hemophilia symptoms, What is cholesterol and its types, symptoms, treatment , Choosing the Best Shampoo for Hair Fall: A Comprehensive Guide
Best shampoo for hair fall
This document discusses malignant melanoma and melasma. Malignant melanoma arises from melanocytes and can spread through the lymphatic and vascular systems. There are four main types of melanoma. Treatment may include surgical resection, chemotherapy, and radiation. Nurses should provide education and support to patients. Melasma is a patchy hyperpigmentation disorder that commonly affects females and may be related to hormones or sun exposure. Patients should take steps to limit sun exposure and use sunscreen.
1. Vascular lesions are classified as vascular tumors (hemangiomas) or vascular malformations. Hemangiomas involve proliferation of endothelial cells while malformations involve abnormal dilation of vessels without proliferation.
2. A history and physical can often diagnose vascular lesions but imaging like MRI may be needed to determine extent and type of lesion. MRI provides better contrast and ability to distinguish lesion types compared to CT or angiography.
3. Hemangiomas are the most common tumor in childhood, often on the head or neck. They have proliferative and involution stages. Malformations are always present at birth and expand over time. Treatment depends on type, location, and stage of lesion and may include laser therapy, steroid injections,
Dermatofibroma is a benign skin growth that is most common on the legs. It is caused by minor injuries or insect bites and occurs more often in women and middle-aged adults. Symptoms include a raised growth under the skin that can vary in size and may bleed if damaged. Treatment options include surgical removal, freezing, or ignoring it if it does not cause problems. Onycholysis is the loosening or detachment of a nail from the nail bed, usually starting at the edges. It can be caused by infections, nail fungus, drug reactions, or underlying medical conditions. Symptoms include nail discoloration and separation from the nail bed. Treatment focuses on identifying and addressing the underlying cause.
Haemangiomas And Vascular Malformationsplasticclinic
Vascular anomalies can be classified as hemangiomas or vascular malformations, with hemangiomas exhibiting rapid growth and slow regression in infants while malformations are present at birth and do not regress. Hemangiomas are the most common tumor in infants and progress through proliferating, involuting, and involuted phases, while various types of vascular malformations including venous, lymphatic, and arteriovenous anomalies can cause complications and are typically treated with sclerotherapy, laser therapy, or surgery. Accurate diagnosis and differentiation of these conditions is important to guide appropriate clinical management and treatment.
Sézary syndrome is an aggressive form of cutaneous T-cell lymphoma characterized by erythroderma (red, scaly skin over large areas of the body), enlarged lymph nodes, and the presence of malignant T-cells known as Sézary cells in the blood, skin, and lymph nodes. If left untreated, Sézary syndrome can be fatal within 3 years. Treatment options include chemotherapy, immunotherapy, targeted therapy, extracorporeal photopheresis, radiation therapy, retinoids, and phototherapy, with the choice of treatment depending on disease stage, symptoms, and tumor burden.
1. This document discusses four main types of oncological disorders in children: leukemia, neuroblastoma, lymphoma, and rhabdomyosarcoma.
2. Leukemia is cancer of the white blood cells and can be acute or chronic. Neuroblastoma arises from nerve tissue and most commonly occurs in young children.
3. Lymphoma includes Hodgkin's lymphoma and non-Hodgkin's lymphoma, both of which can cause swelling of the lymph nodes.
4. Rhabdomyosarcoma is a type of soft tissue cancer that usually begins in muscles and can occur in different parts of the body.
Chronic Venous Insufficiency (CVI) is a common progressive disorder affecting the legs that is caused by chronic venous hypertension. It is estimated to affect 5-15% of the adult population. CVI has major health and economic impacts, consuming 1-2% of European healthcare budgets and costing over 1 billion Euros annually in some countries. The hallmark of CVI is distal venous hypertension leading to valvular incompetence, reflux, and venous obstruction over time.
- Malignant melanoma arises from melanocytes and commonly presents as a changing mole. It can grow both radially and vertically.
- Risk factors include fair skin, numerous moles, family history, and sun exposure. Staging is based on Breslow thickness, ulceration, and metastasis.
- Diagnosis involves biopsy. Subtypes include superficial spreading, nodular, lentigo maligna, and acral lentiginous melanomas.
