This document proposes a diagnostic platform that leverages existing personal glucose meters to provide direct readouts of target concentrations in patient samples. It suggests using this platform for therapeutic drug monitoring in clinical trials, medical diagnoses, and environmental detection. The initial target market was seen as diabetes patients who already own glucose meters and need HbA1c monitoring. However, immediate drug monitoring during clinical trials was identified as a better market that meets the value propositions of immediacy, low cost, multiple tests, and short development cycles. Partnerships with pharmaceutical companies are proposed, with GlucoSentient providing added value to meter manufacturers and the pharmaceutical companies being key customers and providing financial support.
Lawsuit against WCSD alleges breach of contract, lying to courtThis Is Reno
The Washoe County School District was hit again with another lawsuit from a former employee. The suit, filed Friday, alleges that the District’s attorney lied to a judge and violated the Nevada Public Records Act. It also claims that administrators conspired to oust former Superintendent Traci Davis and fired an administrator in violation of a settlement agreement.
This Is Reno’s second public records lawsuit against the City of Reno and Ren...This Is Reno
This Is Reno is suing the city of Reno and Reno Police Department for failing to follow the Nevada Public Records Act. The suit alleges continued violations of state records law, including failing to follow mandated deadlines and not providing reasonable estimates as to when records will be made public. Examples include the city closing records requests without ever providing records and making requesters wait more than a year for records, including body cam footage. It’s the second lawsuit filed by the news media outlet against the city.
The Seven Misconceptions Of Youth MarketingPaul MacGregor
As a youth marketer it's easy to fall back onto your own assumptions about the best way to connect with young people. After all, you were young once, you think you're still a little bit cool, you see kids on the street and (if you're really smart) you read blogs like this.
This Seven Misconceptions presentation is just a little how-to-guide on how to avoid some of the more obvious pitfalls in youth marketing. You'll live by some, a couple may reaffirm what you know already and I hope a few may surprise you. If you take nothing away from it you are doing everything right. Well done.
Sheriff’s deputy, county investigator sue Reno Police Department, former chiefThis Is Reno
A Washoe County Sheriff’s deputy and an investigator with the district attorney’s office last week filed a civil rights lawsuit against the Reno Police Department and former Police Chief Jason Soto. Also named in the litigation is a retired RPD Sergeant, Paul Sifre, who is alleged to have sexually harassed the two plaintiffs.
Apryl McElroy, a detective with the Washoe County Sheriff’s Office, and Jessica Troup, an investigator with the Washoe County District Attorney’s office (previously with University Police Services), both allege Sifre made sexually explicit comments to them while at a conference in Las Vegas. Rather than addressing the issue—and what they called longstanding problematic behavior by Sifre—the plaintiffs allege he received a lucrative disability retirement instead.
Lawsuit against WCSD alleges breach of contract, lying to courtThis Is Reno
The Washoe County School District was hit again with another lawsuit from a former employee. The suit, filed Friday, alleges that the District’s attorney lied to a judge and violated the Nevada Public Records Act. It also claims that administrators conspired to oust former Superintendent Traci Davis and fired an administrator in violation of a settlement agreement.
This Is Reno’s second public records lawsuit against the City of Reno and Ren...This Is Reno
This Is Reno is suing the city of Reno and Reno Police Department for failing to follow the Nevada Public Records Act. The suit alleges continued violations of state records law, including failing to follow mandated deadlines and not providing reasonable estimates as to when records will be made public. Examples include the city closing records requests without ever providing records and making requesters wait more than a year for records, including body cam footage. It’s the second lawsuit filed by the news media outlet against the city.
The Seven Misconceptions Of Youth MarketingPaul MacGregor
As a youth marketer it's easy to fall back onto your own assumptions about the best way to connect with young people. After all, you were young once, you think you're still a little bit cool, you see kids on the street and (if you're really smart) you read blogs like this.
