Eosinophilic esophagitis is characterized by eosinophil-predominant inflammation in the esophagus. Potential etiologies include food and aeroallergen sensitization, genetics involving genes like TSLP, and cytokines/chemokines such as IL-5 and eotaxin-3. The pathogenesis involves activation of epithelial inflammatory pathways producing eotaxin-3, impaired barrier function mediated by loss of desmoglein-1, and increased TGF-β. Clinical features commonly include dysphagia, abdominal pain, failure to thrive, and food impactions. Diagnosis is based on symptoms and histological evidence of ≥15 eosinophils per hpf. Treatment
Rubinstein-Taybi Syndrome - Genetic Research AbstractDavid_Johnson
Comprehensive genetic research abstract concerning Rubinstein-Taybi Syndrome. Topics addressed include, but are not limited to: molecular genetic analysis, etiology, expressivity manifestations, phenotype observations, and lifespan prognosis
The document summarizes information about human granulocytic anaplasmosis (HGA), which is caused by the rickettsia Anaplasma phagocytophilum transmitted by ticks. It is an emerging zoonotic disease reported in over 5,000 cases worldwide. Symptoms of HGA include fever, headache, myalgia and patients can experience complications like pneumonia, respiratory failure, and meningitis/encephalitis. Diagnosis involves identifying the morulae in neutrophils on blood smears or through PCR/serology tests. Treatment involves doxycycline which is generally effective.
This study identified a novel single base deletion mutation in the BBS9 gene in a consanguineous Pakistani family with Bardet-Biedl syndrome (BBS). Whole genome SNP analysis identified a homozygous region linked to BBS on chromosome 7, within which Sanger sequencing revealed a c.299delC mutation in BBS9. This frameshift mutation is predicted to result in a truncated BBS9 protein lacking the C-terminal domain. BBS9 encodes a component of the BBSome protein complex involved in ciliogenesis. The mutation found in this family expands knowledge of the genetic causes of BBS and the mutational spectrum of BBS9.
Rory Eutsey has over 10 years of experience as a laboratory manager and senior microbiologist researching pathogens like Streptococcus pneumoniae and Haemophilus influenzae, with expertise in genomics, molecular biology techniques, and biofilm analysis; he has supervised many students and published numerous papers characterizing bacterial strains, virulence factors, and developing anti-biofilm strategies. Eutsey received his Master's and Bachelor's degrees in microbiology from the University of Georgia and Shippensburg University of Pennsylvania, respectively.
A poster on the incidence and prevalence of Blastocystis and Dientamoeba in IBS patients and controls. Presented by Laura Rindom Krogsgaard (MD, PhD student) at the United European Gastroenterology Week in Berlin, 2013.
Eosinophilic esophagitis is characterized by eosinophil-predominant inflammation in the esophagus. Potential etiologies include food and aeroallergen sensitization, genetics involving genes like TSLP, and cytokines/chemokines such as IL-5 and eotaxin-3. The pathogenesis involves activation of epithelial inflammatory pathways producing eotaxin-3, impaired barrier function mediated by loss of desmoglein-1, and increased TGF-β. Clinical features commonly include dysphagia, abdominal pain, failure to thrive, and food impactions. Diagnosis is based on symptoms and histological evidence of ≥15 eosinophils per hpf. Treatment
Rubinstein-Taybi Syndrome - Genetic Research AbstractDavid_Johnson
Comprehensive genetic research abstract concerning Rubinstein-Taybi Syndrome. Topics addressed include, but are not limited to: molecular genetic analysis, etiology, expressivity manifestations, phenotype observations, and lifespan prognosis
The document summarizes information about human granulocytic anaplasmosis (HGA), which is caused by the rickettsia Anaplasma phagocytophilum transmitted by ticks. It is an emerging zoonotic disease reported in over 5,000 cases worldwide. Symptoms of HGA include fever, headache, myalgia and patients can experience complications like pneumonia, respiratory failure, and meningitis/encephalitis. Diagnosis involves identifying the morulae in neutrophils on blood smears or through PCR/serology tests. Treatment involves doxycycline which is generally effective.
This study identified a novel single base deletion mutation in the BBS9 gene in a consanguineous Pakistani family with Bardet-Biedl syndrome (BBS). Whole genome SNP analysis identified a homozygous region linked to BBS on chromosome 7, within which Sanger sequencing revealed a c.299delC mutation in BBS9. This frameshift mutation is predicted to result in a truncated BBS9 protein lacking the C-terminal domain. BBS9 encodes a component of the BBSome protein complex involved in ciliogenesis. The mutation found in this family expands knowledge of the genetic causes of BBS and the mutational spectrum of BBS9.
Rory Eutsey has over 10 years of experience as a laboratory manager and senior microbiologist researching pathogens like Streptococcus pneumoniae and Haemophilus influenzae, with expertise in genomics, molecular biology techniques, and biofilm analysis; he has supervised many students and published numerous papers characterizing bacterial strains, virulence factors, and developing anti-biofilm strategies. Eutsey received his Master's and Bachelor's degrees in microbiology from the University of Georgia and Shippensburg University of Pennsylvania, respectively.
A poster on the incidence and prevalence of Blastocystis and Dientamoeba in IBS patients and controls. Presented by Laura Rindom Krogsgaard (MD, PhD student) at the United European Gastroenterology Week in Berlin, 2013.
This study investigated the prevalence of two intestinal parasites, Dientamoeba fragilis and Blastocystis, in subjects with and without irritable bowel syndrome (IBS) symptoms over a 1-year period. Stool samples from 328 subjects in 2010 found parasites in 44.5% of subjects, significantly less in those with IBS compared to asymptomatic controls. D. fragilis was found in 30.1% of subjects and Blastocystis in 18.9%, both more prevalent in controls. Follow-up of 275 subjects in 2011 found no significant difference in gastrointestinal symptom development between those initially infected or uninfected with the parasites. The study concludes that harboring D. fragilis or Blastocystis does
Bats and rodents as a source of emerging human disease in KenyaILRI
Poster by E. Cook, E. Dobson, A. Kiyong'a, J Akoko, A. Ogendo, M. Bronsvoort, S. Kemp, B. Agwanda and E. Fèvre presented at the Australasian Society for Infectious Diseases (ASID) annual scientific meeting, Canberra, Australia, 20-23 March 2013.
This document discusses several studies on monogenic disorders and their potential medical applications. It first introduces monogenic disorders as involving mutations in a single gene, which can be inherited or spontaneous. Two studies are then summarized: one finding that brain stimulation may help restore breathing capacity in Duchenne muscular dystrophy patients by activating the diaphragm muscle, and another observing changes in mucus protein structure in cystic fibrosis patients that could provide insight into treatment. The document concludes that these studies bring researchers closer to potential treatments for currently incurable genetic diseases and improve patients' quality of life.
Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningitis in humans. It has a complex life cycle involving rats as the definitive host and various snail and slug species as intermediate hosts. In rats, the worms mature and reproduce in the pulmonary arteries, while in accidental hosts like humans they cannot complete their life cycle and cause meningitis symptoms instead. The document discusses the taxonomy, morphology, identification, and life cycle of A. cantonensis in detail. It also highlights several key publications that have contributed to the understanding of this parasite.
This PhD report aims to develop diagnostic tools to distinguish between protozoan parasites that infect ruminants, including Toxoplasma gondii, Neospora caninum, and Sarcocystis species. The report will identify genus-specific antigens for each parasite and develop antibodies and PCR tests that can detect the parasites individually. Recombinant antigens will be produced and used to generate genus-specific antibodies for diagnosis via immunohistochemistry. Genus-specific DNA targets and primers will also be identified to enable PCR-based detection of the protozoan parasites in tissue samples. Both diagnostic methods will be supported by a tissue bank of samples infected with the parasites.
This document summarizes and reviews several books and publications related to rheumatology and orthopedics. It discusses the following key points in 3 sentences:
The first section summarizes a book on neurology in orthopedics, praising it as a practical guide to the essential neurology knowledge needed for those working with musculoskeletal disorders. The second section summarizes a symposium on autoimmunity and genetics, noting that it gathered existing literature on genetic factors in autoimmune diseases. The third section summarizes a book on gout that established clinical criteria for diagnosing gout and described the authors' observations of 380 gout cases, analyzing etiological factors and various clinical presentations.
Background: VEGF is involved in cancer development by stimulating neo-angiogenesis and tumor proliferation. Anti-angiogenic therapies, especially tyrosine kinase inhibitors such as sunitinib, have significantly improved cancer prognosis. Nevertheless, renal side effects, such as proteinuria and thrombotic microangiopathy, have been reported. The underlying physiopathological mechanisms remain unclear, but animal models and clinical similarities with preeclampsia suggest that such therapies affect the function of the endothelial and epithelial layers of the glomerular basement membrane, with activation of the endothelin signaling system and loss of glomerular slit diaphragm integrity. The aim of this in vitro study was to determine sunitinib effects on normal podocytes and glomerular endothelial cells.
Seven people died within five days with similar symptoms of dizziness, confusion, headache, and difficulty breathing. An autopsy revealed hypoxia as the cause of death along with mitochondrial damage and low ATP levels in cells. Analysis of metabolites suggested a problem with the electron transport chain. Blood tests confirmed cyanide poisoning, which binds to cytochrome c oxidase and prevents electron transfer, explaining the hypoxia despite normal blood oxygen levels. The source was likely an over-the-counter pain reliever taken by some of the victims.
Yeast like fungal infections in medical intensive care unit in Polandwolass
This document summarizes a study on fungal infections in intensive care unit patients in Poland between 1996-2000. The study examined medical histories to create a database divided into groups by Candida species (C. albicans, C. glabrata, C. tropicalis, C. krusei, mixed). The study found that C. glabrata was increasing and linked to diabetes. Less common species were emerging. C. krusei was related to comorbid conditions. Fatal outcomes were associated with certain comorbidities. The study also examined antifungal resistance and fluconazole prophylaxis.
Purpose: To characterize the clinical features of ocular toxoplasmosis (OT) in Central Cuba. Methods: A database at a large regional referral center was searched for patients who, from April 1, 2011 to May 31, 2013, had the potential diagnosis of OT. Inclusion criteria were the clinical diagnosis of OT, characterized by focal retinochoroidal inflammation. Medical records were reviewed to confirm inclusion criteria (visual acuity recorded in decimal form).
Results: 279 patients (329 total eyes) were affected with OT. Overall, 66.7% were diagnosed with acquired OT with a mean age of 35.4 years and 1.8% with congenital OT with a mean age of 3.4 years. The time of onset of OT could not be determined in 28.3% (n=79) of patients. Patient clinical presentations were posterior uveitis (72.8 %), quiescent retinochoroiditis (16.1 %), and panuveitis (11.1%). Fourteen percent of patients had a slight decrease (0.9-0.6) in visual acuity, 44.4% a moderate decrease (0.5-0.2), and 41.6% a marked decrease (< 0.1).
Removal of foreign body from aerodigestive tractBASIT ALI KHAN
1) Foreign body aspiration is common in children under 5 years old and can lodge in the larynx, trachea, or bronchi, most commonly the right main bronchus.
2) Clinical features depend on if the foreign body is acute or chronic, with acute presenting with choking and chronic presenting with coughing or wheezing. Diagnosis involves history, examination, and imaging like CXR.
3) Removal of tracheobronchial foreign bodies is typically done with rigid bronchoscopy under general anesthesia while laryngeal foreign bodies may require procedures like cricothyrotomy or tracheostomy.
Lymphoma of the Tonsil in a Developing Communityasclepiuspdfs
The lymphoma of the tonsil is a rarity. Single case reports have appeared in countries as disparate as China, Greece, India, Japan, and Turkey. Therefore, this paper presents cases found in Nigeria among the Ibo ethnic group. The epidemiological comparisons are deemed to be worthy of documentation such as age ranges and sides of involvement.
This study examined 79 dry crania (55 male and 24 female) from southern Nigeria to determine the incidence and dimensions of single and double hypoglossal canals, and whether these dimensions differ between sexes. Measurements were taken of the internal and external diameters of the hypoglossal canals. The results showed significant differences in all dimensions between males and females. Bilateral single hypoglossal canals were most prevalent. In conclusion, the size of the hypoglossal canal is sex-specific, with significant differences found between males and females in this population.
This study examined 79 dry crania (55 male and 24 female) from southern Nigeria to determine the incidence and dimensions of single and double hypoglossal canals, and whether these dimensions differ between sexes. Measurements were taken of the internal and external diameters of the hypoglossal canals. The results showed significant differences in all dimensions between males and females. Bilateral single hypoglossal canals were most prevalent. In conclusion, the size of the hypoglossal canal is sex-specific, with significant differences found between males and females in this population.
This document presents 5 cases of rare multiple primary neuroblastomas in children. All 5 patients were boys aged 2 months to 4 years who were treated with surgery. Four also received chemotherapy and one received radiotherapy. With treatment, all 5 patients survived and were disease-free for 14 to 32 years of follow up. The cases suggest that diverse tumor differentiation leads to restricted growth and maturation, contributing to the excellent long-term prognosis seen in these rare cases of multiple primary neuroblastomas.
15. Bioarchaeology and Forensic AnthropologyAshley Kendell, MatthewTennant613
15. Bioarchaeology and Forensic Anthropology
Ashley Kendell, Ph.D., D-ABMDI, California State University, Chico
Alex Perrone, M.A., California State University, Chico
Colleen Milligan, Ph.D., California State University, Chico
Learning Objectives
• Define and differentiate bioarchaeology and forensic anthropology as subfields of biological
anthropology
• Describe the six steps carried out during skeletal analysis
• Outline the four major components of the biological profile
• Contrast the four categories of trauma
• Explain how to identify the different taphonomic agents that alter bone
• Discuss ethical considerations for both bioarchaeology and forensic anthropology
Bioarchaeology and forensic anthropology are both subfields of biological anthropology. While the goals of each subfield
are different, each relies on skeletal analysis to gain information about humans, both past and present. This chapter will
provide a general overview of the analysis of human skeletal remains, as it applies to both bioarchaeology and forensic
anthropology.
