This document discusses how stress affects the brain and body and explores mindfulness and meditation as ways to manage stress. It summarizes that stress activates the body's fight or flight response through the autonomic nervous system and hormones. Prolonged stress can impair brain regions and exacerbate mental health issues. The document then outlines how mindfulness and meditation have been shown in studies to produce measurable changes in brain regions involved in stress and emotion regulation, allowing people to better manage stress and negative thought patterns. Regular practice can help people live more in the present moment and cope with stressors in a healthier way.