This Seven Misconceptions presentation is just a little how-to-guide on how to avoid some of the more obvious pitfalls in youth marketing. You'll live by some, a couple may reaffirm what you know already and I hope a few may surprise you. If you take nothing away from it you are doing everything right. Well done.
Sheriff’s deputy, county investigator sue Reno Police Department, former chiefThis Is Reno
A Washoe County Sheriff’s deputy and an investigator with the district attorney’s office last week filed a civil rights lawsuit against the Reno Police Department and former Police Chief Jason Soto. Also named in the litigation is a retired RPD Sergeant, Paul Sifre, who is alleged to have sexually harassed the two plaintiffs.
Apryl McElroy, a detective with the Washoe County Sheriff’s Office, and Jessica Troup, an investigator with the Washoe County District Attorney’s office (previously with University Police Services), both allege Sifre made sexually explicit comments to them while at a conference in Las Vegas. Rather than addressing the issue—and what they called longstanding problematic behavior by Sifre—the plaintiffs allege he received a lucrative disability retirement instead.
Making a commercial success of new products and services dec 11Paul Fileman
An overview of the theory and practice of go to market planning for breaktrough products and services. Based on "Crossing the Chasm" by Geoffrey Moore with added elements around Value Proposition.
Emergency Surgery Workshop Davos 2011: Presentation by Prof Markus Furrer, MD, President Academia Raetica and Head of Surgery Department, Cantonal Hospital Chur, Chur, Switzerland
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Team Networks - 2022 Technology, Innovation & Great Power CompetitionStanford University
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Team Acquistion - 2022 Technology, Innovation & Great Power Competition Stanford University
Technology Innovation and Great Power Competition,TIGPC, Gordian knot Center, DIME-FIL, department of defense, dod, intlpol 340, joe felter, ms&e296, raj shah, stanford, Steve blank, AI, ML, AI/ML, china, Acquistion
Team Climate Change - 2022 Technology, Innovation & Great Power Competition Stanford University
Technology Innovation and Great Power Competition,TIGPC, Gordian knot Center, DIME-FIL, department of defense, dod, intlpol 340, joe felter, ms&e296, raj shah, stanford, Steve blank, AI, ML, AI/ML, china, climate
Team Army venture capital - 2021 Technology, Innovation & Great Power Competi...Stanford University
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Team Army venture capital - 2021 Technology, Innovation & Great Power Competi...Stanford University
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Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
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Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
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Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
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2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Model Attribute Check Company Auto PropertyCeline George
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Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
1. *
Direct Read Out of
Target Concentration!
Drug/Targets
of Patient Samples
interest (Blood/Saliva/
Urine )
Personal Glucose Meter
* Diagnostics platform leveraging personal glucose meters:
Therapeutic drug monitoring (TDM)
Clinical trial companion diagnostics
Medical diagnosis of many diseases
Environmental detection of contaminants
~100 GOOTB connections Gluco = Glucose
Sentient = Responsive to, perceptive or aware
3. *
* Diabetes patients were our initial target market
* Existing glucose meter + need to measure HbA1c
* Key value propositions
* Low cost More frequent tests and
* Home testing better diabetes
management
* Already have PGM Total available
market = $1.2
* Large market billion
* Patient population is huge
Serviceable Available
Market = $600 million
Target market
= $120 million
4. Business Model Canvas #1
Yi Lu, Tian Lan
Sweet Sensors Neil Kane 10-11--2011
Chris Sorensen
Conferences
Product R&D Diabetics
At home Product supports
Glucose monitor QC Clinicians (in rural area)
Convenient Patient
manufacturers
Marketing network/community Triage nurses
Less exposure to
Kit manufacturers infectious diseases Pre-diabetics
in the hospital
Reagent suppliers
Cheaper
More frequent Retailers (Walgreen)
IP
Personnel Better indicator of Online vendors (Amazon)
health (diabetic
management) Direct sales
Reagents
Manufacture
Disposable test kit (used repeatedly
Licensing on a regular basis)
FDA certification?