BIOARCHAEOLOGY
In 2010 Hurricane Earl reached the Caribbean Island of Antigua. The storm brought strong winds and heavy rainfall to
the island. After the storm calmed, accumulated water drained back out to the ocean, carving a channel through one
of the beaches at English Harbor as it went. Out of the newly created channel, human bones were exposed. Although
they had been buried for many years, the remains belonged to 18th–century British sailors who had died from Yellow
Fever while stationed in the Caribbean. While no headstones were present to divulge information about each person
buried on the beach, a large amount of evidence was still accessible through the analysis of each skeleton as well as the
information garnered from the burial context. To gather more information about each of the individuals buried on the
beach, the bones were examined, and a detailed analysis was carried out of the positions of the skeletons, the burial
depth, whether clothing material such as buttons were found with each set of remains, and whether it appeared that the
sailors were buried in coffins. In addition, the sex, age, and other individualizing characteristics were estimated through
careful analysis of the bones themselves.
The remains uncovered by Hurricane Earl in Antigua became part of a bioarchaeological study. Bioarchaeology is the
study of human remains excavated from archaeological sites. Bioarchaeologists glean information about each set of
human remains by examining the skeleton and by considering the archaeological context in which the skeleton was
1 | Bioarchaeology and Forensic Anthropology
recovered. Through this type of detailed skeletal analysis, bioarchaeologists obtain information about each individual
skeleton, which can include age, sex, height, ancestry, disease, diet, and behavior. For a broader understanding of past
peoples, bioarchaeologi ...
15. Bioarchaeology and Forensic AnthropologyAshley Kendell, EttaBenton28
15. Bioarchaeology and Forensic Anthropology
Ashley Kendell, Ph.D., D-ABMDI, California State University, Chico
Alex Perrone, M.A., California State University, Chico
Colleen Milligan, Ph.D., California State University, Chico
Learning Objectives
• Define and differentiate bioarchaeology and forensic anthropology as subfields of biological
anthropology
• Describe the six steps carried out during skeletal analysis
• Outline the four major components of the biological profile
• Contrast the four categories of trauma
• Explain how to identify the different taphonomic agents that alter bone
• Discuss ethical considerations for both bioarchaeology and forensic anthropology
Bioarchaeology and forensic anthropology are both subfields of biological anthropology. While the goals of each subfield
are different, each relies on skeletal analysis to gain information about humans, both past and present. This chapter will
provide a general overview of the analysis of human skeletal remains, as it applies to both bioarchaeology and forensic
anthropology.
BIOARCHAEOLOGY
In 2010 Hurricane Earl reached the Caribbean Island of Antigua. The storm brought strong winds and heavy rainfall to
the island. After the storm calmed, accumulated water drained back out to the ocean, carving a channel through one
of the beaches at English Harbor as it went. Out of the newly created channel, human bones were exposed. Although
they had been buried for many years, the remains belonged to 18th–century British sailors who had died from Yellow
Fever while stationed in the Caribbean. While no headstones were present to divulge information about each person
buried on the beach, a large amount of evidence was still accessible through the analysis of each skeleton as well as the
information garnered from the burial context. To gather more information about each of the individuals buried on the
beach, the bones were examined, and a detailed analysis was carried out of the positions of the skeletons, the burial
depth, whether clothing material such as buttons were found with each set of remains, and whether it appeared that the
sailors were buried in coffins. In addition, the sex, age, and other individualizing characteristics were estimated through
careful analysis of the bones themselves.
The remains uncovered by Hurricane Earl in Antigua became part of a bioarchaeological study. Bioarchaeology is the
study of human remains excavated from archaeological sites. Bioarchaeologists glean information about each set of
human remains by examining the skeleton and by considering the archaeological context in which the skeleton was
1 | Bioarchaeology and Forensic Anthropology
recovered. Through this type of detailed skeletal analysis, bioarchaeologists obtain information about each individual
skeleton, which can include age, sex, height, ancestry, disease, diet, and behavior. For a broader understanding of past
peoples, bioarchaeologi ...
7 Forensic Science Powerpoint Chapter 07 Forensic AnthropologyGrossmont College
The document discusses the role and techniques of forensic anthropology. It covers how forensic anthropologists examine human remains to develop a biological profile of victims and help with identification. They assess bones for characteristics like age, sex, ancestry and compare to records. Forensic anthropologists also study taphonomy and trauma to reconstruct events. Their expertise complements forensic pathologists in investigations.
The document summarizes the genomic analysis of medieval strains of Mycobacterium leprae, the bacteria that causes leprosy. Researchers analyzed DNA extracted from the remains of 9 individuals from a medieval leprosy hospital in Winchester, UK who showed signs of lepromatous leprosy. They were able to detect M. leprae DNA in all 9 individuals. In 5 cases, they could further genotype the strains, finding 3 had the SNP type 3I-1, related to modern strains in South America, while the other 2 had the rare SNP type 2F, the first discovery of this type in the British Isles. Stable isotope analysis found all 3 individuals likely spent their youth in the local Winchester
8 New Scientist 4 January 2020THE tropics are the most.docxtaishao1
8 | New Scientist | 4 January 2020
THE tropics are the most
biodiverse regions on Earth.
Now there is evidence that
they are also the main source
of evolutionary innovation
and diversity.
Complex animals have
dominated Earth for 541 million
years, a time span called the
Phanerozoic eon. Huge
numbers of species have
evolved and gone extinct
during this time, in a complex
story that includes fish, giant
reptiles and whales.
However, in the 1980s
palaeontologist John Sepkoski
analysed the overall pattern
of evolution in the sea,
where the fossil record is best.
He concluded that marine
evolutionary history could
be broken down into three
supergroups, which he called
“great evolutionary faunas”.
The first group was
dominated by trilobites,
which resembled woodlice,
and bristle worms; the second
by shellfish-like creatures called
brachiopods; and the third by
molluscs, which have persisted
to the present day. Other animals
like land mammals probably
followed similar patterns, but
their fossil record isn’t complete
enough for us to know.
Now, by analysing nearly
18,300 marine genera from
the Phanerozoic fossil record,
Alexis Rojas-Briceno of Umeå
University in Sweden and
his colleagues have found
that the evolution of
complex marine life is best
described using four great
groups of fauna, not three
(bioRxiv, doi.org/dg98).
The first supergroup existed
between 541 and 494 million
years ago, spanning the
Cambrian explosion in which
many animal groups first
emerged. As in the original
analysis, trilobites dominated.
The second supergroup,
dubbed the Palaeozoic, lasted
from 494 to 252 million years
ago. Creatures with hard outer
shells were now widespread,
including brachiopods. This
phase ended when the end-
Permian extinction wiped out
almost all complex life on Earth.
