The guidelines provide evidence-based recommendations for the diagnosis and treatment of spontaneous intracerebral hemorrhage (ICH). ICH is a medical emergency requiring rapid diagnosis and management, as neurological deterioration is common in the first few hours. Computed tomography (CT) is the recommended imaging modality to rapidly identify acute hemorrhage. Factors such as hematoma expansion, elevated blood pressure, and medical comorbidities should be aggressively managed to reduce morbidity and mortality. Early treatment involves hemostasis, blood pressure control, and preventing medical complications like fever, hyperglycemia and seizures. Additional treatments including clot removal, controlling intracranial pressure and treating hydrocephalus may be considered depending on the severity and location of
1) The 30-day mortality from spontaneous intracerebral hemorrhage (ICH) ranges from 35-52% with half of deaths occurring within two days. Only 12% of patients have mild or no disability at 30 days.
2) Larger initial ICH volume, lower level of consciousness, hematoma growth, intraventricular extension, early neurologic deterioration, preceding use of oral anticoagulants or antiplatelets, and not limiting care are associated with worse prognosis.
3) Patients on oral anticoagulants have mortality rates over 50% and those with hematoma growth are more likely to die or have worse functional outcomes compared to spontaneous ICH.
Intracerebral hemorrhage is an acute extravasation of blood into the brain parenchyma that may extend into ventricles or subarachnoid space. It accounts for 10-15% of strokes and has a 6-month mortality rate of 30-50%. The most common causes are hypertension (78-88%) and cerebral amyloid angiopathy. Treatment involves controlling blood pressure, treating the underlying cause, preventing hematoma expansion, and managing complications. While early surgery was not shown to improve outcomes in the overall STICH trial, it may be beneficial for lobar hemorrhages, which ISTICH-II aims to further evaluate.
Intracerebral Hemorrhage Case presentationUsama Ragab
1. This document presents the case of a 65-year-old male who presented comatose with right side weakness after suddenly feeling weakness on his right side while eating dinner.
2. His medical history includes hypertension, diabetes, chronic kidney disease, and smoking. On examination he was comatose with a Glasgow Coma Scale of 6.
3. Imaging showed a left basal ganglia hemorrhage. His management involved treatment of hypertension and coagulopathy. Guidelines recommend lowering blood pressure to 140 mmHg for hemorrhagic stroke patients to reduce hematoma expansion and improve outcomes.
Dr. Pradeep Mandal presented on the evidence-based management of haemorrhagic stroke. Haemorrhagic strokes account for 10-20% of all strokes and have a higher mortality than ischemic strokes. For the 74-year-old female patient presented with right-sided weakness and altered sensorium, her ICH scale score of 3 indicates a 30-day mortality risk of 26-72%. Medical management is recommended over surgery based on the STICH trials. Her blood pressure needs to be controlled below 180/130 mmHg to prevent hematoma growth. Seizure prophylaxis, deep vein thrombosis prevention, and glycemic control are also important aspects of conservative management. The presentation concluded that
Current management of Spontaneous intracerebral haemorrhage 2016Woralux Phusoongern
Reference : Dastur CK, Yu W. Current management of spontaneous intracerebral haemorrhage. Stroke and Vascular Neurology 2017;00: e000047. doi:10.1136/svn- 2016-000047
Acute Ischaemic Stroke Mx SCGH - ED UpdateSCGH ED CME
1) Minocycline, a tetracycline antibiotic, may reduce hemorrhagic transformation after acute ischemic stroke when given intravenously with tPA.
2) Endovascular approaches such as intra-arterial thrombolysis and thrombectomy are promising options for treating large vessel occlusions in acute ischemic stroke beyond the current treatment window of 4.5 hours.
3) Pre-hospital administration of therapies such as magnesium may expand the treatment window for acute ischemic stroke if given soon after symptom onset in the field before hospital arrival.
Intracranial hemorrhages account for 8-11% of all acute strokes and have a high mortality rate. The main causes are hypertension, amyloid angiopathy, AVMs, anticoagulation, and tumors. Management involves stabilizing the patient, controlling blood pressure, stabilizing the clot, managing cerebral edema and seizures. Surgery is generally not beneficial except for cerebellar hemorrhages. Clinical trials have found no clear benefit of aggressive blood pressure control or clot evacuation surgery over medical management alone.
The document discusses recent developments in stroke management. It summarizes that (1) endovascular therapy plus usual care is more effective than usual care alone for acute ischemic stroke patients with proximal arterial occlusion within 6 hours of onset, (2) early intensive blood pressure lowering is safe and may improve outcomes for intracerebral hemorrhage patients presenting within 6 hours with systolic BP 150-220 mmHg, and (3) stroke rehabilitation involving early mobilization, drug therapy to enhance motor recovery, and robotic training can improve functional recovery.
1) The 30-day mortality from spontaneous intracerebral hemorrhage (ICH) ranges from 35-52% with half of deaths occurring within two days. Only 12% of patients have mild or no disability at 30 days.
2) Larger initial ICH volume, lower level of consciousness, hematoma growth, intraventricular extension, early neurologic deterioration, preceding use of oral anticoagulants or antiplatelets, and not limiting care are associated with worse prognosis.
3) Patients on oral anticoagulants have mortality rates over 50% and those with hematoma growth are more likely to die or have worse functional outcomes compared to spontaneous ICH.
Intracerebral hemorrhage is an acute extravasation of blood into the brain parenchyma that may extend into ventricles or subarachnoid space. It accounts for 10-15% of strokes and has a 6-month mortality rate of 30-50%. The most common causes are hypertension (78-88%) and cerebral amyloid angiopathy. Treatment involves controlling blood pressure, treating the underlying cause, preventing hematoma expansion, and managing complications. While early surgery was not shown to improve outcomes in the overall STICH trial, it may be beneficial for lobar hemorrhages, which ISTICH-II aims to further evaluate.
Intracerebral Hemorrhage Case presentationUsama Ragab
1. This document presents the case of a 65-year-old male who presented comatose with right side weakness after suddenly feeling weakness on his right side while eating dinner.
2. His medical history includes hypertension, diabetes, chronic kidney disease, and smoking. On examination he was comatose with a Glasgow Coma Scale of 6.
3. Imaging showed a left basal ganglia hemorrhage. His management involved treatment of hypertension and coagulopathy. Guidelines recommend lowering blood pressure to 140 mmHg for hemorrhagic stroke patients to reduce hematoma expansion and improve outcomes.
Dr. Pradeep Mandal presented on the evidence-based management of haemorrhagic stroke. Haemorrhagic strokes account for 10-20% of all strokes and have a higher mortality than ischemic strokes. For the 74-year-old female patient presented with right-sided weakness and altered sensorium, her ICH scale score of 3 indicates a 30-day mortality risk of 26-72%. Medical management is recommended over surgery based on the STICH trials. Her blood pressure needs to be controlled below 180/130 mmHg to prevent hematoma growth. Seizure prophylaxis, deep vein thrombosis prevention, and glycemic control are also important aspects of conservative management. The presentation concluded that
Current management of Spontaneous intracerebral haemorrhage 2016Woralux Phusoongern
Reference : Dastur CK, Yu W. Current management of spontaneous intracerebral haemorrhage. Stroke and Vascular Neurology 2017;00: e000047. doi:10.1136/svn- 2016-000047
Acute Ischaemic Stroke Mx SCGH - ED UpdateSCGH ED CME
1) Minocycline, a tetracycline antibiotic, may reduce hemorrhagic transformation after acute ischemic stroke when given intravenously with tPA.
2) Endovascular approaches such as intra-arterial thrombolysis and thrombectomy are promising options for treating large vessel occlusions in acute ischemic stroke beyond the current treatment window of 4.5 hours.
3) Pre-hospital administration of therapies such as magnesium may expand the treatment window for acute ischemic stroke if given soon after symptom onset in the field before hospital arrival.
Intracranial hemorrhages account for 8-11% of all acute strokes and have a high mortality rate. The main causes are hypertension, amyloid angiopathy, AVMs, anticoagulation, and tumors. Management involves stabilizing the patient, controlling blood pressure, stabilizing the clot, managing cerebral edema and seizures. Surgery is generally not beneficial except for cerebellar hemorrhages. Clinical trials have found no clear benefit of aggressive blood pressure control or clot evacuation surgery over medical management alone.
The document discusses recent developments in stroke management. It summarizes that (1) endovascular therapy plus usual care is more effective than usual care alone for acute ischemic stroke patients with proximal arterial occlusion within 6 hours of onset, (2) early intensive blood pressure lowering is safe and may improve outcomes for intracerebral hemorrhage patients presenting within 6 hours with systolic BP 150-220 mmHg, and (3) stroke rehabilitation involving early mobilization, drug therapy to enhance motor recovery, and robotic training can improve functional recovery.
Ischemic strokes caused by atrial fibrillation are a major health concern in the United States. They account for approximately 69,000 strokes annually. Compared to other causes of ischemic stroke, atrial fibrillation-related strokes tend to be more severe, disabling, and fatal. They are associated with longer hospital stays, higher rates of in-hospital complications, and poorer long-term outcomes. Patients often experience significant physical, emotional, and psychological impacts even years after their stroke. The burden on caregivers is also high. Timely management and treatment are critical to minimize damage from these strokes.
Approach to the patient with anemia dr anjaniAnjaniJha10
This document outlines Dr. Anjani Kumar Jha's approach to patients presenting with anemia. It begins with definitions of anemia and hematopoiesis. It then discusses the classification, clinical presentation, investigations and specific types of anemia. The evaluation of an anemic patient requires a careful history, physical exam, and laboratory tests including complete blood count, iron studies, and bone marrow examination to determine the underlying cause and guide treatment. A thorough approach considers nutritional, medication, family history and examines for signs of blood loss, infection or other diseases.
1. The document discusses pre-hospital and emergency department management of acute stroke. It emphasizes the importance of rapid detection, transport, and treatment to maximize outcomes for stroke patients.
2. Treatment guidelines recommend administering intravenous tissue plasminogen activator (tPA) for ischemic stroke within 3 hours of symptom onset to reduce disability and mortality.
3. In the emergency department, the focus is on quick assessment, diagnosis of hemorrhagic vs ischemic stroke using CT scan, and treatment or referral for definitive care such as thrombolysis within the treatment window.
The document discusses the epidemiology, pathophysiology, risk factors, clinical presentation, and treatment options for hemorrhagic stroke. It recognizes the importance of controlling risk factors like hypertension and anticoagulant use in treatment, and stabilizing vital signs and correcting coagulopathies. The document also evaluates benefits and risks of different pharmacological and surgical interventions for acute hemorrhagic stroke.
Hemorrhagic stroke accounts for 10-15% of all strokes and is associated with higher mortality than ischemic stroke. Patients often present with headache, altered mental status, seizures, nausea/vomiting, or hypertension. The bleeding occurs directly into the brain from damaged arteries, and mortality is high, with 40-80% dying within 30 days. Risk factors include age, hypertension, amyloidosis, coagulopathies, anticoagulation, cocaine abuse, and genetic conditions. Treatment focuses on stabilizing vital signs, controlling blood pressure and seizures, and reducing intracranial pressure if elevated.
ASA/AHA 2014 guidelines for the Primary Prevention of Stroke
Hypertension and dyslipidemia impact on stroke development and prevention
SPRINT and HOPE-3
1. Thrombolysis using intravenous rt-PA within 3-4.5 hours of stroke onset is the primary reperfusion therapy approved by the FDA.
2. Other reperfusion therapies include intra-arterial thrombolysis, mechanical thrombectomy devices, sonothrombolysis, laser thrombolysis, and percutaneous angioplasty.
