Global Medical Cures™ | Blood disorders
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This ppt includes information of Diseases related to Blood, How covid effected blood and Black Fungus.
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Blood cell disorders by hematologist in Pune at Onco Life Cancer CentreOnco Life Cancer Centre
A blood cell disorder is a condition in which there's a problem with red blood cells, white blood cells, or the smaller circulating cells called platelets, which are critical for clot formation.
For more info, please visit: https://www.oncolifehospitals.com/services/hematologist/
THE PRESENTATION INCLUDES INTRODUCTION, CLASSIFICATION( PRIMARY AND SECONDARY POLYCYTHEMIA), ETIOLOGY & PATHOPHYSIOLOGY, CLINICAL MENIFESTATIONS AND MANAGEMENT(MEDICAL AND NURSING) OF POLYCYTHEMIA.
This ppt includes information of Diseases related to Blood, How covid effected blood and Black Fungus.
Please go through the ppt and let me know your views.
AND FOLLOW, LIKE, SHARE AND COMMENT.
Blood cell disorders by hematologist in Pune at Onco Life Cancer CentreOnco Life Cancer Centre
A blood cell disorder is a condition in which there's a problem with red blood cells, white blood cells, or the smaller circulating cells called platelets, which are critical for clot formation.
For more info, please visit: https://www.oncolifehospitals.com/services/hematologist/
THE PRESENTATION INCLUDES INTRODUCTION, CLASSIFICATION( PRIMARY AND SECONDARY POLYCYTHEMIA), ETIOLOGY & PATHOPHYSIOLOGY, CLINICAL MENIFESTATIONS AND MANAGEMENT(MEDICAL AND NURSING) OF POLYCYTHEMIA.
Blood disorders can affect any of the three main components of blood:
Red blood cells, which carry oxygen to the body's tissues.
White blood cells, which fight infections.
Platelets, which help blood to clot.
Blood disorders can also affect the liquid portion of blood, called plasma.
Polycythemia is a rare bone marrow disorder, which causes the increase in the production of cells in the blood, mainly red blood cells. The primary function of the red blood cells is to carry oxygen to the different parts of the body.
Red blood cell (RBC) disorders are conditions that affect red blood cells, the cells of blood that carry oxygen from the lungs to all parts of the body.
INTRODUCTION
• Blood must be maintained in a fluid state in order to function as a transport system, but must be able to solidify to form a clot following vascular injury.
• Successful haemostasis is achieved by complex interactions between vascular endothelium, platelets, coagulation factors etc.
HAEMOSTASIS
• The term haemostasis is derived from the Greek word haem= blood and stasis=halt.
• Process of stoppage of bleeding after blood vessels are punctured , cut , or otherwise damaged.
• It is a complex natural physiological response.
• Bleeding disorders are due to altered ability of blood vessels, platelets , and coagulation factors to maintain haemostasis.
• Steps of natural haemostasis:
• Pre-injury conditions-> Early haemostatic response-> Fibrin clot formation-> Limiting clot formation-> Fibrinolysis
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Blood disorders can affect any of the three main components of blood:
Red blood cells, which carry oxygen to the body's tissues.
White blood cells, which fight infections.
Platelets, which help blood to clot.
Blood disorders can also affect the liquid portion of blood, called plasma.
Polycythemia is a rare bone marrow disorder, which causes the increase in the production of cells in the blood, mainly red blood cells. The primary function of the red blood cells is to carry oxygen to the different parts of the body.
Red blood cell (RBC) disorders are conditions that affect red blood cells, the cells of blood that carry oxygen from the lungs to all parts of the body.
INTRODUCTION
• Blood must be maintained in a fluid state in order to function as a transport system, but must be able to solidify to form a clot following vascular injury.
• Successful haemostasis is achieved by complex interactions between vascular endothelium, platelets, coagulation factors etc.
HAEMOSTASIS
• The term haemostasis is derived from the Greek word haem= blood and stasis=halt.
• Process of stoppage of bleeding after blood vessels are punctured , cut , or otherwise damaged.
• It is a complex natural physiological response.
• Bleeding disorders are due to altered ability of blood vessels, platelets , and coagulation factors to maintain haemostasis.
