This document provides information about influenza viruses. It discusses the different types of influenza viruses (A, B, C), their structure and genetics. It describes how influenza A viruses are classified into subtypes based on H and N proteins, and how antigenic drift and shifts can lead to new variants. It also summarizes the epidemiology of different influenza viruses in humans and other animals like birds, pigs, and horses.
Influenza is caused by RNA viruses of the Orthomyxoviridae family that come in three main types: A, B, and C. Influenza A is the most common cause of epidemics and pandemics as it has multiple subtypes that can reassort. Wild aquatic birds are the natural reservoir for all influenza A subtypes. Seasonal epidemics are caused by antigenic drift while pandemics arise due to antigenic shift involving genetic reassortment between human and avian viruses. The prerequisites for an influenza pandemic are a new virus that humans have little immunity to which can spread efficiently between people. Egypt has reported increased human infections of avian influenza A(H5N1) virus
This document discusses influenza viruses and pandemics. It notes that influenza A viruses can undergo antigenic drift, resulting in seasonal epidemics, or antigenic shift, resulting in pandemics when a completely new virus emerges. Influenza A viruses circulate in birds and can occasionally infect humans. The H5N1 and H7N9 avian influenza viruses pose a pandemic risk if they mutate to spread easily between people. Past pandemics include the 1918 Spanish flu and 1957 Asian flu. Controlling avian influenza in poultry is important to decrease risks to humans.
- Avian influenza is caused by influenza A viruses that primarily infect birds but can infect humans. The H5N1 strain is of particular concern as it is highly pathogenic and can be transmitted from birds to humans.
- While human-to-human transmission of H5N1 is currently rare and inefficient, there is a risk of the virus mutating to allow more efficient human-to-human spread, which could potentially lead to a global pandemic.
- Preventing transmission requires controlling outbreaks in poultry through measures like vaccination, biosecurity protocols, and culling infected flocks. For humans, basic hygiene and avoiding contact with infected birds are the primary defenses until a vaccine specific to
Influenza, or flu, is an acute viral respiratory infection that causes fever, chills, headache, and body aches. Flu pandemics occur approximately every 30 years when a new strain emerges that humans have no immunity to. New flu strains occur through mutation, with avian influenza viruses sometimes exchanging genes with human viruses. The 1918-1919 flu pandemic killed between 20-40 million people worldwide. Influenza is caused by influenza A, B, or C viruses, with type A associated with pandemics. The flu virus is an RNA virus with a lipid envelope containing glycoproteins that allow it to infect cells. Vaccination is the primary prevention method, though vaccines are only 40-60% effective
Swine influenza is caused by influenza A viruses that infect pigs. The document discusses the epidemiology, clinical signs, diagnosis and laboratory testing of swine influenza. It notes that the disease spreads rapidly between pigs through direct contact, with morbidity rates as high as 100% though mortality is generally low. Diagnosis involves virus isolation from nasal swabs or lung tissue within 1-2 days of symptoms, and serological testing to detect antibodies in paired serum samples.
Influenza is caused by RNA viruses of the Orthomyxoviridae family that come in three main types: A, B, and C. Influenza A is the most common cause of epidemics and pandemics as it has multiple subtypes that can reassort. Wild aquatic birds are the natural reservoir for all influenza A subtypes. Seasonal epidemics are caused by antigenic drift while pandemics arise due to antigenic shift involving genetic reassortment between human and avian viruses. The prerequisites for an influenza pandemic are a new virus that humans have little immunity to which can spread efficiently between people. Egypt has reported increased human infections of avian influenza A(H5N1) virus
This document discusses influenza viruses and pandemics. It notes that influenza A viruses can undergo antigenic drift, resulting in seasonal epidemics, or antigenic shift, resulting in pandemics when a completely new virus emerges. Influenza A viruses circulate in birds and can occasionally infect humans. The H5N1 and H7N9 avian influenza viruses pose a pandemic risk if they mutate to spread easily between people. Past pandemics include the 1918 Spanish flu and 1957 Asian flu. Controlling avian influenza in poultry is important to decrease risks to humans.
- Avian influenza is caused by influenza A viruses that primarily infect birds but can infect humans. The H5N1 strain is of particular concern as it is highly pathogenic and can be transmitted from birds to humans.
- While human-to-human transmission of H5N1 is currently rare and inefficient, there is a risk of the virus mutating to allow more efficient human-to-human spread, which could potentially lead to a global pandemic.
- Preventing transmission requires controlling outbreaks in poultry through measures like vaccination, biosecurity protocols, and culling infected flocks. For humans, basic hygiene and avoiding contact with infected birds are the primary defenses until a vaccine specific to
Influenza, or flu, is an acute viral respiratory infection that causes fever, chills, headache, and body aches. Flu pandemics occur approximately every 30 years when a new strain emerges that humans have no immunity to. New flu strains occur through mutation, with avian influenza viruses sometimes exchanging genes with human viruses. The 1918-1919 flu pandemic killed between 20-40 million people worldwide. Influenza is caused by influenza A, B, or C viruses, with type A associated with pandemics. The flu virus is an RNA virus with a lipid envelope containing glycoproteins that allow it to infect cells. Vaccination is the primary prevention method, though vaccines are only 40-60% effective
Swine influenza is caused by influenza A viruses that infect pigs. The document discusses the epidemiology, clinical signs, diagnosis and laboratory testing of swine influenza. It notes that the disease spreads rapidly between pigs through direct contact, with morbidity rates as high as 100% though mortality is generally low. Diagnosis involves virus isolation from nasal swabs or lung tissue within 1-2 days of symptoms, and serological testing to detect antibodies in paired serum samples.
1. Avian influenza, or bird flu, is a zoonotic disease caused by influenza A viruses that infect various bird species as well as humans on rare occasions.
2. The H5N1 strain of avian influenza has caused severe economic losses to poultry industries worldwide and poses a pandemic risk to humans due to a lack of immunity.
3. While vaccination and culling of infected flocks are used to control outbreaks, the spread of the disease is difficult to prevent due to migratory bird movements and lack of rapid detection in some countries including India.
TERM PAPER ON SWINE FLU AND CYTOKINE STORMBikash Singh
Swine flu is caused by influenza A viruses and pigs play an important role in the evolution and transmission of these viruses between humans and animals. Pigs can be infected by both human and avian influenza viruses. Researchers have found that the 2009 H1N1 strain caused a cytokine storm in the body that led to respiratory distress. Studies on mice have provided insights into the multiple pathways through which influenza causes cytokine overproduction. Vaccines have shown some effectiveness against H1N1 but it remains a pandemic threat. People who have recovered from swine flu infection may gain "extraordinary super immunity" with antibodies that can target multiple flu strains.