3. Neuroprotective therapies aim to reduce excitatory neurotransmitters, reperfusion injury, and neuronal cell death through mechanisms such as decreasing calcium influx and free radical production.
management of intraventricular hemorrhage with alteplaseSurendra Patel
A 31-year-old female presented with sudden onset headache, vomiting, and loss of consciousness with right-sided weakness. She had undergone IVF and embryo implantation the previous day. CT scan showed a large intracerebral hemorrhage with intraventricular extension. She was treated with mannitol, lasix, and levetiracetam. An external ventricular drain was inserted. Over the next few weeks, she received intraventricular alteplase to clear the blood and antibiotics due to elevated CSF protein and white cells. The ventricular drain was removed after the bleeding cleared and her condition improved.
The Intensive Care Management of Acute Ischemic Stroke Ade Wijaya
The document provides an overview of the intensive care management of acute ischemic stroke. It discusses indications for ICU admission including oxygenation and ventilation, hemodynamic and fluid management, fever control, and other aspects of care such as anemia, hemorrhagic transformation, and cerebral edema monitoring. The goal of treatment is stabilization and prevention of secondary complications after a stroke occurs.
Blood-Pressure Management in Patients with Acute Cerebral Hemorrhage
Kontroversi hasil studi ATACH-2 dan dampaknya dalam manajemen hipertensi pada stroke perdarahan intraserebral akut.
This document discusses supportive management strategies for patients experiencing acute stroke. It covers positioning, monitoring and treatment of cerebral edema, management of seizures, blood pressure control, glucose control, potential cardiac issues, the role of hypothermia and neuroprotective agents, prevention of venous thromboembolism, and monitoring for infections. Key recommendations include maintaining normothermia, blood sugars between 140-180 mg/dL, treating cerebral edema with osmotic therapies like mannitol if indicated, and early mobilization to prevent complications like DVT.
This document provides information on the management of acute ischemic stroke. It defines stroke, describes the types and risk factors, and outlines the principles of acute stroke care which include timely recanalization, optimizing collateral flow, and avoiding secondary brain injury. Evaluation and management strategies are discussed, including supportive treatment, thrombolysis, and endovascular interventions. The roles of antiplatelets, anticoagulants, and neuroprotection are also summarized.
This document provides an overview of cerebrovascular accidents (stroke) including objectives, outlines, definitions, risk factors, causes, types, signs and symptoms, complications, diagnosis, and nursing care. The main types of stroke are ischemic (70%) caused by blockages and hemorrhagic (25%) caused by bleeding. Risk factors include hypertension, heart disease, diabetes, smoking, and age. Signs may include weakness, vision issues, and speech problems. Diagnosis involves imaging of the brain and blood vessels.
This document discusses the diagnosis and management of acute stroke. It begins by outlining the objectives of reviewing stroke etiology, identifying stroke location/type based on exam, and acute management of ischemic and hemorrhagic strokes. It then provides statistics on stroke prevalence and costs. The document reviews tools for stroke assessment like the NIH Stroke Scale and discusses etiologies of different stroke types. It includes cases demonstrating physical exam findings and determining stroke location. Management topics covered include airway protection, imaging, and treatment algorithms.
1. The document discusses acute ischemic stroke treatment and highlights the importance of timely intravenous thrombolysis administration.
2. It reviews insights on intravenous and intra-arterial thrombolysis and previews future interventional therapies for ischemic stroke.
3. The author examines a clinical trial on the use of Factor VIIa for intracerebral hemorrhage that showed it reduced hematoma growth and mortality in a dose-dependent manner, indicating a potential new treatment for spontaneous ICH.
Guidelines for the prevention of stroke in patients with stroke and transient...NeurologyKota
This document provides guidelines for preventing stroke in patients who have had a stroke or transient ischemic attack. It discusses risk factors for stroke and recommendations for prevention in several conditions including atrial fibrillation, acute myocardial infarction, cardiomyopathy, valvular heart disease, and prosthetic heart valves. Key recommendations include use of oral anticoagulants like warfarin for atrial fibrillation and mechanical heart valves, and antiplatelet therapy for some conditions when anticoagulation is not recommended or possible. Clinical trials are summarized that provide evidence for these guidelines.
An 80-year-old Saudi woman presented to the emergency department with sudden onset weakness in her right hand and difficulty speaking during dinner. She has a history of hypertension, peripheral vascular disease, anemia, and anxiety. A CT scan showed evidence of a left-sided infarct and carotid Doppler revealed 48% stenosis in the left carotid artery, consistent with an ischemic stroke. Her symptoms began suddenly and she was brought to the emergency department within 60 minutes.
This document provides information on acute stroke, including its epidemiology, definition, risk factors, clinical presentation, investigations, imaging, and management. Some key points:
- Stroke is a leading cause of death worldwide and in South Africa. Incidence rates in SA are estimated to be 244 per 100,000 people.
- Risk factors for ischemic stroke include hypertension, tobacco use, diabetes, high cholesterol, physical inactivity, and others.
- Clinical presentation depends on location of stroke in the brain. Imaging such as CT scan is important to distinguish ischemic from hemorrhagic stroke.
- Management involves supportive care as well as specific treatments depending on stroke type, such as intravenous thrombolysis for ischemic strokes within
Prevention of stroke in patients with tiaSachin Shende
This document provides guidelines from the American Heart Association/American Stroke Association for the prevention of future stroke in patients who have experienced an ischemic stroke or transient ischemic attack (TIA). Some key points:
- Over 690,000 adults in the US experience an ischemic stroke each year, and an additional 240,000 will experience a TIA. The risk of future stroke after an initial event is approximately 3-4% annually.
- The aim of the guidelines is to provide evidence-based recommendations to clinicians for controlling risk factors and preventing recurrent brain ischemia in these high-risk patients.
- Important revisions from the previous guidelines include new sections on sleep apnea and aortic arch atherosclerosis, expanded sections
Regional Systems Of Care For Out Of Hospital Cardiac ArrestDavid Hiltz
Abstract—Out-of-hospital cardiac arrest continues to be an important public health problem, with large and important
regional variations in outcomes. Survival rates vary widely among patients treated with out-of-hospital cardiac arrest by
emergency medical services and among patients transported to the hospital after return of spontaneous circulation. Most
regions lack a well-coordinated approach to post– cardiac arrest care. Effective hospital-based interventions for
out-of-hospital cardiac arrest exist but are used infrequently. Barriers to implementation of these interventions include
lack of knowledge, experience, personnel, resources, and infrastructure. A well-defined relationship between an
increased volume of patients or procedures and better outcomes among individual providers and hospitals has been
observed for several other clinical disorders. Regional systems of care have improved provider experience and patient
outcomes for those with ST-elevation myocardial infarction and life-threatening traumatic injury. This statement
describes the rationale for regional systems of care for patients resuscitated from cardiac arrest and the preliminary
recommended elements of such systems. Many more people could potentially survive out-of-hospital cardiac arrest if
regional systems of cardiac resuscitation were established. A national process is necessary to develop and implement
evidence-based guidelines for such systems that must include standards for the categorization, verification, and
designation of components of such systems. The time to do so is now.
Ischemic strokes caused by atrial fibrillation are a major health concern in the United States. They account for approximately 69,000 strokes annually. Compared to other causes of ischemic stroke, atrial fibrillation-related strokes tend to be more severe, disabling, and fatal. They are associated with longer hospital stays, higher rates of in-hospital complications, and poorer long-term outcomes. Patients often experience significant physical, emotional, and psychological impacts even years after their stroke. The burden on caregivers is also high. Timely management and treatment are critical to minimize damage from these strokes.
Approach to the patient with anemia dr anjaniAnjaniJha10
This document outlines Dr. Anjani Kumar Jha's approach to patients presenting with anemia. It begins with definitions of anemia and hematopoiesis. It then discusses the classification, clinical presentation, investigations and specific types of anemia. The evaluation of an anemic patient requires a careful history, physical exam, and laboratory tests including complete blood count, iron studies, and bone marrow examination to determine the underlying cause and guide treatment. A thorough approach considers nutritional, medication, family history and examines for signs of blood loss, infection or other diseases.
1. The document discusses pre-hospital and emergency department management of acute stroke. It emphasizes the importance of rapid detection, transport, and treatment to maximize outcomes for stroke patients.
2. Treatment guidelines recommend administering intravenous tissue plasminogen activator (tPA) for ischemic stroke within 3 hours of symptom onset to reduce disability and mortality.
3. In the emergency department, the focus is on quick assessment, diagnosis of hemorrhagic vs ischemic stroke using CT scan, and treatment or referral for definitive care such as thrombolysis within the treatment window.
The document discusses the epidemiology, pathophysiology, risk factors, clinical presentation, and treatment options for hemorrhagic stroke. It recognizes the importance of controlling risk factors like hypertension and anticoagulant use in treatment, and stabilizing vital signs and correcting coagulopathies. The document also evaluates benefits and risks of different pharmacological and surgical interventions for acute hemorrhagic stroke.
Hemorrhagic stroke accounts for 10-15% of all strokes and is associated with higher mortality than ischemic stroke. Patients often present with headache, altered mental status, seizures, nausea/vomiting, or hypertension. The bleeding occurs directly into the brain from damaged arteries, and mortality is high, with 40-80% dying within 30 days. Risk factors include age, hypertension, amyloidosis, coagulopathies, anticoagulation, cocaine abuse, and genetic conditions. Treatment focuses on stabilizing vital signs, controlling blood pressure and seizures, and reducing intracranial pressure if elevated.
ASA/AHA 2014 guidelines for the Primary Prevention of Stroke
Hypertension and dyslipidemia impact on stroke development and prevention
SPRINT and HOPE-3
1. Thrombolysis using intravenous rt-PA within 3-4.5 hours of stroke onset is the primary reperfusion therapy approved by the FDA.
2. Other reperfusion therapies include intra-arterial thrombolysis, mechanical thrombectomy devices, sonothrombolysis, laser thrombolysis, and percutaneous angioplasty.
3. Neuroprotective therapies aim to reduce excitatory neurotransmitters, reperfusion injury, and neuronal cell death through mechanisms such as decreasing calcium influx and free radical production.
management of intraventricular hemorrhage with alteplaseSurendra Patel
A 31-year-old female presented with sudden onset headache, vomiting, and loss of consciousness with right-sided weakness. She had undergone IVF and embryo implantation the previous day. CT scan showed a large intracerebral hemorrhage with intraventricular extension. She was treated with mannitol, lasix, and levetiracetam. An external ventricular drain was inserted. Over the next few weeks, she received intraventricular alteplase to clear the blood and antibiotics due to elevated CSF protein and white cells. The ventricular drain was removed after the bleeding cleared and her condition improved.
The Intensive Care Management of Acute Ischemic Stroke Ade Wijaya
The document provides an overview of the intensive care management of acute ischemic stroke. It discusses indications for ICU admission including oxygenation and ventilation, hemodynamic and fluid management, fever control, and other aspects of care such as anemia, hemorrhagic transformation, and cerebral edema monitoring. The goal of treatment is stabilization and prevention of secondary complications after a stroke occurs.
Blood-Pressure Management in Patients with Acute Cerebral Hemorrhage
Kontroversi hasil studi ATACH-2 dan dampaknya dalam manajemen hipertensi pada stroke perdarahan intraserebral akut.
This document discusses supportive management strategies for patients experiencing acute stroke. It covers positioning, monitoring and treatment of cerebral edema, management of seizures, blood pressure control, glucose control, potential cardiac issues, the role of hypothermia and neuroprotective agents, prevention of venous thromboembolism, and monitoring for infections. Key recommendations include maintaining normothermia, blood sugars between 140-180 mg/dL, treating cerebral edema with osmotic therapies like mannitol if indicated, and early mobilization to prevent complications like DVT.
