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HER2+ signalling pathways

- HER2+ breast cancer accounts for 20-30% of breast cancers and is characterized by overexpression of the HER2 receptor tyrosine kinase. HER2 overexpression leads to constant activation of downstream signaling pathways like MAPK and PI3K/AKT, promoting cell growth and inhibiting apoptosis. Diagnosis involves tests like mammography, biopsy for HER2 status, and imaging for metastasis. Treatment targets HER2 signaling pathways.

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HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways
HER2+ signalling pathways

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Editor's Notes

  • #14 2nd point - The most active and tumor promoting combination is thought to be the HER2/HER3 dimer. HER2 activation causes gene expression alterations mediated through changes in transcription, translation, and protein stability, which affect cell growth, proliferation, migration, adhesion, and survival.