Fit1012 final Jake Gelvar
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The document describes an e-Diabetes application and associated e-Diabetes Phone Glucometer (eDPG) device that are designed to replace traditional glucometers for diabetics. The eDPG plugs into a smartphone's headphone jack and works just like a regular glucometer by reading blood sugar levels from test strips inserted into the device. The application and eDPG aim to make managing diabetes easier by utilizing the functionality of smartphones.
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5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
How to choose the best dermatologists in Indore.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
How to Control Your Asthma Tips by gokuldas hospital.
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
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Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
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- 2. e-Diabetes • e-Diabetes Application – The e-Diabetes Application will be used to revolutionize the way diabetics check their blood sugar levels. • e-Diabetes Phone Glucometer (eDPG) – Small device that takes advantage of all smartphone’s headphone jacks. Technology inspired by the Square – Replaces the need for big bulky glucose meters.
- 3. Purpose • The main purpose of this app and device is to totally replace the glucometer. • The eDPG acts just like a normal glucometer but uses the phone’s interface and functions instead. – This means, you insert the eDPG into the headphone jack of your phone and insert the blood sugar test strip into the eDPG just like you would a normal meter.
- 4. Objectives • There is one and only one objective for this app to accomplish:
- 5. Objectives Continued • As of 2011, 25.8 million Americans and 347 million people worldwide live with diabetes. http://www.who.int/mediacentre/factsheets/fs312/en/ • Living with a chronic illness is tough and each person deserves for their life to be made a little easier. • I have three chronic diseases myself and two of my closest friends have Diabetes.
- 6. Usage of the Application • First and foremost, this application along with the eDPG replaces the glucometer. • It works just as a glucometer would, using the same exact blood sugar test strips.
- 7. Usage of the Application • To actually perform the primary function: – Run the app on your phone. – Plug in your eDPG – Insert your blood sugar test strip. – Put your blood on the strip. – Touch the GO button. • and the app does the rest! 100 GO
- 8. Who can use this application? • This application and the eDPG will be available for Androids, iPhones, Window’s Phones and Blackberries. • Essentially any smartphone with a headphone jack will work. • Any smartphone user world-wide will have access to this incredible technology.
- 10. References • http://www.diabetes.org/ • http://jdrf.org/ • http://www.who.int/mediacentre/factsheets/fs3 12/en/