• Steps of natural haemostasis:
• Pre-injury conditions-> Early haemostatic response-> Fibrin clot formation-> Limiting clot formation-> Fibrinolysis
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THESE SLIDES ARE PREPAREED TO UNDERSTAND CHILD HEALTH DISORDERS IN EASY WAY Important links- NOTES- https://mynursingstudents.blogspot.com/ youtube channel https://www.youtube.com/c/MYSTUDENTSU... CHANEL PLAYLIST- ANATOMY AND PHYSIOLOGY-https://www.youtube.com/playlist?list=PL93S13oM2gAPM3VTGVUXIeswKJ3XGaD2p COMMUNITY HEALTH NURSING- https://www.youtube.com/playlist?list=PL93S13oM2gAPyslPNdIJoVjiXEDTVEDzs CHILD HEALTH NURSING- https://www.youtube.com/playlist?list=PL93S13oM2gANcslmv0DXg6BWmWN359Gvg FIRST AID- https://www.youtube.com/playlist?list=PL93S13oM2gAMvGqeqH2ZTklzFAZhOrvgP HCM- https://www.youtube.com/playlist?list=PL93S13oM2gAM7mZ1vZhQBHWbdLnLb-cH9 FUNDAMENTALS OF NURSING- https://www.youtube.com/playlist?list=PL93S13oM2gAPFxu78NDLpGPaxEmK1fTao COMMUNICABLE DISEASES- https://www.youtube.com/playlist?list=PL93S13oM2gAOWo4IwNjLU_LCuhRN0ZLeb ENVIRONMENTAL HEALTH- https://www.youtube.com/playlist?list=PL93S13oM2gAPkI6LvfS8Zu1nm6mZi9FK6 MSN- https://www.youtube.com/playlist?list=PL93S13oM2gAOdyoHnDLAoR_o8M6ccqYBm HINDI ONLY- https://www.youtube.com/playlist?list=PL93S13oM2gAN4L-FJ3s_IEXgZCijGUA1A ENGLISH ONLY- https://www.youtube.com/playlist?list=PL93S13oM2gAMYv2a1hFcq4W1nBjTnRkHP facebook profile- https://www.facebook.com/suresh.kr.lrhs/ FACEBOOK PAGE- https://www.facebook.com/My-Student-S... facebook group NURSING NOTES- https://www.facebook.com/groups/24139... FOR MAKING EASY NOTES YOU CAN ALSO VISIT MY BLOG – BLOGGER- https://mynursingstudents.blogspot.com/ Instagram- https://www.instagram.com/mystudentsu... Twitter- https://twitter.com/student_system?s=08 #PEM, #hemophilia,#NEW,#BORN,#ASSESSMENT, #APPEARENCE,#PULSE,#GRIMACE,#REFLEX,#RESPIRATION,#RESUSCITATION,#NEWBORN,#BABY,#VIRGINIA, #CHILD, #OXYGEN,#CYANOSIS,#OPTICNERVE, #SARACHNA,#MYSTUDENTSUPPORTSYSTEM, #rashes,#nursingclasses, #communityhealthnursing,#ANM, #GNM, #BSCNURING,#NURSINGSTUDENTS, #WHO,#NURSINGINSTITUTION,#COLLEGEOFNURSING,#nursingofficer,#COMMUNITYHEALTHOFFICER
10MALLORY WEISE TEARRunning head MALLORY WEISE .docxjesusamckone
10
MALLORY WEISE TEAR
Running head: MALLORY WEISE TEAR 1
Running head: MALLORY WEISE TEAR
Introduction
The following information will be an extensive in-depth review of a patient with a condition known as a Mallory Weise Tear (MWT). The paper will analyze peer-reviewed literature surrounding this condition and the pathophysiology behind it. There are complications that can arise with a diagnosis of an MWT, so the paper will discuss how to recognize the warning signs and how to manage patient care. The paper will also cover the nursing process and treatments for a patient that suffers from MWT. Last but not least, the paper will cover suggested teachings that nurses can go over with their patient and family on the how’s and why’s, along with signs and symptoms of MWT and its complications.
Scenario
A 57-year-old male presents to the emergency department with complaints of abdominal pain, dark black stools for the last four days, and having coffee ground emesis with occasional red streaks. He states a past medical history that includes mild cirrhosis related to alcohol abuse, current smoker of one pack per day, and chronic back pain from an MVA ten years ago that he treats with Aleve and ibuprofen. He has been told that he has hypertension but does not take any medication.
On examination, the vital signs are as follows: blood pressure 138/84, heart rate 105, tympanic temperature 98.9, respirations 19, O2 saturations 98% on room air. He complains of nausea and is guarding his abdomen. There is no asities or obvious jaundice noted. Upon auscultation the patient has normal heart tones and clear breath sounds bilaterally. The doctor was at the bedside and performed a digital rectal exam which reveals black stool, occult blood positive. An 18g IV was stared in his right antecubital vein and labs were sent. The labs showed the following: WBC 11, HGB 8.4 g/DL, HCT 25 %, PLT 150 K/UL, AST 78 U/L, ALT 54 U/L, Albumin 3.5 G/DL, Ammonia level 15 U/DL, Potassium 3.7 mEq/l, Sodium 135mEq/l, BUN 25 mg/dl, Creatinine 1.1 mg/dl, Glucose 96 mg/dl. The doctor mentions that most of the labs are with in normal limits but could be indicative of a hemorrhage.
Literature Review
E. Cherednikov, A.A. Kunun, E.E. Cherednikov, and N.S. Moiseeva (2016), authors of “The Role of Etiopathogenetic Aspects in Prediction and Prevention of Discontinuous-Hemorrhagic (Mallory-Weiss) Syndrome,” provided numerous etiological factors, and new insights into the pathogenesis of the disease. S.S. Flanders (2018), author of “Effective Patient Education: Evidence and Common Sense,” takes a close look at patient education related to MWT, and what aspects are most beneficial for knowledge retention. K. Hyun-Soo (2015), author of “Endoscopic Management of Mallory-Weiss tearing,” discusses surgical, nonsurgical options, and treatments available. J. Jahraus (2018), author .
10MALLORY WEISE TEARRunning head MALLORY WEISE .docxRAJU852744
10
MALLORY WEISE TEAR
Running head: MALLORY WEISE TEAR 1
Running head: MALLORY WEISE TEAR
Introduction
The following information will be an extensive in-depth review of a patient with a condition known as a Mallory Weise Tear (MWT). The paper will analyze peer-reviewed literature surrounding this condition and the pathophysiology behind it. There are complications that can arise with a diagnosis of an MWT, so the paper will discuss how to recognize the warning signs and how to manage patient care. The paper will also cover the nursing process and treatments for a patient that suffers from MWT. Last but not least, the paper will cover suggested teachings that nurses can go over with their patient and family on the how’s and why’s, along with signs and symptoms of MWT and its complications.
