This document discusses fever in the intensive care unit. It begins with definitions of terms like fever and hypothermia. It then discusses the pathogenesis and significance of fever. Fever can both enhance immune function but also lead to poor outcomes in some cases like stroke patients. In the ICU, fever often complicates many admissions and can be caused by infectious or non-infectious etiologies. Common infectious causes are discussed like ventilator-associated pneumonia, catheter-associated bloodstream infections, and urinary tract infections. Non-infectious causes such as drug reactions, adrenal crisis, and blood transfusions are also outlined. The document concludes with a discussion of antibiotic use and strategies to optimize treatment in the ICU.
Austin Tuberculosis: Research & Treatment is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Tuberculosis.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Tuberculosis. Austin Tuberculosis: Research & Treatment accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Tuberculosis.
Austin Tuberculosis: Research & Treatment strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Tuberculosis: Research & Treatment is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Tuberculosis.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Tuberculosis. Austin Tuberculosis: Research & Treatment accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Tuberculosis.
Austin Tuberculosis: Research & Treatment strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Antibiotics are most common therapeutic agents used in hospitals across world, however, microbial world is becoming resistant day by day, posing special challenges to clinicians specially working in ICU set ups. There are multiple ways to curb this menace, if approached together in antibiotic stewardship way, can bring about wonders and retain therapeutic potentials of these drugs.
a double-stranded DNA virus : human herpesvirus-3 subfamily Alphaherpersvirinae
only one serotype is known
humans are the only reservoir
VZV enters the host through the nasopharyngeal mucosa, and almost invariably produces clinical disease in susceptible individuals
Following varicella, the virus persists in sensory nerve ganglia, from where it may later be reactivated to cause herpes zoster (Shingles)
Pneumonia - Community Acquired Pneumonia (CAP)Arshia Nozari
An overview to Community Acquired Pneumonia; It's Pathophysiology, Etiology, Epidemiology, Diagnosis and Treatment according to Harrison's Internal Medicine, 20th Edition (2018).
Antibiotics are most common therapeutic agents used in hospitals across world, however, microbial world is becoming resistant day by day, posing special challenges to clinicians specially working in ICU set ups. There are multiple ways to curb this menace, if approached together in antibiotic stewardship way, can bring about wonders and retain therapeutic potentials of these drugs.
a double-stranded DNA virus : human herpesvirus-3 subfamily Alphaherpersvirinae
only one serotype is known
humans are the only reservoir
VZV enters the host through the nasopharyngeal mucosa, and almost invariably produces clinical disease in susceptible individuals
Following varicella, the virus persists in sensory nerve ganglia, from where it may later be reactivated to cause herpes zoster (Shingles)
Pneumonia - Community Acquired Pneumonia (CAP)Arshia Nozari
An overview to Community Acquired Pneumonia; It's Pathophysiology, Etiology, Epidemiology, Diagnosis and Treatment according to Harrison's Internal Medicine, 20th Edition (2018).
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The entire scope of febrile neutropaenia in paediatrics subpopulation undergoin cancer chemotherapy including guidelines for risk stratification and mangement.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. FEVER IN INTENSIVE CARE
UNIT
Dr. Nathan Muluberhan(E M
r e s i d e n t )
August
2017
2. OUTLINE
DEFINITIONS OF TERMS
PATHOGENESIS OF FEVER
SIGNIFICANCE OF FEVER
FEVER IN ICU
INFECTIOUS CAUSE
NON INFECTIOUS CAUSE
3. DEFINITIONS
F E V E R :
elevation of body temperature that exceeds the normal daily
variation and occurs in conjunction with an increase in the hypothalamic set point.
H Y P E R T H E R M I A :
elevation of body temperature in a setting of unchanged the hypothalamic
thermoregulatory center is
HYPERPYREXIA:
an extraordinarily high fever (>41.5ºC)
P Y R O G E N S :
is any substance that causes fever
5. TEMPERATURE MEASUREMENT
Normal body temperature is generally considered to be
37.0°C (98.6°F) with a circadian variation of between 0.5
to 1.0°C.
The Society of Critical Care Medicine define fever in the
ICU as a temperature >38.3°C (>101°F).