This document provides an overview of influenza viruses including what influenza is, the history and classification of influenza viruses, their structure and types (A, B, C), how they change through antigenic drift and shift, examples of avian and swine influenza, seasonal flu vs pandemics, and treatment for H1N1 flu. It discusses that influenza A viruses can infect humans and animals, cause pandemics, and are the subject of antigenic drift and shift. Influenza B primarily infects humans. It also summarizes that the 1918, 1957, and 1968 pandemics were caused by antigenic shifts in influenza A viruses H1N1, H2N2, and H3N2 respectively.
Everything you should know about Influenza virus!ankitvkc
Influenza viruses belong to the Orthomyxoviridae family and have an enveloped structure containing proteins like hemagglutinin and neuraminidase. They contain a single-stranded RNA genome composed of 8 segments that encode 11 proteins. Influenza spreads through aerosols or contaminated surfaces and causes flu epidemics annually, as well as occasional pandemics arising from antigenic shift. The virus enters cells by binding hemagglutinin to sialic acid receptors and uncoating inside endosomes. Vaccination and antiviral drugs can help prevent and treat flu, while hand washing and masks can reduce transmission.
This document discusses the history and epidemiology of influenza viruses, including swine influenza. It notes that influenza A viruses circulate in humans, birds, and pigs. While swine influenza viruses typically do not infect humans, human infections can occur through direct contact with pigs. The viruses can reassort their genes, occasionally resulting in new virus subtypes that spread among humans. Swine influenza is currently a concern in parts of Asia and India, where cases have been reported. Close proximity to infected pigs is the primary risk factor for transmission to humans.
The document provides information from a presentation on pandemic influenza planning and preparedness. It defines pandemic influenza and describes factors that cause pandemics. It discusses past pandemics like the 1918 Spanish Flu pandemic. It also addresses the current threat of influenza, describing seasonal flu, avian flu, and the possibility of another influenza pandemic.
The document discusses avian influenza (H5N1) and pandemic influenza. It provides details on clinical features of H5N1 influenza in humans, including persistent fever and lymphopenia. It notes most human cases of H5N1 have occurred in children exposed to sick or dead poultry. Early treatment with oseltamivir is associated with improved survival. The document also discusses strategies for containing a potential influenza pandemic through rapid detection of cases and use of antiviral prophylaxis.
Influenza types A and B are responsible for annual epidemics and can cause illness ranging from mild to severe or deadly. Each year, the WHO recommends updated influenza vaccine strains to protect against the viruses likely to circulate that season, based on global surveillance. Although the recommended strains remained the same from 2010-2012, annual vaccination is still recommended since immunity declines over time.
This document discusses influenza virus, which belongs to the family Orthomyxoviridae. It describes the three main types of influenza - types A, B, and C - and their characteristics. Influenza A has multiple subtypes defined by hemagglutinin and neuraminidase proteins and can infect various species including humans and birds. Avian influenza is the most virulent group of influenza A.
The novel H1N1 influenza virus is a new strain caused by genetic reassortment between pig, bird, and human influenza viruses. It is structurally similar to seasonal influenza viruses with an RNA genome and envelope containing hemagglutinin and neuraminidase proteins. While it spreads easily between people, the H1N1 virus has relatively low virulence, with most infections causing only mild symptoms. The virus could become more virulent over time through antigenic drift or shift, but currently poses less severe disease than seasonal influenza.
Influenza is a contagious respiratory illness caused by influenza viruses. There are three main types of influenza viruses (A, B, C) with Type A causing the most severe illness. Influenza viruses are constantly evolving through antigenic drift and antigenic shift, allowing them to evade host immunity. Vaccines aim to induce antibodies against predicted circulating strains, but the viruses' evolution requires continuous surveillance and vaccine updates. Influenza poses a significant disease burden, with estimated annual deaths ranging from 3,000 to 48,000 in the US alone.
The document discusses the threat of a potential bird flu pandemic. It notes that the H5N1 avian influenza virus has caused human deaths in Asia and has a high mortality rate. Experts fear it could mutate and spread efficiently between humans, causing a global pandemic. Key risks include asymptomatic infection, limited immunity, and potential for the virus to reassort genes allowing human-to-human transmission. Proper management requires vaccines, social distancing, antiviral drugs, and pandemic preparedness. However, it remains unknown whether or when the virus may gain efficient human transmission.
Avian influenza, or bird flu, is a highly contagious viral disease affecting poultry caused by influenza A viruses. The document discusses the causative virus, clinical signs and gross lesions, diagnosis, and prevention and control methods. It notes that avian influenza virus has two subtypes - low pathogenic (LPAI) and high pathogenic (HPAI) viruses capable of causing severe disease and 100% mortality. HPAI outbreaks tend to be self-limiting as few birds survive to act as carriers. Diagnosis involves hemagglutination inhibition and immunodiffusion tests. Prevention focuses on vaccination and treating flocks with antibiotics to control secondary infections.
Influenza viruses are RNA viruses in the Orthomyxoviridae family that cause seasonal flu epidemics and pandemics. They are spherical, 80-120nm in size, with segmented negative-sense RNA and replicate in the nucleus. Influenza A has different subtypes based on its hemagglutinin and neuraminidase proteins that determine its antigenicity and ability to cause pandemics through genetic reassortment. Seasonal flu is associated with upper respiratory illness but can lead to pneumonia. Diagnosis involves PCR, antigen detection, virus isolation and serology. Treatment focuses on antivirals while vaccination provides moderate protection against matched strains. High risk groups like the elderly are more susceptible to flu complications.
This document provides information about trivalent inactivated seasonal influenza vaccine (TIV) for 2015-2016. It discusses the types and subtypes of influenza viruses, how they change and cause annual epidemics, as well as pandemics. The global burden of influenza is estimated at 1 billion cases annually with 3-500,000 deaths. Vaccination is recommended for everyone over 6 months of age as the best way to prevent influenza. The vaccine contains inactivated influenza A and B viruses and must be administered via intramuscular injection annually due to antigenic drift.
- Avian influenza, or bird flu, is caused by influenza A viruses that naturally infect wild birds and can infect domestic poultry and occasionally humans.
- There are different subtypes of avian influenza viruses based on two surface proteins (H and N), with H5N1, H7N9, and H9N2 having caused human infections. These viruses usually do not transmit easily between people but can cause severe disease.
- Symptoms of avian influenza in humans are similar to seasonal influenza but can also cause severe pneumonia, acute respiratory distress, multi-organ failure and death. Human cases have occurred primarily after unprotected contact with infected birds.
