GRF 2nd One Health Summit 2013: Presentation by TROSKO, Dr. James Edward, Michigan State University

1.
“GLOBAL HEALTH CRISES CAUSED BY THE COLLISION OF
BIOLOGICAL AND CULTURAL EVOLUTION: PRE-NATAL INFLUENCES
ON ACUTE AND CHRONIC DISEASES LATER IN LIFE”
Prof. James E. Trosko
Department of Pediatrics/Human
Development
College of Human Medicine
&
Prof. Reza Nassiri
Institute International Health
College of Osteopathic Medicine
Michigan State University
East Lansing, Michigan 48824
E-mail: james.trosko@ht.msu.edu

2. THE GLOBAL HEALTH PROBLEM
•
Currently there are 7 Billion people on Earth. By the end of this Century, Earth will have 3
billion more babies.
•
Earth’s physical environment (water, air, Global Warming) is being Irreversibly altered.
•
Earth’s Bio-ecosystem, as it relates to human food supply, is stressed (Crop failures,new
microbial invasions,etc.).
•
Human biological adaptive genome, acquired slowly over millions of years by biological
evolution, is becoming stressed by the laser-speed changes in our cultural evolution, by
the food/diets that are changing. This includes changes in the human gut microbiome.
•
Currently, the limited health care resources, devoted towards the Global Health Crisis, is
via “crisis medicine” [dealing with the Metabolic Diseases, e.g., diabetes, cardiovascular
diseases, cancer, dementia, which are, in large part, caused by bad diets/nutrition] are
insufficient to meet the needs of these adult chronic diseases.
One Planet-One Health

3. EARLY HUMAN DIET
MODERN WESTERN DIET
1. “Feast or Famine” style of eating
1. Caloric Unrestricted.
2. Eat within walking distance.
2. Foods are processed
3. Eat only during the day
3. Foods are found year-round
4. Seasonally-available foods
4. Eat 24 hours a day.
5. Grains, nuts, fruits, waterassociated animals ( omega-3fatty acid-rich foods).
5. Red meat/ grilled or fried
6. Ate these foods without grilling.
7. Low caloric intake
6. Use of dietary supplements

4. Potential Partial Solution to these Problems
Since many of these acute and chronic human disease are influenced
during normal human development during in uterine exposures,
prevention of harmful factors during the pregnancy of these 3 Billion new
babies would seem to be both moral and scientifically achievable goals.
Education of new parents of healthy diets during pregnancy and neonatal
development should be a moral and political global challenge,
recognizing enormous cultural , economic , political and
scientific/technological barriers. A shift in how the distribution of limited
health care resources are to be spent on “crisis” versus “preventive”
Medicine will take courage.
This goal is based on the scientific basis of the Barker Hypothesis.

5. THE BARKER HYPOTHESIS
THE BARKER HYPOTHESIS
Prenatal
exposures can
influence the
risks to diseases
later in life

6. PREVENTIVE MEDICINE STARTS
PREVENTIVE MEDICINE STARTS
HERE
HERE

7. BARKER HYPOTHESIS
Few Examples
•
Maternal obesity increases risks to
offspring obesity, metabolic syndrome,
hypertension, kidney size, lung function,
polycystic ovaries and cancers.
•
•
David Parker: Fetal
Experience Affects
Chronic Diseases later in
Life
Diethylstilbestrol (DES)- induction of
human vaginal cancers
Bis-Phenol A induction coat color &
obesity in rats
•
Soy product reduction of breasts, breast
cancer and induction of osteoporesis.
Facts of the study of the atomic bomb
survivors.
•
C. Lau, eta., Fetal Programming of Adult
Diseases .Obstetrics & Gynecology 117:

8. BARKER HYPOTHESIS: IN UTERO EXPOSURES & RISKS TO DISEASES
LATER IN LIFE
C.M. Powers, Tox Sci 134: 225-242, 2013

9. BREAST CANCER NEWS
BREAST CANCER NEWS

10. • Genistein & Bowman-Birk Inhibitor as Bioactive
Components of Soy Products
Hsieh CY,& Chang, C.C. “Stem Cell Differentiation and Reduction as a Potential
Mechanism for Chemoprevention of Breast Cancer. Clin Pharm J. 51: 15-30, 1999.
[ and inducer of osteoporoses]

11. Induction of Differentiation of Human Adult Breast Stem Cells
Panel A. Solvent control; Panel B Cholera Toxin-Positive Control; Panel C.
Genistein (10-7 M); and Panel D. Vitamin D3. 12 days after treatment.

12. THE TROSKO HYPOTHESIS
THE TROSKO HYPOTHESIS
Alteration of organ-specific stem cells by
environmental pollutants, stress, nutrition,
and drugs can modify the risk to stem cellbased diseases later in life

13. GLOBAL DIET & DISEASE
GLOBAL DIET & DISEASE
Global Incidence of Colon
Cancer

14. Size of
spheres
BREAST TUMOR PROMOTERS
E2
TCDD
BPA
Non-M
M1
M10
NC : Negative control
E2 : 10nM estrogen
TCDD : 100nM
BPA : 10uM
M1 : Metformin 1mM
M10 : Metformin 10mM
USE OF HUMAN ADULT BREAST CANCER
STEM CELLS in 3-D CULTURES to SCREEN
FOR TUMOR PROMOTERS &
CHEMOPREVENTIVE AGENTS
BREAST CHEMOPREVENTIVE AGENTS
Control

15. “When diet is wrong,
medicine is of no use.
When diet is correct,
medicine is of no need”
Ancient Ayurvedic
Proverb

16. THANK YOU
THANK YOU