6. SIGNIFICANCE OF FEVER
Enhance the resistance of animals to infection
Enhance several parameters of immune
function
some pathogens such as Streptococcus
pneumoniae are inhibited by febrile
temperatures.
a To of 38°C shown to increased survival in
patients with SBP
7. Increase
cardiac output
oxygen consumption
carbon dioxide production
energy expenditure
Poor neurologic outcome in patients with stroke and TBI.
Maternal fever has been suggested to be a cause
fetal malformations and spontaneous abortions
SIGNIFICANCE OF FEVER CONT…
8. FEVER IN ICU
Fever complicates up to 70 % of all ICU admissions.
DIFFERENTIAL:
Fevers between 38.3ºC (101ºF) and 38.8ºC (101.8ºF) may be
infectious or noninfectious.
Fevers between 38.9 (102ºF) and 41ºC (105.8ºF) can be
assumed to be infectious.
Fevers ≥41.1ºC (106ºF) are usually noninfectious.
11. Typically presents with:
a new or progressive pulmonary infiltrate
one or more of the following findings:
fever, purulent tracheobronchial secretions,
leukocytosis,
increased respiratory rate, decreased tidal
volume, increased minute ventilation, and
decreased oxygenation
VENTILATOR-ASSOCIATED PNEUMONIA
CONT…
12. CATHETER-ASSOCIATED SEPSIS
is defined as blood stream infection due to an organism
that has colonized a vascular catheter
Approximately 5% of patients with indwelling vascular
catheters (uncoated) will develop blood stream infection
13. If catheter sepsis is suspected
the catheter should be changed to a new site
Send culture of the catheter tip.
CATHETER-ASSOCIATED SEPSIS
CONT…
14. URINARY TRACT INFECTIONS (UTIS)
account for between 25 to 50% of all infections
Defined as:
the presence of fever >38ºC, SPT, CVAT
Urine culture with
>10(5) cfu/mL irrespective of urinalysis
>10(3) cfu/mL with evidence of pyuria
15. Bacteriuria should be treated following
urinary tract manipulation or surgery
patients with kidney stones & urinary tract
obstruction
Patient with neutropenia
URINARY TRACT INFECTIONS CONT…
16. CLOSTRIDIA DIFFICILE Colitis
About 20% of all hospitalized patients become
“infected” with C difficile
only 1/3 develop diarrhea.
Use of clindamycin, 3rd generation cephalosporin
and fluoroquinolones is the risk factor
Other risk factors:
use of PPI, GI surgery, prolonged ICU stay and tube
feeding
17. Symptoms usually begins shortly after
antibiotics therapy
Clinical spectrum includes:
Colitis, pseudomembranous colitis, fulminant
colitis
Stool assay for toxin A and B by ELISA
Further work up: cytotoxic assay,
sigmoidoscopy and CT scan
CLOSTRIDIA DIFFICILE Colitis
CONT…
18. Stop the offending antibiotics if possible
Provide adequate fluid and electrolytes
Don’t use antimotility agents
If specific rx required use metronidazole
Strict contact isolation of the patient
CLOSTRIDIA DIFFICILE Colitis
CONT…
19. SINUSITIS
sinusitis is common following nasal
intubation
with an incidence of up to 85% after a week of
intubation.
The maxillary sinus is most commonly
involved
20. Major criteria: cough & purulent nasal discharge
Minor criteria: headache or earache, facial or tooth
pain, fever, malodours breath sore throat and
wheezing
Sinusitis on CT
total opacification
the presence of an air fluid level within any of the
paranasal sinuses.
SINUSITIS CONT…
21. MICROBIOLOGY:
Pseudomonas (60%)
Stap. Aureus (33%)
Treatment
Remove all nasal tubes
Drainage (Needle(Maxillary) or surgical (ethmoid and
sphenoid))
Antibiotics
SINUSITIS CONT…
23. DRUG FEVER
It can occur several days after the initiation of the
drug,
can produce high fevers (>38.9ºC) without other
signs.
The true incidence is unknown.