Swine flu, also known as H1N1 influenza A virus, was detected in patients presenting with respiratory illness at a hospital in India from mid-January to early March 2015. A retrospective analysis of 28 patients found that over half were male and between 15-50 years of age. The most common symptoms were cough, fever, and respiratory distress. Nine patients died, resulting in a mortality rate of 32%. Risk factors for severe illness and death included age under 4 or over 65, pregnancy, and underlying chronic conditions.
LAIV in India - Should we use it? Sep 2014Gaurav Gupta
LAIV Nasovac S by Serum Institute of India, should it be used in India?
Influenza vaccine, Flu, India, Live, Inactivated, Children, injection, vaccine, asthma
The document discusses swine flu (H1N1 virus), including its history, classification, symptoms, diagnosis and treatment. It notes that swine flu was first identified in 1918 and is caused by various subtypes of influenza A viruses. The document describes the virus's structure and genetics. It also discusses how swine flu spreads among pigs and from pigs to humans. Symptoms in humans are typically mild and include coughing, fever and body aches. Doctors can diagnose swine flu through tests.
This document provides information about influenza viruses, including:
1) Influenza viruses belong to the Orthomyxoviridae family and infect hosts through respiratory and digestive tracts. They are single-stranded RNA viruses that are unstable and mutate frequently.
2) Influenza virus type A is further classified based on pathogenicity and includes highly, medium, and low pathogenic strains. Swine can be infected by multiple strains simultaneously and act as mixing vessels for genetic reassortment.
3) Influenza causes diseases in birds, swine, and humans. Avian influenza strains like H5N1 can cause severe disease in birds and occasionally infect humans. Swine influenza strains periodically infect
This document provides an overview of influenza (the flu) including:
- Differences between colds and flu in terms of symptoms and severity
- Types of influenza viruses (A, B, C) and their characteristics including ability to cause pandemics
- Structure and proteins (hemagglutinin and neuraminidase) of influenza viruses
- Seasonal flu, pandemic flu, avian flu, and potential complications of flu infection
- Methods of prevention including vaccination and hygiene practices
- Treatments including antiviral medications
1. Avian influenza, or bird flu, is a zoonotic disease caused by influenza A viruses that infect various bird species as well as humans on rare occasions.
2. The H5N1 strain of avian influenza has caused severe economic losses to poultry industries worldwide and poses a pandemic risk to humans due to a lack of immunity.
3. While vaccination and culling of infected flocks are used to control outbreaks, the spread of the disease is difficult to prevent due to migratory bird movements and lack of rapid detection in some countries including India.
TERM PAPER ON SWINE FLU AND CYTOKINE STORMBikash Singh
Swine flu is caused by influenza A viruses and pigs play an important role in the evolution and transmission of these viruses between humans and animals. Pigs can be infected by both human and avian influenza viruses. Researchers have found that the 2009 H1N1 strain caused a cytokine storm in the body that led to respiratory distress. Studies on mice have provided insights into the multiple pathways through which influenza causes cytokine overproduction. Vaccines have shown some effectiveness against H1N1 but it remains a pandemic threat. People who have recovered from swine flu infection may gain "extraordinary super immunity" with antibodies that can target multiple flu strains.
This document provides an overview of influenza viruses including what influenza is, the history and classification of influenza viruses, their structure and types (A, B, C), how they change through antigenic drift and shift, examples of avian and swine influenza, seasonal flu vs pandemics, and treatment for H1N1 flu. It discusses that influenza A viruses can infect humans and animals, cause pandemics, and are the subject of antigenic drift and shift. Influenza B primarily infects humans. It also summarizes that the 1918, 1957, and 1968 pandemics were caused by antigenic shifts in influenza A viruses H1N1, H2N2, and H3N2 respectively.
Everything you should know about Influenza virus!ankitvkc
Influenza viruses belong to the Orthomyxoviridae family and have an enveloped structure containing proteins like hemagglutinin and neuraminidase. They contain a single-stranded RNA genome composed of 8 segments that encode 11 proteins. Influenza spreads through aerosols or contaminated surfaces and causes flu epidemics annually, as well as occasional pandemics arising from antigenic shift. The virus enters cells by binding hemagglutinin to sialic acid receptors and uncoating inside endosomes. Vaccination and antiviral drugs can help prevent and treat flu, while hand washing and masks can reduce transmission.
This document discusses the history and epidemiology of influenza viruses, including swine influenza. It notes that influenza A viruses circulate in humans, birds, and pigs. While swine influenza viruses typically do not infect humans, human infections can occur through direct contact with pigs. The viruses can reassort their genes, occasionally resulting in new virus subtypes that spread among humans. Swine influenza is currently a concern in parts of Asia and India, where cases have been reported. Close proximity to infected pigs is the primary risk factor for transmission to humans.
The document provides information from a presentation on pandemic influenza planning and preparedness. It defines pandemic influenza and describes factors that cause pandemics. It discusses past pandemics like the 1918 Spanish Flu pandemic. It also addresses the current threat of influenza, describing seasonal flu, avian flu, and the possibility of another influenza pandemic.
The document discusses avian influenza (H5N1) and pandemic influenza. It provides details on clinical features of H5N1 influenza in humans, including persistent fever and lymphopenia. It notes most human cases of H5N1 have occurred in children exposed to sick or dead poultry. Early treatment with oseltamivir is associated with improved survival. The document also discusses strategies for containing a potential influenza pandemic through rapid detection of cases and use of antiviral prophylaxis.
Influenza types A and B are responsible for annual epidemics and can cause illness ranging from mild to severe or deadly. Each year, the WHO recommends updated influenza vaccine strains to protect against the viruses likely to circulate that season, based on global surveillance. Although the recommended strains remained the same from 2010-2012, annual vaccination is still recommended since immunity declines over time.
This document discusses influenza virus, which belongs to the family Orthomyxoviridae. It describes the three main types of influenza - types A, B, and C - and their characteristics. Influenza A has multiple subtypes defined by hemagglutinin and neuraminidase proteins and can infect various species including humans and birds. Avian influenza is the most virulent group of influenza A.
The novel H1N1 influenza virus is a new strain caused by genetic reassortment between pig, bird, and human influenza viruses. It is structurally similar to seasonal influenza viruses with an RNA genome and envelope containing hemagglutinin and neuraminidase proteins. While it spreads easily between people, the H1N1 virus has relatively low virulence, with most infections causing only mild symptoms. The virus could become more virulent over time through antigenic drift or shift, but currently poses less severe disease than seasonal influenza.
Influenza is a contagious respiratory illness caused by influenza viruses. There are three main types of influenza viruses (A, B, C) with Type A causing the most severe illness. Influenza viruses are constantly evolving through antigenic drift and antigenic shift, allowing them to evade host immunity. Vaccines aim to induce antibodies against predicted circulating strains, but the viruses' evolution requires continuous surveillance and vaccine updates. Influenza poses a significant disease burden, with estimated annual deaths ranging from 3,000 to 48,000 in the US alone.
