GPA (Guided Progression Analysis) tools can help identify patients who are progressing, rapidly progressing, or stable based on visual field tests. GPA provides visual tools to educate patients and drive compliance. Future releases will expand GPA analysis to additional devices and tests. GPA for HFA is the standard progression analysis tool, analyzing events and trends using EMGT study criteria and common language terms. It is installed on thousands of HFA devices and helps easily identify progression.

1. Guided Progression Analysis™ (GPA) The Future of Progression Tools for Structure and Function

2. GPA TM progression tools can help Identify patients who: Are progressing and may require a change in treatment Are rapidly progressing and may truly need aggressive therapy Are stable and may need less monitoring and/or treatment . Provide visual tools to educate patients To drive compliance

3. A continuum of innovation in progression products Future Releases: Enhanced GPA Progression Analysis for HFA GPA Progression Analysis for GDx GPA Advanced Serial Analysis for Stratus OCT GPA Progression Analysis for Stratus OCT MD rate of progression on HFA i GPA on the HFA (v4.0) 2005 1986 2008 Glaucoma Change Probability Analysis 1989

4. The standard in progression: GPA for HFA Analyzes events and trends EMGT study criteria Common language terms Installed on 1000’s of HFAs

5. GPA for HFA helps identify progression easily Likely Progression Simple to use: Default settings for seamless workflow Single page printout with GPA Summary Common language reporting Automatic baseline selection

6. GPA for HFA offers both “event” analysis and “trend” analysis Location of visual field changes For correlating to imaging findings MD slope shows long term trends Choice of baseline exams can be verified Slope of MD values in dB is calculated

7. Intuitive GPA symbols make identifying progression fast and easy Three in one exam “ Likely Progression” Three in one exam “ Possible Progression” GPA Alert TM Progressing point repeated in 3 consecutive exams Progressing point repeated in 2 consecutive exams Progression at 95% significance level GPA Symbols

8. Extending GPA TM across structure and function GPA TM tools integrate your structure and function analysis by using consistent terms and rules.

9. Under development … more innovations in GPA for HFA Improved metric of visual field loss New graphical trend display VF Index plotted against age Single page printout Available 2007

10. Under development…Visual Field Index (VFI) An improved metric for assessing rate of progression Central points weighted more heavily than those on periphery Reduces cataract contribution to the measurement of VF loss “ B ”has more damaged central points and lower VFI than“ A ”. A B VFI = 90% VFI = 81%

11. Under development … more innovations in GPA for HFA The Regression Graph The VFI Bar

12. VF Index shows vision loss in terms of %’s Under development … more innovations in GPA for HFA

13. Visual Field Index Bar Shows vision loss in terms of % Enhanced visual presentation Under development … more innovations in GPA for HFA 100% % loss to date % loss in next 5 years

14. VF Index plotted against age: Characterizes trend significance over next 5 years Aids in interpretation & patient education Helps formulate individualized treatment decisions Under development … more innovations in GPA for HFA