- Treatment involves wide local excision, sentinel lymph node biopsy, and lymphadenectomy for involved nodes. Advanced disease may require isolated limb perfusion or resection of isolated metastases.
This document discusses malignant melanoma and melasma. Malignant melanoma arises from melanocytes and can spread through the lymphatic and vascular systems. There are four main types of melanoma. Treatment may include surgical resection, chemotherapy, and radiation. Nurses should provide education and support to patients. Melasma is a patchy hyperpigmentation disorder that commonly affects females and may be related to hormones or sun exposure. Patients should take steps to limit sun exposure and use sunscreen.
1. Vascular lesions are classified as vascular tumors (hemangiomas) or vascular malformations. Hemangiomas involve proliferation of endothelial cells while malformations involve abnormal dilation of vessels without proliferation.
2. A history and physical can often diagnose vascular lesions but imaging like MRI may be needed to determine extent and type of lesion. MRI provides better contrast and ability to distinguish lesion types compared to CT or angiography.
3. Hemangiomas are the most common tumor in childhood, often on the head or neck. They have proliferative and involution stages. Malformations are always present at birth and expand over time. Treatment depends on type, location, and stage of lesion and may include laser therapy, steroid injections,
Dermatofibroma is a benign skin growth that is most common on the legs. It is caused by minor injuries or insect bites and occurs more often in women and middle-aged adults. Symptoms include a raised growth under the skin that can vary in size and may bleed if damaged. Treatment options include surgical removal, freezing, or ignoring it if it does not cause problems. Onycholysis is the loosening or detachment of a nail from the nail bed, usually starting at the edges. It can be caused by infections, nail fungus, drug reactions, or underlying medical conditions. Symptoms include nail discoloration and separation from the nail bed. Treatment focuses on identifying and addressing the underlying cause.
Haemangiomas And Vascular Malformationsplasticclinic
Vascular anomalies can be classified as hemangiomas or vascular malformations, with hemangiomas exhibiting rapid growth and slow regression in infants while malformations are present at birth and do not regress. Hemangiomas are the most common tumor in infants and progress through proliferating, involuting, and involuted phases, while various types of vascular malformations including venous, lymphatic, and arteriovenous anomalies can cause complications and are typically treated with sclerotherapy, laser therapy, or surgery. Accurate diagnosis and differentiation of these conditions is important to guide appropriate clinical management and treatment.
Sézary syndrome is an aggressive form of cutaneous T-cell lymphoma characterized by erythroderma (red, scaly skin over large areas of the body), enlarged lymph nodes, and the presence of malignant T-cells known as Sézary cells in the blood, skin, and lymph nodes. If left untreated, Sézary syndrome can be fatal within 3 years. Treatment options include chemotherapy, immunotherapy, targeted therapy, extracorporeal photopheresis, radiation therapy, retinoids, and phototherapy, with the choice of treatment depending on disease stage, symptoms, and tumor burden.
1. This document discusses four main types of oncological disorders in children: leukemia, neuroblastoma, lymphoma, and rhabdomyosarcoma.
2. Leukemia is cancer of the white blood cells and can be acute or chronic. Neuroblastoma arises from nerve tissue and most commonly occurs in young children.
3. Lymphoma includes Hodgkin's lymphoma and non-Hodgkin's lymphoma, both of which can cause swelling of the lymph nodes.
4. Rhabdomyosarcoma is a type of soft tissue cancer that usually begins in muscles and can occur in different parts of the body.
Chronic Venous Insufficiency (CVI) is a common progressive disorder affecting the legs that is caused by chronic venous hypertension. It is estimated to affect 5-15% of the adult population. CVI has major health and economic impacts, consuming 1-2% of European healthcare budgets and costing over 1 billion Euros annually in some countries. The hallmark of CVI is distal venous hypertension leading to valvular incompetence, reflux, and venous obstruction over time.
- Malignant melanoma arises from melanocytes and commonly presents as a changing mole. It can grow both radially and vertically.
- Risk factors include fair skin, numerous moles, family history, and sun exposure. Staging is based on Breslow thickness, ulceration, and metastasis.