Scenario
A 57-year-old male presents to the emergency department with complaints of abdominal pain, dark black stools for the last four days, and having coffee ground emesis with occasional red streaks. He states a past medical history that includes mild cirrhosis related to alcohol abuse, current smoker of one pack per day, and chronic back pain from an MVA ten years ago that he treats with Aleve and ibuprofen. He has been told that he has hypertension but does not take any medication.
On examination, the vital signs are as follows: blood pressure 138/84, heart rate 105, tympanic temperature 98.9, respirations 19, O2 saturations 98% on room air. He complains of nausea and is guarding his abdomen. There is no asities or obvious jaundice noted. Upon auscultation the patient has normal heart tones and clear breath sounds bilaterally. The doctor was at the bedside and performed a digital rectal exam which reveals black stool, occult blood positive. An 18g IV was stared in his right antecubital vein and labs were sent. The labs showed the following: WBC 11, HGB 8.4 g/DL, HCT 25 %, PLT 150 K/UL, AST 78 U/L, ALT 54 U/L, Albumin 3.5 G/DL, Ammonia level 15 U/DL, Potassium 3.7 mEq/l, Sodium 135mEq/l, BUN 25 mg/dl, Creatinine 1.1 mg/dl, Glucose 96 mg/dl. The doctor mentions that most of the labs are with in normal limits but could be indicative of a hemorrhage.
Literature Review
E. Cherednikov, A.A. Kunun, E.E. Cherednikov, and N.S. Moiseeva (2016), authors of “The Role of Etiopathogenetic Aspects in Prediction and Prevention of Discontinuous-Hemorrhagic (Mallory-Weiss) Syndrome,” provided numerous etiological factors, and new insights into the pathogenesis of the disease. S.S. Flanders (2018), author of “Effective Patient Education: Evidence and Common Sense,” takes a close look at patient education related to MWT, and what aspects are most beneficial for knowledge retention. K. Hyun-Soo (2015), author of “Endoscopic Management of Mallory-Weiss tearing,” discusses surgical, nonsurgical options, and treatments available. J. Jahraus (2018), author .
10MALLORY WEISE TEARRunning head MALLORY WEISE .docxaulasnilda
10
MALLORY WEISE TEAR
Running head: MALLORY WEISE TEAR 1
Running head: MALLORY WEISE TEAR
Introduction
The following information will be an extensive in-depth review of a patient with a condition known as a Mallory Weise Tear (MWT). The paper will analyze peer-reviewed literature surrounding this condition and the pathophysiology behind it. There are complications that can arise with a diagnosis of an MWT, so the paper will discuss how to recognize the warning signs and how to manage patient care. The paper will also cover the nursing process and treatments for a patient that suffers from MWT. Last but not least, the paper will cover suggested teachings that nurses can go over with their patient and family on the how’s and why’s, along with signs and symptoms of MWT and its complications.
Scenario
A 57-year-old male presents to the emergency department with complaints of abdominal pain, dark black stools for the last four days, and having coffee ground emesis with occasional red streaks. He states a past medical history that includes mild cirrhosis related to alcohol abuse, current smoker of one pack per day, and chronic back pain from an MVA ten years ago that he treats with Aleve and ibuprofen. He has been told that he has hypertension but does not take any medication.
On examination, the vital signs are as follows: blood pressure 138/84, heart rate 105, tympanic temperature 98.9, respirations 19, O2 saturations 98% on room air. He complains of nausea and is guarding his abdomen. There is no asities or obvious jaundice noted. Upon auscultation the patient has normal heart tones and clear breath sounds bilaterally. The doctor was at the bedside and performed a digital rectal exam which reveals black stool, occult blood positive. An 18g IV was stared in his right antecubital vein and labs were sent. The labs showed the following: WBC 11, HGB 8.4 g/DL, HCT 25 %, PLT 150 K/UL, AST 78 U/L, ALT 54 U/L, Albumin 3.5 G/DL, Ammonia level 15 U/DL, Potassium 3.7 mEq/l, Sodium 135mEq/l, BUN 25 mg/dl, Creatinine 1.1 mg/dl, Glucose 96 mg/dl. The doctor mentions that most of the labs are with in normal limits but could be indicative of a hemorrhage.
Literature Review
E. Cherednikov, A.A. Kunun, E.E. Cherednikov, and N.S. Moiseeva (2016), authors of “The Role of Etiopathogenetic Aspects in Prediction and Prevention of Discontinuous-Hemorrhagic (Mallory-Weiss) Syndrome,” provided numerous etiological factors, and new insights into the pathogenesis of the disease. S.S. Flanders (2018), author of “Effective Patient Education: Evidence and Common Sense,” takes a close look at patient education related to MWT, and what aspects are most beneficial for knowledge retention. K. Hyun-Soo (2015), author of “Endoscopic Management of Mallory-Weiss tearing,” discusses surgical, nonsurgical options, and treatments available. J. Jahraus (2018), author ...
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Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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1. Blood Disorders 103
Blood Disorders
Blood is essential for life. It carries oxygen and nutrients to every
part of the body. Blood also fights infections and heals injuries.
Therefore, disorders of the blood can have a great effect on your
health.
You can protect your health by understanding the symptoms
of common blood disorders. If you think you may have one of
these conditions, talk to your doctor. With early diagnosis and
the right treatment, many women with blood disorders are able
to live full and healthy lives.