This document provides information on the management of acute ischemic stroke. It defines stroke, describes the types and risk factors, and outlines the principles of acute stroke care which include timely recanalization, optimizing collateral flow, and avoiding secondary brain injury. Evaluation and management strategies are discussed, including supportive treatment, thrombolysis, and endovascular interventions. The roles of antiplatelets, anticoagulants, and neuroprotection are also summarized.
This document provides an overview of cerebrovascular accidents (stroke) including objectives, outlines, definitions, risk factors, causes, types, signs and symptoms, complications, diagnosis, and nursing care. The main types of stroke are ischemic (70%) caused by blockages and hemorrhagic (25%) caused by bleeding. Risk factors include hypertension, heart disease, diabetes, smoking, and age. Signs may include weakness, vision issues, and speech problems. Diagnosis involves imaging of the brain and blood vessels.
This document discusses the diagnosis and management of acute stroke. It begins by outlining the objectives of reviewing stroke etiology, identifying stroke location/type based on exam, and acute management of ischemic and hemorrhagic strokes. It then provides statistics on stroke prevalence and costs. The document reviews tools for stroke assessment like the NIH Stroke Scale and discusses etiologies of different stroke types. It includes cases demonstrating physical exam findings and determining stroke location. Management topics covered include airway protection, imaging, and treatment algorithms.
1. The document discusses acute ischemic stroke treatment and highlights the importance of timely intravenous thrombolysis administration.
2. It reviews insights on intravenous and intra-arterial thrombolysis and previews future interventional therapies for ischemic stroke.
3. The author examines a clinical trial on the use of Factor VIIa for intracerebral hemorrhage that showed it reduced hematoma growth and mortality in a dose-dependent manner, indicating a potential new treatment for spontaneous ICH.
Guidelines for the prevention of stroke in patients with stroke and transient...NeurologyKota
This document provides guidelines for preventing stroke in patients who have had a stroke or transient ischemic attack. It discusses risk factors for stroke and recommendations for prevention in several conditions including atrial fibrillation, acute myocardial infarction, cardiomyopathy, valvular heart disease, and prosthetic heart valves. Key recommendations include use of oral anticoagulants like warfarin for atrial fibrillation and mechanical heart valves, and antiplatelet therapy for some conditions when anticoagulation is not recommended or possible. Clinical trials are summarized that provide evidence for these guidelines.
An 80-year-old Saudi woman presented to the emergency department with sudden onset weakness in her right hand and difficulty speaking during dinner. She has a history of hypertension, peripheral vascular disease, anemia, and anxiety. A CT scan showed evidence of a left-sided infarct and carotid Doppler revealed 48% stenosis in the left carotid artery, consistent with an ischemic stroke. Her symptoms began suddenly and she was brought to the emergency department within 60 minutes.
This document provides information on acute stroke, including its epidemiology, definition, risk factors, clinical presentation, investigations, imaging, and management. Some key points:
- Stroke is a leading cause of death worldwide and in South Africa. Incidence rates in SA are estimated to be 244 per 100,000 people.
- Risk factors for ischemic stroke include hypertension, tobacco use, diabetes, high cholesterol, physical inactivity, and others.
- Clinical presentation depends on location of stroke in the brain. Imaging such as CT scan is important to distinguish ischemic from hemorrhagic stroke.
- Management involves supportive care as well as specific treatments depending on stroke type, such as intravenous thrombolysis for ischemic strokes within
Prevention of stroke in patients with tiaSachin Shende
This document provides guidelines from the American Heart Association/American Stroke Association for the prevention of future stroke in patients who have experienced an ischemic stroke or transient ischemic attack (TIA). Some key points:
- Over 690,000 adults in the US experience an ischemic stroke each year, and an additional 240,000 will experience a TIA. The risk of future stroke after an initial event is approximately 3-4% annually.
- The aim of the guidelines is to provide evidence-based recommendations to clinicians for controlling risk factors and preventing recurrent brain ischemia in these high-risk patients.
- Important revisions from the previous guidelines include new sections on sleep apnea and aortic arch atherosclerosis, expanded sections
Regional Systems Of Care For Out Of Hospital Cardiac ArrestDavid Hiltz
Abstract—Out-of-hospital cardiac arrest continues to be an important public health problem, with large and important
regional variations in outcomes. Survival rates vary widely among patients treated with out-of-hospital cardiac arrest by
emergency medical services and among patients transported to the hospital after return of spontaneous circulation. Most
regions lack a well-coordinated approach to post– cardiac arrest care. Effective hospital-based interventions for
out-of-hospital cardiac arrest exist but are used infrequently. Barriers to implementation of these interventions include
lack of knowledge, experience, personnel, resources, and infrastructure. A well-defined relationship between an
increased volume of patients or procedures and better outcomes among individual providers and hospitals has been
observed for several other clinical disorders. Regional systems of care have improved provider experience and patient
outcomes for those with ST-elevation myocardial infarction and life-threatening traumatic injury. This statement
describes the rationale for regional systems of care for patients resuscitated from cardiac arrest and the preliminary
recommended elements of such systems. Many more people could potentially survive out-of-hospital cardiac arrest if
regional systems of cardiac resuscitation were established. A national process is necessary to develop and implement
evidence-based guidelines for such systems that must include standards for the categorization, verification, and
designation of components of such systems. The time to do so is now.
Guidelines for the primary prevention of strokeSachin Shende
- Approximately 795,000 people in the US have a stroke each year, with 610,000 being first attacks, resulting in 6.8 million stroke survivors. Stroke is the fourth leading cause of death in the US.
- Risk factors such as hypertension, smoking, diabetes and hyperlipidemia account for approximately 90% of stroke risk and can be modified to help prevent first strokes. Preventive measures such as controlling these risk factors are important for reducing the burden of stroke.
- The guidelines provide evidence-based recommendations for preventing initial stroke through risk factor control, screening high-risk groups, and treating conditions like atrial fibrillation that increase stroke risk.
Aha guidelines for primary prevention of cardiovascular disease and strokeΑθανάσιος Παπαδόπουλος
The guidelines provide recommendations for comprehensive risk reduction for adult patients without cardiovascular disease:
1) Risk assessment should begin at age 20 and include regular screening and monitoring of risk factors.
2) All adults age 40 or older should have their 10-year risk of coronary heart disease assessed to determine their absolute risk level.
3) Recommendations are provided for lifestyle modifications and medical treatments to reduce risk and lower blood pressure, improve diet, encourage physical activity, and consider aspirin for those at higher risk. The goal is to match interventions to individual risk levels.
A less-invasive-approach-of-medial-meniscectomy-in-rat-a-model-to-target-earl...science journals
In order for insulin to exert its biological actions on target cells in peripheral tissues like muscle and adipose tissues, Insulin must pass through the endothelial barrier into the interstitium.
Circulation 2015-criterios de jones reviewgisa_legal
This document revises the Jones criteria for diagnosing acute rheumatic fever to better align with current evidence and international guidelines. It recognizes that acute rheumatic fever remains a serious health problem globally. The revisions define high-risk populations, acknowledge variability in clinical presentation among these groups, and include Doppler echocardiography as a tool for diagnosing cardiac involvement even without overt symptoms. This represents the first major revision to the Jones criteria by the American Heart Association in over 20 years and applies their classification system for recommendations and evidence levels.
Circulation 2015-criterios de jones reviewgisa_legal
This document revises the Jones criteria for diagnosing acute rheumatic fever to better align with current evidence and international guidelines. It recognizes that acute rheumatic fever remains a serious health problem globally. The revisions define high-risk populations, acknowledge variability in clinical presentation among these groups, and include Doppler echocardiography as a tool for diagnosing cardiac involvement even without overt symptoms. This represents the first major revision to the Jones criteria by the American Heart Association in over 20 years and applies their classification system for recommendations and evidence levels.
Advanced Heart Failure Trans-Atlantic Perspectives On The Heart Failure Asso...Martha Brown
The document summarizes a position statement from the Heart Failure Association of the European Society of Cardiology on advanced heart failure. It defines advanced heart failure as severe, persistent heart failure symptoms along with impaired exercise capacity and at least one unplanned clinical event in the past year. It estimates 500,000 to 750,000 people in Europe have advanced heart failure. The position statement provides an updated definition and recommendations for identifying and managing these patients, including considering advanced therapies like transplantation or mechanical circulatory support. It also calls for improved coordination between specialized heart failure centers and local providers to help more patients receive expert care.
The Indian Consensus Document on Cardiac BiomarkerApollo Hospitals
Despite recent advances, the diagnosis and management of heart failure evades the clinicians. The etiology of congestive heart failure (CHF) in the Indian scenario comprises of coronary artery disease, diabetes mellitus and hypertension. With better insights into the pathophysiology of CHF, biomarkers have evolved rapidly and received diagnostic and prognostic value. In CHF biomarkers prove as measures of the extent of pathophysiological derangement; examples include biomarkers of myocyte necrosis, myocardial remodeling,
neurohormonal activation, etc.
The document provides the top 10 take-home messages from the 2021 ACC/AHA/AATS/STS/SCAI Guideline for Coronary Artery Revascularization. It emphasizes using a multidisciplinary Heart Team approach for unclear treatment cases, considering surgical revascularization for left main disease and triple-vessel disease, and using radial artery access for percutaneous interventions to reduce complications. It also recommends strategies to improve equity in treatment decisions and shared decision-making.
The document provides the top 10 take-home messages from the 2021 ACC/AHA/AATS/STS/SCAI Guideline for Coronary Artery Revascularization. It emphasizes using a multidisciplinary Heart Team approach for unclear treatment cases, considering surgical revascularization for left main disease and triple-vessel disease, and using radial artery access for percutaneous interventions to reduce complications. It also recommends strategies to improve equity in treatment decisions and shared decision-making.
MWEBAZA VICTOR - Nuclear Cardiology The Basics-How To Set Up And Maintain A ...Dr. MWEBAZA VICTOR
This document provides an overview of how to establish and maintain a nuclear cardiology laboratory. It discusses the necessary equipment, staff qualifications, patient preparation, stress testing protocols, imaging acquisition and processing parameters, image analysis and display, reporting, quality assurance, and laboratory accreditation. The goal is to offer practical guidance to cardiologists and nuclear medicine physicians on setting up and running a high-quality outpatient nuclear cardiology facility.
Guia de manejo de pacientes con aneurismas subaracnoideos del año 2023, contiene manejo nivel de evidencia, para neurocirugía, anestesiología, unidad de cuidados intensivos, trata de unificar criterios, y lo que debe y no debe hacerse se encuentra clasificado como tal, contiene también recomendación de expertos, entre otros
Some atrial fibrillation patients who are at low risk for stroke are receiving unnecessary blood thinners according to a study by UCSF researchers. The study found that about 25% of AF patients under age 60 without heart disease or other risk factors were prescribed blood thinners, contrary to guidelines. The researchers believe cardiology specialists may not be fully aware of the low stroke risk for certain AF patients and the potential health risks of blood thinners. Being prescribed unnecessary blood thinners could expose low-risk patients to risks of bleeding that outweigh the benefits of stroke reduction.
AHA guideline on stroke in neonates and children stroke 2019Carmenlahiffjenkins
This document provides an overview and update on perinatal and childhood stroke. It discusses the purpose, methods, results, and conclusions of the scientific statement from the American Heart Association/American Stroke Association on the management of stroke in neonates and children. Key points include:
- Stroke is an important cause of acquired brain injury in children, occurring most commonly in neonates and throughout childhood.
- Annual pediatric stroke incidence ranges from 3 to 25 per 100,000 children in developed countries, with newborns having the highest risk.
- Stroke in children can be ischemic or hemorrhagic and classification includes differences by age (perinatal vs. childhood) and subtype.
