approval.
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9. CELL BASED
DRUG TESTING
QPS Austria provides
a comprehensive portfolio of
standardized cell culture systems,
including primary neurons from
rat, mouse and chicken as well as
transgenic & non transgenic cell
Cultures can be analysed for a wide
spectrum of parameters:
 Cell viability, apoptosis, necrosis
 Mitochondrial impairment
 Inflammation related parameters
 Neurite growth
 Disease related markers
 Secretase inhibition or modulation
 Tau phosphorylation
 Broad range of analytes on a
multiplex platform
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We continuously establish new
models and perform validations on
request.
lines.

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11. DISEASE RELATED IN VITRO
DRUG TESTING OPTIONS
At QPS Austria the effects of your
compounds on the most well-known
hallmarks of neurodegenerative
diseases can be tested in validated
assays.
Amyloid pathology can be
investigated using several different
aggregation, toxicity and secretase
assays. Drug mediated alteration of
Tau phosphorylation can be studied
using cells overexpressing human
mutant Tau441 or primary cultured
neurons.
Parkinson drug development
projects can be supported
by performing studies with
dopaminergic neuroblastoma cells,
MPP+ lesions and other disease
specific models.
Inflammation represents a major
topic in several neurodegenera-
tive diseases. Consequently QPS
established a range of assays to
study cytokines, NO release and
others.
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13. BIOANALYTICAL
SERVICES
QPS Austria is a GLP certified CRO
and experienced in high quality
performance of various bioanalytical
tasks within mono- or multicentral
clinical studies and other projects.
Covering the entire drug
development process, biomarker
and numerous other analyses are
performed by an experienced team.
 Synucleins
 Cellular aggregates (TDP-43, SOD1)
 Neurotransmitters
Beyond the established assays we
provide customized development
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 Tau & pTau species
 Amyloid peptides (all Aβ species &
aggregation states)
 Inflammation markers
and validation assays.
 Lipid profile
 Neurotrophic factors

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15. GENERATION AND
CHARACTERIZATION
OF TRANSGENIC ANIMALS
New drug targets opening
effective pathways to treat neuro-
degenerative diseases represent
an interesting challenge and new
opportunities in drug development.
QPS Austria is experienced
in creating and validating new
transgenic animals. Custom tailored
transgenic mouse and rat models
are perfect tools to perform proof of
concept studies.
Beyond the generation of the
desired animal model we routinely
run breeding programs using
any rat or mouse model available.
As a further option we can apply
viral vectors carrying the genetic
information to be expressed.
The genetic, behavioral,
histological and biochemical
characterisation and validation
of the newly created models is
performed by our experienced
team at QPS Austria.
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17. QPS Austria provides a wide range of
transgenic mouse and rat models.
The most requested models are the
following:
Alzheimer’s disease
 APPSL
 APP x hQCSL

5 x FAD


 TAU441
tg2576
Parkinson’s disease
 human wt alpha-synuclein D-line
 human wt alpha-synuclein Line 61
 human alpha-synuclein A53T
Huntington’s disease
 R6/2 mouse
Others
 SOD1-G93A mouse (ALS)
 TDP43-TARDBP (ALS & FTD)
TRANSGENIC
MOUSE AND RAT MODELS
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 NPC1 -/- (Niemann Pick Disease)
APP x ApoB100SL

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19. Test compounds are applied via
validated routes like ip, iv, in, po, im,
sc but also intrathecally, intraventri-
cularly or with devices like osmotic
mini pumps or implantable pellets.
Drug application via drinking water
or diet is also always an option.
Moreover, we apply viruses (e.g. LV
or AAV) for gene therapeutic or other
approaches.
Skilled personnel is able to sample
blood as well as cerebrospinal fluid
in vivo.
At the end of a drug application
period any organ as well as blood
and cerebrospinal fluid can be
sampled in sufficient amounts and
processed further for histological
and / or biochemical investigations
made in house or at any facility
defined by the sponsor.
SUPERIOR DRUG
APPLICATION & SAMPLING
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21. In many of the transgenic and
non-transgenic disease models
drug mediated behavioral changes
belong to the most important
experimental outcomes.
All behavioral paradigms are perfor-
med, recorded and evaluated using
automated up to date equipment.
Beyond experimental paradigms as
listed below we perform high level
techniques for drug testing and
phenotyping including homecage
phenotyping and others.
 Poke hole activity
 Rota rod
 Two choice swim test
 New object recognition
 Social interaction
 Prepulse inhibition
 Ultrasound vocalisation
DRUG TESTING SERVICES
BEHAVIOR
 Active and passive avoidance
 Beam walk
 Challenging beam walk
 Pole test
 Y – maze
 T – maze
 Elevated plus maze
 Contextual fear conditioning
 Fear conditioning
 Cylinder test
 Forced swim test
 Morris water maze
 Buried food test
 Open field
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23. Studies at QPS Austria GmbH
provide quantitative and
qualitative histological readouts.
In the scope of neurodegenerative
diseases pathological hallmark
detection is highly standardized
like:
 Plaque quantification (e.g.
6E10, ThioflavinS, Congo red)
 Inflammation markers (e.g
Mac-1, Iba-1, GFAP)
 α-synuclein: quantification of
Lewy body counts (e.g. α-syn,
phospho-α-syn, Campbell Switzer)
 Neuron and synaptic counts
(e.g. TH, NeuN, Synaptophysin)
 Tau pathology (e.g. AT180, HT7,
AT270)
Microbleeding and BBB
permeability (e.g. Prussian blue,
HRP)
 Ischemic damage (e.g. TTC and
NBT staining)
Beyond standard evaluations
our team will be happy to help
with expertise in development
of appropriate study setups and
protocols. As special services we
are able to offer unbiased
stereology and electron micro -
scopy beside standard brightfield
and fluorescence microscopy.
DRUG TESTING SERVICES
HISTOLOGICAL EVALUATION
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QPS' reputation in neuro-
pharmacology and the
acknowledged bioanalytical
experience in all phases of drug
discovery and development create a
unique combination of services to
study pharmacokinetics, and
pharmacodynamics of discovery
candidates developed specifically for
neurological indications.
These services combine:
 Administration of candidates in
various tissues (incl. intrathecal)
 Usage of transgenic animals
 Behavioral studies
 Various sampling techniques
(including brain, CSF, spinal cord)
 Wide range of bioanalytical
methods for PK and biomarker
assessments.
RAPID IN VIVO PK/PD/EFFICACY
SCREENING
IN TG & NTG ANIMALS

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Our regional facilities and ofces are located in:
USA, China, Japan, Taiwan, India, Netherlands, Austria, Czech Republic, Croatia, Israel, Serbia, Bosnia, Hungary, Spain, Germany,
United Kingdom, Slovakia, Bulgaria, Romania, Lithuania, Ukraine, Poland, France and South Korea

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27QPS helps you navigate
QPS is a reputable and profitable
provider of world-class pharma-
ceutical development services,
possessing unparalleled scientific
expertise within our
core competencies:
 Neuropharmacology
 DMPK
 Toxicology
 Bioanalysis
 Translational Medicine
 Early Stage Clinical
 Phase II - IV Clinical
 Program Management
QPS WORLDWIDE
OUR CORE COMPETENCIES

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QPS AUSTRIA GMBH
Parkring 12 | 8074 Grambach | Austria | Tel.: +43 316 258111
ofce-austria@qps.com | www.qps-austria.com | www.qps.com