What is blood?
Blood is made up of several types of cells and proteins:
• Red blood cells carry oxygen from the lungs to cells
throughout the body.
• White blood cells help fight infections.
• Platelets help form clots to stop bleeding.
• Plasma, the liquid part of blood, contains many types
of proteins. These include proteins that help the blood
to clot and proteins that protect the body from viruses
and infection. Plasma also contains substances such
as dissolved salts, sugars, and hormones.
Blood cells are produced by the soft tissue inside your
bones, called bone marrow. Your body produces hun-
dreds of billions of new blood cells each day.
Blood disorders
Blood disorders are diseases that af-
fect one or more parts of the blood.The
symptoms depend on the part of the
blood affected:
l Bleeding disorders prevent the
blood from forming clots, which
stop bleeding after an injury. (See pag-
es 106 and 107 for more information
on different bleeding disorders.)
l Clotting disorders cause blood to clot
too easily,creating a condition called
thrombophilia (throm-boh-FIL-ee-uh).
(See page 109 for more information.)
2. 104 The Healthy Woman: A Complete Guide for All Ages
l Anemia (uh-NEE-mee-uh) is a con-
dition in which the blood has too few
healthy red blood cells. (See page 109
for more information.)
l Disorders of the bone marrow, such as
leukemia (loo-KEE-mee-uh), may af-
fect the production of blood cells. (See
page 58 of the Cancer chapter for more
information.)
Causes of blood disorders
Many blood disorders are inherited. If
you have a history of a blood disorder in
your family, you might have a higher risk
of developing the disorder yourself or
carrying the gene for the disorder. Blood
disorders may also be caused by:
l other diseases or conditions
l the side effects of medications
l a lack of certain nutrients in your diet
Blood disorders can be acute or chronic.
Acute blood disorders occur suddenly
and last a short time. For example, rapid
or excessive blood loss may cause acute
anemia. Once the bleeding is stopped
and blood levels return to normal, the
anemia is cured.
A chronic blood disorder is a disorder
that develops slowly or lasts a long time.
Many chronic disorders, such as sickle
What is coagulation?
Coagulation (koh-ag-yuh-LAY-shuhn)—
or clotting—stops bleeding after a
blood vessel is injured. There are three
steps in this process:
1. The blood vessel narrows, slowing
the flow of blood.
2.The platelets begin to “stick” to the
site of the injury and form a clot.
3.Clotting factors in the blood help to
build the clot and keep it in place.
After the bleeding stops, the blood
vessel starts to heal, and the clot
begins to break down.
Bleeding disorders can disrupt any
part of this process.
cell anemia, cannot be cured. But the
symptoms can be treated.
It is important to have blood disorders
diagnosed and treated as early as pos-
sible. Proper treatment can relieve symp-
toms and prevent complications.
Bleeding disorders
If you have a bleeding disorder, your
blood may not clot normally.The chart
on pages 106 and 107 describes several
common bleeding disorders that affect
women.
Causes of bleeding disorders
Some bleeding disorders are inher-
ited, including von Willebrand disease
(vWD) and hemophilia (hee-muh-FIL-
ee-uh). If there is a history of bleeding
problems in your family, talk to your
doctor. You may need to be tested.
Other factors that prevent or slow clot-
ting include:
3. Blood Disorders 105
l certain types of drugs—including as-
pirin, nonsteroidal anti-inflammatory
drugs (NSAIDs), antibiotics, and che-
motherapy drugs
l a lack of vitamin K
l other disorders, including autoimmune
(aw-toh-ih-MYOON) diseases, bone
marrow disorders, leukemia, thyroid
disease, Cushing syndrome, and liver
and renal diseases
Symptoms of bleeding disorders
Bleeding disorders often cause unusual
bleeding of the female reproductive
system. You may have heavy menstrual
bleeding. If you have a reproductive dis-
order that causes bleeding, such as en-
dometriosis (EN-doh-MEE-tree-OH-
suhss), a bleeding disorder can make
your symptoms worse. (See page 158 of
the Reproductive Health chapter for more
information.)
Other symptoms of bleeding disorders are:
l bleeding or bruising easily
l bleeding too much or for a long time
l nosebleeds
Getting diagnosed
Mild bleeding disorders often go undi-
agnosed. Because women normally bleed
with menstruation and childbirth, it may
be hard for you or your doctor to recog-
nize abnormal bleeding.
Discuss your symptoms with your doctor.
You may need to be tested for a bleeding
disorder if you:
l have heavy menstrual bleeding
l have a history of bleeding disorders in
your family
Pregnancy
Pregnancy boosts levels of proteins
that help the blood to clot. This may
help control bleeding. However, levels
of these clotting proteins will still be
lower than normal. If you have a bleed-
ing disorder, you may be at risk for
problems during pregnancy such as:
• miscarriage or stillbirth
• bleeding during pregnancy
• heavy bleeding after childbirth
These are symptoms that your menstrual
bleeding might be heavier than normal:
l soaking through a pad or tampon ev-
ery hour for 2 to 3 hours in a row
l blood clots more than 1 inch in diam-
eter
l anemia (See page 109 for more infor-
mation.)
You may need to consult a hematologist,
a specialist in blood disorders, for ad-
ditional blood tests.Tests for one of the
most common disorders, vWD, may be
uncertain. You may need repeated testing
to find out if you have vWD.