This matches Sepkoski’s
analysis, but the new study
splits his third great fauna into
two. In this version, the third
supergroup is called the
Mesozoic. It began in the wake
of the Permian extinction and
ended 129 million years ago, in
the middle of the dinosaur era.
This time cephalopods, the
group that includes squid
and octopuses, were the rulers.
The fourth and final
supergroup, the Cenozoic, is
still dominant today. During
this time, clams and snails have
made up much of the diversity.
The team found that all four
supergroups originated in the
tropics, then expanded through
the oceans. This is in line with
the idea that the tropics are
hotbeds of evolutionary
innovation, which has been
promoted by David Jablonski
at the University of Chicago.
It may be that the warmer
temperatures and ample
sunlight ensure there is plenty
of food to nourish a multitude
of species. However, John Alroy
at Macquarie University in
Australia isn’t convinced. “I have
always been sceptical about the
out-of-the-tropics hypothesis,
because they have never
seriously dealt with sampling
biases, as far .
8 New Scientist 4 January 2020THE tropics are the most.docxevonnehoggarth79783
8 | New Scientist | 4 January 2020
THE tropics are the most
biodiverse regions on Earth.
Now there is evidence that
they are also the main source
of evolutionary innovation
and diversity.
Complex animals have
dominated Earth for 541 million
years, a time span called the
Phanerozoic eon. Huge
numbers of species have
evolved and gone extinct
during this time, in a complex
story that includes fish, giant
reptiles and whales.
However, in the 1980s
palaeontologist John Sepkoski
analysed the overall pattern
of evolution in the sea,
where the fossil record is best.
He concluded that marine
evolutionary history could
be broken down into three
supergroups, which he called
“great evolutionary faunas”.
The first group was
dominated by trilobites,
which resembled woodlice,
and bristle worms; the second
by shellfish-like creatures called
brachiopods; and the third by
molluscs, which have persisted
to the present day. Other animals
like land mammals probably
followed similar patterns, but
their fossil record isn’t complete
enough for us to know.
Now, by analysing nearly
18,300 marine genera from
the Phanerozoic fossil record,
Alexis Rojas-Briceno of Umeå
University in Sweden and
his colleagues have found
that the evolution of
complex marine life is best
described using four great
groups of fauna, not three
(bioRxiv, doi.org/dg98).
The first supergroup existed
between 541 and 494 million
years ago, spanning the
Cambrian explosion in which
many animal groups first
emerged. As in the original
analysis, trilobites dominated.
The second supergroup,
dubbed the Palaeozoic, lasted
from 494 to 252 million years
ago. Creatures with hard outer
shells were now widespread,
including brachiopods. This
phase ended when the end-
Permian extinction wiped out
almost all complex life on Earth.
This matches Sepkoski’s
analysis, but the new study
splits his third great fauna into
two. In this version, the third
supergroup is called the
Mesozoic. It began in the wake
of the Permian extinction and
ended 129 million years ago, in
the middle of the dinosaur era.
This time cephalopods, the
group that includes squid
and octopuses, were the rulers.
The fourth and final
supergroup, the Cenozoic, is
still dominant today. During
this time, clams and snails have
made up much of the diversity.
The team found that all four
supergroups originated in the
tropics, then expanded through
the oceans. This is in line with
the idea that the tropics are
hotbeds of evolutionary
innovation, which has been
promoted by David Jablonski
at the University of Chicago.
It may be that the warmer
temperatures and ample
sunlight ensure there is plenty
of food to nourish a multitude
of species. However, John Alroy
at Macquarie University in
Australia isn’t convinced. “I have
always been sceptical about the
out-of-the-tropics hypothesis,
because they have never
seriously dealt with sampling
biases, as far .
This study investigated the prevalence of two intestinal parasites, Dientamoeba fragilis and Blastocystis, in subjects with and without irritable bowel syndrome (IBS) symptoms over a 1-year period. Stool samples from 328 subjects in 2010 found parasites in 44.5% of subjects, significantly less in those with IBS compared to asymptomatic controls. D. fragilis was found in 30.1% of subjects and Blastocystis in 18.9%, both more prevalent in controls. Follow-up of 275 subjects in 2011 found no significant difference in gastrointestinal symptom development between those initially infected or uninfected with the parasites. The study concludes that harboring D. fragilis or Blastocystis does
Bats and rodents as a source of emerging human disease in KenyaILRI
Poster by E. Cook, E. Dobson, A. Kiyong'a, J Akoko, A. Ogendo, M. Bronsvoort, S. Kemp, B. Agwanda and E. Fèvre presented at the Australasian Society for Infectious Diseases (ASID) annual scientific meeting, Canberra, Australia, 20-23 March 2013.
This document discusses several studies on monogenic disorders and their potential medical applications. It first introduces monogenic disorders as involving mutations in a single gene, which can be inherited or spontaneous. Two studies are then summarized: one finding that brain stimulation may help restore breathing capacity in Duchenne muscular dystrophy patients by activating the diaphragm muscle, and another observing changes in mucus protein structure in cystic fibrosis patients that could provide insight into treatment. The document concludes that these studies bring researchers closer to potential treatments for currently incurable genetic diseases and improve patients' quality of life.
Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningitis in humans. It has a complex life cycle involving rats as the definitive host and various snail and slug species as intermediate hosts. In rats, the worms mature and reproduce in the pulmonary arteries, while in accidental hosts like humans they cannot complete their life cycle and cause meningitis symptoms instead. The document discusses the taxonomy, morphology, identification, and life cycle of A. cantonensis in detail. It also highlights several key publications that have contributed to the understanding of this parasite.
This PhD report aims to develop diagnostic tools to distinguish between protozoan parasites that infect ruminants, including Toxoplasma gondii, Neospora caninum, and Sarcocystis species. The report will identify genus-specific antigens for each parasite and develop antibodies and PCR tests that can detect the parasites individually. Recombinant antigens will be produced and used to generate genus-specific antibodies for diagnosis via immunohistochemistry. Genus-specific DNA targets and primers will also be identified to enable PCR-based detection of the protozoan parasites in tissue samples. Both diagnostic methods will be supported by a tissue bank of samples infected with the parasites.
This document summarizes and reviews several books and publications related to rheumatology and orthopedics. It discusses the following key points in 3 sentences:
The first section summarizes a book on neurology in orthopedics, praising it as a practical guide to the essential neurology knowledge needed for those working with musculoskeletal disorders. The second section summarizes a symposium on autoimmunity and genetics, noting that it gathered existing literature on genetic factors in autoimmune diseases. The third section summarizes a book on gout that established clinical criteria for diagnosing gout and described the authors' observations of 380 gout cases, analyzing etiological factors and various clinical presentations.