The document discusses the threat of a potential bird flu pandemic. It notes that the H5N1 avian influenza virus has caused human deaths in Asia and has a high mortality rate. Experts fear it could mutate and spread efficiently between humans, causing a global pandemic. Key risks include asymptomatic infection, limited immunity, and potential for the virus to reassort genes allowing human-to-human transmission. Proper management requires vaccines, social distancing, antiviral drugs, and pandemic preparedness. However, it remains unknown whether or when the virus may gain efficient human transmission.
Avian influenza, or bird flu, is a highly contagious viral disease affecting poultry caused by influenza A viruses. The document discusses the causative virus, clinical signs and gross lesions, diagnosis, and prevention and control methods. It notes that avian influenza virus has two subtypes - low pathogenic (LPAI) and high pathogenic (HPAI) viruses capable of causing severe disease and 100% mortality. HPAI outbreaks tend to be self-limiting as few birds survive to act as carriers. Diagnosis involves hemagglutination inhibition and immunodiffusion tests. Prevention focuses on vaccination and treating flocks with antibiotics to control secondary infections.
Influenza viruses are RNA viruses in the Orthomyxoviridae family that cause seasonal flu epidemics and pandemics. They are spherical, 80-120nm in size, with segmented negative-sense RNA and replicate in the nucleus. Influenza A has different subtypes based on its hemagglutinin and neuraminidase proteins that determine its antigenicity and ability to cause pandemics through genetic reassortment. Seasonal flu is associated with upper respiratory illness but can lead to pneumonia. Diagnosis involves PCR, antigen detection, virus isolation and serology. Treatment focuses on antivirals while vaccination provides moderate protection against matched strains. High risk groups like the elderly are more susceptible to flu complications.
This document provides information about trivalent inactivated seasonal influenza vaccine (TIV) for 2015-2016. It discusses the types and subtypes of influenza viruses, how they change and cause annual epidemics, as well as pandemics. The global burden of influenza is estimated at 1 billion cases annually with 3-500,000 deaths. Vaccination is recommended for everyone over 6 months of age as the best way to prevent influenza. The vaccine contains inactivated influenza A and B viruses and must be administered via intramuscular injection annually due to antigenic drift.
- Avian influenza, or bird flu, is caused by influenza A viruses that naturally infect wild birds and can infect domestic poultry and occasionally humans.
- There are different subtypes of avian influenza viruses based on two surface proteins (H and N), with H5N1, H7N9, and H9N2 having caused human infections. These viruses usually do not transmit easily between people but can cause severe disease.
- Symptoms of avian influenza in humans are similar to seasonal influenza but can also cause severe pneumonia, acute respiratory distress, multi-organ failure and death. Human cases have occurred primarily after unprotected contact with infected birds.
Swine flu, also known as H1N1 influenza A virus, was detected in patients presenting with respiratory illness at a hospital in India from mid-January to early March 2015. A retrospective analysis of 28 patients found that over half were male and between 15-50 years of age. The most common symptoms were cough, fever, and respiratory distress. Nine patients died, resulting in a mortality rate of 32%. Risk factors for severe illness and death included age under 4 or over 65, pregnancy, and underlying chronic conditions.
LAIV in India - Should we use it? Sep 2014Gaurav Gupta
LAIV Nasovac S by Serum Institute of India, should it be used in India?
Influenza vaccine, Flu, India, Live, Inactivated, Children, injection, vaccine, asthma
The document discusses swine flu (H1N1 virus), including its history, classification, symptoms, diagnosis and treatment. It notes that swine flu was first identified in 1918 and is caused by various subtypes of influenza A viruses. The document describes the virus's structure and genetics. It also discusses how swine flu spreads among pigs and from pigs to humans. Symptoms in humans are typically mild and include coughing, fever and body aches. Doctors can diagnose swine flu through tests.
This document provides information about influenza viruses, including:
1) Influenza viruses belong to the Orthomyxoviridae family and infect hosts through respiratory and digestive tracts. They are single-stranded RNA viruses that are unstable and mutate frequently.
2) Influenza virus type A is further classified based on pathogenicity and includes highly, medium, and low pathogenic strains. Swine can be infected by multiple strains simultaneously and act as mixing vessels for genetic reassortment.
3) Influenza causes diseases in birds, swine, and humans. Avian influenza strains like H5N1 can cause severe disease in birds and occasionally infect humans. Swine influenza strains periodically infect
This document provides an overview of influenza (the flu) including:
- Differences between colds and flu in terms of symptoms and severity
- Types of influenza viruses (A, B, C) and their characteristics including ability to cause pandemics
- Structure and proteins (hemagglutinin and neuraminidase) of influenza viruses
- Seasonal flu, pandemic flu, avian flu, and potential complications of flu infection
- Methods of prevention including vaccination and hygiene practices
- Treatments including antiviral medications
Influenza viruses and rhabdoviruses are enveloped RNA viruses. Influenza viruses cause seasonal flu epidemics and pandemics. They have segmented RNA genomes and spike proteins including hemagglutinin and neuraminidase that determine subtypes like H1N1. Rhabdoviruses include rabies virus, which causes rabies in humans and animals. Rabies virus has a bullet shape and glycoprotein spikes that induce protective neutralizing antibodies in infected individuals. Both families of viruses are inactivated by heat, detergents, and lipid solvents.
Influenza is caused by RNA viruses of type A or B. Type A influenza evolves rapidly through antigenic drift and shift, causing seasonal epidemics and pandemics when new strains emerge that humans have no immunity against. The 2009 H1N1 pandemic originated from genetic reassortment between human, avian, and swine influenza viruses. While H5N1 avian influenza is a pandemic threat, it has so far not achieved efficient human-to-human transmission. Genetic sequencing of influenza viruses allows public health officials to track their evolution and spread globally.
- Influenza viruses are divided into types A, B, and C. Type A is further divided into subtypes based on the H and N surface proteins, with 16 H and 9 N combinations possible.
- Wild birds are the natural reservoir for all influenza A subtypes. Antigenic drift causes small changes in circulating strains over time, necessitating annual vaccine updates. Antigenic shift involves genetic reassortment between human and animal viruses and can cause pandemics.
- Seasonal influenza causes annual epidemics that typically infect 10-20% of the population. While most recover without treatment, influenza can cause severe illness or death in high-risk groups. Avian influenza viruses usually do not
influenza.ant it's causes and treatment and sign symptomswajidullah9551
- Influenza is a viral infection that affects the nose, throat, bronchi and occasionally the lungs. Common symptoms include fever, muscle aches, cough and fatigue.