5. *
(I) spent a lot of time,
money looking at this
(HbA1c) market for
LifeScan – stay away. The best test is one
where the result
affects the behavior.
Find a test where
immediate results have
value.
6. *
“You might even have a
flexible Drugs of Abuse
Analyzer “Bank” which
is actually a rack which
holds a number of small
individual analyzers.”
“The “Holy Grail” now is
matching drug dosages to
individual patients based on a
wide range of factors (age,
weight, gender, ethnicity, body
chemistry, etc.)
So ONE DOSE DOES NOT FIT
ALL”
7. *
* Immediacy
* Inexpensive/cost savings
* Multiple tests
* Short and inexpensive
development cycles
…….became our value propositions
8. *
* Home monitoring of HbA1c does not meet
immediacy requirement
* Large effort is necessary to promote the usage of
home HbA1c test kit in the US
* Competition from product from Bayer
* Large regulatory hurdle
* One market that meets all the value
propositions is drug monitoring during
clinical trials and after the market
9. Business Model Canvas #4
Yi Lu, Tian Lan
Sweet Sensors Neil Kane 10-25-2011
Chris Sorensen
Conferences
Product R&D Immediacy
Glucose monitor Out of clinic Diabetics
QC Marketing Product support
manufacturers
- Abbott? Clinicians (in rural area)
FDA approval for in Convenient Patient
vitro diagnostics network/community
Pre-diabetics
Kit manufacturers
Food safety and
Reagent suppliers security related
Cheaper
Drug monitoring
KOL More frequent Retailers (Walgreen)
IP Personnel Medical Products Distributors
Pharmaceutical Cos
Disposable test kit (used repeatedly
Reagents Licensing on a regular basis)
Manufacturing FDA approval for in Reimbursement strategy
vitro diagnostics
Licensing Sponsored development or JDA
10. Business Model Canvas #5
Yi Lu, Tian Lan, Brian Wong
Sweet Sensors Neil Kane 11-01-2011
Chris Sorensen
Conferences
R&D
Pharmaceutical Pharmaceutical
QC
companies One to one companies for
Immediacy
Therapeutic Drug
Glucometer/strip Long term Monitoring (TDM)
Convenient monitoring
manufacturer and safer dosage
Exclusive
Pharmaceutical Cos
IP
Pharmaceutical Cos
Personnel
Licensing
R&D Sales (to pharmaceutical companies)
11. *
* Better drug monitoring reduces the costs of drug
development
* “One-drug-for-all” is gone; new drugs are more likely
to be effective for certain patients at certain dosage.
* They are willing to provide financial support
* They only want to buy the final products
* Therefore we need to find partners
12. *
Glucose meter GlucoSentient, Inc. Pharmaceutical
companies companies
Provide the
Meter targets
Added value for meter
engineering Key customers
manufacturers
Strip design Low cost, fast Key market
FDA approval monitoring improves knowledge
clinical trials for
pharmaceutical
13. Business Model Canvas #7
Yi Lu, Tian Lan, Brian Wong
Sweet Sensors Neil Kane 11-15-2011
Chris Sorensen
Conferences
R&D
Pharmaceutical Immediate results Pharmaceutical
companies Publicity companies for
Direct
Convenient monitoring Therapeutic Drug
Insurance and safer dosage Monitoring (TDM)
Glucometer mfr Long term
Reimbursement
Strip mfr Robust/extensible Diagnostic
companies
Diagnostics Inexpensive
companies Contract research
Simple Pharmaceutical Cos organizations
IP Investors
Contract research
organizations Personnel
Pharmaceutical Cos
Licensing Licensing?