- Diagnosis involves biopsy. Subtypes include superficial spreading, nodular, lentigo maligna, and acral lentiginous melanomas.
- Treatment involves wide local excision, sentinel lymph node biopsy, and lymphadenectomy for involved nodes. Advanced disease may require isolated limb perfusion or resection of isolated metastases.
This document discusses leukemia, which are cancers of the white blood cells. It describes the main types of leukemia - acute and chronic forms of myeloid and lymphoblastic leukemia. Acute leukemias involve immature white blood cells while chronic leukemias involve more mature cells. The most common chronic leukemia is chronic myeloid leukemia, which results from a genetic abnormality known as the Philadelphia chromosome. Signs, symptoms, diagnosis and treatment of acute myeloid leukemia and chronic myeloid leukemia are summarized.
Lymphomas account for 10-15% of childhood cancers and are cancers of lymphocytes. The two main forms are Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hodgkin's lymphoma is characterized by abnormal Reed-Sternberg cells in lymph nodes and commonly presents with painless lymphadenopathy. It has a bimodal age distribution and is treated with chemotherapy and/or radiation. Non-Hodgkin's lymphoma is more aggressive and heterogeneous, involving lymphocytes at different developmental stages. It has a variety of clinical presentations depending on the site of spread and commonly presents with widespread disease.
This document discusses various types of skin swellings and lumps. It defines swelling and lumps, and discusses examining factors like size, shape, and skin characteristics. Common superficial causes of lumps are then outlined, including sebaceous cysts, lipomas, and neurofibromas. Diagnosis is usually clinical based on appearance. Treatment options are provided for each condition, often involving surgical removal if causing symptoms. Malignant growths like basal cell carcinoma and squamous cell carcinoma are also summarized, providing characteristics, risk factors, diagnostic approaches, and treatment options.
This document provides an outline and overview of multiple myeloma. It begins with definitions of multiple myeloma and the monoclonal proteins involved. It then discusses the epidemiology, etiology, pathogenesis, clinical manifestations including bone disease, renal failure, neurologic symptoms, and more. It covers the workup, diagnosis involving bone marrow plasmacytosis and monoclonal proteins. It concludes with sections on prognosis, standard therapeutic agents, treatment of relapsed multiple myeloma, supportive care, monitoring response, and reference materials.
This document provides information on benign tumors, including their definition, differences between benign and malignant tumors, and descriptions of specific benign tumor types. Some key points:
- Benign tumors are slow-growing and do not invade other structures or spread to other parts of the body, while malignant tumors are rapidly growing and can invade nearby tissues and spread via lymphatics or bloodstream.
- Common benign tumor types described include lipomas, fibromas, papillomas, neurofibromas, and pigmented nevi. Specific features and classifications of lipomas and neurofibromas are outlined.
- Treatment options for benign tumors typically involve surgical excision to address cosmetic concerns or prevent complications from
The document discusses the use of radiotherapy in treating benign diseases. It provides examples of benign diseases like Graves' ophthalmopathy and pituitary adenomas that can cause debilitating symptoms if left untreated. Radiotherapy is an effective treatment for many benign conditions and is safer and more precise with modern techniques. The document outlines indications for radiotherapy in specific benign diseases like meningiomas and pituitary adenomas. It discusses factors like tumor size, location and pathology that influence radiotherapy approaches and outcomes.
Venous thromboembolism is a condition where a blood clot forms in a vein. Deep vein thrombosis is a blood clot that forms in deep leg veins and can dislodge and travel to the lungs, called a pulmonary embolism. Risk factors include prolonged bed rest, surgery, cancer, pregnancy, oral contraceptives, and genetic conditions. Diagnosis involves a clinical assessment, D-dimer blood test, and ultrasound or venography imaging of the legs. Treatment consists of blood thinners like heparin and warfarin to prevent further clotting and embolism.
1) The document discusses benign and malignant breast tumors. Benign tumors include fibrocystic changes, galactocele, and fibroadenoma. Breast cancer is the most common cancer in women.
2) Risk factors for breast cancer include genetic, hormonal, environmental factors as well as increasing age. Clinical manifestations may include breast lumps, nipple discharge, and enlarged lymph nodes.