- Influenza viruses are classified into types A, B and C. Types A and B cause seasonal epidemics and can evolve over time through antigenic drift or shift.
- Influenza spreads through respiratory droplets from infected individuals. The virus can be isolated from nasal secretions during the infectious period which is a couple days before and after symptoms start.
- Risk factors for severe illness include age over 65, young children, and those with chronic health conditions. Seasonal patterns, human mobility and lack of immunity also influence transmission.
This document discusses influenza (the flu) viruses. It describes the three main types - influenza A, B, and C. Influenza A is the most virulent in humans and can infect various animals. It is divided into subtypes. Influenza B only infects humans. Influenza C causes mild illness in children. The virus structure, antigens HA and NA, and modes of transmission are outlined. Clinical manifestations include fever, cough, and muscle aches. Prevention methods include vaccination, antiviral drugs, and infection control.
Influenza is caused by RNA viruses of the Orthomyxoviridae family, with three main types - A, B, and C. Type A is further divided into subtypes based on surface proteins hemagglutinin and neuraminidase, and can cause pandemics by antigenic shift or drift. The 1918 Spanish flu pandemic killed 20-50 million people. Later pandemics in 1957 and 1968 were caused by new subtype viruses. Seasonal flu is managed through vaccination against the predicted circulating strains each year.
Influenza, commonly known as the flu, is a viral infection that affects the nose, throat, bronchi and occasionally the lungs. Common symptoms include fever, sore throat, muscle pains, coughing and fatigue. The influenza virus is classified into types A, B and C. Types A and B are responsible for seasonal flu epidemics and pandemics. The virus undergoes antigenic drift and shift, requiring new vaccines each year. At risk groups like the elderly are recommended for annual flu vaccination to prevent severe complications.
Swine influenza is an acute, highly contagious, respiratory diseas.docxmattinsonjanel
Swine influenza is an acute, highly contagious, respiratory disease that results from infection with type A influenza virus. Field isolates of variable virulence exist, and clinical manifestation may be determined by secondary organisms. Pigs are the principal hosts of classic swine influenza virus. (Human infections have been reported, but porcine strains of influenza A do not appear to easily spread in the human population. However, deaths have occurred in immunocompromised people.) In 2009 a pandemic strain of H1N1 influenza A virus spread globally. It infected people, swine, and poultry, as well as a small number of dogs, cats, and other animals. The disease in swine occurs commonly in the midwestern USA (and occasionally in other states), Mexico, Canada, South America, Europe (including the UK, Sweden, and Italy), Kenya, China, Japan, Taiwan, and other parts of eastern Asia.
Having a single one of these symptoms does not mean you have pandemic swine flu, but, you don't need to have all of these symptoms to suspect infection, either. The symptoms of swine flu in people are similar to the symptoms of regular human seasonal influenza. Watch for some combination of the following symptoms:
1. Fever of 101°F (41°C) or higher
2. Coughing
3. Headache
4. Sneezing
5. Body Aches
6. Fatigue
7. Dizziness
8. Chest pain
9. Abdominal pain
10. Shortness of breath
11. Malaise
12. Runny Nose
13. Sore throat
14. Vomiting
15. Diarrhea
16. Rigors (chills or shivers)
Caution: If you suspect that you might have a flu infection, consult a physician as soon as possible. Don't wait!
It is important for people who have chronic health conditions, women who are pregnant, and people with other high risk factors to pay special attention to warning signs. Influenza can make the symptoms, of other chronic medical conditions, worse
Swine flu and regular flu are both types of illness caused by different strains of the influenza virus. Regular flu is generally of types A, B or C, whereas swine flu is a strain (H1N1 virus) that is said to have originated in pigs.
Of the three genera of influenza viruses that cause human flu, two also cause influenza in pigs, with influenza A being common in pigs and influenza C being rare. Influenza B has not been reported in pigs. Within influenza A and influenza C, the strains found in pigs and humans are largely distinct, although because of reassortment there have been transfers of genes among strains crossing swine, avian, and human species boundaries.
Influenza C
Influenza viruses infect both humans and pigs, but do not infect birds. Transmission between pigs and humans have occurred in the past. For example, influenza C caused small outbreaks of a mild form of influenza amongst children in Japan and California. Because of its limited host range and the lack of genetic diversity in influenza C, this form of influenza does not cause pandemics in humans.
Influenza A
Swine influenza is known to be caused by influenza A subtypes H1 ...
Influenza, commonly known as flu, is caused by influenza viruses that infect the respiratory tract. It is highly contagious and spreads through respiratory droplets when infected individuals cough, sneeze or talk. The influenza virus is always mutating, sometimes resulting in global pandemics. Current research focuses on developing a universal flu vaccine and monitoring outbreaks of avian and swine flu strains with pandemic potential. Public health measures emphasize annual vaccination, hand hygiene and limiting contact with infected individuals to prevent influenza transmission.
The document provides an overview of the history of influenza pandemics, including details on the 1918 Spanish Flu pandemic that killed an estimated 50 million people globally. It discusses the H1N1 influenza virus and 2009 H1N1 pandemic, symptoms of H1N1 infection, and guidelines for testing and diagnosing suspected cases of H1N1. The document also reviews pathogenesis of H1N1 and strategies for prevention and treatment of influenza.
The document discusses pandemics that have impacted India, specifically smallpox in 1974 and the swine flu pandemic of 2009. It notes that both pandemics slowed India's economic growth and caused the country to impose restrictions on movement to curb the spread of disease. The cultural response was that people united across cultural barriers to fight the pandemics as the population of the nation.
Influenza, commonly known as the flu, is caused by influenza viruses that infect the respiratory tract. The most common symptoms are fever, cough, sore throat, and body aches. While similar to the common cold, influenza is typically more severe. There are three main types of influenza viruses - A, B, and C. Type A is the most common cause of epidemics and can undergo antigenic drift or shift, which can cause pandemics. Influenza spreads through respiratory droplets from coughs or sneezes. High-risk groups like the elderly are more likely to experience severe complications from the flu.
Influenza is caused by RNA viruses of the Orthomyxoviridae family that infect the respiratory tract. There are three main types of influenza viruses - A, B, and C. Influenza A is further divided into subtypes based on two surface proteins and can undergo antigenic drift or shift. Influenza spreads through respiratory droplets from coughing or sneezing. Symptoms include fever, cough, sore throat and fatigue. Vaccination and antiviral drugs can help prevent and treat influenza.