Cause:
Stimulation of heat production(eg. Thyroxine)
Limit of heat dissipation (eg. atropine)
Alter thermoregultion (eg. antihistamines,
24. ADRENAL CRISIS
occurs in patients with previously adrenal
insufficiency who are subjected to a serious
infection or other major stress.
manifestation
Distributive shock is the predominant
fever, nausea, vomiting, abdominal pain, fatigue,
lethargy, hypoglycemia, confusion, or coma
25. EMERGENCY TREATMENT
Adequate fluid resuscitation
Draw blood for electrolytes, glucose, cortisol and
ACTH
Glucocorticoid
Dexamethasone
Hydrocortisone is preferred with known primary
adrenal insufficiency with potassium >6.0 meq/L.
(because of its mineralocorticoid activity)
ADRENAL CRISIS CONT…
26. ACUTE HEMOLYTIC TRANSFUSION
REACTION
A medical emergency that results from the
rapid destruction of donor red blood cells by
recipient antibodies.
Usually due to ABO incompatibility.
Common clinical manifestations
fever, chills, distributive shock, disseminated
intravascular coagulation, and acute kidney injury.
27. Stop the transfusion.
Maintain the patient's airway, blood pressure, and
heart rate.
Begin an infusion of normal saline immediately
Avoid the use of Ringer's lactate solution because its
content of calcium may initiate clotting of any blood
remaining in the intravenous line.
Avoid dextrose- containing solutions because the dextrose
may hemolyze any of the remaining red cells in the line.
ACUTE HEMOLYTIC TRANSFUSION
REACTION CONT…
28. ACALCULOUS CHOLECYSTITIS
0.2 to 1.5 % of patients in ICU
presents with fever, leukocytosis, and vague
abdominal discomfort.
May progress to gangrene and perforation.
have a mortality rate as high as 30 to 40 %
29. ULTRASOUND
Absence of gallstones or sludge
Thickening of the gallbladder wall (>5 mm) with pericholecystic
fluid
A positive Murphy's sign induced by the ultrasound probe
Failure to visualize the gallbladder
Frank perforation of the gallbladder with associated abscess
formation
TREATMENT
broad spectrum antibiotics
cholecystectomy with drainage of any associated abscess
ACALCULOUS CHOLECYSTITIS
CONT…
30. ANTIBIOTIC USE IN INTENSIVE
CARE UNIT
Dr. Nathan Muluberhan(E M
r e s i d e n t )
August 2017
31. OBJECTIVES
principles of antibiotic use
optimize use of antibiotic
multidrug resistant bacteria
To look at the role of novel biomarker
in guiding antibiotic therapy
32. PRINCIPLES OF ANTIBIOTIC
PRESCRIPTION
Send for appropriate investigations (minimum required
for dx, prognosis and follow up) before initiation of
antibiotics
Change in antibiotics would be done after sending fresh
culture
Follow the hospital antibiotics policy. If alternative has
chosen, document the reason
Check for factors which will affects drug choice and
dose(eg. Renal function, interaction and allergy)
Check appropriate dose is prescribed
33. All IV antibiotics may only given for 48-72 hrs without
review
Once culture result available descalate and if not,
document the reason
Emperic therapy initation delay for await of micro report
would be life threatining and mortality rate will be
increased
Antibiotics therapy based on a clinically defined infection
is justified
Rapid tests such as gram stain can help determine
theraputic choice when emperic therapy is required
PRINCIPLES OF ANTIBIOTIC
PRESCRIPTION
34. STRATEGIES TO OPTIMIZE THE USE
OF ANTIMICROBIALS
1. Use of PK/PD parameters for dose
adjustment
2. De-escalation therapy
3. Antibacterial cycling
4. Pre-emptive therapy
37. 1. CONCENTRATION DEPENDENT KILLING ACTIVITY
AND MODERATE TO PROLONGED PERSISTENT
EFFECTS
More rapid killing effect against micro organisms than
low concentrations
Allows the administrations of high doses with widely
separated frequencies of administration
Aminoglycosides, Fluoroquinolones, Metronidazole,
Colistin, Rifampicin, Clindamycin
38. CONCENTRATION DEPENDENT CONT…
AMINOGLYCOSIDES
Doses of these antimicrobials administered to critically ill patients
are frequently insufficient
Rea RS, et al. Suboptimal aminoglycoside dosing in critically ill patients. Ther
Drug Monit 2008; 30: 674-81
FLUOROQUINOLONES
Using a Monte Carlo dosing simulation, doses of 400mg every 8-
12hrs givento 1-2 patients did not reach the necessary killing
concentrations for P.aeruginosa, A.baumannii strains
39. 2. TIME DEPENDENT KILLING ACTIVITY AND
MINIMAL PERSISTENT EFFECTS
Maintain blood concentrations above MIC for
prolonged time periods
These drugs should be given by continuous
infusion
Beta lactams and Linezolid
40. 3. TIME DEPENDENT KILLING ACTIVITY AND
MODERATE TO PROLONGED PERSISTENT EFFECTS
Glycopeptides (Vancomycin, Teicoplanin)
The duration of effect is longer and the possibility of
regrowth of micro-organisms during the dosing
interval is more limited
In humans, AUC/MIC value >350 was an independent
factor associated with clinical success in patients with
S.aureus proven lower respiratory tract infection
Tetracyclines
41. DE-ESCALATION THERAPY
Initial administration of broad spectrum empirical
treatment
To cover pathogens, most frequently related to the
infection
Rapid adjustment of antibacterial treatment
once the causative pathogen has been identified
43. DURATION OF ANTIBIOTIC THERAPY
The optimal duration of antibiotic therapy for
bacteremia is unknown.
