Hairy Cell Leukemia (HCL) is a chronic leukemia primarily impacting the blood and bone marrow. The nomenclature of this condition is derived from the hair-like projections observed on affected B cells. Despite being less recognized than other leukemia forms, grasping the nuances of HCL is imperative for accurate diagnosis and efficient management, particularly when considering the expertise of Bone Marrow Transplant BMT Specialists.

1. Dr Pawan Kumar Singh has the experience
of performing more than 500 bone
marrow transplants (including
Autologous /Allogenic /Haplo /MDU )for
both malignant and non-malignant
disorders.
Dr Pawan Kumar Singh
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Dr.Pawan Kumar Singh
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2. INTRODUCTION
INTRODUCTION
Hairy Cell Leukemia (HCL) is a chronic
leukemia primarily impacting the blood
and bone marrow. The nomenclature of
this condition is derived from the hair-like
projections observed on affected B cells.
Despite being less recognized than other
leukemia forms, grasping the nuances of
HCL is imperative for accurate diagnosis
and efficient management, particularly
when considering the expertise of Bone
Marrow Transplant BMT Specialists.
BEST BMT
Dr.Pawan Kumar Singh

3. TREATMENT
TREATMENT
If your Hairy Cell Leukemia (HCL) progresses
slowly without causing noticeable symptoms,
your doctor may opt for a "watchful waiting"
approach, delaying immediate treatment.
1)-Chemotherapy
2)-Immunotherapy
3)-Surgery
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4. CHEMOTHERAPY
CHEMOTHERAPY
Chemotherapy a treatment involving potent drugs that either
eliminate or slow down the growth of cancer cells, is a common option.
Cladribine (Leustatin) and pentostatin (Nipent) are two chemotherapy
drugs administered intravenously (IV). Many individuals with HCL
experience complete or partial remission, indicating the absence of
cancer signs in the blood.
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Dr.Pawan Kumar Singh

5. IMMUNOTHERAPY
IMMUNOTHERAPY
Utilizes your immune system to combat
HCL. Interferon and rituximab (Rituxan)
are two prevalent immunotherapies.
Moxetumomab (Lumoxiti) might be
considered if other treatments prove
ineffective.
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Dr.Pawan Kumar Singh

6. SURGERY
SURGERY
In cases where the spleen becomes painful or
ruptures, surgical intervention may be necessary. A
splenectomy, the removal of the spleen, won't cure
HCL, but it could restore normal blood counts.
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7. RISK FACTORS
RISK FACTORS
The likelihood of developing hairy cell leukemia may be
heightened in:
Older individuals: While this condition can manifest at any
age, it predominantly afflicts those in their fifth or sixth decade.
Its occurrence in children is infrequent.
Males: While hairy cell leukemia can affect individuals of any
gender, its prevalence is notably higher in males.
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8. SYMPTOMS OF HAIRY CELL
LEUKEMIA
SYMPTOMS OF HAIRY CELL
LEUKEMIA
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Dr.Pawan Kumar Singh
Persistent Fatigue: Individuals with HCL frequently endure persistent
and inexplicable fatigue, unalleviated by rest, significantly impacting
daily activities.Enlarged Spleen and Liver: HCL can induce enlargement
of the spleen and liver, resulting in abdominal discomfort, a sense of
fullness, or even abdominal pain.

9. Easy Bruising and Bleeding: Hairy Cell Leukemia may lead to diminished platelet counts,
causing easy bruising and prolonged bleeding, even from minor traumas. This may
manifest as recurrent nosebleeds, bleeding gums, or the emergence of petechiae, small
red spots on the skin.
Frequent Infections: The abnormal proliferation of B cells in HCL can compromise the
immune system, rendering individuals more susceptible to infections. Recurrent
infections or protracted recovery from common illnesses may signal HCL.
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