3) Diagnostic tests for breast cancer include mammography, biopsy and laboratory tests to detect metastasis. Treatment involves surgery such as lumpectomy or mastectomy followed by radiation, chemotherapy and hormonal therapy.
leukemia is one among the common congenital malformations in children. it is also called as cancer of blood cells where immature blood cells are formed due to mutations in progenitor stem cell. This content includes types of leukemia especially categorized in children with description of diagnosis and management.
Malignant melanoma diagnosis and management has advanced recently. Melanoma arises from melanocytes and can affect the skin, eyes, or internal organs. Recent trends include more accurate staging using tumor thickness, ulceration, and mitosis rate rather than Clark's level. Sentinel lymph node biopsy helps stage intermediate thickness melanomas. For advanced cases, targeted therapies like BRAF inhibitors and immunotherapies have improved outcomes. Wide local excision remains the main surgical treatment, with reconstruction to optimize function and allow adjuvant therapies. Long-term follow-up is important due to the risk of late recurrence.
The document discusses tumor lysis syndrome, which occurs when large numbers of tumor cells are destroyed rapidly, releasing their contents into the bloodstream. This can cause hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, potentially leading to acidosis and renal failure. It also summarizes paraneoplastic syndromes, which are symptom complexes not directly caused by the tumor's location or metastasis. Common types include endocrine, neurological, mucocutaneous, and hematological syndromes. The grading and staging of cancers is also summarized, with grading based on differentiation and growth rate, and staging assessing tumor size, lymph node involvement, and metastasis.
Disseminated intravascular coagulation (DIC) is an acquired syndrome where there is widespread activation of the coagulation system, leading to microvascular thrombosis and organ damage. It can occur acutely when large amounts of procoagulants are suddenly released, or chronically with small continuous releases over time. Left untreated, it can cause life-threatening hemorrhage. Diagnosis involves looking for signs of bleeding and thrombosis, as well as using scoring systems to assess coagulation markers. Treatment focuses on treating the underlying condition while providing supportive care and replacing clotting factors.
Summary - Neoplasms of infancy and childhood - Asem M. Shadid Asem Shadid
Neoplasms of infancy and childhood :
obj :
1. Describe the findings from the history and physical exam that suggest malignant disease.
2. Know the incidence rates of the major childhood neoplasms and the significance of neoplasms in childhood mortality.
3. Identify the presenting symptoms, physical findings, and diagnostic tests for the major neoplasms (leukemia, CNS tumors, lymphoma, neuroblastoma and Wilm's tumors).
4. Recognize the major therapeutic modalities for childhood neoplasms and the relative advantages and disadvantages of each (chemotherapy, surgery, irradiation, bone marrow transplants).
Haematological malignancies arise from mutations in blood cells that disrupt normal cell proliferation and death. These include both indolent neoplasms like chronic leukaemias where patients can survive for many years, as well as rapidly progressive cancers like acute leukaemias. Leukaemias are malignant disorders of blood stem cells characterized by increased white blood cells in bone marrow and blood. The main types are acute myeloid leukaemia, acute lymphoblastic leukaemia, chronic myeloid leukaemia, and chronic lymphocytic leukaemia. Treatment involves intensive chemotherapy to induce remission, followed by consolidation and maintenance therapy to prevent relapse. Supportive care including transfusions and antibiotics is also important.
This document provides information about leukemia, including:
- Leukemia is a group of cancers that affect the blood and bone marrow. It results from abnormal bone marrow stem cells and causes an overproduction of immature white blood cells.
- There are four main types of leukemia - acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia, and chronic myelogenous leukemia. They are distinguished based on the type of blood cell affected and speed of progression.
- Treatment depends on the leukemia type and involves chemotherapy, targeted therapy, radiation therapy, stem cell transplant, or watchful waiting. The goal is to destroy signs of leukemia and induce remission while managing side effects.
-
Non-Hodgkin's lymphoma is a cancer of the lymphatic system that can involve B or T cells. It causes abnormal lymph node accumulation and often spreads diffusely. Risk factors include viruses, immune deficiencies, and genetic syndromes. Symptoms depend on subtype and location but may include enlarged lymph nodes, fever, weight loss, or masses. Diagnosis involves biopsy and testing. Treatment typically involves chemotherapy regimens like CHOP but can include radiation or monoclonal antibodies. Complications include infections, organ damage, and secondary cancers.
