The document discusses genetic disorders and provides examples of conditions whose causes and cures are not fully understood. It defines genetic disorders as diseases caused by DNA abnormalities ranging from single gene mutations to full chromosome changes. Common genetic disorders are then listed in categories of single gene disorders, chromosomal abnormalities, and multifactorial disorders. Finally, an assignment is outlined requiring students to research one of the listed disorders and be assessed based on a rubric.

1. Step 4: Provide examples of genetic conditions whose causes and cures are not
understood according to current scientific and technological knowledge
http://www.youtube.com/watch?v=GieZ3pk9YVo

2. What is a genetic disorder?
A genetic disorder is a disease that is caused by an abnormality in an individual's
DNA.
Abnormalities can be as small as a single-base mutation in just one gene, or they can
involve the addition or subtraction of entire chromosomes
https://www.youtube.com/watch?v=xguyxdmeUK8
https://www.youtube.com/watch?v=vP8-5Bhd2ag

3. Common Genetic disorders:
Adenosine deaminase (ADA) deficiency
Single Gene Disorders
alpha-1 antitrypsin deficiency (Alpha-1)
Cystic Fibrosis
Galactosemia
Huntington's Disease
Maple Syrup Urine Disease (MSUD)
neurofibromatosis type 1 (NF1)
Pachyonychia Congenita
phenylketonuria (PKU)
Combined Immunodeficiency (SCID)
sickle cell disease
Smith-Lemli-Opitz syndrome (SLOS)
Chromosomal Abnormalities
Cri-du-Chat syndrome
Down syndrome
47, XXY (Klinefelter syndrome)
Turner syndrome
Williams syndrome
Multifactorial Disorders
Alzheimers Disease
Breast/Ovarian Cancer
Colon Cancer
Hypothyroidism

4. Genetic Disorder Inquiry Assignment
- individual assignment
- choose one of the disorders listed
- What should we find out? (co-created criteria)
- assessment based on rubric (co created next class)
- What does the final product have to look like?
- it is due ______________________