Organic Chemistry
1. History
2. Properties of Organic Chemistry
3. comparison of Compounds
4. Sources of Organic Compounds
5. Types of Organic Compounds
6.Types of Organic Formula
7. Carbon
8. Structural Formulas of Carbon
9. Isomerism
10 Classification of Organic Compounds
11. HydroCarbons
Organic Chemistry
1. History
2. Properties of Organic Chemistry
3. comparison of Compounds
4. Sources of Organic Compounds
5. Types of Organic Compounds
6.Types of Organic Formula
7. Carbon
8. Structural Formulas of Carbon
9. Isomerism
10 Classification of Organic Compounds
11. HydroCarbons
. INTRODUCTION
Insecticides are chemicals specifically designed to kill or control insect populations. They are widely used in agriculture, public health, and other industries to protect crops, livestock, and human health from insect-related damage and diseases. Once applied, insecticides undergo various metabolic processes in insects, which can affect their effectiveness and potential environmental impact.
The metabolism of insecticides in insects involves several key mechanisms:
1. Absorption: Insecticides can enter an insect's body through various routes, such as ingestion, contact with the exoskeleton, or inhalation. The mode of entry depends on the formulation and application method of the insecticide.
2. Phase I metabolism: In this initial phase, insecticides are often transformed by enzymes into more polar compounds through processes such as oxidation, reduction, or hydrolysis. These metabolic reactions aim to make the insecticides more water-soluble and facilitate their elimination from the body.
3. Phase II metabolism: Once insecticides undergo phase I metabolism, they may be further conjugated with endogenous compounds such as sugars, amino acids, or glutathione. Conjugation reactions increase the water solubility of the insecticides even more, making them easier to excrete from the insect's body.
4. Detoxification mechanisms: Insects have developed various enzymatic systems to break down insecticides and render them less toxic. For example, insects possess enzymes like cytochrome P450 monooxygenases, esterases, and glutathione-S-transferases, which are involved in the detoxification of many insecticides. These enzymes can modify the chemical structure of insecticides, making them less harmful to the insect.
5. Excretion: Once metabolized, insecticides and their metabolites are eliminated from the insect's body. This process generally occurs through excretory organs such as Malpighian tubules, which function similarly to the kidneys in vertebrates. Insecticides and their metabolites can be excreted in the faeces, urine, or through other excretory pathways.
Microsomal oxidation refers to a type of metabolic reaction that occurs in the microsomes, which are subcellular organelles found in cells. Microsomes contain various enzymes, including cytochrome P450 enzymes, responsible for catalyzing oxidative reactions in the body.
A. Cytochrome P450 enzymes are a family of enzymes involved in the metabolism of a wide range of endogenous and exogenous compounds, including pesticides, toxins, and foreign substances. These enzymes play a crucial role in the oxidation, reduction, and hydrolysis of various molecules, making them more water-soluble and easier to eliminate from the body.
B. Microsomal oxidation mediated by cytochrome P450 enzymes involves the addition of an oxygen atom to a substrate molecule, resulting in the oxidation of the substrate.
Hypervalent refers to the main group elements that breaks the octet rule and firmly has more than right electrons in it's valence shell. These are non - metallic oxidation reagents.
Presented by Dhanashree Kavhale. M. Pharm.(Pharmaceutical Chemistry) 1st year.
Various organic named reactions are there in Advanced Organic Chemistry I, as some of them are explained along with their mechanism.
Course title: Medical Microbiology
Course code: MBIO-210
Group members name participate:- Arafat Rahman Parvez, Shirajum monira,Jafor Iqbal,Shakila jannatul shampa,Tanjim kamal aurnob, Shayla akter
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Model Attribute Check Company Auto PropertyCeline George
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Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
How to Make a Field invisible in Odoo 17Celine George
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Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Palestine last event orientationfvgnh .pptxRaedMohamed3
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Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Growth with aromatic hydrocarbon, Degradation of phenylalanine and tyrosine by homogentisate pathway.
1. P R I M E A S I A U N I V E R S I T Y
a mission with a vision
Assignment : 1,2.