This document discusses H1N1 influenza (swine flu). It provides an introduction to swine influenza viruses and how they can be transmitted from pigs to humans. It then discusses the history of swine flu in humans, including the 1918 Spanish flu pandemic. It describes outbreaks of swine flu that occurred in the US in 1976 and India in 2009. The document goes on to describe the influenza virus structure, transmission, pathogenesis and immunity. It notes that people at high risk for H1N1 include young children, elderly, pregnant women and those with chronic health conditions. The most common symptoms of the 2009 H1N1 pandemic are also summarized.
Influenza, commonly known as the flu, is a viral infection of the nose, throat, bronchi and occasionally the lungs. It is caused by influenza viruses of the family Orthomyxoviridae. Common symptoms include fever, sore throat, muscle pains, coughing and fatigue. While similar to other influenza-like illnesses like the common cold, influenza is typically more severe. Influenza viruses are classified into types A, B and C, with types A and B causing seasonal epidemics. The virus enters respiratory tract cells and causes inflammation. Complications can include pneumonia. Diagnosis involves virus isolation from nasal secretions or serological testing. Prevention is through annual flu vaccines that target the predicted circulating strains for
This document provides a review of swine flu (H1N1 influenza). It discusses how swine flu is caused by influenza viruses that typically infect pigs but can be transmitted from pigs to humans. The review summarizes the epidemiology and transmission of swine flu, noting it is highly contagious. It also describes the typical symptoms of swine flu in humans, which are similar to common flu, as well as potential severe complications like pneumonia. The review provides an overview of the pathogenesis of swine flu infection and highlights groups at increased risk of severe illness.
This document provides an overview of influenza virus. It discusses that influenza is caused by RNA viruses that affect birds and mammals. Common symptoms include fever, sore throat, and coughing. There are three types of influenza viruses - A, B, and C. Type A and B are responsible for epidemics and can undergo antigenic drift or shift. The virus enters through the respiratory tract. Prevention is through annual flu vaccines that target the most common strains expected that season.
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1. INFLUENZA
Lecture was prepared by
Candidate of Medicine, assosiate
professor of Sumy State University
Zakhlebaeva V.V.
2. INFLUENZA – sharp respiratory
virus disease with the air-drop
mechanism of the transfer,
characterised by the sharp
beginning, primary defeat of the
upper respiratory ways and the
general intoxication
3. Actuality:
• The Most widespread infection, is registered on all
continents.
•Improbable speed of distribution - for 1,5-2 weeks -
covers a city.
•During epidemic 30-50 % of the population fall ill.
•The Flu – an uncontrollable infection.
•Ability of a virus of a human flu to exchange the genetic
information with agents of an avian flu and of an animals
flu demands the further studying of a flu.
4. etiology
• Belongs to the group of orthomyxoviruses.
• Has the spherical form, diameter of 80-120 nm;
The kernel contains RNA and ribonucleid, defining an accessory to types A, B, C.
• The kernel is surrounded by a membrane, which consists of a double lipid
layer and of a membrane fiber.
• The Cover contains hemagglutinin (HA) and neuraminidase (NA).
• Hemagglutinin and neuraminidase are factors of aggression of a virus of a
flu.
• Hemagglutinin defines an intoxication, neuraminidase renders
immunosuppresive action.
• The flu Virus has 12 types НA and 9 types NA. HA 1,2,3 types and NA 1,2
types are peculiar to viruses of a flu of the person.
• NA and HA have high changeability. Antigene drift – little changes in
structure HA, it is carried out continuously, from year to year. Full replacement НA
and NA a new antigene variant is called as antigene shift. Shift registered 1 time in
10 - 12 years.
Viruses are unstable in an environment, and dies at a room temperature in couple
hours. At 50-600С inactivated in few minutes, at freezing remains for years
5. Influenza A viruses:
Influenza A viruses includes avian,swine, equine and canine influenza viruses, as
well as the human influenza A virus. Influenza A viruses are classified into 2
subtypes based on their surface antigens H and N proteins. There are 16
hemagglutinin antigens (H1-H16) and 9 Neuraminidase antigens( N1-N9). These
2 proteins are involved in cell attachments and released from cells, and are also
major targets for new response. Only limited subtypes are found in each species
of mammal. Influenza A viruses are also classified into strains. Strains of
Influenza viruses are described by their type, host, place of first isolation, strain
number, year of isolation and antigenic subtype.
Antigenic shift and drift in Influenza A viruses:
• Influenza A viruses change frequently. Strains evolve as they accumulate point
mutations during virus replication; this process is sometimes called ‘antigenic
drift’. A more abrupt change can occur during genetic reassortment.
Reassortment is possible whenever 2 different influenza viruses infect a cell
simultaneously. Reassortment between 2 subtypes can result in the emergence of
a new subtype. Reassortment can also occur between avian, swine, equine,
canine and human influenza A virus resulting in a ‘hybrid’ virus , for example both
avian and human influenza virus proteins
• An abrupt change in the subtypes found in a host specie is called an “antigenic
shift”
6. Antigenic shift can result from 3 mechanisms;
• Genetic reassortment between subtypes.
• The direct transfer of a whole virus from one host species to another.
• Re-emergence of a virus that was found previously in a specie, but is no
longer in circulation. E.g Human viruses can continue to circulate in pigs
and could re-emerge into human population
Antigenic shift and drift can result in periodic emergence of novel influenza
viruses. By evading the immune response, these viruses can cause
influenza epidemics and pandemics.
Avian influenza virus
Avian influenza viruses circulates in a variety of domesticated and wild birds.
They are isolated occasionally from mammals including humans. They are
classified as either high pathogenicity (HPAI) or low pathogenicity (LPAI)
viruses based on genetic features of the virus and the severity of disease in
experimentally inoculated chickens. HPAI viruses usually cause severe
disease in poultry while LPAI are generally much milder. HPAI viruses
contain the H5 or H7 hemagglutinin ; subtypes that contained other
hemagglutinins have been found only in the LPAI form .
7. SWINE INFLUENZA VIRUSES
• This mainly affects pigs but they can cause disease in turkeys. Outbreaks
have been described recently in FERRETS and MINK. One H1N1 swine
influenza virus which was avirulent for both poultry and pigs was isolated
from a dog in HONGKONG and experimental infections have been reported
in calves. The most common subtypes currently found in pigs are H1N1,
H1N2, H3N2; however the situation is complex as two or more viruses of
each subtype are circulating in swine populations. One H1N1 virus found in
North America is the “classical” H1N1 swine influenza virus. This virus, the
first influenza virus known to have infected pigs was first detected in swine
population in 1918. An “asian -like” H1N1 virus circulates mainly in
European pigs.
• In North America some of the most important swine influenza viruses are
the triple reassortant H3N2 viruses. These viruses first emerged in the US
pigs in the late 1990s, mainly in the mid-west and they have been detected
in Canada since 2005. The H3N2 triple reassortant viruses contain
hemagglutinin and neuraminidase proteins from a human influenza virus
and internal proteins from the classical swine influenza virus, an avian
influenza virus and a human influenza virus. The particular combination of
internal genes carried by these viruses is known as the triple reassortment
internal gene (TRIG) cassette..