Background: VEGF is involved in cancer development by stimulating neo-angiogenesis and tumor proliferation. Anti-angiogenic therapies, especially tyrosine kinase inhibitors such as sunitinib, have significantly improved cancer prognosis. Nevertheless, renal side effects, such as proteinuria and thrombotic microangiopathy, have been reported. The underlying physiopathological mechanisms remain unclear, but animal models and clinical similarities with preeclampsia suggest that such therapies affect the function of the endothelial and epithelial layers of the glomerular basement membrane, with activation of the endothelin signaling system and loss of glomerular slit diaphragm integrity. The aim of this in vitro study was to determine sunitinib effects on normal podocytes and glomerular endothelial cells.
Seven people died within five days with similar symptoms of dizziness, confusion, headache, and difficulty breathing. An autopsy revealed hypoxia as the cause of death along with mitochondrial damage and low ATP levels in cells. Analysis of metabolites suggested a problem with the electron transport chain. Blood tests confirmed cyanide poisoning, which binds to cytochrome c oxidase and prevents electron transfer, explaining the hypoxia despite normal blood oxygen levels. The source was likely an over-the-counter pain reliever taken by some of the victims.
Yeast like fungal infections in medical intensive care unit in Polandwolass
This document summarizes a study on fungal infections in intensive care unit patients in Poland between 1996-2000. The study examined medical histories to create a database divided into groups by Candida species (C. albicans, C. glabrata, C. tropicalis, C. krusei, mixed). The study found that C. glabrata was increasing and linked to diabetes. Less common species were emerging. C. krusei was related to comorbid conditions. Fatal outcomes were associated with certain comorbidities. The study also examined antifungal resistance and fluconazole prophylaxis.
Purpose: To characterize the clinical features of ocular toxoplasmosis (OT) in Central Cuba. Methods: A database at a large regional referral center was searched for patients who, from April 1, 2011 to May 31, 2013, had the potential diagnosis of OT. Inclusion criteria were the clinical diagnosis of OT, characterized by focal retinochoroidal inflammation. Medical records were reviewed to confirm inclusion criteria (visual acuity recorded in decimal form).
Results: 279 patients (329 total eyes) were affected with OT. Overall, 66.7% were diagnosed with acquired OT with a mean age of 35.4 years and 1.8% with congenital OT with a mean age of 3.4 years. The time of onset of OT could not be determined in 28.3% (n=79) of patients. Patient clinical presentations were posterior uveitis (72.8 %), quiescent retinochoroiditis (16.1 %), and panuveitis (11.1%). Fourteen percent of patients had a slight decrease (0.9-0.6) in visual acuity, 44.4% a moderate decrease (0.5-0.2), and 41.6% a marked decrease (< 0.1).
Removal of foreign body from aerodigestive tractBASIT ALI KHAN
1) Foreign body aspiration is common in children under 5 years old and can lodge in the larynx, trachea, or bronchi, most commonly the right main bronchus.
2) Clinical features depend on if the foreign body is acute or chronic, with acute presenting with choking and chronic presenting with coughing or wheezing. Diagnosis involves history, examination, and imaging like CXR.
3) Removal of tracheobronchial foreign bodies is typically done with rigid bronchoscopy under general anesthesia while laryngeal foreign bodies may require procedures like cricothyrotomy or tracheostomy.
Lymphoma of the Tonsil in a Developing Communityasclepiuspdfs
The lymphoma of the tonsil is a rarity. Single case reports have appeared in countries as disparate as China, Greece, India, Japan, and Turkey. Therefore, this paper presents cases found in Nigeria among the Ibo ethnic group. The epidemiological comparisons are deemed to be worthy of documentation such as age ranges and sides of involvement.
This study examined 79 dry crania (55 male and 24 female) from southern Nigeria to determine the incidence and dimensions of single and double hypoglossal canals, and whether these dimensions differ between sexes. Measurements were taken of the internal and external diameters of the hypoglossal canals. The results showed significant differences in all dimensions between males and females. Bilateral single hypoglossal canals were most prevalent. In conclusion, the size of the hypoglossal canal is sex-specific, with significant differences found between males and females in this population.
This study examined 79 dry crania (55 male and 24 female) from southern Nigeria to determine the incidence and dimensions of single and double hypoglossal canals, and whether these dimensions differ between sexes. Measurements were taken of the internal and external diameters of the hypoglossal canals. The results showed significant differences in all dimensions between males and females. Bilateral single hypoglossal canals were most prevalent. In conclusion, the size of the hypoglossal canal is sex-specific, with significant differences found between males and females in this population.
This document presents 5 cases of rare multiple primary neuroblastomas in children. All 5 patients were boys aged 2 months to 4 years who were treated with surgery. Four also received chemotherapy and one received radiotherapy. With treatment, all 5 patients survived and were disease-free for 14 to 32 years of follow up. The cases suggest that diverse tumor differentiation leads to restricted growth and maturation, contributing to the excellent long-term prognosis seen in these rare cases of multiple primary neuroblastomas.
15. Bioarchaeology and Forensic AnthropologyAshley Kendell, MatthewTennant613
15. Bioarchaeology and Forensic Anthropology
Ashley Kendell, Ph.D., D-ABMDI, California State University, Chico
Alex Perrone, M.A., California State University, Chico
Colleen Milligan, Ph.D., California State University, Chico
Learning Objectives
• Define and differentiate bioarchaeology and forensic anthropology as subfields of biological
anthropology
• Describe the six steps carried out during skeletal analysis
• Outline the four major components of the biological profile
• Contrast the four categories of trauma
• Explain how to identify the different taphonomic agents that alter bone
• Discuss ethical considerations for both bioarchaeology and forensic anthropology
Bioarchaeology and forensic anthropology are both subfields of biological anthropology. While the goals of each subfield
are different, each relies on skeletal analysis to gain information about humans, both past and present. This chapter will
provide a general overview of the analysis of human skeletal remains, as it applies to both bioarchaeology and forensic
anthropology.
BIOARCHAEOLOGY
In 2010 Hurricane Earl reached the Caribbean Island of Antigua. The storm brought strong winds and heavy rainfall to
the island. After the storm calmed, accumulated water drained back out to the ocean, carving a channel through one
of the beaches at English Harbor as it went. Out of the newly created channel, human bones were exposed. Although
they had been buried for many years, the remains belonged to 18th–century British sailors who had died from Yellow
Fever while stationed in the Caribbean. While no headstones were present to divulge information about each person
buried on the beach, a large amount of evidence was still accessible through the analysis of each skeleton as well as the
information garnered from the burial context. To gather more information about each of the individuals buried on the
beach, the bones were examined, and a detailed analysis was carried out of the positions of the skeletons, the burial
depth, whether clothing material such as buttons were found with each set of remains, and whether it appeared that the
sailors were buried in coffins. In addition, the sex, age, and other individualizing characteristics were estimated through
careful analysis of the bones themselves.