The document describes the steps for examining an eyelid mass, including inspection and palpation to evaluate characteristics like shape, size, color, texture, and mobility. It then covers the anatomy and types of benign and malignant eyelid lesions. Common benign lesions include seborrheic keratosis, actinic keratosis, melanocytic nevi, dermoid cysts, and chalazia. Malignant lesions include basal cell carcinoma and melanoma. Surgical excision is a common treatment, while some lesions may be observed or treated with cryotherapy, laser, or radiation.
More than 1 million skin cancer cases are diagnosed in the United States each year, with basal cell carcinoma making up about 80% of cases, squamous cell carcinoma making up about 16% of cases, and malignant melanoma making up about 4% of cases. Risk factors for skin cancer include sun exposure, older age, fair skin, and genetic factors. Common signs of skin cancer include changes to moles and lesions including asymmetry, irregular borders, varied color, diameter larger than 6mm, and evolving size or appearance. Diagnosis involves examination, biopsy, and sometimes imaging, while treatment involves surgical excision and may include lymph node assessment and other procedures depending on cancer type and stage. Prognosis depends on cancer type, thickness or
This document discusses topics related to leukopoiesis and hematological disorders, including: 1) an overview of leukopoiesis and the processes of myelopoiesis and lymphopoiesis; 2) quantitative disorders of white blood cells; 3) infectious mononucleosis caused by the Epstein-Barr virus; 4) an introduction to leukemias; and 5) Hodgkin's lymphoma including its causes, symptoms, diagnosis, and treatment options such as chemotherapy and radiation therapy. The document is from a course on hematology and hematological disorders.
Impact of solar energy on human. environment benefitthayaf3860
Solar energy has significant positive impacts on human life through various environmental, economic, social and geopolitical benefits. It reduces greenhouse gas emissions and air pollution, creates jobs, and provides long-term cost savings. Solar power also enhances energy security by diversifying energy sources and increases access to electricity for remote areas. Additionally, it helps mitigate climate change impacts and supports educational opportunities through technological advancements. While solar energy has many advantages, challenges remain such as intermittent generation and high upfront installation costs.
Research Methodology with Research Methodologyhayaf3860
This article discusses the potential impacts of a world without study or education. It notes that study allows humans to gain knowledge and skills that help progress society. Without study, innovation would slow or stop, technical progress would halt, and civilizations would decline. Over time, living standards and life expectancy would fall without continued education and development of new ideas. The article presents a bleak view of what life could become without the ability to learn and study.
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Similar to hemophilia symptoms .cholesterol and its types
This document discusses leukemia, which are cancers of the white blood cells. It describes the main types of leukemia - acute and chronic forms of myeloid and lymphoblastic leukemia. Acute leukemias involve immature white blood cells while chronic leukemias involve more mature cells. The most common chronic leukemia is chronic myeloid leukemia, which results from a genetic abnormality known as the Philadelphia chromosome. Signs, symptoms, diagnosis and treatment of acute myeloid leukemia and chronic myeloid leukemia are summarized.
Lymphomas account for 10-15% of childhood cancers and are cancers of lymphocytes. The two main forms are Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hodgkin's lymphoma is characterized by abnormal Reed-Sternberg cells in lymph nodes and commonly presents with painless lymphadenopathy. It has a bimodal age distribution and is treated with chemotherapy and/or radiation. Non-Hodgkin's lymphoma is more aggressive and heterogeneous, involving lymphocytes at different developmental stages. It has a variety of clinical presentations depending on the site of spread and commonly presents with widespread disease.
This document discusses various types of skin swellings and lumps. It defines swelling and lumps, and discusses examining factors like size, shape, and skin characteristics. Common superficial causes of lumps are then outlined, including sebaceous cysts, lipomas, and neurofibromas. Diagnosis is usually clinical based on appearance. Treatment options are provided for each condition, often involving surgical removal if causing symptoms. Malignant growths like basal cell carcinoma and squamous cell carcinoma are also summarized, providing characteristics, risk factors, diagnostic approaches, and treatment options.