some evidence that would suggest that there
is no significant difference in mortality, clinical
and microbiological cure b/n shorter and long
durations
i.e. 5 – 7 days versus 8 -21 days in critically ill
patients with bacteremia.
44. ANTIBACTERIAL CYCLING
The scheduled rotation of one class of
antibacterial
One or more different classes with comparable
spectra of activity
Different mechanisms of resistance
Some weeks and a few months
45. PRE-EMPTIVE THERAPY
The administration of antimicrobials in certain
patients at very high risk of opportunistic infections
before the onset of clinical signs of infection
Developed in hematological patients and/or transplant
recipients
CMV, aspergillosis
In critical illness patients at high risk of candidemia or
invasive candidiasis
46. CANDIDA SCORE
A bedside scoring system for preemptive antifungal
treatment in nonneutropenic critically ill patients with
Candida colonization. Crit Care Med 2006; 34: 730-7
“Candida score” >2.5 accurately selected patients who
would benefit from early antifungal treatment.
Candida score = 0.908* (TPN) + 0.997* (surgery)+ 1.112* (multifocal candida
colonization) + 2.038* (severe sepsis)
1 if present
0 if absent
47. MULTIDRUG RESISTANT
BACTERIA
Increasing prevalence of multidrug-resistant
pathogens in ICUs
CDC Report shows from 1999 and 2006/2007
VRE (from 24.7% to 33.3 % of enterococci isolates)
MRSA (from 53.5 % to 56.2 % of S. aureus isolates)
P. aeruginosa resistant to imipenem (from16.4 to
25.3) or fluoroquinolones (from 23.0 to 30.7) from P.
aeruginosa isolates
48. RISK FACTORS
Older age
Presence of underlying comorbid conditions
higher severity of illness indices
Long hospital courses prior to the ICU admission,
Receipt of antimicrobial therapy prior to the ICU
admission.
Presence of indwelling devices
Recent surgery or other invasive procedure
Frequent manipulation and contact with healthcare
person
49. PREVENTION OF RESISTANCE IN THE ICU
Strategies can be separated into two major
categories:
strategies that attempt to improve the efficacy and
utilization of antimicrobial therapy
infection control measures
50. INFECTION CONTROL MEASURES
good hand hygiene compliance
Active surveillance of patients for
asymptomatic colonization
Institution surveillance for infections with
multidrug-resistant bacteria
Daily chlorhexidine bathing
51. NOVEL BIOMARKERS
PROCALCITONIN
best studied biomarker for guiding antibiotic treatment
duration in the hospital setting.
It’s dynamics within 72 hours after onset of sepsis may be
correlated both with appropriateness of the empirical
antibiotic therapy
integrated in clinical algorithms have been shown to
reduce the duration of antibiotic courses by 25-65% in
hospitalized and more severely ill patients with CAP and
sepsis
52. REFERENCES
Harrison's Principles of Internal Medicine, 19th ed
Up-to-date 21.6
Practice Guidelines for Evaluating New Fever in
Critically Ill Adult Patients. From the National Institutes
of Health, Bethesda, and the Johns Hopkins Hospital and St.
Agnes Hospital
Annual Update in Intensive Care and Emergency
Medicine 2016