The remains uncovered by Hurricane Earl in Antigua became part of a bioarchaeological study. Bioarchaeology is the
study of human remains excavated from archaeological sites. Bioarchaeologists glean information about each set of
human remains by examining the skeleton and by considering the archaeological context in which the skeleton was
1 | Bioarchaeology and Forensic Anthropology
recovered. Through this type of detailed skeletal analysis, bioarchaeologists obtain information about each individual
skeleton, which can include age, sex, height, ancestry, disease, diet, and behavior. For a broader understanding of past
peoples, bioarchaeologi ...
15. Bioarchaeology and Forensic AnthropologyAshley Kendell, EttaBenton28
15. Bioarchaeology and Forensic Anthropology
Ashley Kendell, Ph.D., D-ABMDI, California State University, Chico
Alex Perrone, M.A., California State University, Chico
Colleen Milligan, Ph.D., California State University, Chico
Learning Objectives
• Define and differentiate bioarchaeology and forensic anthropology as subfields of biological
anthropology
• Describe the six steps carried out during skeletal analysis
• Outline the four major components of the biological profile
• Contrast the four categories of trauma
• Explain how to identify the different taphonomic agents that alter bone
• Discuss ethical considerations for both bioarchaeology and forensic anthropology
Bioarchaeology and forensic anthropology are both subfields of biological anthropology. While the goals of each subfield
are different, each relies on skeletal analysis to gain information about humans, both past and present. This chapter will
provide a general overview of the analysis of human skeletal remains, as it applies to both bioarchaeology and forensic
anthropology.
BIOARCHAEOLOGY
In 2010 Hurricane Earl reached the Caribbean Island of Antigua. The storm brought strong winds and heavy rainfall to
the island. After the storm calmed, accumulated water drained back out to the ocean, carving a channel through one
of the beaches at English Harbor as it went. Out of the newly created channel, human bones were exposed. Although
they had been buried for many years, the remains belonged to 18th–century British sailors who had died from Yellow
Fever while stationed in the Caribbean. While no headstones were present to divulge information about each person
buried on the beach, a large amount of evidence was still accessible through the analysis of each skeleton as well as the
information garnered from the burial context. To gather more information about each of the individuals buried on the
beach, the bones were examined, and a detailed analysis was carried out of the positions of the skeletons, the burial
depth, whether clothing material such as buttons were found with each set of remains, and whether it appeared that the
sailors were buried in coffins. In addition, the sex, age, and other individualizing characteristics were estimated through
careful analysis of the bones themselves.
The remains uncovered by Hurricane Earl in Antigua became part of a bioarchaeological study. Bioarchaeology is the
study of human remains excavated from archaeological sites. Bioarchaeologists glean information about each set of
human remains by examining the skeleton and by considering the archaeological context in which the skeleton was
1 | Bioarchaeology and Forensic Anthropology
recovered. Through this type of detailed skeletal analysis, bioarchaeologists obtain information about each individual
skeleton, which can include age, sex, height, ancestry, disease, diet, and behavior. For a broader understanding of past
peoples, bioarchaeologi ...
7 Forensic Science Powerpoint Chapter 07 Forensic AnthropologyGrossmont College
The document discusses the role and techniques of forensic anthropology. It covers how forensic anthropologists examine human remains to develop a biological profile of victims and help with identification. They assess bones for characteristics like age, sex, ancestry and compare to records. Forensic anthropologists also study taphonomy and trauma to reconstruct events. Their expertise complements forensic pathologists in investigations.
The document summarizes the genomic analysis of medieval strains of Mycobacterium leprae, the bacteria that causes leprosy. Researchers analyzed DNA extracted from the remains of 9 individuals from a medieval leprosy hospital in Winchester, UK who showed signs of lepromatous leprosy. They were able to detect M. leprae DNA in all 9 individuals. In 5 cases, they could further genotype the strains, finding 3 had the SNP type 3I-1, related to modern strains in South America, while the other 2 had the rare SNP type 2F, the first discovery of this type in the British Isles. Stable isotope analysis found all 3 individuals likely spent their youth in the local Winchester
8 New Scientist 4 January 2020THE tropics are the most.docxtaishao1
8 | New Scientist | 4 January 2020
THE tropics are the most
biodiverse regions on Earth.
Now there is evidence that
they are also the main source
of evolutionary innovation
and diversity.
Complex animals have
dominated Earth for 541 million
years, a time span called the
Phanerozoic eon. Huge
numbers of species have
evolved and gone extinct
during this time, in a complex
story that includes fish, giant
reptiles and whales.
However, in the 1980s
palaeontologist John Sepkoski
analysed the overall pattern
of evolution in the sea,
where the fossil record is best.
He concluded that marine
evolutionary history could
be broken down into three
supergroups, which he called
“great evolutionary faunas”.
The first group was
dominated by trilobites,
which resembled woodlice,
and bristle worms; the second
by shellfish-like creatures called
brachiopods; and the third by
molluscs, which have persisted
to the present day. Other animals
like land mammals probably
followed similar patterns, but
their fossil record isn’t complete
enough for us to know.
Now, by analysing nearly
18,300 marine genera from
the Phanerozoic fossil record,
Alexis Rojas-Briceno of Umeå
University in Sweden and
his colleagues have found
that the evolution of
complex marine life is best
described using four great
groups of fauna, not three
(bioRxiv, doi.org/dg98).
The first supergroup existed
between 541 and 494 million
years ago, spanning the
Cambrian explosion in which
many animal groups first
emerged. As in the original
analysis, trilobites dominated.
The second supergroup,
dubbed the Palaeozoic, lasted
from 494 to 252 million years
ago. Creatures with hard outer
shells were now widespread,
including brachiopods. This
phase ended when the end-
Permian extinction wiped out
almost all complex life on Earth.
This matches Sepkoski’s
analysis, but the new study
splits his third great fauna into
two. In this version, the third
supergroup is called the
Mesozoic. It began in the wake
of the Permian extinction and
ended 129 million years ago, in
the middle of the dinosaur era.
This time cephalopods, the
group that includes squid
and octopuses, were the rulers.
The fourth and final
supergroup, the Cenozoic, is
still dominant today. During
this time, clams and snails have
made up much of the diversity.
The team found that all four
supergroups originated in the
tropics, then expanded through
the oceans. This is in line with
the idea that the tropics are
hotbeds of evolutionary
innovation, which has been
promoted by David Jablonski
at the University of Chicago.
It may be that the warmer
temperatures and ample
sunlight ensure there is plenty
of food to nourish a multitude
of species. However, John Alroy
at Macquarie University in
Australia isn’t convinced. “I have
always been sceptical about the
out-of-the-tropics hypothesis,
because they have never
seriously dealt with sampling
biases, as far .
8 New Scientist 4 January 2020THE tropics are the most.docxevonnehoggarth79783
8 | New Scientist | 4 January 2020
THE tropics are the most
biodiverse regions on Earth.
Now there is evidence that
they are also the main source
of evolutionary innovation
and diversity.
Complex animals have
dominated Earth for 541 million
years, a time span called the
Phanerozoic eon. Huge
numbers of species have
evolved and gone extinct
during this time, in a complex
story that includes fish, giant
reptiles and whales.