- Risk factors,
Research proposal focus cardiovascular and other disease biology - Pubrica ...Pubrica
This document discusses research on improving risk assessment for cardiovascular disease through the integration of multidimensional data sets using systems medicine approaches. It focuses on using implantable cardioverter defibrillators (ICDs) that can both diagnose and treat cardiac conditions to help prevent cardiac death. While early ICDs were large and invasive, requiring open chest surgery, improvements in size, detection algorithms, battery technology and electrodes have enabled widespread use today for both secondary and primary prevention of life-threatening arrhythmias. Continued advances incorporating data from various omics fields, imaging, and other sources promise to enhance understanding of disease mechanisms and improve personalized treatment.
This document proposes a new 5-stage classification system (A-E) for cardiogenic shock to improve communication and help guide treatment. Stage A is "at risk" for shock, stage B is "beginning" shock, stage C is "classic" shock with hypoperfusion, stage D means initial interventions did not restore stability despite 30 minutes of observation, and stage E is "extremis" with cardiovascular collapse. The goal is to have a simple, clinically applicable system that can be used across care settings and potentially help identify patients most likely to benefit from different treatments.
Similar to Guidelines for the management of spontaneous ich (20)
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise stimulates the production of endorphins in the brain which elevate mood and reduce stress levels.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
3. Morgenstern et al Intracerebral Hemorrhage Guideline 2109
S pontaneous, nontraumatic intracerebral hemorrhage (ICH)
is a significant cause of morbidity and mortality throughout
the world. Although much has been made of the lack of a
deterioration is common in the first few hours after ICH
onset. More than 20% of patients will experience a decrease
in the Glasgow Coma Scale (GCS) score of 2 points
specific targeted therapy, much less is written about the success between the prehospital emergency medical services assess-
and goals of aggressive medical and surgical care for this ment and the initial evaluation in the emergency department
disease. Recent population-based studies suggest that most (ED).7 Among those patients with prehospital neurological
patients present with small ICHs that are readily survivable with decline, the GCS score decreases by an average of 6 points
good medical care.1 This suggests that excellent medical care and the mortality rate is 75%. Further, within the first hour
likely has a potent, direct impact on ICH morbidity and mortality of presentation to a hospital, 15% of patients demonstrate a
now, even before a specific therapy is found. Indeed, as decrease in the GCS score of 2 points.8 The risk for early
discussed later, the overall aggressiveness of ICH care is directly neurological deterioration and the high rate of poor long-term
related to mortality from this disease.2 One of the purposes of outcomes underscores the need for aggressive early
this guideline, therefore, is to remind clinicians of the impor- management.
tance of their care in determining ICH outcome and to provide
an evidence-based framework for that care. Prehospital Management
In order to make this review brief and readily useful to The primary objective in the prehospital setting is to provide
practicing clinicians, the reader is referred elsewhere for the ventilatory and cardiovascular support and to transport the patient to
details of ICH epidemiology.1,3,4 Similarly, there are many the closest facility prepared to care for patients with acute stroke
ongoing clinical studies throughout the world related to this (see ED Management section that follows). Secondary priorities for
disease. The reader is encouraged to consider referring emergency medical services providers include obtaining a focused
patients to these important efforts, which can be found at history regarding the timing of symptom onset (or the time the
http://www.strokecenter.org/trials/. We will not discuss on- patient was last normal) and information about medical history,
going studies because we cannot cover them all; the focus of medication, and drug use. Finally, emergency medical services
this statement is on currently available therapies. Finally, a providers should provide advance notice to the ED of the impending
recent guideline on pediatric stroke was published5 that arrival of a potential stroke patient so that critical pathways can be
obviates the need to repeat the issues of pediatric ICH here. initiated and consulting services can be alerted. Advance notice by
The last ICH Guidelines were published in 2007,6 and this emergency medical services has been demonstrated to significantly
current article serves to update those guidelines. As such, shorten time to computed tomography (CT) scanning in the ED.9
differences from former recommendations are specified in the
current work. The writing group met by phone to determine ED Management
subcategories to evaluate. These included emergency diagnosis It is of the utmost importance that every ED be prepared to
and assessment of ICH and its causes; hemostasis, blood treat patients with ICH or have a plan for rapid transfer to a
pressure (BP); intracranial pressure (ICP)/fever/glucose/ tertiary care center. The crucial resources necessary to man-
seizures/hydrocephalus; iron; ICP monitors/tissue oxygenation; age patients with ICH include neurology, neuroradiology,
clot removal; intraventricular hemorrhage (IVH); withdrawal of neurosurgery, and critical care facilities including adequately
technological support; prevention of recurrent ICH; nursing trained nurses and physicians. In the ED, appropriate consul-
care; rehab/recovery; future considerations. Each subcategory tative services should be contacted as quickly as possible and
was led by an author with 1 or 2 additional authors making the clinical evaluation should be performed efficiently, with
contributions. Full MEDLINE searches were done of all physicians and nurses working in parallel. Table 4 describes
English-language articles regarding relevant human disease the integral components of the history, physical examination,
treatment. Drafts of summaries and recommendations were and diagnostic studies that should be obtained in the ED.
circulated to the whole writing group for feedback. A conference For patients with ICH, emergency management may in-
call was held to discuss controversial issues. Sections were clude neurosurgical interventions for hematoma evacuation,
revised and merged by the Chair. The resulting draft was sent to external ventricular drainage or invasive monitoring and
the whole writing group for comment. Comments were incor- treatment of ICP, BP management, intubation, and reversal of
porated by the Vice Chair and Chair, and the entire committee coagulopathy. Although many centers have critical pathways
was asked to approve the final draft. Changes to the document developed for the treatment of acute ischemic stroke, few
were made by the Chair and Vice Chair in response to peer have protocols for the management of ICH.18 Such pathways
review, and the document was again sent to the entire writing may allow for more efficient, standardized, and integrated
group for suggested changes and approval. Recommendations management of critically ill patients with ICH.
follow the American Heart Association Stroke Council’s
methods of classifying the level of certainty of the treatment Neuroimaging
effect and the class of evidence (Tables 1 and 2). All Class I The abrupt onset of focal neurological symptoms is presumed to
recommendations are listed in Table 3. be vascular in origin until proven otherwise. However, it is
impossible to know whether symptoms are due to ischemia or
Emergency Diagnosis and Assessment of ICH hemorrhage based on clinical characteristics alone. Vomiting,
and Its Causes systolic BP 220 mm Hg, severe headache, coma or decreased
ICH is a medical emergency. Rapid diagnosis and attentive level of consciousness, and progression over minutes or hours all
management of patients with ICH is crucial because early suggest ICH, although none of these findings are specific;
Downloaded from stroke.ahajournals.org by on January 25, 2011
4. 2110 Stroke September 2010
Table 1. Applying Classification of Recommendations and Level of Evidence
*Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as sex, age, history of diabetes, history of prior
myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imply that the recommendation is weak.
Many important clinical questions addressed in the guidelines do not lend themselves to clinical trials. Even though randomized trials are not available, there may
be a very clear clinical consensus that a particular test or therapy is useful or effective.
†In 2003, the ACCF/AHA Task Force on Practice Guidelines developed a list of suggested phrases to use when writing recommendations. All guideline
recommendations have been written in full sentences that express a complete thought, such that a recommendation, even if separated and presented apart from
the rest of the document (including headings above sets of recommendations), would still convey the full intent of the recommendation. It is hoped that this will
increase readers’ comprehension of the guidelines and will allow queries at the individual recommendation level.
neuroimaging is thus mandatory.19 CT and magnetic resonance follow-up CT.8,25 Hematoma expansion is predictive of
imaging (MRI) are both reasonable for initial evaluation. CT is clinical deterioration and increased morbidity and mortali-
very sensitive for identifying acute hemorrhage and is consid- ty.8,10,15,25 As such, identifying patients at risk for hematoma
ered the gold standard; gradient echo and T2*susceptibility- expansion is an active area of research. CT angiography and
weighted MRI are as sensitive as CT for detection of acute blood contrast-enhanced CT may identify patients at high risk of
and are more sensitive for identification of prior hemorrhage.20,21 ICH expansion based on the presence of contrast extravasa-
Time, cost, proximity to the ED, patient tolerance, clinical status, tion within the hematoma.26 –30 MRI/angiogram/venogram
and MRI availability may, however, preclude emergent MRI in and CT angiogram/venogram are reasonably sensitive at
a sizeable proportion of cases.22 identifying secondary causes of hemorrhage, including arte-
The high rate of early neurological deterioration after ICH is riovenous malformations, tumors, moyamoya, and cerebral
in part related to active bleeding that may proceed for hours after vein thrombosis.31–33 A catheter angiogram may be consid-
symptom onset. The earlier time from symptom onset to first ered if clinical suspicion is high or noninvasive studies are
neuroimage, the more likely subsequent neuroimages will suggestive of an underlying vascular cause. Clinical suspicion
demonstrate hematoma expansion.15,23,24 Among patients of a secondary cause of ICH may include a prodrome of
undergoing head CT within 3 hours of ICH onset, 28% to headache, neurological, or constitutional symptoms. Radio-
38% have hematoma expansion of greater than one third on logical suspicions of secondary causes of ICH should be
Downloaded from stroke.ahajournals.org by on January 25, 2011
5. Morgenstern et al Intracerebral Hemorrhage Guideline 2111
Table 2. Definition of Classes and Levels of Evidence Used in useful to evaluate for underlying structural lesions,
American Heart Association Stroke Council Recommendations including vascular malformations and tumors when
there is clinical or radiological suspicion (Class IIa;
Class I Conditions for which there is evidence for
Level of Evidence: B). (New recommendation)
and/or general agreement that the
procedure or treatment is useful and
effective Medical Treatment for ICH
Class II Conditions for which there is conflicting Hemostasis/Antiplatelets/Deep Vein
evidence and/or a divergence of Thrombosis Prophylaxis
opinion about the usefulness/efficacy Underlying hemostatic abnormalities can contribute to ICH.
of a procedure or treatment Patients at risk include those on oral anticoagulants (OACs),
Class IIa The weight of evidence or opinion is in those with acquired or congenital coagulation factor deficien-
favor of the procedure or treatment cies, and those with qualitative or quantitative platelet abnormal-
Class IIb Usefulness/efficacy is less well ities. Patients undergoing treatment with OACs constitute 12%
established by evidence or opinion to 14% of patients with ICH,34,35 and with increased use of
Class III Conditions for which there is evidence warfarin, the proportion appears to be increasing.36 Recognition
and/or general agreement that the
of an underlying coagulopathy thus provides an opportunity to
procedure or treatment is not
useful/effective and in some cases
target correction in the treatment strategy. For patients with a
may be harmful coagulation factor deficiency and thrombocytopenia, replace-
Therapeutic recommendations
ment of the appropriate factor or platelets is indicated.
For patients being treated with OACs who have life-threatening
Level of Evidence A Data derived from multiple randomized
clinical trials or meta-analyses
bleeding, such as intracranial hemorrhage, the general recommen-
dation is to correct the international normalized ratio (INR) as
Level of Evidence B Data derived from a single randomized
trial or nonrandomized studies
rapidly as possible.37,38 Infusions of vitamin K and fresh-frozen
plasma (FFP) have historically been recommended, but more
Level of Evidence C Consensus opinion of experts, case
studies, or standard of care recently, prothrombin complex concentrates (PCCs) and recom-
binant factor VIIa (rFVIIa) have emerged as potential therapies.