4. 106 The Healthy Woman: A Complete Guide for All Ages
Treating bleeding disorders
Inherited bleeding disorders cannot be
cured. But treatments can:
l relieve symptoms
l prevent dangerous bleeding during or
after surgery or dental work
l prevent complications during and after
pregnancy
The treatments below can reduce blood
loss. Your treatment plan will depend on
the type of bleeding disorder you have
and your symptoms.
l Birth control pills may help reduce
menstrual bleeding.
l Desmopressin acetate (dess-moh-
PRESS-uhn A-suh-tayt) is a
drug that can control menstrual bleed-
ing and prevent excessive bleeding
during and after surgery or dental
work.
l Antifibrinolytics (an-teye-FEYE-
bruhn-uhl-IHT-ihks) are drugs that
keep clots from breaking down.They
can help reduce menstrual bleeding,
nosebleeds, and excess bleeding from
surgery or dental work.
l Clotting factor concentrates—medi-
cines that provide extra factors to help
blood clot—may improve symptoms
when other treatments don’t work.
Heavy menstrual bleeding can interfere
with your personal and professional life.
If the treatments above don’t help con-
trol this symptom, there are surgeries
that can permanently stop menstruation.
However, these surgeries will cause you
to be unable to get pregnant.
Talk to your doctor about the risks and
benefits of treatments. You may need to
try several treatments to find out what
works best for you.
Common Bleeding Disorders in Women
von Willebrand Disease (vWD)
Causes vWD is the most common inherited bleeding disorder. It is caused by deficiencies or
defects in von Willebrand Factor (vWF). vWF is a substance in the blood that helps clots
to form.
Symptoms • Heavy bleeding during periods (the most common symptom)
• Bruising easily
• Prolonged or excessive bleeding after dental work or surgery
• Excessive postpartum bleeding
Diagnosis • Blood tests can measure vWF activity in your blood.
• Hormones and medications affect vWF levels, making diagnosis difficult.
• If you have symptoms but your blood tests are negative for vWD, you may need to be
tested again.
Treatments vWD cannot be cured, but the following treatments may relieve your symptoms:
• Birth control pills
• Desmopressin acetate
• Antifibrinolytics
• Clotting factor concentrates
• Surgery to stop menstruation
5. Blood Disorders 107
Common Bleeding Disorders in Women
Hemophilia Carrier Status
Causes Hemophilia is caused by an inherited genetic mutation on the X chromosome. If men
inherit this trait, they have hemophilia, a severe bleeding disorder. Women who inherit
this mutation are carriers of the disease—they do not have hemophilia, but they may
pass the disease on to their children.
Symptoms Most hemophilia carriers do not have symptoms. Some women have mild bleeding
symptoms, such as:
• Heavy bleeding during periods
• Prolonged or excessive bleeding after dental work, surgery, serious injury, or
childbirth
Diagnosis If you have a family history of hemophilia, genetic testing can determine whether you
are a carrier.
Treatments Hemophilia cannot be cured. The following treatments can stop or prevent excessive
bleeding:
• Birth control pills
• Desmopressin acetate
• Antifibrinolytics
• Clotting factor replacement
Scientists are studying gene therapy, which may treat, or even cure, hemophilia in the
future.
Thrombocytopenia
Causes Thrombocytopenia (throm-buh-syt-uh-PEE-nee-uh) is a condition in which there are too
few platelets in the blood. It is caused by medications and by other diseases, including:
• Anemia
• Leukemia
• HIV
• Disorders such as Gaucher’s disease that cause the spleen to become enlarged and
trap platelets
• Disorders in which platelets break down too quickly
Symptoms • Bruising easily
• Heavy bleeding during periods
• Bleeding under the skin and bleeding of the gums and digestive tract
Diagnosis Blood tests can detect low platelet levels. Additional testing may be needed to find the
cause.
Treatments The underlying cause must be treated.
Clotting disorders
If you have a clotting disorder, your
blood may clot too easily.This condition
is called thrombophilia (throm-boh-
FIL-ee-uh). It may cause blood clots to
form in veins and sometimes in arteries.
These clots can move through the blood-
stream and block small blood vessels.
Causes of thrombophilia
Thrombophilia may be inherited or ac-
quired. Common causes include gene
6. 108 The Healthy Woman: A Complete Guide for All Ages
Valve
Blood clot
Blood flow
mutations, protein deficiencies, and cer-
tain autoimmune disorders.
If you have thrombophilia, some condi-
tions or drugs can increase your risk of
clotting:
l heart failure
l obesity, which puts pressure on veins
l pregnancy
l using the birth control pill or meno-
pausal hormonal therapy
Your risk can also be raised by sitting
or lying in one position for a long time,
such as during recovery from surgery or
sitting still during a long flight.
Symptoms of thrombophilia
The main symptom is clotting in veins or
arteries. Clots may cause swelling, pain,
or redness.
Thrombophilia may cause blood clots to
form in veins deep inside the leg.This
is called deep vein thrombosis (throm-
BOH-suhss), commonly known as DVT.
These clots can break loose and block
blood vessels in the lung.This is called a
pulmonary embolism (PE). Symptoms
of PE are shortness of breath or sharp
chest pains, especially when you inhale.
Because the clot stops the flow of blood,
PE can damage lung tissue and even
cause death.
Thrombophilia is a common disorder,
affecting about 1 in every 5 Americans.
Many people with thrombophilia never
develop clots. Because pregnancy and
medications that contain hormones in-
crease the risk of blood clots, women are
at higher risk for clotting than men.