However, in the 1980s
palaeontologist John Sepkoski
analysed the overall pattern
of evolution in the sea,
where the fossil record is best.
He concluded that marine
evolutionary history could
be broken down into three
supergroups, which he called
“great evolutionary faunas”.
The first group was
dominated by trilobites,
which resembled woodlice,
and bristle worms; the second
by shellfish-like creatures called
brachiopods; and the third by
molluscs, which have persisted
to the present day. Other animals
like land mammals probably
followed similar patterns, but
their fossil record isn’t complete
enough for us to know.
Now, by analysing nearly
18,300 marine genera from
the Phanerozoic fossil record,
Alexis Rojas-Briceno of Umeå
University in Sweden and
his colleagues have found
that the evolution of
complex marine life is best
described using four great
groups of fauna, not three
(bioRxiv, doi.org/dg98).
The first supergroup existed
between 541 and 494 million
years ago, spanning the
Cambrian explosion in which
many animal groups first
emerged. As in the original
analysis, trilobites dominated.
The second supergroup,
dubbed the Palaeozoic, lasted
from 494 to 252 million years
ago. Creatures with hard outer
shells were now widespread,
including brachiopods. This
phase ended when the end-
Permian extinction wiped out
almost all complex life on Earth.
This matches Sepkoski’s
analysis, but the new study
splits his third great fauna into
two. In this version, the third
supergroup is called the
Mesozoic. It began in the wake
of the Permian extinction and
ended 129 million years ago, in
the middle of the dinosaur era.
This time cephalopods, the
group that includes squid
and octopuses, were the rulers.
The fourth and final
supergroup, the Cenozoic, is
still dominant today. During
this time, clams and snails have
made up much of the diversity.
The team found that all four
supergroups originated in the
tropics, then expanded through
the oceans. This is in line with
the idea that the tropics are
hotbeds of evolutionary
innovation, which has been
promoted by David Jablonski
at the University of Chicago.
It may be that the warmer
temperatures and ample
sunlight ensure there is plenty
of food to nourish a multitude
of species. However, John Alroy
at Macquarie University in
Australia isn’t convinced. “I have
always been sceptical about the
out-of-the-tropics hypothesis,
because they have never
seriously dealt with sampling
biases, as far .
Researchers used time-lapse imaging to observe enteric neural crest cells (ENCCs) that migrate during development to form the enteric nervous system in the mouse gut. They discovered that a population of ENCCs migrate across the mesentery from the midgut to the hindgut when these regions are temporarily next to each other. This challenges the traditional view that ENCC migration only occurs from front to back. The trans-mesenteric ENCCs appear to constitute a large part of the enteric nervous system in the colon. Failure of ENCC migration leads to Hirschsprung disease, and the researchers suggest a defect in trans-mesenteric ENCC migration causes this condition. They plan
The Effect Of Team Assisted Individualization ( Tai ) And...Jennifer Campbell
This essay discusses how insects can provide important evidence for criminal investigators at crime scenes, such as estimating time of death. However, this requires knowledge of the local insect populations. The study aimed to survey beetle (Coleoptera) populations in Lyon County, Kansas in early spring using light traps. DNA was extracted and a gene (cytochrome oxidase I) was amplified from each collected beetle specimen to characterize the local populations at a genetic level and aid future forensic investigations.
This document provides a summary of several unethical human and animal experimentation projects throughout history. It describes experiments conducted by the Nazis, Japanese Unit 731, Soviets, Americans and others. Many involved deliberately infecting or injuring prisoners and concentration camp inmates without consent. The goal of many was to study disease progression, test weapons/toxins, or advance racial ideology. Notable projects included Nazi twin and hypothermia experiments, Japanese plague dispersal tests, US syphilis studies and more. Overall, the document outlines some of the worst violations of medical ethics in history.
Researchers at NYU have discovered that spermathecal secretory cells (SSCs) in the female fruit fly reproductive tract play two key roles: 1) moving fertilized eggs through the tract and 2) storing sperm. By removing SSCs genetically, the researchers found sperm could no longer reach storage areas and lost motility, preventing egg hatching. This discovery could help understand reproduction in other insects like honeybees or mosquitoes.
Forensic entomology "Past, Present and the Future"Nagwa2012
Forensic entomology is the study of insects in legal investigations. It has developed from determining time of death to identifying location and cause of death. Key developments include the use of DNA to identify insect species and detect toxins in insects to determine cause of death. However, more research is still needed to fully understand insect populations and drug effects on growth rates. Future areas of focus include identifying more insect species, studying regional ecosystems, and extracting human DNA from insects to aid identification. Increased popularity of the field is also important to drive further innovation.
This case report describes a rare case of triple intestinal atresia involving the jejunum, ileum, and colon in a newborn female with Down syndrome and imperforate anus. The baby underwent emergency laparotomy which revealed atresias in the jejunum, ileum, and colon. Histopathology of the resected intestinal segments showed no specific cellular abnormalities. Unfortunately, the baby did not survive due to post-operative cardiopulmonary complications. Triple intestinal atresia is an extremely uncommon condition. The presence of Down syndrome and imperforate anus with triple atresia makes this an especially rare case.
Correlation between Human Origin and the Severity of COVID19ijtsrd
It has been reported that the severity of coronavirus infectious disease COVID 19 is due to several factors such as age and the presence or absence of chronic disease. Furthermore, it has been reported that genetic factors affect the severity of COVID 19. A recently published study of the COVID 19 Host Genetics Initiative suggests that genetic manifolds in the region located on chromosome 3 may increase the risk of the severity of COVID 19. Takuma Hayashi | Ikuo Konishi "Correlation between Human Origin and the Severity of COVID19" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33684.pdf Paper Url: https://www.ijtsrd.com/medicine/other/33684/correlation-between-human-origin-and-the-severity-of-covid19/takuma-hayashi
Oesophagostomum bifurcum is a parasitic nematode that infects humans. It belongs to the phylum Nematoda, order Strongylida, and family Strongylidae. The life cycle involves eggs passed in feces that hatch on soil into larvae, which are then accidentally ingested. In the intestine, larvae mature into adult worms that reproduce and lay eggs, completing the cycle. Infection causes thickening of the colon wall and formation of nodules. While usually self-limiting, heavy burdens can cause obstruction. Diagnosis involves finding eggs in stool samples under microscopy. The parasite is found endemically in parts of Africa and can infect humans directly without an animal reservoir.
Similar to Forensic Case of Passerby Girl Hit by Crate Falling from a Truck-Crimson Publishers (20)
Influencing Factors on Age-Friendly Interiors by Abraham George in Forensic Science & Addiction Research: Population
Aging is a progressive accumulation of changes in the living human body with time that are associated with susceptibility to disease, excessive physical strain, lack of physical capability with advancing age. Modernisation and development in science and technology have directly and indirectly affected the aged in living independently. It is for the benefit of all age groups to be together so that each will benefit from others, especially the elder and younger generations. Thus it is imperative to include the preferences of aged in the designing of residential spaces for their productive inclusion in the society. The paper discusses on age-friendly residential spaces which supports the aged to improve their quality of life, self-dependence and wellness.