R&D Product Sales
14. *
Conventional
Development costs
Lab Test
POC tests
Our Technology
Time to obtain the test results
15. *
Total available market
~$20 billion
Serviceable available
Market ~ 2 billion
Target market
~$645 million
Source: American Association for Clinical Chemistry
Source: Point of Care Testing, Biophoenix 2010
Axis Shield (clinic based, fluidics Claros (sensitive fluidics device for HIV
tests for HbA1c, CRP…)acquired detection using antibodies) acquired
Alere for $366 million (10/2011) for $46 million by OPKO (11/2011)
16. *
* Pitch to other pharmaceutical and diagnostic companies
* Develop prototype for the BEST targets in therapeutic drug
monitoring to demonstrate our technology
* Apply SBIRs to reduce technical risks
* License the technology from the University of Illinois
* Move into the Research Park at the University of Illinois
through the I-Start program
17. Business Model Canvas #1
Yi Lu, Tian Lan
Sweet Sensors Neil Kane
Chris Sorensen
Conferences
Product R&D
Glucose monitor At home Diabetics
QC Product supports
manufacturers
Clinicians (in rural area)
Marketing Convenient Patient
Kit manufacturers network/community Triage nurses
Less exposure to
Reagent suppliers infectious diseases Pre-diabetics
in the hospital
Cheaper
More frequent Retailers (Walgreen)
IP
Personnel Better indicator of Online vendors (Amazon)
health (diabetic
management) Direct sales
Reagents
Manufacture
Disposable test kit (used repeatedly
Licensing on a regular basis)
FDA certification?
18. Business Model Canvas #2
Yi Lu, Tian Lan
Sweet Sensors Neil Kane
Chris Sorensen
Conferences
Product R&D
Glucose monitor At home Diabetics
*
QC Marketing Product supports
manufacturers
Clinicians (in rural area)
FDA approval for in Convenient Patient
Kit manufacturers vitro diagnostics network/community Triage nurses
Less exposure to
Reagent suppliers infectious diseases Pre-diabetics
in the hospital
Cheaper
IP Personnel More frequent Retailers (Walgreen)
Better indicator of Online vendors (Amazon)
KOL
health (diabetic
management) Direct sales
Reagents
Manufacture
Disposable test kit (used repeatedly
Licensing on a regular basis)
FDA approval for in
vitro diagnostics
19. Business Model Canvas #3
Yi Lu, Tian Lan
Sweet Sensors Neil Kane 10-18-2011
Chris Sorensen
Conferences
Product R&D Immediacy
Glucose monitor At home Diabetics
*
QC Marketing Product supports
manufacturers
Clinicians (in rural area)
FDA approval for in Convenient Patient
Kit manufacturers vitro diagnostics network/community
Less exposure to
Reagent suppliers infectious diseases Pre-diabetics
in the hospital
Food safety and
Cheaper security related
IP Personnel More frequent Retailers (Walgreen)
Better indicator of Online vendors (Amazon)
KOL
health (diabetic
management)
Reagents
Manufacture
Disposable test kit (used repeatedly
Licensing on a regular basis)
FDA approval for in
vitro diagnostics
20. Business Model Canvas #4
Yi Lu, Tian Lan
Sweet Sensors Neil Kane 10-25-2011
Chris Sorensen
Conferences
Product R&D Immediacy
Glucose monitor Out of clinic Diabetics
*
QC Marketing Product support
manufacturers
- Abbott? Clinicians (in rural area)
FDA approval for in Convenient Patient
vitro diagnostics network/community
Pre-diabetics
Kit manufacturers
Food safety and
Reagent suppliers security related
Cheaper
Drug monitoring
IP Personnel More frequent Retailers (Walgreen)
Medical Products Distributors
KOL
Pharmaceutical Cos
Reagents Disposable test kit (used repeatedly
on a regular basis)
Manufacture
Reimbursement strategy
Licensing
FDA approval for in Licensing Sponsored development or JDA
vitro diagnostics
21. Business Model Canvas #4
Yi Lu, Tian Lan
Sweet Sensors Neil Kane 10-25-2011
Chris Sorensen
Conferences
Product R&D Immediacy