Diagnostic recommendations
Vitamin K remains an adjunct to more rapidly acting initial
Level of Evidence A Data derived from multiple prospective
therapy for life-threatening OAC-associated hemorrhage be-
cohort studies using a reference
standard applied by a masked cause even when given intravenously, it requires hours to correct
evaluator the INR.39 – 41 The efficacy of FFP is limited by risk of allergic
Level of Evidence B Data derived from a single grade A study, and infectious transfusion reactions, processing time, and the
or one or more case-control studies, or volume required for correction. Likelihood of INR correction at
studies using a reference standard 24 hours was linked to time to FFP administration in 1 study,
applied by an unmasked evaluator although 17% of patients still did not have an INR 1.4 at this
Level of Evidence C Consensus opinion of experts time, suggesting that FFP administered in this manner may be
insufficient for rapid correction of coagulopathy.42
PCCs are plasma-derived factor concentrates primarily
invoked by the presence of subarachnoid hemorrhage, un-
used to treat factor IX deficiency. Because PCCs also contain
usual (noncircular) hematoma shape, the presence of edema
factors II, VII, and X in addition to IX, they are increasingly
out of proportion to the early time an ICH is first imaged, an
recommended for warfarin reversal. PCCs have the advan-
unusual location for hemorrhage, and the presence of other
tages of rapid reconstitution and administration, having high
abnormal structures in the brain like a mass. An MR or CT
concentrations of coagulation factors in small volumes, and
venogram should be performed if hemorrhage location, rela-
processing to inactivate infectious agents. Though different
tive edema volume, or abnormal signal in the cerebral sinuses
PCC preparations differ in relative amounts of factors (with
on routine neuroimaging suggest cerebral vein thrombosis.
VII the most likely to be low), several studies have shown
In summary, ICH is a medical emergency, characterized by high that PCCs can rapidly normalize INR (within minutes) in
morbidity and mortality, which should be promptly diagnosed and patients taking OACs (reviewed in43– 45). Nonrandomized
aggressively managed. Hematoma expansion and early deteriora- retrospective reviews and a small case-control study have
tion are common within the first few hours after onset. shown more rapid correction of INR with vitamin K and PCC
than vitamin K and FFP, but have not revealed a difference in
Recommendations clinical outcome.46 – 48 One randomized trial compared the use
1. Rapid neuroimaging with CT or MRI is recommended
of a PCC (Konyne) to supplement FFP versus FFP alone in
to distinguish ischemic stroke from ICH (Class I; Level
patients with OAC-related ICH, finding that those who
of Evidence: A). (Unchanged from the previous guideline)
2. CT angiography and contrast-enhanced CT may be received PCC had significantly shorter time to INR correction
considered to help identify patients at risk for hema- and received less volume of FFP. Although there was no
toma expansion (Class IIb; Level of Evidence: B), and difference in outcome, those who received FFP also had more
CT angiography, CT venography, contrast-enhanced adverse events, primarily attributable to fluid overload.49
CT, contrast-enhanced MRI, magnetic resonance an- Although PCCs may theoretically increase the risk of throm-
giography, and magnetic resonance venography can be botic complications, this risk appears relatively low.43 De-
Downloaded from stroke.ahajournals.org by on January 25, 2011
6. 2112 Stroke September 2010
Table 3. Class I Recommendations
Recommendations Class/Level of Evidence
Emergency diagnosis and assessment of ICH and Rapid neuroimaging with CT or MRI is recommended to distinguish Class I, Level A
its causes ischemic stroke from ICH. (Unchanged from the previous
guideline)
Medical treatment for ICH Patients with a severe coagulation factor deficiency or severe Class I, Level C
thrombocytopenia should receive appropriate factor replacement
therapy or platelets, respectively. (New recommendation)
Hemostasis/antiplatelets/DVT prophylaxis Patients with ICH whose INR is elevated due to OAC should have Class I, Level C
their warfarin withheld, receive therapy to replace vitamin
K–dependent factors and correct the INR, and receive
intravenous vitamin K. (Revised from the previous guideline)
Patients with ICH should have intermittent pneumatic compression Class I, Level B
for prevention of venous thromboembolism in addition to elastic
stockings. (Unchanged from the previous guideline)
Inpatient management and prevention of
secondary brain injury
General monitoring Initial monitoring and management of ICH patients should take Class I, Level B
place in an intensive care unit, preferably one with physician
and nursing neuroscience intensive care expertise. (Unchanged
from the previous guideline)
Management of glucose Glucose should be monitored and normoglycemia is recommended Class I, Level C
Seizures and antiepileptic drugs Patients with clinical seizures should be treated with antiepileptic Class I, Level A
drugs. (Revised from previous guideline)
Patients with a change in mental status who are found to have Class I, Level C
electrographic seizures on EEG should be treated with
antiepileptic drugs
Procedures/surgery—clot removal Patients with cerebellar hemorrhage who are deteriorating Class I, Level B
neurologically or who have brainstem compression and/or
hydrocephalus from ventricular obstruction should undergo
surgical removal of the hemorrhage as soon as possible.
(Revised from the previous guideline)
Prevention of recurrent ICH After the acute ICH, absent medical contraindications, BP should Class I, Level A
be well controlled, particularly for patients with ICH location
typical of hypertensive vasculopathy. (New recommendation)
CT indicates computed tomography; MRI, magnetic resonance imaging; DVT, deep vein thrombosis; INR, international normalized ratio; OAC, oral anticoagulants;
and EEG, electroencephalogram.
spite the lack of large, well-controlled, randomized trials, (7% versus 2%).60 A subsequent phase 3 study comparing
PCCs are being increasingly recommended as an option in placebo with 20 g/kg and 80 g/kg of rFVIIa failed to show
guidelines promulgated for warfarin reversal in the setting differences in clinical outcome, despite confirming the ability
of OAC-associated life-threatening or intracranial hemor- of both doses to diminish hematoma enlargement.61 Although
rhages.37,38,50 –52 Table 5 provides a list of several products overall serious thromboembolic adverse events were similar,
for factor replacement in warfarin reversal that are commer- the higher rFVIIa (80 g/kg) group had significantly more
cially available in the United States at the present time. arterial events than the placebo group. The authors noted
rFVIIa, licensed to treat hemophilia patients with high titer imbalances in the treatment groups, particularly the greater
inhibitors or congenital factor VII deficiency, has garnered number of patients with IVH in the higher-dose rFVIIa
attention as a potential treatment for spontaneous and OAC- group.60 It remains to be determined whether rFVIIa will
associated ICH. Although rFVIIa can rapidly normalize INR benefit a particular subset of patients with ICH, but currently
in the setting of OAC-associated ICH,53–57 it does not its benefits in ICH patients, whether or not they are under-
replenish all of the vitamin K– dependent factors and there- going treatment with OACs, remain unproven.
fore may not restore thrombin generation as well as PCCs.58 Studies of the effect of prior antiplatelet agent use or
In light of the limited data, a recent American Society of platelet dysfunction on ICH hematoma growth and outcome
Hematology evidence-based review recommended against have found conflicting results. Reported antiplatelet agent use
routine use of rFVIIa for warfarin reversal.59 was not associated with hematoma expansion or clinical
rFVIIa has also been tested in patients with non-OAC ICH. outcome in the placebo group of an ICH neuroprotective
A phase 2 randomized trial showed that treatment with study.62 However, others have suggested that platelet dys-
rFVIIa within 4 hours after ICH onset limited hematoma function as measured by platelet function assays may be
growth and improved clinical outcomes relative to placebo, associated with hematoma expansion and clinical out-
though with increased frequency of thromboembolic events come.63,64 The utility and safety of platelet transfusion or
Downloaded from stroke.ahajournals.org by on January 25, 2011
7. Morgenstern et al Intracerebral Hemorrhage Guideline 2113
Table 4. Integral Components of the History, Physical Table 4. Continued
Examination, and Work-Up of the Patient With ICH in the ED
Comments
Comments Toxicology screen in young Cocaine and other sympathomimetic
History or middle-aged patients to drugs are associated with ICH
Time of symptom onset (or detect cocaine and other
time the patient was last sympathomimetic drugs of
normal) abuse
Initial symptoms and Urinalysis and urine culture
progression of symptoms and a pregnancy test in a
woman of childbearing age
Vascular risk factors Hypertension, diabetes,
hypercholesterolemia, and smoking Other routine tests
Medications Anticoagulants, antiplatelet agents, ECG To assess for active coronary ischemia or
decongestants, antihypertensive prior cardiac injury that may indicate
medications, stimulants (including diet poor cardiac function and to obtain a
pills), sympathomimetics baseline in the event of
cardiopulmonary issues during
Recent trauma or surgery Carotid endarterectomy or carotid stenting hospitalization
in particular, as ICH may be related to
hyperperfusion after such procedures Chest radiograph
Dementia Associated with amyloid angiopathy Neuroimaging As described in the text
Alcohol or illicit drug use Cocaine and other sympathomimetic GCS indicates Glasgow Coma Scale; ECG, electrocardiogram.
drugs are associated with ICH,
stimulants
other agents in patients with a normal platelet count, but use
Seizures of antiplatelet agents or platelet dysfunction, is not known.
Liver disease May be associated with coagulopathy Patients with ICH have a high risk of thromboembolic
Cancer and hematologic May be associated with coagulopathy disease.65 Women and African Americans appear to be at greater
disorders risk.65– 67 Intermittent pneumatic compression combined with
Physical examination elastic stockings has been shown by a randomized trial to be
Vital signs Fever is associated with early neurologic superior to elastic stockings alone in reducing occurrence of
deterioration10 asymptomatic deep vein thrombosis after ICH (4.7% versus
Higher initial blood pressure is associated 15.9%).68 Graduated compression stockings alone are ineffec-
with early neurologic deterioration and tive in preventing deep vein thrombosis.69 Less clear, however, is
increased mortality11 the role of adding anticoagulation to pneumatic compression. Two
A general physical small randomized studies found no difference in deep vein throm-
examination focusing on
bosis incidence, and no increase in bleeding, in patients given low-
the head, heart, lungs,
abdomen, and extremities dose subcutaneous heparin initiated at day 4 or at day 10 after
ICH.70,71 An uncontrolled study of treatment initiated on day 2
A thorough but time-urgent A structured examination such as the
neurologic examination National Institutes of Health Stroke found a reduction in thromboembolic disease without increased
Scale can be completed in minutes and rebleeding.70
provides a quantification that allows
easy communication of the severity of Recommendations
the event to other caregivers. GCS 1. Patients with a severe coagulation factor deficiency or
score is similarly well known and severe thrombocytopenia should receive appropriate fac-
easily computed, and the initial GCS tor replacement therapy or platelets, respectively (Class I;
score is a strong predictor of long-term
Level of Evidence: C). (New recommendation)
outcome.12,13 These can be
2. Patients with ICH whose INR is elevated due to OACs
supplemented as needed
should have their warfarin withheld, receive therapy to
Serum and urine tests replace vitamin K– dependent factors and correct the
Complete blood count, Higher creatinine is associated with INR, and receive intravenous vitamin K (Class I; Level
electrolytes, blood urea hematoma expansion. Higher serum of Evidence: C). PCCs have not shown improved
nitrogen and creatinine, glucose is associated with hematoma outcome compared with FFP but may have fewer
and glucose expansion and worse outcome complications compared with FFP and are reasonable
(although there are no data to suggest
to consider as an alternative to FFP (Class IIa; Level of
that normalization improves
Evidence: B). rFVIIa does not replace all clotting
outcome)11,14
factors, and although the INR may be lowered, clotting
Prothrombin time or INR Warfarin-related hemorrhages are may not be restored in vivo; therefore, rFVIIa is not
and an activated partial associated with an increased
routinely recommended as a sole agent for OAC re-
thromboplastin time hematoma volume, greater risk of
versal in ICH (Class III; Level of Evidence: C). (Revised
expansion, and increased morbidity and
mortality15–17
from the previous guideline).
