The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural, ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination : Colour – Yellowish brown, Appearance – Homogeneous, Smooth nature, Transparency – Translucent and Relative density – 10.5, No microbial growth in sample plate, pH – 7.5, Viscosity – 3100cp, Extrudability amount present – 91.33, Spreadability – 6.5cm/sec and observed good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25µg/ml. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.

1. FORMULATION AND EVALUATION OF TOOTH GEL FROM ALOE VERA
LEAVES EXTRACT : COMPARED STUDY WITH MARKETED
PREPARATIONS
Author : Vaibhav Shende*
Kamla Nehru College of Pharmacy, Butibori, Nagpur – 441108
Introduction
The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple
clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and
curing oral mucosal lesions. Aloe vera is natural, ancient ingredient. The formulated Aloe vera tooth gel
evaluated by physical examination : Colour – Yellowish brown, Appearance – Homogeneous, Smooth
nature, Transparency – Translucent and Relative density – 10.5, No microbial growth in sample plate,
pH – 7.5, Viscosity – 3100cp, Extrudability amount present – 91.33, Spreadability – 6.5cm/sec and
observed good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that
formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25µg/ml. The
outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth
gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic
formulation and good scope in future about dental research in natural remedies.
Material and Method
Final Batch Formula
Sr No Ingredients Quantity taken
1 Carbapol-940 (g) 1.5
2 Sodium CMC (g) 1
3 Sodium Saccharin (g) 0.5
4 Sodium Lauryl Sulphate SLS (g) 2
5 Polyethylene Glycol 4000 (g) 2
6 Sodium Benzoate (g) 0.5
7 Triethanolamine (ml) q.s
8 Distilled Water (ml) q.s
9 Aloe vera (ml) 5
Results and Discussion
1. Transparency
The formulated tooth gel was translucent and appearance homogeneous.
2. Smoothness
The formulated tooth gel was smooth in nature.
3. Colour
The colour of formulated tooth gel was yellowish brown observed.
%Moisture Content
4. Relative density
The formulated tooth gel was relative density 10.5 observed.
5. pH
The formulated tooth gel pH was 7.5 observed.
6. Viscosity
The formulated tooth gel viscosity was 3100cp observed.
7. Microbial growth
In the formulated tooth gel no microbial growth was observed.
8. Extrudability
Sr No Extrudability Mean of three tube
1 Net weight of formulation in tube (g) 12.23
2 Weight of tooth gel extruded (g) 11.17
3 Extrudability amount percentage (%) 91.33
The formulated tooth gel was good extrudability observed.
9. Spreadability and Fomability
The formulated tooth gel spreadability was 6.5cm/sec observed that indicate the tooth gel easily
spreadable by small amount of shear.
10. Stability
At 25ºC±2ºC / 60%±5%RH (3rd
month)
At 30ºC±2ºC / 65%±5%RH (3rd
month)
Colour Appearance Spreadability pH
Yellowish brown Homogeneous 6.35 6.90
At 40ºC±2ºC± / 75%±5%RH (3rd
month
References :
1. Tambe R, Kulkarni M, Joice A, Gilani I. Formulation and evaluation of Aloe vera gels. J
Pharm Res. 2009;2(10): 1588-1590
2. Devi D L, Srinivas B, Rao B N. An evaluation Antimicrobial Activity of Aloe
barbadensis Miller(Aloe vera) Gel Extract. J Pharm Biomed Sci. 2012;21(03): 1-4.
KNCP, NATIONAL SEMINAR ON ‘PHYTHOMEDINCINA:
A NOVELAPPROACH FOR TREATMENT’ DATE ON
25TH -26TH MARCH 2017
0
50
1 2 3 4
% Moisture content
% Moisture
content
0246810
1 2 3 4
pH
pH
0
10
20
1 2 3 4
Spreadability
Foamability
Ingredient Biological Name Uses
Aloe vera
Aloe barbadensis
(Liliaceae)
Anti-microbial,
Carminative
Colour Appearance Spreadability pH
Yellowish brown Homogeneous 6.4 7.2
Colour Appearance Spreadability pH
Yellowish brown Homogeneous 6.21 6.84