Glucose monitor Out of clinic Diabetics
*
QC Marketing Product support
manufacturers
- Abbott? Clinicians (in rural area)
FDA approval for in Convenient Patient
vitro diagnostics network/community
Pre-diabetics
Kit manufacturers
Food safety and
Reagent suppliers security related
Cheaper
Drug monitoring
KOL More frequent Retailers (Walgreen)
IP Personnel Medical Products Distributors
Pharmaceutical Cos
Reagents Disposable test kit (used repeatedly
on a regular basis)
Manufacture
Reimbursement strategy
Licensing
FDA approval for in Licensing Sponsored development or JDA
vitro diagnostics
22. Business Model Canvas #5b
Yi Lu, Tian Lan, Brian Wong
Sweet Sensors Neil Kane 11-01-2011
Chris Sorensen
Conferences
R&D
Pharmaceutical Pharmaceutical
*
QC
companies One to one companies for
Immediacy
Therapeutic Drug
Glucometer/strip Long term Monitoring (TDM)
Convenient monitoring
manufacturer and safer dosage
Exclusive
Pharmaceutical Cos
IP
Pharmaceutical Cos
Personnel
Licensing
R&D Sales (to pharmaceutical companies)
23. Business Model Canvas #6
Yi Lu, Tian Lan, Brian Wong
Sweet Sensors Neil Kane 11-01-2011
Chris Sorensen
Conferences
R&D
Pharmaceutical Pharmaceutical
*
QC
companies One to one companies
Immediacy
Glucometer/strip Convenient monitoring Long term Glucometer/strip
manufacturer and safer dosage manufacturer
Diagnostics Exclusive Diagnostic
companies company
Contract research Contract research
Pharmaceutical Cos
organization organization
IP
Pharmaceutical Cos
Personnel
Licensing
R&D Sales (to pharmaceutical companies)
24. Business Model Canvas # 7 w/changes
Yi Lu, Tian Lan, Brian Wong
Sweet Sensors Neil Kane 11-08-2011
Chris Sorensen
Conferences
R&D
Pharmaceutical Pharmaceutical
*
QC
companies Direct companies
Immediacy
Publicity
Glucometer/strip Convenient monitoring Long term Glucometer/strip
manufacturer Insurance Reimbursement and safer dosage manufacturer
Diagnostics Exclusive Diagnostic
companies companies
Inexpensive
Contract research Pharmaceutical Cos Contract research
Pharmaceutical Cos Simple
organizations organizations
IP Investors
Glucometer mfr Robust/extensible
Strip mfr Personnel
Licensing Licensing?
R&D Product Sales
25. Business Model Canvas # 8
Yi Lu, Tian Lan, Brian Wong
Sweet Sensors Neil Kane 11-15-2011
Chris Sorensen
Conferences
R&D
Pharmaceutical Immediate results Pharmaceutical
*
companies Publicity companies
Direct
Convenient monitoring
Diagnostics Insurance Reimbursement and safer dosage Long term
companies Diagnostic
Robust/extensible companies
Contract research
organizations
Inexpensive Contract research
organizations
Simple Pharmaceutical Cos
Pharmaceutical Cos
Glucometer mfr IP Investors
Strip mfr Personnel
Licensing Licensing?
R&D Product Sales
26. *
* NSF I-Corps program
* The I-Corps teaching team
28. *
GlucoSentient
Glucose meter Pharmaceutical /
manufacturer • Added value for diagnostic companies
• Meter engineering meter manufacturers • Provide the target of
• Strip design • Low cost, fast interest
• FDA approval monitoring improves • Key customers
clinical trials • Key market
knowledge
Editor's Notes
ImmediacyInstant results gives a reaction time advantage over tests done in a lab settingInexpensiveBy taking tests out of the lab and letting patients do them at home, we can save insurance companies a lot of money. Potential advantage in emerging markets too. Multiple testsMultiple tests (markers) for the same health care issue (glucose and cholesterol for diabetics, for example) leverage the same device. This translates into cost advantage, efficiency for the patience and may improve compliance. Short and inexpensive development cyclesMakes it practical to develop POC tests for indications with small populations such as during drug clinical trials