Getting diagnosed
If you have a personal or family his-
tory of blood clots, DVT, or PE, talk to
your doctor about whether you should
be tested for thrombophilia. You should
also talk to your doctor before using the
birth control pill, birth control patch, or
menopausal hormone therapy. Finding
out whether you have the disorder can
help you get the proper treatment.
Treating thrombophilia
Inherited thrombophilia cannot be
cured. However, blood-thinning drugs
prevent excessive clotting. You may need
these drugs only when you are at high
risk of clots—during pregnancy, for in-
stance. Some women need to take these
drugs throughout their lives.
7. Blood Disorders 109
Common Clotting Disorders in Women
Thrombophilia
Causes Inherited conditions that cause thrombophilia include:
• Mutated genes, such as Factor V Leiden (LAY-din) mutation and prothrombin (proh-
THROM-bin) 20210 mutation
• A lack of certain blood proteins, including protein C, protein S, and antithrombin
• Hyperhomocysteinemia (heye-pur-hoh-moh-siss-tuh-NEE-mee-uh), an increase in an
amino acid in the blood caused by a mutation in the MTHFR gene
Scientists are still studying how genes contribute to thrombophilia. This research may
help to improve diagnosis and treatment.
Thrombophilia may be caused by some autoimmune disorders (see the Autoimmune
Diseases chapter on page 83 for more information about these diseases):
• Antiphospholipid (an-teye-FOSS-foh-lip-ihd) antibody syndrome
• Systemic lupus erythematosus (LOO-puhss ur-ih-thee-muh-TOH-suhss)
Symptoms • Blood clots in veins or arteries, such as deep vein thrombosis
• Pulmonary embolism
Diagnosis Blood tests can diagnose thrombophilia and determine its cause.
Treatments • Blood thinning drugs heparin and warfarin can prevent future clots.
• Some women need to take blood thinners only when they are at high risk of a clot.
• Some women may need continuous treatment.
Disseminated Intravascular Coagulation (DIC)
Causes DIC is a type of acquired thrombophilia. Excessive clotting depletes platelets and clot-
ting factors. DIC may be caused by:
• Severe infections
• Cancer
• Pregnancy complications, such as placental abruption (the breaking away of the
placenta from the womb) or a dead fetus that remains in the womb
This clotting removes platelets and clotting factors from the blood, causing uncon-
trolled bleeding.
Symptoms • Blood clots throughout the bloodstream
• Excessive bleeding
Diagnosis Blood tests
Treatments The cause of DIC must be treated. Platelets and clotting factors are administered to
control bleeding.
Anemia
Anemia is caused by a lack of healthy red
blood cells. It is a common disorder, af-
fecting more than 3 million Americans.
Women, especially women of childbear-
ing age, are more likely to have anemia
than men.This is because women lose
blood during menstruation and
childbirth.
Causes of anemia
There are many different types of anemia
and a variety of causes, including:
l major blood loss
8. 110 The Healthy Woman: A Complete Guide for All Ages
l lack of iron, vitamin B12
, folic acid, or
vitamin C
l diseases that damage bone marrow
l inherited disorders that cause defects
in red blood cells
l disorders that cause your immune sys-
tem to attack red blood cells
Symptoms of anemia
Anemia is a condition in which the
number of healthy red blood cells in
your blood is lower than normal.This
lowers oxygen levels in the blood. If you
have mild anemia, you may not have
symptoms, or you may have symptoms
only when you are physically active.
What is sickle cell disease?
Sickle cell disease is an inher-
ited blood disorder. It causes red
blood cells to be crescent-shaped
instead of round. These sickle
cells break down more quickly
than normal cells, causing ane-
mia. Sickle cells may also block
blood vessels, a condition called
a sickle cell crisis. Crises cause
pain and complications such
as stroke, infections, and organ
damage.
If you inherit two sickle cell
genes, one from each parent, you
will have sickle cell disease. If
you inherit only one gene, you will
have the sickle cell trait. Although
women with sickle cell trait may
not have any symptoms, they can
pass the trait on to their children.
People whose ancestors are from
sub-Saharan Africa have the
greatest risk of the disease.
ILLuSTRATION uSED WITH PERMISSION
FROM THE NATIONAL HEART, LuNG, AND
BLOOD INSTITuTE, NATIONAL INSTITuTES OF
HEALTH, u.S. DEPARTMENT OF HEALTH AND
HuMAN SERVICES. ILLuSTRATION: MICHAEL
LINkINHOkER, LINk STuDIO, LLC.
9. Blood Disorders 111
Symptoms include fatigue, dizziness, and
shortness of breath.
Getting diagnosed
If you experience these symptoms, talk
to your doctor. Blood tests can find out
whether you have anemia. Additional
tests may be needed to find the cause.
Treating anemia
Your treatment will depend on the type
of anemia you have. In some cases, treat-
ing the cause will cure anemia. Inherited
forms of anemia, such as sickle cell dis-
ease, cannot be cured, but treatments can
relieve the symptoms and prevent com-
plications. Scientists are studying new
medicines and treatments such as gene
therapy and bone marrow transplants.
These may provide even better treat-
ments for anemia in the future.
Types of Anemia
Acute blood loss anemia
Causes Blood loss may be caused by:
• Injury
• Surgery
• Childbirth
• Heavy menstrual bleeding
• Bleeding from the digestive or urinary tracts
Symptoms • Fatigue
• Dizziness
• Shortness of breath
• Pale skin
• Cold hands and feet
• Chest pain
Diagnosis • Blood tests are used to diagnose anemia.