Submitted to
Name: Aneeka Nawar fatema
Designation: Lecturer
Department: Microbiology
Institute: Primeasia University
Submitted by
Name: Md Azizul Haque
Student ID: 193016031
Course Code: MBIO 202
Course Title: Microbial Metabolism - I
Department: Microbiology
Date of Submission: January 13, 2021
2. Assignment : 01
Growth with aromatic hydrocarbon
Aromatic compounds produced by plants include mostly ligin and aromatic amino acids and
vitamins are consitituents of very organisms.
Characteristics of Aromatic Compounds
1) Cyclic structure.
2) Coplanar structure.
3) Each atom of the ring must have a p orbital to form a delocalized it system i.e. no atoms in
the ring can be spa hybridized instead all atoms must be sp2
hybridized (N.B. carbocation
and carbanions are sp2
hybridized or an unshared pair electrons).
4) Fulfill Huckel rule i.e. the system must have 4n + 2 pi electrons :
thus by calculating n value it will be an integral number i.e. n=0, 1, 2, 3,
Aromatic Compounds metabolizing microbes:-
Aromatic compounds are chemical compounds that consist of conjugated planar ring systems
accompanied by delocalized pi-electron clouds in place of individual alternating double and
single bonds. They are also called aromatics or arenes. The best examples
are toluene and benzene.
Acinetobacter
Alcaligenes
Agrobacterium
Bacilus
Aspergillus
Candida
3. Atypical aromatic compounds
Aromaticity also occurs in compounds that are not carbocyclic or heterocyclic; inorganic six-
membered-ring compounds analogous to benzene have been synthesized. For
example, borazine is a six-membered ring composed of alternating boron and nitrogen atoms,
each with one hydrogen attached. It has a delocalized π system and undergoes electrophilic
substitution reactions appropriate to aromatic rings rather than reactions expected of non-
aromatic molecules.
Quite recently, the aromaticity of planar Si6−
5 rings occurring in the Zintl phase Li12Si7 was experimentally evinced by Li solid-state NMR.
Metal aromaticity is believed to exist in certain clusters of aluminium, for example.
Homoaromaticity is the state of systems where conjugation is interrupted by a single
sp3
hybridized carbon atom.
Y-aromaticity is used to describe a Y-shaped, planar (flat) molecule with resonance bonds. The
concept was developed to explain the extraordinary stability and high basicity of
the guanidinium cation. Guanidinium is not a ring molecule, and is cross-conjugated rather than
a π system of consecutively attached atoms, but is reported to have its six π-electrons delocalized
over the whole molecule. The concept is controversial and some authors emphasize different
effects. This has also been suggested as the reason that the trimethylenemethane dication is more
stable than the butadienyl dication.
σ-aromaticity refers to stabilization arising from the delocalization of sigma bonds. It is often
invoked in cluster chemistry and is closely related to Wade's Rule.
Reactions
Aromatic ring systems participate in many organic reactions.
Aromatic substitution
In aromatic substitution one substituent on the arene ring, usually hydrogen, is replaced by
another substituent. The two main types are electrophilic aromatic substitution when the active
reagent is an electrophile and nucleophilic aromatic substitution when the reagent is a
nucleophile. In radical-nucleophilic aromatic substitution the active reagent is a radical. An
example of electrophilic aromatic substitution is the nitration of salicylic acid.
4. Coupling reactions
In coupling reactions a metal catalyses a coupling between two formal radical fragments.
Common coupling reactions with arenes result in the formation of new carbon–carbon bonds
e.g., alkylarenes, vinyl arenes, biraryls, new carbon–nitrogen bonds (anilines) or new carbon–
oxygen bonds (aryloxy compounds). An example is the direct arylation of perfluorobenzenes.
Hydrogenation
Hydrogenation of arenes create saturated rings. The compound 1-naphthol is completely reduced
to a mixture of decalin-ol isomers.
The compound resorcinol, hydrogenated with Raney nickel in presence of aqueous sodium
hydroxide forms an enolate which is alkylated with methyl iodide to 2-methyl-1,3-
cyclohexandione:
Cycloadditions.