8. • The H1N2 viruses in the US is a reassortant of the classical H1N1 swine
influenza virus and the North American triple reassortant H3N2 virus. The
H1N2 virus in Europe is a reassortant of a human H1N1 virus and the
human-like European H3N2 virus.
• New subtypes have also been found in some swine populations. The novel
subtype H3N1 has recently been isolated from pigs in the US. This subtype
appears to contain genes from human, swine and avian influenza viruses. A
different H3N1 influenza virus containing human and swine influenza virus
genes has been found in Korea.
The NOVEL H1N1 VIRUS OF SWINE ORIGIN.
• In 2009, a novel H1N1 virus which seems to have originated from one or
more swine influenza viruses emerged in human populations. This virus
appears to be a reassortant between north America and Eurasian swine
influenza viruses. It contains a hemagglutinin gene that is most closely
related to swine influenza virus in North America, a neuraminidase gene that
is related to swine influenza viruses in Eurasia and internal genes from two
or more swine influenza viruses including the North America triple
reassortant H3N2 viruses and the Eurasian virus.
9. HUMAN INFLUENZA A VIRUS.
• These are mainly found in people , but they can also infect ferrets and
sometimes swines.
• Human viruses can also replicate to a limited extent in the nasal epithelium
of experimentally infected horses. H1N1,H1N2 and H3N2 viruses are
currently in general circulation in humans. H1N2 viruses were first seen in
human population in 2001, probably as a result of genetic reassortment
between the H3N2 and H1N1 viruses. H2N2 viruses circulated in the human
population between 1957 and 1968. A novel H1N1 virus emerged in human
population in 2009.
• Human influenza viruses change frequently as a result of antigenic drift, and
occasionally as a result of antigenic shift. Human pandemics resulting from
antigenic shifts were most recently reported in 1918, 1957, 1968 and 2009.
Influenza A viruses in other species .
• These viruses are occasionally isolated from outbreaks or isolated cases in
other species of mammals.
• Avian influenza viruses have infected pinnipeds, cetaceans and mink; and
swine influenza viruses have caused outbreak in mink and ferrets.
Antibodies to influenza viruses have been detected in other species
including raccoons, cattle , yak, sheep, goats , reindeers, and deer and a
variety of mammals have been infected experimentally.
10. INFLUENZA B VIRUS.
• Influenza B viruses are known to circulate only in human populations.
• These viruses can cause epidemics, but they have not till date been
responsible for pandemics.
• They have also been found occasionally in animals. Influenza B viruses are
categorized into lineages rather than subtypes. They are also classified into
strains. These viruses undergo antigenic drift, though it occurs more slowly
than in influenza A viruses. Until recently, the B/Victoria/2/87 lineage
predominated in the human populations, and influenza B viruses were said
not to undergo antigenic shift. In the 1990s, viruses of the
B/Yamagata/16/88 lineage circulated to a very limited extent in Asia. This
lineage emerged in various parts of the world in 2001 and it is now co-circulating
with the B/Victoria/2/87. Recent evidence suggests that
recombination between this two lineages is resulting in antigenic shifts.
11. INFLUENZA C VIRUSES
• These viruses circulate in human [populations and are mainly associated
with diseases in people. Until recently, they had never been linked to large
scale epidemics. However, a nation-wide epidemic of influenza C was
reported in Japan between January and July 2004. These viruses have also
been found in animals. They are not classified into subtypes but into strains.
Each strain is antigenically stable , and accumulates few changes over time.
Recent evidence suggest that reassortment occurs frequently between
different strains of influenza C viruses.
12. Epidemiology:
• An infection Source – the sick person or a virus carrier
(that is not proved).
• The person in the first 2 days of disease is most
infectious.
• The Virus of a flu A have most changeable antigen. It
causes annual seasonal lifting the diseases everyone of 2-3
years – the epidemic flashes everyone of 10-30 years –
pandemics (owing to antigene shift).
• The flu Virus B does not cause a pandemic. Causes
disease lifting once in 3-4 years, epidemics – in 5-7 years.
• The Virus of a flu C causes sporadic cases.
• The transfer Mechanism – air-drop.
• The Susceptibility – very high in all age groups.
• Seasonal prevalence - in winter months.
13. Pathogenesis:
1. Penetration and virus reproduction into cells of the upper
respiratory ways. The main target of a virus – cylindrical ciliated
epithelium. The virus overcomes factors of nonspecific resistance of the
upper respiratory ways:
• Viscous properties of slime;
• Constant movement of ciliated epithelium;
• Nonspecific inhibitors of a virus replication;
• Macrophages;
• Ig A;
• Interferons.
2. A virus exit in intercellular space, destruction of the damaged
cells – catarrhal syndrome, virusaemia;
3. virusaemia, toxaemia – neurotoxic action, a fever,
capillarotoxicosis, immunosuppresion, defeats of organs, a secondary
infection, complications;
4. recovering, immunity formation.
14. Flu classification
1. Serological virus type: A (H1N1, H2N2, H3N2), B, C.
2. Clinical forms:
• Typical (intoxication syndromes, catarrhal)
• The atypical:
a) without high temperature;
b) without catarrhal sympthoms;
c) fulminant.
3. On severity of disease: light, medium, hard, hypertoxic.
4. On presence of complications:
• With complications: a sinusitis, an otitises, a meningitis, an
encephalitis, a myocarditis, a pneumonia, a bronchiolitis, a bronchitis, a
pyelonephritis.
• Without complications.
The diagnosis:
Flu A (H2N2), the typical form, an easy current.
15. Clinic
1. The incubatory period from several hours till 1 days;
2. Allocate 2 basic of a syndrome – intoxication and catarrhal;
3. The beginning is sharp; a fever;
4. The temperature raises to 39-40 0C;
5. The maximum expressiveness of illness in the first day;
6. A headache sharp in fronto-temporal and eyebrow areas;
7. A photophobia, a pain in the eyeballs, amplifying at their
movement;
8. Muscular pains, weakness, adinamia;
9. Hyperemia of face, an injection of vessels of white of the eye;
10. A herpetic rash on lips and nose wings;
11. Bright hyperemia of mucous of oropharinx;
12. Granularity of a back wall of pharynx (Morozkin’s symptom);
13. A tachycardia, systolic noise on a top of the heart, a hypotonia;
14. Since 2-3rd day moderately expressed a catarrhal syndrome;
15. A tracheitis;
16. The temperature keeps 2-3 days, then decreases critically or by
truncated lisis
16. • Uncomplicated infections with human influenza A or B viruses are usually
characterized by upper respiratory symptoms, which may include fever,
chills, anorexia, headache, myalgia, weakness, sneezing, rhinitis, sore-throat
and non-productive cough.
