Session Four: Exploring the financial mechanisms that can be harnessed to increase investment in dementia. Mr. George Vradenburg, Convenor, The Global CEO Initiative on Alzheimer's and Chairman of USAgainstAlzheimer’s & World Dementia Council Member

1. George Vradenburg
Convener, The Global CEO Initiative on Alzheimer’s Disease
Member, World Dementia Council
1

2. Mobilizing the Needed Resources
Increasing our Productivity
Increasing Investor
Reward/Reducing their Risk
Innovative Finance Mechanisms
and Approaches
2

3. Increasing our Productivity
Global Alzheimer’s Platform
3Examples only, not comprehensive
U.K.
Dementia
Platform
Global Goals: Longitudinal Data, Biomarkers/Diagnostics, New Targets,
Reduce Time/Cost to Market, Regulatory Alignment

4. Increasing Investor
Reward/Reducing Risk
4
Mechanism Example
Reward: Extension of
Exclusivity/IP Period
Orphan Drug Policy Changes
Risk: Shortening
Development Times
HIV/AIDS; Biomarkers +
Conditional Approval; Trial-
Ready Infrastructure
Both: Reduce Uncertainty Accelerated and Globally
Aligned Regulatory Pathways
►Here are mechanisms to change the risk/reward
equation
►Each has been done elsewhere; we can do it

5. Drug
Discovery/
Diagnostics
Care
Delivery
Venture
Capital
Drug
Development
Arc of Disease Management
Finance Mechanisms - Today
Government Grants
5
Non-Profit,
Philanthropy
Industry
Private
Equity
Hedge
Funds
Today
Innovative Finance
Mechanisms and Approaches
Basic
Research
Government

6. Drug
Discovery/
Diagnostics
Care
Delivery
Basic
Research
Venture
Capital
Drug
Development
Arc of Disease Management
Finance Mechanisms – In The Future
Government Grants
6
Non-Profit,
Philanthropy
Industry
Private
Equity
Hedge
Funds
Future
Government
Sovereign
Wealth
Crowd
Funding
Global Fund
Social
Impact
Bonds
Crowd Equity

7. Government
Drug
Discovery/
Diagnostics
Care
Delivery
Basic
Research
Venture
Capital
Drug
Development
Arc of Disease Management
Finance Mechanisms – In The Future
Government Grants
7
Non-Profit,
Philanthropy
Industry
Private
Equity
Hedge
Funds
Future
Crowd
Funding
Global Fund
Crowd Equity
Non-Profit,
Philanthropy
&
Venture
Capital
Global Fund
&
Government
&
Industry
Sovereign
Wealth
Social
Impact
Bonds
Government
&
Private
Equity

8. THANK YOU
8
Maike Stenull, Johnson & Johnson
Luc Truyen, Janssen (a Johnson & Johnson Company)
Cynthia Duggan, New York Academy of Sciences
The Member Companies of
The Global CEO Initiative on Alzheimer’s