3. Although rFVIIa can limit the extent of hematoma
(Continued)
expansion in noncoagulopathic ICH patients, there
Downloaded from stroke.ahajournals.org by on January 25, 2011
8. 2114 Stroke September 2010
Table 5. Products Commercially Available in the United States for Coagulation Factor Replacement
Dose (Consultation With a Hematologist
Product Factor(s) Is Recommended for Specific Dosing) Uses
Fresh-frozen plasma I (fibrinogen), II, V, VII, IX, X, XI, 10 –15 mL/kg with ideal recovery OAC reversal
XIII, antithrombin would raise factor levels 15%–20% Consumptive coagulopathy
Hepatic dysfunction
Cryoprecipitate I, VIII, XIII, vWF 1–2 U/10 kg Hypo/a-fibrinogenemia
Lack of factor-specific products for
factor VIII deficiency or vWD
Factor XIII deficiency
Prothrombin complex II, IX, X (small amounts of VII) Assayed in factor IX activity Factor IX deficiency (hemophilia B)
concentrates
Bebulin VH (Baxter), Profilnine Both Bebulin and Profilnine are OAC reversal (not FDA-approved)
SD (Grifols) 3-factor PCCs that have
approximately 1/10th the factor VII
activity relative to factor IX activity.
The amounts of factor II and X
relative to IX is variable, but for
Bebulin X II IX and for Profilnine
II X IX
Dosing for factor IX deficiency—
1 U/kg raises activity by 1%
Dosing for OAC reversal has not been
well established
NovoSeven RT (Novo Nordisk) Recombinant activated VII Higher risk of thromboembolic Factor VIII or IX deficiency with inhibitors
complications with higher doses to factor VIII or IX
For hemophilia A or B patients with Congenital factor VII deficiency
inhibitors, 90 g/kg every 2 h Not recommended for spontaneous ICH
For factor VII–deficient patients, 15–30 or OAC reversal
g/kg every 4–6 h
Factor VIII concentrates VIII Each factor VIII unit/kg raises the Factor VIII deficiency (hemophilia A)
Plasma-derived serum factor VIII level by 2%
Alphanate (Grifols)*† (typically, a 50-U/kg dose is used to
Humate-P (CSL-Behring)*† raise the factor VIII level to 100%)
Koate-DVI (Bayer)*
Wilate (Octapharma)*† Wilate is not indicated for hemophilia A.
Immunoaffinity purified
Hemofil-M (Baxter)
Monarc-M (Baxter)
Monoclate-P (CSL-Behring)
Recombinant
Advate (Baxter)
Helixate FS (CSL-Behring)
Kogenate FS (Bayer)
Recombinate (Baxter)
Xyntha (Wyeth)
Factor IX concentrates IX Each Factor IX unit/kg raises the Factor IX deficiency (hemophilia B)
Plasma-derived serum level by 1% (typically, a
AlphaNine SD (Grifols) 100-U/kg dose is used to raise the
Mononine (Baxter) level to 100%)
Recombinant
BeneFix (Wyeth) One unit of BeneFix raises the serum
level by 0.83%, so 120 U/kg raises
the activity to 100%.
vWD indicates von Willebrand disease; FDA, US Food and Drug Administration; and PCCs, prothrombin complex concentrates.
*Also contains von Willebrand factor.
†Indicated for von Willebrand disease (dose by ristocetin cofactor units; ratio of fVIII to ristocetin cofactor unit varies by product).
is an increase in thromboembolic risk with rFVIIa from this therapy is needed before any recommenda-
and no clear clinical benefit in unselected patients. tion for its use can be made.
Thus rFVIIa is not recommended in unselected 4. The usefulness of platelet transfusions in ICH pa-
patients. (Class III; Level of Evidence: A). (New tients with a history of antiplatelet use is unclear and
recommendation) Further research to determine is considered investigational (Class IIb; Level of
whether any selected group of patients may benefit Evidence: B). (New recommendation)
Downloaded from stroke.ahajournals.org by on January 25, 2011
9. Morgenstern et al Intracerebral Hemorrhage Guideline 2115
5. Patients with ICH should have intermittent pneu- Table 6. Suggested Recommended Guidelines for Treating
matic compression for prevention of venous throm- Elevated BP in Spontaneous ICH
boembolism in addition to elastic stockings (Class I;
1. If SBP is 200 mm Hg or MAP is 150 mm Hg, then consider
Level of Evidence: B). (Unchanged from the previous aggressive reduction of BP with continuous intravenous infusion, with
guideline) frequent BP monitoring every 5 min.
6. After documentation of cessation of bleeding, low-
2. If SBP is 180 mm Hg or MAP is 130 mm Hg and there is the
dose subcutaneous low-molecular-weight heparin or
possibility of elevated ICP, then consider monitoring ICP and reducing BP
unfractionated heparin may be considered for pre- using intermittent or continuous intravenous medications while
vention of venous thromboembolism in patients with maintaining a cerebral perfusion pressure 60 mm Hg.
lack of mobility after 1 to 4 days from onset (Class
3. If SBP is 180 mm Hg or MAP is 130 mm Hg and there is not
IIb; Level of Evidence: B). (Revised from the previous
evidence of elevated ICP, then consider a modest reduction of BP (eg,
guideline) MAP of 110 mm Hg or target BP of 160/90 mm Hg) using intermittent or
continuous intravenous medications to control BP and clinically
Blood Pressure reexamine the patient every 15 min.
Blood Pressure and Outcome in ICH Note that these recommendations are Class C. SBP indicates systolic blood
Blood pressure (BP) is frequently, and often markedly, pressure; MAP, mean arterial pressure.
elevated in patients with acute ICH; these elevations in BP
are greater than that seen in patients with ischemic stroke.72,73 and absolute growth in hematoma volumes from baseline to
Although BP generally falls spontaneously within several 24 hours in the intensive treatment group compared with the
days after ICH, high BP persists in a substantial proportion of control group. In addition, there was no excess of neurolog-
patients.72,73 Potential pathophysiologic mechanisms include ical deterioration or other adverse events related to intensive
stress activation of the neuroendocrine system (sympathetic BP lowering, nor were there any differences across several
nervous system, renin-angiotensin axis, or glucocorticoid sys- measures of clinical outcome, including disability and quality
tem) and increased intracranial pressure. Hypertension theoreti- of life between groups, although the trial was not powered to
cally could contribute to hydrostatic expansion of the hematoma, detect such outcomes. The study provides an important proof
peri-hematoma edema, and rebleeding, all of which may con- of concept for early BP lowering in patients with ICH, but the
tribute to adverse outcomes in ICH, although a clear association data are insufficient to recommend a definitive policy. An-
between hypertension within the first few hours after ICH and other study, the Antihypertensive Treatment in Acute Cere-
the risk of hematoma expansion (or eventual hematoma volume) bral Hemorrhage (ATACH) trial,81 also confirms the feasi-
has not been clearly demonstrated.25,74 bility and safety of early rapid BP lowering in ICH.82 This
A systematic review75 and a recent large multisite study in study used a 4-tier, dose escalation of intravenous
China73 show that a measurement of systolic BP above 140 to nicardipine-based BP lowering in 80 patients with ICH.
150 mm Hg within 12 hours of ICH is associated with more Thus, advances have been made in our knowledge of the
than double the risk of subsequent death or dependency. mechanisms of ICH and the safety of early BP lowering since
Compared with ischemic stroke, where consistent U- or the publication of the 2007 American Heart Association ICH
J-shaped associations between BP levels and poor outcome guidelines. INTERACT and ATACH now represent the best
have been shown,76 only 1 study of ICH has shown a poor available evidence to help guide decisions about BP lowering
outcome at very low systolic BP levels ( 140 mm Hg).77 For in ICH. Although these studies have shown that intensive BP
both ischemic stroke and possibly ICH, a likely explanation lowering is clinically feasible and potentially safe, the BP
for such association is reverse causation, whereby very low pressure target, duration of therapy, and whether such treat-
BP levels occur disproportionately in more severe cases, so ment improves clinical outcomes remain unclear.
that although low BP levels may be associated with a high
case fatality, it may not in itself be causal.
Recommendations
1. Until ongoing clinical trials of BP intervention for
ICH are completed, physicians must manage BP on
Effects of BP-Lowering Treatments
the basis of the present incomplete efficacy evidence.
The strong observational data cited previously and sophisti-
Current suggested recommendations for target BP
cated neuroimaging studies that fail to identify an ischemic in various situations are listed in Table 6 and may be
penumbra in ICH78 formed the basis for the INTensive Blood considered (Class IIb; Level of Evidence: C). (Un-
Pressure Reduction in Acute Cerebral Hemorrhage Trial changed from the previous guideline)
(INTERACT) pilot study, published in 2008.79 INTERACT 2. In patients presenting with a systolic BP of 150 to
was an open-label, randomized, controlled trial undertaken in 220 mm Hg, acute lowering of systolic BP to
404 mainly Chinese patients who could be assessed, treated, 140 mm Hg is probably safe (Class IIa; Level of
and monitored within 6 hours of the onset of ICH; 203 were Evidence: B). (New recommendation)
randomized to a treatment with locally available intravenous
BP-lowering agents to target a low systolic BP goal of Inpatient Management and Prevention of
140 mm Hg within 1 hour and maintained for at least the next Secondary Brain Injury
24 hours, and 201 were randomized to a more modest systolic General Monitoring
BP target of 180 mm Hg, as recommended in an earlier AHA Patients with ICH are frequently medically and neurologi-
guideline.80 The study showed a trend toward lower relative cally unstable, particularly within the first few days after
Downloaded from stroke.ahajournals.org by on January 25, 2011
10. 2116 Stroke September 2010
onset. Care of ICH patients in a dedicated neuroscience treatment with outcome. Similarly, therapeutic cooling has not
intensive care unit is associated with a lower mortality rate.83 been systematically investigated in ICH patients.
Frequent vital sign checks, neurological assessments, and
continuous cardiopulmonary monitoring including a cycled Seizures and Antiepileptic Drugs
automated BP cuff, electrocardiographic telemetry, and O2 The incidence of clinical seizures within the first 2 weeks after
saturation probe should be standard. Continuous intra-arterial ICH has been reported to range from 2.7% to 17%, with the
BP monitoring should be considered in patients receiving majority occurring at or near onset.96 –100 Studies of continuous
intravenous vasoactive medications. electroencephalography (EEG) have reported electrographic sei-
zures in 28% to 31% of select cohorts of ICH patients, despite
Nursing Care most having received prophylactic anticonvulsants.101,102 In a
The specific nursing care required for ICH patients in large, single-center study, prophylactic antiepileptic drugs did
intensive care units may include (1) surveillance and moni- significantly reduce the number of clinical seizures after lobar
toring of ICP, cerebral perfusion pressure and hemodynamic ICH.98 However, in prospective and population-based
function; (2) titration and implementation of protocols for studies, clinical seizures have not been associated with
management of ICP, BP, mechanical ventilation, fever, and worsened neurological outcome or mortality.97,103,104 The
serum glucose; and (3) prevention of complications of im- clinical impact of subclinical seizures detected on EEG is also
mobility through positioning, airway maintenance, and mo- not clear. A recent analysis from the placebo arm of an ICH
bilization within physiological tolerance. The consensus doc- neuroprotectant study found that patients who received anti-
ument from the Brain Attack Coalition on comprehensive epileptic drugs (primarily phenytoin) without a documented
stroke centers delineates these as specific areas of monitoring seizure were significantly more likely to be dead or disabled
and complication prevention in which nurses should be at 90 days, after adjusting for other established predictors of
trained. This document also recommends that nurses be ICH outcome.105 Another recent single-center observational
trained in detailed assessment of neurological function in- study had similar findings, specifically for phenytoin.106 Thus
cluding standardized scales such as the National Institutes of only clinical seizures or electrographic seizures in patients
Health Stroke Scale, GCS, and the Glasgow Outcome Scale. with a change in mental status should be treated with
In a Canadian study of 49 hospitals that included ICH antiepileptic drugs. Continuous EEG monitoring should be
patients, a higher proportion of registered nurses and better considered in ICH patients with depressed mental status out
nurse–physician communications were independently associ- of proportion to the degree of brain injury. The utility of
ated with lower 30-day mortality even after adjusting for prophylactic anticonvulsant medication remains uncertain.
