This document provides an overview of setting up co-simulation between ANSYS Mechanical and ANSYS Fluent using System Coupling. It discusses the necessary setup steps in Mechanical including analysis settings, fluid-solid interfaces, and output controls. It also covers the Fluent setup, including defining dynamic mesh zones, solution stabilization options, and notes on fluid compressibility. Finally, it addresses the System Coupling setup for defining data transfers and solution controls between the two solvers.