gold (Au) nanoparticles (in medicine)

1. Bi of
Gold Sanoparficles
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2. • Most stable metal nanoparticles
• Biocompatibility
• Lack of toxicity
• Ease of functionalization
• Relatively inert in biological systems.
Synthesis Methods
galvanic
• bitrate-mediated reduction
• Seeded growth (CTAB)
• Nanosphere self-assembly
• PW-stabilized polyol,
displacement
• Alkanethiol/phosphine-stabilized
reduction
• Hydrothernial methods

3. Optical Properties of AuNPs
Surface plasmon resonnnce (SPR)
• When AuNPs are irradiated with light of specific frequencies, which results in the
collective oscillation of electrons along the metallic surface.
• Depending on the size and shape of the nanoparticle, that resonance results in a strong
absorption band that appears in a certain region of the electromagnetic spectrum.

4. Functionalization of AuNPs
• DNA/RNA, oligonucleotide, peptides and antibodies, fluorescent dyes, polymers,
drugs, tumor markers, enzymes and other proteins.
• Conjugation strategy dependent on a number of factors such as Size of the partiCle, its
surface chemistry, as well aS the type Ofligands and functional groups added to the
system.

5. Applications
Piegncstics Therat›rutics

6. Phututhei mal & photudynamic therapy mediated bj GhPs
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Laser
photodyniimic therapy
Cell death
Photothermal therapy
Turn ral t ell Near InfmRed NIR] Light
Cell death

7. Biosensing
• Unique optical and electronic properties
• Biocompatibility.
Alulticolor Biosensor
SPR biosensors
The fluorescence quenching and
enhancing abilities of GNPs have
also been exploited for the detection
of biomolecules

8. Gold Nanoparticles as Drug Carrier
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