disease severity, comorbidities, and hospital characteristics.84
Recommendations
Recommendation
1. Initial monitoring and management of ICH patients Management of Glucose
should take place in an intensive care unit with 1. Glucose should be monitored and normoglycemia is
physician and nursing neuroscience intensive care recommended (Class I: Level of Evidence: C). (New
recommendation)
expertise (Class I; Level of Evidence: B). (Unchanged
from the previous guideline) Seizures and Antiepileptic Drugs
1. Clinical seizures should be treated with antiepileptic
Management of Glucose drugs (Class I; Level of Evidence: A). (Revised from
High blood glucose on admission predicts an increased risk of the previous guideline) Continuous EEG monitoring
mortality and poor outcome in patients with and without diabetes is probably indicated in ICH patients with depressed
and ICH.85– 87 A randomized trial showing improved outcomes mental status out of proportion to the degree of
with tight glucose control (range 80 to 110 mg/dL) using insulin brain injury (Class IIa; Level of Evidence: B). Pa-
infusions in mainly surgical critical care patients88 has increased tients with a change in mental status who are found
the use of this therapy. However, more recent studies have to have electrographic seizures on EEG should be
treated with antiepileptic drugs (Class I; Level of
demonstrated increased incidence of systemic and cerebral Evidence: C). Prophylactic anticonvulsant medica-
hypoglycemic events and possibly even increased risk of mor- tion should not be used (Class III; Level of Evidence:
tality in patients treated with this regimen.89 –92 At present the B). (New recommendation)
optimal management of hyperglycemia in ICH and the target
glucose remains to be clarified. Hypoglycemia should be avoided. Iron
Systemic treatment with the iron chelator deferoxamine
Temperature Management ameliorates ICH-induced changes in markers of DNA dam-
Fever worsens outcome in experimental models of brain inju- age, attenuates brain edema, and improves functional recov-
ry.93,94 The incidence of fever after basal ganglionic and lobar ery in rat models of ICH.107–111 A few studies have examined
ICH is high, especially in patients with IVH. In patients the role of iron in ICH patients and reported that high serum
surviving the first 72 hours after hospital admission, the duration ferritin levels are associated with poor outcome after ICH112
of fever is related to outcome and appears to be an independent and correlate with the perihematoma edema volume.113,114
prognostic factor in these patients.95 These data provide a Limiting iron-mediated toxicity is a promising therapeutic
rationale for aggressive treatment to maintain normothermia in target in ICH. Besides chelating iron, deferoxamine exhibits
patients with ICH; however, there are no data linking fever other neuroprotective properties.115 It induces transcription of
Downloaded from stroke.ahajournals.org by on January 25, 2011
11. Morgenstern et al Intracerebral Hemorrhage Guideline 2117
Figure. Intracranial pressure treatment
algorithm. CPP indicates cerebral perfu-
sion pressure; CSF, cerebrospinal fluid.
Adapted from Brain Trauma Foundation
Head Injury Guidelines.126 Copyright
2000, Brain Trauma Foundation.
heme oxygenase-1 and inhibits hemoglobin-mediated glutamate ICP monitor insertion and use include infection and intracra-
excitotoxicity and hypoxia inducible factor prolyl hydroxy- nial hemorrhage. In general, the risk of hemorrhage or
lases.116 –119 Further studies in this area are warranted, but no infection is thought to be higher with VC than with paren-
current therapeutic recommendation can be made at present. chymal catheters, although data on these rates are not derived
from patients with ICH, but rather principally from those with
Procedures/Surgery traumatic brain injury or aneurysmal subarachnoid hemor-
ICP Monitoring and Treatment rhage. In a 1997 series of 108 intraparenchymal devices, the
ICP monitoring is often performed in patients with ICH. rate of infection was 2.9% and the rate of intracranial
However, only very limited published data exist regarding the hemorrhage was 2.1% (15.3% in patients with coagulopa-
frequency of elevated ICP and its management in patients thies).123 A direct comparison of the complications associated
with ICH.120,121 There is evidence for differential pressure with each type of monitoring device was reported in a 1993 to
gradients in at least some cases so that ICP may be elevated 1997 series of 536 intracerebral monitoring devices (274 VCs,
in and around the hematoma but not distant from it.122 229 intraparenchymal parenchymal catheters, and 33 other types
Because the usual causes of elevated ICP are hydrocephalus of devices) in which the overall rate of infection was 4% and the
from IVH or mass effect from the hematoma (or surrounding overall rate of intracranial hemorrhage was 3%.124 Before
edema), patients with small hematomas and limited IVH insertion of a monitoring device, the patient’s coagulation status
usually will not require treatment to lower ICP. should be evaluated. Prior use of antiplatelet agents may justify
ICP is measured using devices inserted into the brain platelet transfusion before the procedure, and the use of warfarin
parenchyma, typically at the bedside. Fiberoptic technology may require reversal of coagulopathy before placement. The
can be used in both types of devices. A ventricular catheter decision to use a VC or a parenchymal catheter device should be
(VC) inserted into the lateral ventricle allows for drainage of based on the specific need to drain cerebrospinal fluid in patients
cerebrospinal fluid, which can help reduce ICP in patients with hydrocephalus or trapped ventricle and the balance of
with hydrocephalus. A parenchymal catheter ICP device is monitoring risks with the unknown utility of ICP management in
inserted into the brain parenchyma and allows for monitoring patients with ICH.
of ICP, but not cerebrospinal fluid drainage. The absence of ICP treatment should be directed at the underlying cause,
published studies showing that management of elevated ICP especially if due to hydrocephalus or mass effect from the
impacts on ICH outcome makes the decision whether to hematoma. Because of limited data regarding ICP in ICH,
monitor and treat elevated ICP unclear. Risks associated with management principles for elevated ICP are borrowed from
Downloaded from stroke.ahajournals.org by on January 25, 2011
12. 2118 Stroke September 2010
traumatic brain injury guidelines, which emphasize maintaining Some reports suggest alternative procedures for IVH such
a cerebral perfusion pressure of 50 to 70 mm Hg, depending on as endoscopic surgical evacuation and ventriculostomy,144 –146
the status of cerebral autoregulation125,126 (see Figure). ICH ventriculoperitoneal shunting,147 or lumbar drainage for hy-
patients with a GCS score of 8, those with clinical evidence of drocephalus.148 Few data exist to support these strategies.
transtentorial herniation, or those with significant IVH or hydro-
cephalus may be considered for ICP monitoring and treatment. Recommendation
Numerous studies have assessed ventricular size and effects 1. Although intraventricular administration of recom-
of enlargement on ICH outcome.127–130 Among 902 patients binant tissue-type plasminogen activator in IVH
with follow-up data randomized into the international Surgical appears to have a fairly low complication rate,
Trial of Intracerebral Hemorrhage (STICH) trial of early hema- efficacy and safety of this treatment is uncertain and
toma evacuation, 377 had IVH and 208 of these had hydroceph- is considered investigational (Class IIb; Level of
alus (23% of all patients, 55% of those with IVH).131 Hydro- Evidence: B). (New recommendation)
cephalus predicted poor outcome in this study, as well as other
previous studies.127 Thus, hydrocephalus is an important cause Clot Removal
of ICH-related morbidity and mortality,1 and treatment should Surgical Treatment of ICH
be considered in patients with decreased level of consciousness. The decision about whether and when to surgically remove
Small case series have described the use of brain tissue ICH remains controversial. The pathophysiology of brain
oxygen and cerebral microdialysis monitoring in patients injury surrounding the hematoma is due to the mechanical
with ICH.132,133 Because of the small numbers of patients and effects of the growing mass of blood as well as the subsequent
limited data, no recommendation can be made regarding the toxic effects of blood in the surrounding brain tissue. Early
use of these technologies at this time. surgery to limit the mechanical compression of brain and the
toxic effects of blood may limit injury, but the surgical risks
Recommendations
in a patient with ongoing bleeding may be greater. In
1. Patients with a GCS score of <8, those with clinical
addition, operative removal of hemorrhage by craniotomy in
evidence of transtentorial herniation, or those with
significant IVH or hydrocephalus might be consid- all but the most superficial hemorrhages involves cutting
ered for ICP monitoring and treatment. A cerebral through uninjured brain. Among the limitations of ICH surgical
perfusion pressure of 50 to 70 mm Hg may be trials is that young and middle-aged patients at risk of herniation
reasonable to maintain depending on the status of from large ICHs were unlikely to be randomized for treatment.
cerebral autoregulation (Class IIb; Level of Evi- Recommendations for these patients are uncertain.
dence: C). (New recommendation)
2. Ventricular drainage as treatment for hydrocepha- Craniotomy by Location of ICH
lus is reasonable in patients with decreased level of Most but not all149 of the randomized trials of surgery for ICH
consciousness (Class IIa; Level of Evidence: B). (New excluded patients with cerebellar ICH, which comprises 10% to
recommendation)
15% of cases. Previous versions of these guidelines6 cited
Intraventricular Hemorrhage nonrandomized studies showing that patients with cerebellar
IVH occurs in 45% of patients with spontaneous ICH.134 IVH ICH larger than 3 cm in diameter or those with brainstem
can be primary (confined to the ventricles) or secondary compression or hydrocephalus had good outcomes with surgery
(originating as an extension of an ICH). Most IVHs are to remove the hematoma, whereas similar patients managed
secondary and are related to hypertensive hemorrhages in- medically did poorly.150 –155 If the hemorrhage is 3 cm in
volving the basal ganglia and the thalamus.134,135 diameter and there is no brainstem compression or hydroceph-
Although inserting a VC should theoretically aid in drainage alus, reasonable outcomes may be achieved without surgery.