Cycloaddition reaction are not common. Unusual thermal Diels–Alder reactivity of arenes can be
found in the Wagner-Jauregg reaction.Other photochemical cycloaddition reactions with alkenes
occur through excimers.
5. Dearomatization
In dearomatization reactions the aromaticity of the reactant is permanently lost.
Polycyclic aromatic hydrocarbons
Hexabenzocoronene is a large polycyclic aromatic hydrocarbon.
Polycyclic aromatic hydrocarbon
Polycyclic aromatic hydrocarbons(PAHs) are aromatic hydrocarbons that consist of
fused aromatic rings and do not contain heteroatoms or carry substituents. Naphthalene is the
simplest example of a PAH. PAHs occur in oil, coal, and tar deposits, and are produced as
byproducts of fuel burning (whether fossil fuel or biomass). As pollutants, they are of concern
because some compounds have been identified as carcinogenic, mutagenic, and teratogenic.
PAHs are also found in cooked foods. Studies have shown.
6. Refference:-
• CAIN RB. The microbial metabolism of nitro-aromatic compounds. J Gen Microbiol. 1958
Aug;19(1):1–14. [PubMed] [Google Scholar]
• Cain RB. The metabolism of protocatechuic acid by certain micro-organisms. A reassessment of
the evidence for the participation of 2:6-dioxa-3:7-dioxobicyclo[3:3:0]octane as an
intermediate. Biochem J. 1961 May;79(2):312–316. [PMC free article] [PubMed] [Google
Scholar]
• DURHAM NN. Effect of structurally related compounds on the oxidation of p-aminobenzoic acid
by Pseudomonas fluorescens. J Bacteriol. 1957 May;73(5):612–615. [PMC free
article] [PubMed] [Google Scholar]
• Evans WC. Oxidation of phenol and benzoic acid by some soil bacteria. Biochem
J. 1947;41(3):373–382. [PMC free article] [PubMed] [Google Scholar]
• EVANS WC, SMITH BSW, LINSTEAD RP, ELVIDGE JA. Chemistry of the oxidative
metabolism of certain aromatic compounds by micro-organisms. Nature. 1951 Nov
3;168(4279):772–775. [PubMed] [Google Scholar]
• GABY WL, FREE E. Differential diagnosis of Pseudomonas-like microorganisms in the clinical
laboratory. J Bacteriol. 1958 Oct;76(4):442–444. [PMC free article] [PubMed] [Google Scholar]
• GABY WL, HADLEY C. Practical laboratory test for the identification of Pseudomonas
aeruginosa. J Bacteriol. 1957 Sep;74(3):356–358. [PMC free article] [PubMed] [Google Scholar]
• HAYNES WC. Pseudomonas aeruginosa--its characterization and identification. J Gen
Microbiol. 1951 Nov;5(5 Suppl):939–950. [PubMed] [Google Scholar]
• KILBY BA. The formation of beta-ketoadipic acid by bacterial fission of aromatic
rings. Biochem J. 1951 Oct;49(5):671–674. [PMC free article] [PubMed] [Google Scholar]
• KRAMER N, DOETSCH RN. The growth of phenol-utilizing bacteria on aromatic carbon
sources. Arch Biochem. 1950 May;26(3):401–405. [PubMed] [Google Scholar]
• MARR EK, STONE RW. Bacterial oxidation of benzene. J Bacteriol. 1961 Mar;81:425–
430. [PMC free article] [PubMed] [Google Scholar]
• ROGOFF MH, WENDER I. Methylnaphthalene oxidations by pseudomonads. J Bacteriol. 1959
Jun;77(6):783–788. [PMC free article] [PubMed] [Google Scholar]
• Stanier RY. Simultaneous Adaptation: A New Technique for the Study of Metabolic Pathways. J
Bacteriol. 1947 Sep;54(3):339–348. [PMC free article] [PubMed] [Google Scholar]
• Stanier RY. The Oxidation of Aromatic Compounds by Fluorescent Pseudomonads. J
Bacteriol. 1948 Apr;55(4):477–494. [PMC free article] [PubMed] [Google Scholar]
• STANIER RY. The bacterial oxidation of aromatic compounds. IV. Studies on the mechanism of
enzymatic degradation of protocatechuic acid. J Bacteriol. 1950 Apr;59(4):527–532. [PMC free
article] [PubMed] [Google Scholar]
• STANIER RY, SLEEPER BP, TSUCHIDA M, MACDONALD DL. The bacterial oxidation of
aromatic compounds; III. The enzymatic oxidation of catechol and protocatechuic acid to beta-
ketoadipic acid. J Bacteriol. 1950 Feb;59(2):137–151. [PMC free article] [PubMed] [Google
Scholar]
• Zobell CE. ACTION OF MICROORGANISMS ON HYDROCARBONS. Bacteriol Rev. 1946
Mar;10(1-2):1–49. [PMC free article] [PubMed] [Google Scholar]
• ZOBELL CE. Assimilation of hydrocarbons by microorganisms. Adv Enzymol Relat Subj
Biochem. 1950;10:443–486. [PubMed] [Google Scholar].