This document provides an outline and overview of multiple myeloma. It begins with definitions of multiple myeloma and the monoclonal proteins involved. It then discusses the epidemiology, etiology, pathogenesis, clinical manifestations including bone disease, renal failure, neurologic symptoms, and more. It covers the workup, diagnosis involving bone marrow plasmacytosis and monoclonal proteins. It concludes with sections on prognosis, standard therapeutic agents, treatment of relapsed multiple myeloma, supportive care, monitoring response, and reference materials.
This document provides information on benign tumors, including their definition, differences between benign and malignant tumors, and descriptions of specific benign tumor types. Some key points:
- Benign tumors are slow-growing and do not invade other structures or spread to other parts of the body, while malignant tumors are rapidly growing and can invade nearby tissues and spread via lymphatics or bloodstream.
- Common benign tumor types described include lipomas, fibromas, papillomas, neurofibromas, and pigmented nevi. Specific features and classifications of lipomas and neurofibromas are outlined.
- Treatment options for benign tumors typically involve surgical excision to address cosmetic concerns or prevent complications from
The document discusses the use of radiotherapy in treating benign diseases. It provides examples of benign diseases like Graves' ophthalmopathy and pituitary adenomas that can cause debilitating symptoms if left untreated. Radiotherapy is an effective treatment for many benign conditions and is safer and more precise with modern techniques. The document outlines indications for radiotherapy in specific benign diseases like meningiomas and pituitary adenomas. It discusses factors like tumor size, location and pathology that influence radiotherapy approaches and outcomes.
Venous thromboembolism is a condition where a blood clot forms in a vein. Deep vein thrombosis is a blood clot that forms in deep leg veins and can dislodge and travel to the lungs, called a pulmonary embolism. Risk factors include prolonged bed rest, surgery, cancer, pregnancy, oral contraceptives, and genetic conditions. Diagnosis involves a clinical assessment, D-dimer blood test, and ultrasound or venography imaging of the legs. Treatment consists of blood thinners like heparin and warfarin to prevent further clotting and embolism.
1) The document discusses benign and malignant breast tumors. Benign tumors include fibrocystic changes, galactocele, and fibroadenoma. Breast cancer is the most common cancer in women.
2) Risk factors for breast cancer include genetic, hormonal, environmental factors as well as increasing age. Clinical manifestations may include breast lumps, nipple discharge, and enlarged lymph nodes.
3) Diagnostic tests for breast cancer include mammography, biopsy and laboratory tests to detect metastasis. Treatment involves surgery such as lumpectomy or mastectomy followed by radiation, chemotherapy and hormonal therapy.
leukemia is one among the common congenital malformations in children. it is also called as cancer of blood cells where immature blood cells are formed due to mutations in progenitor stem cell. This content includes types of leukemia especially categorized in children with description of diagnosis and management.
Malignant melanoma diagnosis and management has advanced recently. Melanoma arises from melanocytes and can affect the skin, eyes, or internal organs. Recent trends include more accurate staging using tumor thickness, ulceration, and mitosis rate rather than Clark's level. Sentinel lymph node biopsy helps stage intermediate thickness melanomas. For advanced cases, targeted therapies like BRAF inhibitors and immunotherapies have improved outcomes. Wide local excision remains the main surgical treatment, with reconstruction to optimize function and allow adjuvant therapies. Long-term follow-up is important due to the risk of late recurrence.
The document discusses tumor lysis syndrome, which occurs when large numbers of tumor cells are destroyed rapidly, releasing their contents into the bloodstream. This can cause hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, potentially leading to acidosis and renal failure. It also summarizes paraneoplastic syndromes, which are symptom complexes not directly caused by the tumor's location or metastasis. Common types include endocrine, neurological, mucocutaneous, and hematological syndromes. The grading and staging of cancers is also summarized, with grading based on differentiation and growth rate, and staging assessing tumor size, lymph node involvement, and metastasis.
Disseminated intravascular coagulation (DIC) is an acquired syndrome where there is widespread activation of the coagulation system, leading to microvascular thrombosis and organ damage. It can occur acutely when large amounts of procoagulants are suddenly released, or chronically with small continuous releases over time. Left untreated, it can cause life-threatening hemorrhage. Diagnosis involves looking for signs of bleeding and thrombosis, as well as using scoring systems to assess coagulation markers. Treatment focuses on treating the underlying condition while providing supportive care and replacing clotting factors.