• Physical exams and other tests may be needed to find the cause of the blood loss.
Treatment • If your anemia is caused by internal bleeding, surgery may be needed to stop the
blood loss.
• Lost blood may be replaced with a blood transfusion.
10. 112 The Healthy Woman: A Complete Guide for All Ages
Types of Anemia
Iron deficiency anemia
Causes You may have low iron because of:
• Blood loss
• Lack of iron in your diet
• Problems absorbing the iron in your diet
Symptoms • Fatigue
• Dizziness
• Shortness of breath
• Pale skin
• Cold hands and feet
• Chest pain
• A condition called pica, in which you crave nonfood items (ice, dirt, or paint, for ex-
ample)
• Restless leg syndrome
Diagnosis • Blood tests can diagnose anemia.
• A physical exam and other tests may be needed to determine the cause.
• Because iron deficiency anemia is very common during pregnancy, pregnant women
should be tested.
Treatment Iron deficiency anemia may be treated (and even prevented) by:
• Taking iron supplements, as directed by your doctor
• Eating iron-rich foods, such as:
• meat (especially red meat)
• eggs
• iron-fortified grains and cereals
• beans and nuts
• dried fruit
• dark green, leafy vegetables
• Eating foods that contain vitamin C, folate, and vitamin B12
, which help your body
absorb iron
11. Blood Disorders 113
Types of Anemia
Sickle cell disease
Causes Sickle cell disease is an inherited disorder that affects red blood cells.
• Red blood cells are crescent-shaped, instead of round.
• Sickle cells die more quickly than normal cells, causing anemia.
• Sickle cells may block blood vessels, leading to painful crises and organ damage.
Symptoms • Fatigue
• Pale skin
• Jaundice
• Shortness of breath
• Sickle cell crises (caused by blocked blood vessels)
Diagnosis • Blood tests can determine whether you have sickle cell disease or the sickle cell
trait.
Treatment Treatments include:
• Hydroxyurea (heye-DRAHk-see-yoo-REE-uh), a drug that can prevent sickle cell crises
• Flu shots and vaccinations to prevent infection
• Pain medications
To prevent crises:
• Get regular checkups.
• Avoid conditions that may trigger a crisis, such as stress and dehydration.
• Maintain a healthy lifestyle.
Thalassemia
Causes Thalassemia (thal-uh-SEE-mee-uh) is a group of inherited blood disorders that
cause defective red blood cells and anemia. These disorders are most common
among people from Africa, the Middle East, Southeast Asia, Southern China, and
the Mediterranean.
Symptoms Anemia symptoms may be mild to severe, depending on the type of thalassemia.
Diagnosis Blood and genetic tests are used to diagnose the disease.
Treatment • Blood transfusions supply healthy red blood cells.
• Iron chelation (kee-LAY-shuhn) therapy may be needed to remove iron, which builds
up after repeated blood transfusions.
12. 114 The Healthy Woman: A Complete Guide for All Ages
Bone marrow disorders
Some disorders damage bone marrow,
where blood cells are produced.This
may increase or decrease the number of
healthy cells in your blood, causing ex-
cessive bleeding or clotting, anemia, or
increased fevers and infections.
Myeloproliferative (MEYE-uh-loh-
pruh-LIF-uh-ruh-tiv) diseases and
myelodysplastic (MEYE-uh-loh-diss-
PLASS-tik) syndromes are bone marrow
disorders that are most common among
older adults.
l Myeloproliferative diseases cause too
many blood cells to be produced.These
cells may be red blood cells, white
blood cells, or platelets.
l Myelodysplastic syndromes reduce
the number of healthy blood cells.
You may have too few red blood cells,
white blood cells, or platelets.
These disorders may turn into leukemia,
a cancer that affects the bone marrow.
(See page 58 of the Cancer chapter for
more information.)
Fertility and pregnancy
Many blood disorders cause complica-
tions during pregnancy. You may also
worry about passing these disorders on
to your children. Getting diagnosed be-
fore you conceive can help you protect
your health and the health of your chil-
dren.The following chart describes com-
mon fertility and pregnancy issues that
women with blood disorders may face.
Blood Disorders, Fertility, and Pregnancy
Bleeding disorders
Fertility issues •
•
•
Treatments for heavy menstrual bleeding can interfere with fertility. The effects
of the birth control pill are temporary. Surgeries to prevent menstruation, such as
hysterectomy or endometrial ablation (destruction of the lining of the uterus), result
in permanent sterility. If you plan to become pregnant, ask your doctor about other
treatment options.
Women with a family history of hemophilia may worry about passing the disease on
to their children. It is important to get tested before you conceive.
If you are a hemophilia carrier, genetic counseling can help you understand your
risks and your options.
Pregnancy • Because pregnancy increases certain clotting proteins in the blood, you may have
issues
•
•
fewer symptoms during pregnancy.
Women with some types of bleeding disorders have a higher risk of:
• miscarriage and stillbirth
• bleeding during pregnancy
• excessive bleeding after childbirth
Talk to your doctor about treatments to prevent these complications.
