This comprehensive guide delves into Polycythemia Vera (PV), a rare hematologic condition characterized by the excessive production of red blood cells in the bone marrow. Classified under myeloproliferative neoplasms, PV causes an overabundance of blood cells, which thickens the blood and leads to potential complications. Throughout this exploration, we'll delve into the intricate details of PV, discussing its symptoms, causes, diagnostic methods, and treatment options. Furthermore, we'll underscore the significance of seeking expert medical assistance, including the quest for the finest bone marrow transplant (BMT) Specialist In Delhi.

1. www.bestbmt.com
www.bestbmt.com
Dr Pawan
Kumar Singh
Dr Pawan Kumar Singh has the
experience of performing more than
500 bone marrow transplants
(including Autologous /Allogenic /Haplo
/MDU )for both malignant and non-
malignant disorders.
BEST BMT
Dr.Pawan Kumar Singh

2. Content List
Introduction Polycythemia
Vera
Symptoms Of PV
Causes Of PV
Treatment Options

3. This comprehensive guide delves into Polycythemia Vera (PV), a rare
hematologic condition characterized by the excessive production of red
blood cells in the bone marrow. Classified under myeloproliferative
neoplasms, PV causes an overabundance of blood cells, which thickens
the blood and leads to potential complications. Throughout this
exploration, we'll delve into the intricate details of PV, discussing its
symptoms, causes, diagnostic methods, and treatment options.
Furthermore, we'll underscore the significance of seeking expert medical
assistance, including the quest for the finest bone marrow transplant
(BMT) Specialist In Delhi.
Introduction

4. Understanding
Polycythemia Vera
Polycythemia Vera originates from a mutation in the bone
marrow's stem cells, leading to the uncontrolled production of
red blood cells. This overproduction thickens the blood, making it
flow more sluggishly through the body's blood vessels, increasing
the risk of clotting. PV can affect individuals of any age but is
more common in adults around 60 years of age.

5. Symptoms of
Polycythemia Vera
Headaches: Frequent and severe
headaches are a common
complaint among PV patients.
Fatigue: Due to the thickened
blood, the body's organs may not
receive adequate oxygen, leading
to persistent fatigue.
Itching: Unexplained itching,
particularly after exposure to warm
water, is a common symptom of PV.

6. Blurred vision: The increased
viscosity of blood can affect
blood flow to the eyes, resulting
in blurred vision.
Dizziness or lightheadedness:
Reduced blood flow to the brain
can cause dizziness or
lightheadedness.

7. Causes of
Treatment Options
The exact cause of PV remains unknown,
although it is primarily linked to a
mutation in the JAK2 gene. This
mutation leads to the uncontrolled
production of red blood cells in the bone
marrow. While the specific triggers for
this mutation are unclear, certain risk
factors may increase the likelihood of
developing PV, including genetic
predisposition and environmental
factors.

8. Diagnosis of Polycythemia Vera
Diagnosing PV involves a combination of medical history
review, physical examination, and laboratory tests. Key
diagnostic tests include:
Complete Blood Count (CBC): Elevated red blood cell
count is a primary indicator of PV.
JAK2 Mutation Test: This genetic test helps identify the
JAK2 mutation present in the majority of PV patients.
Bone Marrow Biopsy: A sample of bone marrow is
examined to confirm the diagnosis and assess the
extent of cell proliferation.

9. Treatment Options for Polycythemia Vera
Phlebotomy: This procedure involves removing a specific
amount of blood to reduce the thickness and viscosity of the
blood.
Medications: Prescription medications such as hydroxyurea or
interferon-alpha may be prescribed to suppress the bone
marrow's overactivity.
Aspirin Therapy: Low-dose aspirin is often recommended to
reduce the risk of blood clots.
Biological Therapies: In some cases, biological therapies such
as JAK inhibitors may be used to target the underlying genetic
mutation

10. + 9 1 - 9 3 5 4 7 0 0 8 6 0 / 8 7 5 0 6 3 7 2 1 2
09:00 AM - 05:00 PM
Thank
You!