Summary - Neoplasms of infancy and childhood - Asem M. Shadid Asem Shadid
Neoplasms of infancy and childhood :
obj :
1. Describe the findings from the history and physical exam that suggest malignant disease.
2. Know the incidence rates of the major childhood neoplasms and the significance of neoplasms in childhood mortality.
3. Identify the presenting symptoms, physical findings, and diagnostic tests for the major neoplasms (leukemia, CNS tumors, lymphoma, neuroblastoma and Wilm's tumors).
4. Recognize the major therapeutic modalities for childhood neoplasms and the relative advantages and disadvantages of each (chemotherapy, surgery, irradiation, bone marrow transplants).
Haematological malignancies arise from mutations in blood cells that disrupt normal cell proliferation and death. These include both indolent neoplasms like chronic leukaemias where patients can survive for many years, as well as rapidly progressive cancers like acute leukaemias. Leukaemias are malignant disorders of blood stem cells characterized by increased white blood cells in bone marrow and blood. The main types are acute myeloid leukaemia, acute lymphoblastic leukaemia, chronic myeloid leukaemia, and chronic lymphocytic leukaemia. Treatment involves intensive chemotherapy to induce remission, followed by consolidation and maintenance therapy to prevent relapse. Supportive care including transfusions and antibiotics is also important.
This document provides information about leukemia, including:
- Leukemia is a group of cancers that affect the blood and bone marrow. It results from abnormal bone marrow stem cells and causes an overproduction of immature white blood cells.
- There are four main types of leukemia - acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia, and chronic myelogenous leukemia. They are distinguished based on the type of blood cell affected and speed of progression.
- Treatment depends on the leukemia type and involves chemotherapy, targeted therapy, radiation therapy, stem cell transplant, or watchful waiting. The goal is to destroy signs of leukemia and induce remission while managing side effects.
-
Non-Hodgkin's lymphoma is a cancer of the lymphatic system that can involve B or T cells. It causes abnormal lymph node accumulation and often spreads diffusely. Risk factors include viruses, immune deficiencies, and genetic syndromes. Symptoms depend on subtype and location but may include enlarged lymph nodes, fever, weight loss, or masses. Diagnosis involves biopsy and testing. Treatment typically involves chemotherapy regimens like CHOP but can include radiation or monoclonal antibodies. Complications include infections, organ damage, and secondary cancers.
The document describes the steps for examining an eyelid mass, including inspection and palpation to evaluate characteristics like shape, size, color, texture, and mobility. It then covers the anatomy and types of benign and malignant eyelid lesions. Common benign lesions include seborrheic keratosis, actinic keratosis, melanocytic nevi, dermoid cysts, and chalazia. Malignant lesions include basal cell carcinoma and melanoma. Surgical excision is a common treatment, while some lesions may be observed or treated with cryotherapy, laser, or radiation.
More than 1 million skin cancer cases are diagnosed in the United States each year, with basal cell carcinoma making up about 80% of cases, squamous cell carcinoma making up about 16% of cases, and malignant melanoma making up about 4% of cases. Risk factors for skin cancer include sun exposure, older age, fair skin, and genetic factors. Common signs of skin cancer include changes to moles and lesions including asymmetry, irregular borders, varied color, diameter larger than 6mm, and evolving size or appearance. Diagnosis involves examination, biopsy, and sometimes imaging, while treatment involves surgical excision and may include lymph node assessment and other procedures depending on cancer type and stage. Prognosis depends on cancer type, thickness or
This document discusses topics related to leukopoiesis and hematological disorders, including: 1) an overview of leukopoiesis and the processes of myelopoiesis and lymphopoiesis; 2) quantitative disorders of white blood cells; 3) infectious mononucleosis caused by the Epstein-Barr virus; 4) an introduction to leukemias; and 5) Hodgkin's lymphoma including its causes, symptoms, diagnosis, and treatment options such as chemotherapy and radiation therapy. The document is from a course on hematology and hematological disorders.