7. Assignment : 02
Degradation of phenylalanine and tyrosine by homogentisate
pathway.
Figure 1: Tyrosine metabolism pathway
8. Phenylalanine
Phenylalanine is an essential α-amino acid with the formula C
9H
11NO
2. It can be viewed as a benzyl group substituted for the methyl group of alanine, or
a phenyl group in place of a terminal hydrogen of alanine. This essential amino acid is classified
as neutral, and nonpolar because of the inert and hydrophobic nature of the benzyl side chain.
The L-isomer is used to biochemically form proteins, coded for by DNA. Phenylalanine is a
precursor for tyrosine, the monoamine
neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), and
the skin pigment melanin. It is encoded by the codons UUU and UUC.
Phenylalanine is found naturally in the breast milk of mammals. It is used in the manufacture of
food and drink products and sold as a nutritional supplement for its
reputed analgesic and antidepressant effects. It is a direct precursor to
the neuromodulator phenethylamine, a commonly used dietary supplement. As an essential
amino acid, phenylalanine is not synthesized de novo in humans and other animals, who must
ingest phenylalanine or phenylalanine-containing proteins.
Figure:- Phenylalanine in humans may ultimately be metabolized into a range of different substances.
9. D-, L- and DL-phenylalanine
The stereoisomer D-phenylalanine (DPA) can be produced by conventional organic synthesis,
either as a single enantiomer or as a component of the racemic mixture. It does not participate
in protein biosynthesis although it is found in proteins in small amounts - particularly aged
proteins and food proteins that have been processed. The biological functions of D-amino acids
remain unclear, although D-phenylalanine has pharmacological activity at niacin receptor 2.[14]
DL-Phenylalanine (DLPA) is marketed as a nutritional supplement for its
purported analgesic and antidepressant activities. DL-Phenylalanine is a mixture of D-
phenylalanine and L-phenylalanine. The reputed analgesic activity of DL-phenylalanine may be
explained by the possible blockage by D-phenylalanine of enkephalin degradation by
the enzyme carboxypeptidase A.[15][16]
The mechanism of DL-phenylalanine's supposed
antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the
synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain levels of
norepinephrine and dopamine are thought to have an antidepressant effect. D-Phenylalanine is
absorbed from the small intestine and transported to the liver via the portal circulation. A small
amount of D-phenylalanine appears to be converted to L-phenylalanine. D-Phenylalanine is
distributed to the various tissues of the body via the systemic circulation. It appears to cross
the blood–brain barrier less efficiently than L-phenylalanine, and so a small amount of an
ingested dose of D-phenylalanine is excreted in the urine without penetrating the central nervous
system.[17]
L-Phenylalanine is an antagonist at α2δ Ca2+
calcium channels with a Ki of 980 nM.[18]
In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA
receptor[19]
and at the glutamate binding site of AMPA receptor.[20]
At the glycine binding site
of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of
573 μM estimated by Schild regression[21]
which is considerably lower than brain L-
phenylalanine concentration observed in untreated human phenylketonuria.[22]
L-Phenylalanine
also inhibits neurotransmitter release
at glutamatergic synapses in hippocampus and cortex with IC50 of 980 μM, a brain concentration
seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect.