13. Blood Disorders 115
Blood Disorders, Fertility, and Pregnancy
Thrombophilia
Pregnancy
issues
Blood clots more easily during pregnancy. Therefore, women with thrombophilia are at
even greater risk of developing clots in blood vessels. Thrombophilia also increases the
risk of:
• miscarriages
• stillbirth
• placental abruption (detachment of the placenta)
Pregnant women should be tested for thrombophilia if they have had:
• A blood clot
• Family members who have experienced blood clots before the age of 50
• The pregnancy complications listed above
Treatment with blood thinning drugs such as heparin can help prevent dangerous blood
clots and pregnancy complications.
Anemia
Fertility issues • Women who have sickle cell disease or thalassemia—or who carry the genes for
these disorders—may worry about passing the diseases on to their children.
• Genetic counseling and testing can help you understand your risks and options.
Pregnancy
issues
• Talk to your doctor about whether you need to take iron supplements, change your
diet to prevent or treat anemia, or both.
• Women need more iron during pregnancy. Therefore, iron deficiency anemia is
common, affecting about half of all pregnant women.
• You should be tested for anemia during pregnancy, even if you do not have any
symptoms.
Living with blood disorders
Blood disorders do not have to interfere
with your day-to-day activities, work, or
quality of life.
l Get diagnosed. If you have a family
or personal history of blood disorders
or symptoms, talk to your doctor. You
may need to be tested.
l Get the treatment you need. Al-
though many blood disorders cannot
be cured, treatments can relieve your
symptoms and help you feel better.
l Take care of your health. For some
disorders, there are steps you can take
to prevent symptoms and dangerous
complications.
l Take care of your emotions. You may
have symptoms, such as heavy men-
strual bleeding or fatigue, that affect
your life on a daily basis. You may also
face fears about your own health or the
health of your children. Counseling
can help you cope with your disorder
and make informed choices about your
health. n
14. 116 The Healthy Woman: A Complete Guide for All Ages
One Woman’s Story
In the summer of 2003, my marriage began to unravel, and by December my husband
had moved out of our home. In January I began to feel tired and listless, leading my
doctor to diagnose me with depression. Agreeing that I had enough to be depressed
about, I began taking antidepressants. I realized immediately that depression was not my
problem; the antidepressants were making me feel even worse.
For weeks I went to the doctor, spent
my lunch hours resting in my car, and
was barely able to work. I depended on
my coworkers to do most of my work.
Finally, one of my coworkers confronted
me in tears, worried about me. Out
of desperation, and in tears myself, I
called a friend who is a physician, al-
though not mine. She took blood sam-
ples and found that I was very anemic.
She gave me a prescription for iron
tablets and asked to see me again in a
week. At the end of the week I had not
improved at all. In fact, my hemoglobin
was dangerously low. At that point she
called my doctor, explained the situa-
tion, and asked her to admit me to the
hospital. Reluctantly, my doctor admit-
ted me, and I spent a week having tests
and getting blood transfusions. At the end of the hospital stay we knew I was bleeding
somewhere internally—we just didn’t know where.
I had my medical records moved to my friend’s office and she continued to search for a
solution to my bleeding problem. Finally, after I had consulted with an oncologist and re-
ceived several doses of iron intravenously, it was discovered that I have spots on my in-
testines that seep blood. The good news was that I could manage the condition. If I never
take aspirin, keep a close watch on my hemoglobin, and get transfusions of iron when my
hemoglobin is low, I am fine.
My experience shows that you have to trust your instincts and not be afraid to switch doc-
tors to find the answers you need. Anemia can be a sign of a variety of health issues, and
I am so glad we were able to get to the root cause of mine.
Anemia can be a
sign of a variety of
health issues, and I
am so glad we were
able to get to the
root cause of mine.
Jackee
Burlington, North Carolina
15. Blood Disorders 117
For More Information…
Office on Women’s Health, HHS
200 Independence Ave SW, Room 712E
Washington, DC 20201
Web site: www.womenshealth.gov/faq/
bleed.htm
Phone number: (800) 994-9662,
(888) 220-5446 TDD
Division of Blood Disorders, CDC
1600 Clifton Rd
Atlanta, GA 30333
Web site: www.cdc.gov/ncbddd/hbd
Phone number: (800) 232-4636,
(888) 232-6348 TTY
National Heart, Lung, and Blood Institute
Information Center, NIH
PO Box 30105
Bethesda, MD 20824-0105
Web site: www.nhlbi.nih.gov
Phone number: (301) 592-8573,
(240) 629-3255 TTY
National Hematologic Diseases
Information Service, NIH
7 Information Way
Bethesda, MD 20892–3571
Web site: www.hematologic.niddk.nih.gov
Phone number: (888) 828–0877
American Society of Hematology
1900 M St NW, Suite 200
Washington, DC 20036
Web site: www.hematology.org
Cooley’s Anemia Foundation
330 Seventh Ave, Suite 900
New York, NY 10001
Web site: www.thalassemia.org
Phone number: (800) 522-7222
Iron Disorders Institute
2722 Wade Hampton Blvd, Suite A
Greenville, SC 29615
Web site: www.irondisorders.org
Phone number: (888) 565-4766
National Anemia Action Council
555 E Wells St, Suite 1100
Milwaukee, WI 53202
Web site: www.anemia.org
National Hemophilia Foundation
116 W 32nd St, 11th Floor
New York, NY 10001
Web site: www.hemophilia.org
www.projectredflag.org
Phone number: (800) 424-2634
Sickle Cell Disease Association of
America
231 E Baltimore St, Suite 800
Baltimore, MD 21202
Web site: www.sicklecelldisease.org
Phone number: (800) 421-8453