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Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
1. hemophilia symptoms
Some common symptoms associated with hemophilia
What is hemophilia
Hemophilia is a rare genetic disorder that affects the blood’s
ability to clot.
2. There are several types of hemophilia, the most common
being hemophilia A and hemophilia B.
Clotting
Clotting is the process by which blood forms solid clumps to
prevent excessive bleeding. Individuals with hemophilia
experience difficulties in clotting, which can result in
prolonged bleeding after injuries or surgery.
symptoms of hemophilia
The symptoms of hemophilia can vary depending on the
severity of the condition. There are three levels of severity:
mild, moderate, and severe. Here are some common
symptoms associated with hemophilia
Excessive Bleeding:
3. Individuals with hemophilia may bleed for a more extended
period than usual after an injury, surgery, or even
spontaneously. The bleeding can be internal or external.
Easy Bruising
People with hemophilia tend to bruise easily. Bruises may
occur with minimal or no apparent trauma.
Joint Bleeding
Bleeding into joints (hemarthrosis) is a common
complication, particularly in severe cases. This can cause
swelling, warmth, and pain in the affected joint. Recurrent
joint bleeding can lead to chronic joint disease.
Muscle Bleeding
Bleeding in muscles can cause swelling, pain, and limited
movement in the affected area.
Nosebleeds
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Frequent or prolonged nosebleeds (epistaxis) may occur.
Excessive Menstrual Bleeding
Women with hemophilia may experience heavy and
prolonged menstrual bleeding.
Blood in Urine or Stool
Internal bleeding can occur in the digestive or urinary tract,
leading to blood in the urine or stool.
Intracranial Hemorrhage
In severe cases, bleeding can occur in the brain, leading to
symptoms such as severe headache, vomiting, neck pain,
and changes in mental status. Intracranial hemorrhages are
medical emergencies.
5. It’s important to note that individuals with mild hemophilia
may not experience symptoms until later in life or may have
minimal bleeding problems. In contrast, those with
moderate or severe hemophilia often experience more
frequent and severe bleeding episodes.
Understanding the Stages of
Skin Cancer
Melanoma skin cancer stages article
Introduction:
Melanoma, a type of skin cancer originating in
pigment-producing cells called melanocytes, represents a
significant health concern due to its potential for rapid
spread and metastasis. Accurate staging is crucial for
determining the appropriate treatment plan and predicting
6. prognosis. This article provides an in-depth overview of the
stages of melanoma, outlining the key characteristics and
implications associated with each stage
Stages of Melanoma:
Stage 0 — Melanoma in Situ:
7. ● Confined to the top layer of the skin (epidermis) and
has not invaded deeper layers. Considered
non-invasive.
Stage I:
● The tumor is confined to the skin, with no lymph
node involvement or distant metastasis.
Stage II:
● Melanoma has invaded deeper layers of the skin but
has not spread to lymph nodes or distant sites.
Stage III:
● Presence of lymph node involvement, indicating
regional spread, but without distant metastasis.
Stage IV — Metastatic Melanoma:
8. ● Melanoma has spread beyond the skin and regional
lymph nodes to distant organs or distant lymph
nodes.
Sub-Stages:
● Within each main stage, sub-stages further refine
the classification based on specific criteria such as
tumor thickness, ulceration, and the number of
affected lymph nodes.
Treatment Implications:
Treatment approaches vary based on the stage of melanoma
and may include:
Surgery:
Surgical excision is a common treatment for early-stage
melanomas to remove the tumor and a margin of healthy
tissue.
9. Lymph Node Dissection:
In cases of lymph node involvement, surgical removal of
affected lymph nodes may be recommended.
Immunotherapy and Targeted Therapy:
Advanced stages often involve systemic treatments like
immunotherapy or targeted therapy to address metastatic
disease.
Radiation Therapy:
Used in certain cases to target specific areas affected by
melanoma
Conclusion:
Understanding the stages of melanoma is pivotal for
patients, healthcare professionals, and researchers alike.
Early detection and accurate staging facilitate timely and
10. appropriate interventions, improving the chances of
successful treatment and long-term survival. Regular skin
examinations, awareness of risk factors, and prompt
medical attention are essential components of melanoma
management, underscoring the importance of public
education and ongoing research in the fight against this
formidable skin cancer.
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