Age-friendly space facilitates health, well-being and creative participation of people, even as they age; and assures accessible, equitable, inclusive, safe, secure, and supportive built forms. Age-friendly approach looks for equal and healthy participation of aged along with the other age groups. Effective planning for aged involves in-depth understanding of their limitations and problems related to the living space and resolving them in Indian context. Problems faced by elderly are related to vision, mobility, audibility, accessibility and thermal comfort apart from psychological, which are to be considered in design. Selection of materials plays an important role in making the spaces age-friendly. Ergonomic designs following appropriate human anthropometry are central to generate effective designs. Psychological issues are to be dealt separately and improving their self-worth calls for societal interactions and participation in decision making.
Crimson Publishers-Impulsive Traits of In-Jail Female with Selling Substance ...Crimson-ForensicScience
Impulsive Traits of In-Jail Female with Selling Substance Crime by Elham Foroozandeh in Forensic Science & Addiction Research: Drugs
Substance and drug sale becomes an important social, political and health problem in Iran. In this report, the impulsive behavior of Iranian female prisoners associated with the crime of selling substance and drugs was investigated. For this aim a sample of 55 women was selected by simple random sampling method and they were asked to complete Bart's impulsivity questionnaire. The findings showed that incarcerated women are more impulsive than the average rate. It can be stated that impulsive non-planning behaviors in women lead to using weaker strategies in problem solving and produce a defective cycle for women with components of behavioral disabilities and selling substance and drugs.
Crimson Publishers: Practical Issues of Inhibition in Forensic Body Fluid Ide...Crimson-ForensicScience
The main objectives of forensic biological examinations are body fluid analysis and identification of persons involved in a criminal act. Recent molecular biological techniques have enabled the analysis of trace and impure forensic samples. In particular, polymerase chain reaction (PCR)-based DNA typing is the standard test used in human identification worldwide [1]. PCR technology is suitable for analysis of trace particles of evidence; however, the problem with PCR inhibition is known for making proper amplification difficult
Crimson Publishers: Effect of Strength Training on Physical Variable of Colle...Crimson-ForensicScience
Effect of Strength Training on Physical Variable of College Men Cricket Players by Zahoor Ahmad Bhat* in Forensic Science & Addiction Research
The purpose of the present study was to find out the effect of strength training on Physical Variable of college men cricket players. To achieve the purpose twenty male students (n=20) were randomly selected as subjects and the age were ranged between 18 and 24 years. The selected subjects were randomly assigned into two equal groups such as training group (TG) and control group (CG) for the strengths of fifteen (n=10) each. Experimental training group underwent respective strength training program me for twelve weeks for three days per week and a session on each day. The control group did not involve in any special training apart from their regular activities. The criterion variable arm strength was measured by pull-ups. Analysis of covariance (ANCOVA) was used to analyse the collected data. The results revealed that that the strength training was made significant improvement (p≤0.05) in arm strength of the selected subjects. The level of confidence was fixed at 0.05 in all cases.
Crimson Publishers: Impact of Resistance Training on Flexibility of Male Coll...Crimson-ForensicScience
The aim of this study was to find out the effect of resistance training on flexibility of male college hostel students. Twenty male hostel students (n=20) were randomly selected from the Government Degree College, Anantnag. The ages were ranged between 18 and 22 years. The selected subjects were randomly assigned into two equal groups as training group (TG) control group (CG). The training group (TG) underwent respective resistance training programme for twelve weeks duration for three days per week and a session on each day. The control group (CG) did not expose any special training apart from their regular activities. The flexibility was taken as a dependant variable for the study and it was measured by using sit and reach test. Analysis of covariance (ANCOVA) was used to analyze the collected data. The result revealed that resistance training was made significant improvement (p≤0.05) in Physical Fitness of selected subjects. The level of confidence was fixed at 0.05 levels.
Crimson Publishers: Neglected Physical Evidence during Crime Scene InvestigationCrimson-ForensicScience
Forensic is a fascinating term used not only by the forensic personnel but also by non-forensic personnel for various purposes. Many movies and dramas include forensic elements in their storylines which use forensic techniques contributing to the crime scene investigation and solve the mystery within hours. The gap between forensic science fiction and reality is far wide. The aspects of forensic fiction are different from real-life forensic investigation. Contrary to the way it is portrayed in popular media, crime scene investigation is not glamorous or accomplished in an easy manner [1].
Crimson Publishers: Contributions of Forensic Odontology in Human IdentificationCrimson-ForensicScience
The forensic science is concerned investigation of crime and administration of justice, requiring coordinated efforts of an interdisciplinary team. This temperament involves the cooperation & coordination of law enforcement officials, forensic pathologists, forensic anthropologists, forensic odontologists, criminalistics, and other specialists as deemed necessary. Human identification is one of the most challenging subjects that man has been confronted with. Forensic odontology has become an integral part of forensic medicine and has aroused growing interest in the globalized world, where different cultures have tightened their links, magnifying social, cultural, political, economic and scientific exchange, needing to promote interdisciplinary identification of people traveling around the world, victims of traffic accidents, violent crimes, kidnappings and terrorist attacks. The dental experts are members of such teams, involved in various tasks to respond to the departments responsible for administering justice.
Effect of Circuit Training on Agility of College Male Students-Crimson Publis...Crimson-ForensicScience
The purpose of this investigation was to find out the influence of circuit training on agility among college students. Thirty male college students (n=30) were randomly selected as subjects and their age ranged between 18 and 22 years. The selected subjects were randomly assigned into two equal groups such as circuit training group (CTG), and control group (CG) with fifteen subjects each (n=15). The experimental group underwent their respective experimental treatment for eight weeks three days per week and a session on each day. Control group was not undergone any specific training apart from their regular activities. Agility was taken as dependent variable for this study and it was measured by shuttle run. The collected data was analyzed by using analysis of covariance (ANCOVA). The result revealed that the circuit training group produced significant improvement (p≤0.05) on agility as compare to control group.
Assessment of Aggression among Under19 Football Players-Crimson PublishersCrimson-ForensicScience
The present study aimed to find out the level of aggression among under 19 football players. The present study is based on the sample of 60 under 19 football players equally divided into two groups (boys and girls); further these two groups were also divided into two more sub groups as junior and senior selected through purposive sampling technique. Aggression in Sport and Business Questionnaire developed by R. Makarowski was used for data collection. Mean, Frequency, and t-test, was applied for statistical analysis. Results reveal that there is a significant difference found between the mean scores of aggression of boys and girls. But insignificant difference was found between the mean scores of junior and senior in respect to their aggression scores. Results also demonstrated that boys and junior player are more aggressive than girls and senior players. Further it is also revealed that 11(18.33%) have high level of aggression, 46(76.67%) have moderate level, and 3(5%) players have low level of aggression (Table 2, Figure 1).
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.