• Diarrhea , abdominal pain and photophobia are also possible. Most people
recover in 1-7 days, but in some cases the symptoms may last up to two
weeks or longer.
• More severe symptoms including pneumonia can be seen in some
individuals especially those with chronic respiratory or heart disease.
Secondary bacterial or viral infections may also occur. In addition, influenza
A had been associated with encephalopathy, transverse myelitis, Reye
syndrome, myocarditis , pericarditis and myositis. Because influenza C
viruses are difficult to isolate, there are few reports on their clinical features.
• Some recent descriptions suggests that clinical cases may be
indistinguishable from influenza A or B. In one recent study, the most
common clinical signs were fever, cough and rhinorrhea, but 29 of 179
children were hospitalized with more serious illnesses such as pneumonia,
bronchitis or bronchiolitis. Serious disease was most common in children
less than 2years of age. Fever and cough were the most common signs in
14 patients from France, with rhinitis, pharyngitis, wheezing, and otitis in
some individuals.
17. • In most people , the novel H1N1 virus causes a relatively mild illness which
resembles the disease caused by other human influenza viruses. Vomiting
and diarrhea have been reported in a significant number of cases. Most
people have self limiting illness , and recover within a week . Severe primary
viral pneumonia or acute respiratory distress syndrome occur in a small
percentage of cases and maybe fatal. Patients who become severely ill
usually begin to deteriorate 3-5 days after the onset of the symptoms, and
their condition rapidly becomes serious, often progressing to respiratory
failure within 24 hours.
• Multiple organ failure may be seen. Like other influenza viruses, the novel
H1N1 virus can also exacerbate chronic medical conditions, especially
respiratory diseases such as asthma or COPD and some cases maybe
complicated by secondary bacterial infection.
18. Flu complications
1. The complications caused by direct action
of a virus: toxic hemorrhagic hypostasis of
lungs, a false croup, glomerulonephritis, a
brain hypostasis, arachnoiditis, a Rey’s
syndrome; a syndrome of sudden death;
2. The Complications caused by a secondary
infection: a pneumonia, diseases of LOR-ORGANS
(a sinusitis, an otitis, a
pharyngitis, an antritis, etc.).
19. Flu Diagnostics
1. The REEF (slime from oropharynx);
2. Virologic research on a chicken embryo;
3. Serological research – HAR, RHAI,CB;
4. The immunefluorescent method.
CRITERIA OF THE DIAGNOSIS
1.
1. The epidemiological diagnosis (disease lifting in a cold season);
2. A sharp, sudden onset of the illness;
3. Prevalence intoxication over a catarrhal syndrome (tracheitis);
4. Appearance of the patient («face of the tear-stained child»);
5. Poured hyperemia an oral cavity mucous membrane;
6. Leucopenia with relative lymphocytosis at normal ERS.
20. Flu treatment
Hospitalisation – on epidemical indications (hotel accommodation, a hostel) and
clinical (a heavy current with hypertermia, meningeal symptoms, vomiting, spasms,
etc.,).
Etiotropic therapy:
Remantadin: 1 days 0,1 г х 3 times, 2 and 3 days on 0,1 g х 2 times a day;
Antiinfluenza gamma-globulin – on 3-6 ml х 2 times a day in muscle;
Interferon leukocytic or recombinant α - interferon (inhalations, drops in a nose);
0,25 % oxolini ointment in nasal courses.
• Children of first 2 years of a life and elder people
•Supportive care for uncomplicated Influenza in humans include fluids and rest. More
severe cases or infectious that have an elevated risk of complications may be
treated with anti viral drugs.
Four(4) drugs are used to treat Influenza, they are Amantadine, Rimantadine,
Zanamivir, and Oseltamivir.
•Amantadine and Rimantadine (Adamantanes) are active against human influenza
A viruses if treatment is begun within the first 48 hours.
•Zanamivir and Oseltamivir are effective for both Influenza A and B. Side effects
including neuropsychiatric events may occur.
21. • Testing must be done to determine each individual drug susceptibility. Drug
resistance develops rapidly in viruses exposed to Amantadine and
Rimantadine and may emerge during treatment.
• During the 2006 to 2008 flu seasons, human influenza viruses circulating in
the US and Canada exhibited high resistance to Rimantadine and
Amantadine. The CDC recommends that this two (2) drugs be avoided until
the circulating strains become susceptible again.
• Laboratory studies have shown that influenza viruses can also become
resistant to Zanamivir and Oseltamivir, however this appears to be less
common than resistance to Rimantadine.
• The novel (swine origin)H1N1 virus circulating among humans in 2009 is
resistant to Amantadine and Rimantadine but sensitive to Oseltamivir and
Zanamivir.
• Oseltamivir appears to increase the chance of survival in patients infected
with asian lineage H5N1 viruses, particularly if it is given early. These
viruses are resistant to Amantadine and Rimantadine. Although resistance
to Zanamivir and Oseltamoivir has also been reported in H5N1 viruses, it
is currently uncommon
22. Pathogenetic therapy:
• Light febrifugal at very high temperature (analginum, мефенамовая acid,
ibuprofen,paracetamol);
• Plentiful drink (2-2,5 l a day) from broths and infusions of medicinal grasses
(lime colour, tea with a lemon, a raspberry, a cranberry);
• Mustard plasters (is reflex improve blood circulation in respiratory organs);
• Ascorbic acid, ascorutin;
• Antihistaminic preparations (Tavegil, Diasolin);
• Immunomodulators (Methyluracil 0,5 г х 4 times a day, 4-5 days; Amizon
0,25 г х 3 times a day, 5 days; Arbidol, etc.);
• Mucolytic (a grass of thermopsis, mucaltin, АCC, etc.)
Indications for prescription of antibiotics at flu:
• Chronic centre of an infection;
• Signs of joining of a secondary infection (complication);
• The long fever (more than 5 days);
23. Flu preventive maintenance
Nonspecific seasonal preventive maintenance: training,
vitamins, adaptogens (tincture элеутерококка,
заманихи, эхинацеи), immunomodulators
(мефенамовая acid, Arbidol, Amozon, Interferon,
Amixin, etc.).
Specific preventive maintenance: an antiinfluenza
vaccine "Vaksigripp" (France), "Fljuariks" (Belgium),
"Influvak" (Netherlands), "Grippol" (Russia), «Infiksal In»
(Switzerland). The vaccine contains epidemicaly actual
types a virus of a flu of 3 types, recommended the
CART for an epidemic season.