of blood and cerebrospinal fluid from the ventricles, VC use Even though randomized trials of cerebellar hematoma evacua-
alone may be ineffective because of difficulty maintaining tion have not been undertaken, the differences in outcome in the
catheter patency and the slow removal of intraventricular earlier studies are such that clinical equipoise does not exist for
blood.136 Thus there has been recent interest in the use of a trial. Furthermore, the use of a VC alone instead of immediate
thrombolytic agents as adjuncts to VC use in the setting of IVH. cerebellar hematoma evacuation is generally considered insuffi-
Animal studies and clinical series reported that intraventricu- cient and is not recommended, especially in patients with
lar administration of fibrinolytic agents, including urokinase, compressed cisterns.155
streptokinase, and recombinant tissue-type plasminogen activa- The STICH trial found that patients with hematomas extend-
tor, in IVH may reduce morbidity and mortality by accelerating ing to within 1 cm of the cortical surface had a trend toward
blood clearance and clot lysis.137–142 Recently the Clot Lysis: more favorable outcome with surgery within 96 hours, although
Evaluating Accelerated Resolution of IVH (CLEAR-IVH) Trial this finding did not reach statistical significance (odds ratio,
prospectively evaluated the safety of open-label doses of intra- 0.69; 95% confidence interval, 0.47 to 1.01).156 Patients with
ventricular recombinant tissue-type plasminogen activator in 52 lobar hemorrhages and a GCS score of 9 to 12 also had a trend
IVH patients. Symptomatic bleeding occurred in 4% and bacte- toward better outcome. Because the benefit of surgery for
rial ventriculitis in 2%, and the 30-day mortality rate was patients with superficial ICH was not statistically significant
17%.143 The efficacy of this treatment requires confirmation after adjusting for multiple testing, the authors recommended
before its use can be recommended outside of a clinical trial. additional clinical trials to confirm this benefit.157
Downloaded from stroke.ahajournals.org by on January 25, 2011
13. Morgenstern et al Intracerebral Hemorrhage Guideline 2119
By contrast, patients in the STICH study with an ICH 1 and/or hydrocephalus from ventricular obstruction
cm from the cortical surface or with a GCS score of 8 should undergo surgical removal of the hemorrhage as
tended to do worse with surgical removal as compared with soon as possible (Class I; Level of Evidence: B). (Revised
medical management. Another study randomized 108 patients from the previous guideline) Initial treatment of these
with supratentorial subcortical or putaminal ICH 30 mL in patients with ventricular drainage alone rather than
volume to craniotomy or medical management within 8 hours of surgical evacuation is not recommended (Class III; Level
onset.158 Good outcome (good recovery or moderate disability of Evidence: C). (New recommendation)
3. For patients presenting with lobar clots >30 mL and
on the Glasgow Outcome Scale at 1 year) was significantly
within 1 cm of the surface, evacuation of supraten-
better in those treated with surgery, but there was no difference torial ICH by standard craniotomy might be consid-
in overall survival. Other randomized trials have had too few ered (Class IIb; Level of Evidence: B). (Revised from
patients to determine outcomes in subgroups by location, ran- the previous guideline)
domized only patients with deep ICH, or did not report these 4. The effectiveness of minimally invasive clot evacua-
results.159 –161 Enthusiasm for surgical evacuation of thalamic tion utilizing either stereotactic or endoscopic aspi-
and pontine ICH has been limited.154,162,163 ration with or without thrombolytic usage is uncer-
tain and is considered investigational (Class IIb;
Minimally Invasive Surgical Removal of ICH Level of Evidence: B). (New recommendation)
If the indications for surgical evacuation of intracerebral 5. Although theoretically attractive, no clear evidence at
hematomas are controversial, the means by which to achieve present indicates that ultra-early removal of supraten-
this evacuation are even less well established. Several groups torial ICH improves functional outcome or mortality
have developed minimally invasive clot removal techniques. rate. Very early craniotomy may be harmful due to
These techniques tend to make use of stereotactic guidance increased risk of recurrent bleeding (Class III; Level of
combined with either thrombolytic-enhanced or endoscopic- Evidence: B). (Revised from the previous guideline)
enhanced aspiration. Both randomized trials of thrombolytic-
enhanced aspiration for subcortical ICH149,161,164 and Outcome Prediction and Withdrawal of
endoscopic-enhanced aspiration165–167 with or without ste- Technological Support
reotaxis have reported increased clot removal and de- Many observational and epidemiological studies have identified a
creased mortality in those subjects treated surgically wide range of factors that are predictive of outcome after acute ICH.
within 12 to 72 hours, but improved functional outcome From these studies numerous outcome prediction models have been
has not been consistently demonstrated. developed for mortality and functional outcome. Features found in
most of these prediction models include individual patient charac-
Timing of Surgery teristics such as the score on the GCS or National Institutes of
One key issue has been the lack of consensus on the time frame Health Stroke Scale, age, hematoma volume and location, and the
of what constitutes early surgery. Clinical studies have reported presence and amount of IVH.12,172–180 No outcome prediction
a wide variability in the timing of surgery, ranging from within model for ICH, however, has considered the impact of care
4 hours up to 96 hours from the onset of symptoms to time of limitations such as do not resuscitate (DNR) orders or withdrawal of
operation.156,158,161,168 Such time variance among the studies has technological support.
made direct comparison and analysis of the impact of surgical Most patients that die from ICH do so during the initial acute
timing difficult. A retrospective Japanese series of surgical hospitalization, and these deaths usually occur in the setting of
removal of 100 putaminal ICHs within 7 hours of onset (60 withdrawal of support due to presumed poor prognosis.181,182
within 3 hours) reported better than expected outcomes.169 Several studies, however, have now identified withdrawal of
However, subsequent randomized trials that treated subjects medical support and other early care limitations, such as DNR
within 12 hours of onset reported mixed results.158,161,168 An orders within the first day of hospitalization, as independent
increased risk of rebleeding was noted in the small trial of outcome predictors.2,183,184 It is likely that current outcome
subjects randomized within 4 hours of onset.170 prediction models as well as more informal methods of early
Trials that randomized patients within 24 hours,171 48 prognostication after ICH are biased by the failure to account for
hours,159,165 72 hours,149,160 and 96 hours156 have also demon- these care limitations. Concern has been raised that decisions by
strated no clear benefit for surgery as compared with initial physicians to limit care early after ICH are resulting in self-
medical management except for improved outcome in the fulfilling prophecies of poor outcome due to inaccurately pessi-
subgroup of patients in the STICH trial with superficial ICH and mistic prognostication and failure to provide initial aggressive
decreased mortality in those patients with subcortical hemor- therapy in severely ill ICH patients who nonetheless still have
rhages treated with minimally invasive methods within 12 to 72 the possibility of favorable outcome.
hours, as noted above. Although a DNR order by definition means that no attempt
at resuscitation should be made in the event that a cardiopul-
Recommendations
monary arrest occurs, in practical use, when administered
1. For most patients with ICH, the usefulness of sur-
early after ICH, it is a proxy for overall lack of aggres-
gery is uncertain (Class IIb; Level of Evidence: C).
(New recommendation) Specific exceptions to this siveness of care.2 This implies that the overall aggressive-
recommendation follow ness of ICH care at a hospital may be critically important
2. Patients with cerebellar hemorrhage who are deteriorat- in determining patients’ outcome, irrespective of specific
ing neurologically or who have brainstem compression individual characteristics.2,83,185
Downloaded from stroke.ahajournals.org by on January 25, 2011
14. 2120 Stroke September 2010
Although prognostication early after ICH may be desired Committee on Prevention, Detection, Evaluation, and Treatment
by physicians, patients, and families, it is currently based on of High Blood Pressure.197
uncertain ground. Given this uncertainty and the potential for Oral anticoagulation is associated with worse ICH out-
self-fulfilling prophecies of poor outcome, great caution come198,199 and increased risk of recurrence,188 raising the
should be undertaken in attempting precise prognostication question of whether the benefits of anticoagulation for prevent-
early after ICH, especially if the purpose is to consider ing thromboembolism outweigh its risks after initial ICH. For a
withdrawal of support or DNR orders.186 Thus, aggressive hypothetical 69-year-old man with nonvalvular atrial fibrillation
guideline-concordant therapy is recommended for all ICH and prior lobar ICH, Markov modeling predicted that long-term
patients who do not have advanced directives specifying that anticoagulation would shorten quality-adjusted survival because
this should not be undertaken. Care limitations such as DNR of the high risk of recurrence after lobar ICH.200 The results for
orders or withdrawal of support should not be recommended anticoagulation after deep hemispheric ICH were less clear-cut
by treating physicians during the first few days after ICH. and varied depending on assumptions about risk of future
thromboembolism or ICH. The effects of antiplatelet agents on
Recommendation ICH recurrence and severity appear to be substantially smaller
1. Aggressive full care early after ICH onset and than for anticoagulation,16,62,189,201 suggesting that antiplatelet
postponement of new DNR orders until at least the treatment may be a safer alternative to anticoagulation after ICH.
second full day of hospitalization is probably recom- Recently, the ACTIVE A (Atrial Fibrillation Clopidogrel Trial
mended (Class IIa; Level of Evidence: B). Patients with Irbesartan for Prevention of Vascular Events–Aspirin)
with preexisting DNR orders are not included in this study reported on a randomized, double-blind study of the safety
recommendation. Current methods of prognostica- and efficacy of adding clopidogrel 75 mg daily to aspirin 75 to
tion in individual patients early after ICH are likely
100 mg daily in patients with high-risk atrial fibrillation and a
biased by failure to account for the influence of
withdrawal of support and early DNR orders. Pa- contraindication to warfarin. Although previous ICH was listed
tients who are given DNR status at any point should as one of the many reasons for study entry, the authors did not report
receive all other appropriate medical and surgical the proportion of subjects with previous ICH, and therefore the
interventions unless otherwise explicitly indicated. study results may not directly apply to those with previous ICH.
(Revised from the previous guideline) Subjects who received clopidogrel added to aspirin had a 0.8% per
year absolute risk reduction of major vascular events at the cost of
Prevention of Recurrent ICH 0.7% per year increase in major bleeding events.202
Population-based studies of survivors of a first hemorrhagic The recent Stroke Prevention with Aggressive Reductions in
stroke have identified rates of recurrent ICH of 2.1% to 3.7% Cholesterol Levels (SPARCL) study found increased risk of
per patient-year,187,188 substantially higher than these individ- subsequent ICH (unadjusted hazard ratio, 1.68; 95% confidence
uals’ rate of subsequent ischemic stroke. interval, 1.09 to 2.59) among subjects with prior stroke random-
The most consistently identified risk factor for recurrent ICH ized to high-dose atorvastatin.203 It remains unclear whether this
is lobar location of the initial ICH.187,189 This finding likely effect outweighs the benefits of statin treatment in reducing ische-
represents the association of cerebral amyloid angiopathy with mic cardiac and cerebral events in ICH survivors. Frequent alcohol
lobar location and increased recurrence.190,191 Hemorrhage in use (defined in the Greater Cincinnati/Northern Kentucky study as
locations characteristic of hypertensive vasculopathy, such as 2 drinks per day) has been linked to increased ICH risk204 and is
basal ganglia, thalamus, or brainstem,192 also recur, but less therefore reasonable to avoid after ICH. Other behaviors, such as
frequently. Other factors linked to ICH recurrence in some physical exertion, sexual activity, or stress, have not been linked to
studies include older age,188 post-ICH anticoagulation,188 previ- ICH,205 though little systematic data have been reported.
ous hemorrhage before the presenting ICH,191 carriership of the
apolipoprotein E 2 or 4 alleles,191,193 and greater number of Recommendations
microbleeds on T2*-weighted gradient-echo MRI.194 1. In situations where stratifying a patient’s risk of
Hypertension is the most important currently modifiable risk recurrent ICH may affect other management deci-
factor for prevention of ICH recurrence.195,196 The importance of sions, it is reasonable to consider the following risk
BP control was supported by data from the Perindopril Protec- factors for recurrence: lobar location of the initial
tion Against Recurrent Stroke Study (PROGRESS) showing that ICH, older age, ongoing anticoagulation, presence of
subjects with cerebrovascular disease randomized to perindopril the apolipoprotein E 2 or 4 alleles, and greater
plus optional indapamide had significantly lower risk of first number of microbleeds on MRI (Class IIa; Level of
ICH (adjusted hazard ratio, 0.44; 95% confidence interval, 0.28 Evidence: B). (New recommendation)
to 0.69) and a similar, though statistically insignificant, reduction 2. After the acute ICH period, absent medical contra-
indications, BP should be well controlled, particu-
in recurrent ICH (adjusted hazard ratio, 0.37; 95% confidence
larly for patients with ICH location typical of hyper-
interval, 0.10 to 1.38).193 Notably, this reduction appeared to tensive vasculopathy (Class I; Level of Evidence: A).
apply to lobar as well as deep hemispheric ICH. Although (New recommendation)
specific data on the optimal BP for reducing ICH recurrence are 3. After the acute ICH period, a goal target of a normal
not available, a reasonable target is a BP 140/90 (or 130/80 BP of <140/90 (<130/80 if diabetes or chronic
in the presence of diabetes or chronic kidney disease) as kidney disease) is reasonable (Class IIa; Level of
suggested by the most recent report from the Joint National Evidence: B). (New recommendation)
Downloaded from stroke.ahajournals.org by on January 25, 2011