10. Refference:-
• BLAKLEY ER, SIMPSON FJ. THE MICROBIAL METABOLISM OF CINNAMIC
ACID. Can J Microbiol. 1964 Apr;10:175–185. [PubMed] [Google Scholar]
• Dagley S, Chapman PJ, Gibson DT. The metabolism of beta-phenylpropionic acid by an
Achromobacter. Biochem J. 1965 Dec;97(3):643–650. [PMC free
article] [PubMed] [Google Scholar]
• EVANS WC. THE MICROBIOLOGICAL DEGRADATION OF AROMATIC
COMPOUNDS. J Gen Microbiol. 1963 Aug;32:177–184. [PubMed] [Google Scholar]
• FINKLE BJ, LEWIS JC, CORSE JW, LUNDIN RE. Enzyme reactions with phenolic
compounds: formation of hydroxystyrenes through the decarboxylation of 4-
hydroxycinnamic acids by Aerobacter. J Biol Chem. 1962 Sep;237:2926–
2931. [PubMed] [Google Scholar]
• HENDERSON ME. The metabolism of aromatic compounds related to lignin by some
hyphomycetes and yeast-like fungi of soil. J Gen Microbiol. 1961 Sep;26:155–
165. [PubMed] [Google Scholar]
• HENDERSON ME, FARMER VC. Utilization by soil fungi of p-hydroxybenzaidehyde,
ferulic acid, syringaldehyde and vanillin. J Gen Microbiol. 1955 Feb;12(1):37–
46. [PubMed] [Google Scholar]
• IBRAHIM RK, TOWERS GH. The identification, by chromatography, of plant phenolic
acids. Arch Biochem Biophys. 1960 Mar;87:125–128. [PubMed] [Google Scholar]
• KLUYVER AJ, VAN ZIJP JC. The production of homogentisic acid out of phenylacetic
acid by Aspergillus niger. Antonie Van Leeuwenhoek. 1951;17(5):315–
324. [PubMed] [Google Scholar]
• KOUKOL J, CONN EE. The metabolism of aromatic compounds in higher plants. IV.
Purification and properties of the phenylalanine deaminase of Hordeum vulgare. J Biol
Chem. 1961 Oct;236:2692–2698. [PubMed] [Google Scholar]
• LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ. Protein measurement
with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–
275. [PubMed] [Google Scholar]
• MEAD JA, SMITH JN, WILLIAMS RT. Studies in detoxication. 72. The metabolism of
coumarin and of o-coumaric acid. Biochem J. 1958 Jan;68(1):67–74. [PMC free
article] [PubMed] [Google Scholar]
• NAIR PM, VAIDYANATHAN CS. A COLORIMETRIC METHOD FOR
DETERMINATION OF PYROCATECHOL AND RELATED SUBSTANCES. Anal
Biochem. 1964 Mar;7:315–321. [PubMed] [Google Scholar]
• PITTARD AJ, GIBSON F, DOY CH. A possible relationship between the formation of
o-dihydric phenols and tryptophan biosynthesis by Aerobacter aerogens. Biochim
Biophys Acta. 1962 Feb 26;57:290–298. [PubMed] [Google Scholar]
• Power DM, Towers GH, Neish AC. Biosynthesis of phenolic acids by certain wood-
destroying basidiomycetes. Can J Biochem. 1965 Sep;43(9):1397–
1407. [PubMed] [Google Scholar]
• ROGOFF MH. Oxidation of aromatic compounds by bacteria. Adv Appl
Microbiol. 1961;3:193–221. [PubMed] [Google Scholar]
• Vollmer KO, Reisener HJ, Grisebach H. The formation of acetic acid from p-
hydroxycinnamic acid during its degradation to p-hydroxybenzoic acid.