This document discusses the use of fetal magnetic resonance imaging (MRI) as a valuable adjunct to ultrasound in evaluating fetal abnormalities. It provides advantages of fetal MRI such as detailed anatomical imaging without radiation exposure. The document outlines the MRI protocol for fetal imaging and describes various fetal abnormalities that can be evaluated, including central nervous system anomalies like ventriculomegaly, corpus callosum abnormalities, holoprosencephaly, neural tube defects, and anencephaly. It emphasizes the role of fetal MRI in confirming suspected anomalies seen on ultrasound and detecting additional abnormalities.
Shared Decision Making, Decision Support and Breast Conservation TherapyMatthew Katz
Shared Decision Making, Decision Support and Breast Conservation Therapy explores how breast cancer patients interpret decisions around making decisions about mastectomy vs. lumpectomy.
EBCTCG METAANALYSIS
INDICATION OF POST OP RADIOTHERAPY
Immobilization devices
Conventional planning
Alignment of the Tangential Beam with the Chest Wall Contour
Doses To Heart & Lung By Tangential Fields
Adrenal Mass in Pregnancy: Diagnostic Approach and DilemmasApollo Hospitals
An adrenal incidentaloma is a mass lesion greater than 1 cm in diameter, incidentally found during radiologic examination for other reasons.
1. Such “adrenal incidentalomas” are increasingly recognised in clinical practice.
2. This is attributed to routine use of sophisticated and sensitive imaging techniques, with a reported prevalence of 4.4%.
3. Incidental findings of such masses pose dilemmas in evaluation and management, as current recommendations based on expert opinion.
4. Are open to debate in terms of cost and clinical
benefits. The uncertainties in management multiply with
such adrenal incidentalomas in the context of pregnancy.
We report a rare case of a large adrenal incidentaloma
complicating second trimester of pregnancy. This case
outlines the huge decisional dilemmas, both for the patient
and healthcare provider.
Thermal Imaging: Opportunities and Challenges for Breast Cancer DetectionTarek Gaber
Thermal Imaging: Opportunities and Challenges for Breast Cancer Detection
Abstract:
Breast cancer is the most common cancer among women in the world. It is estimated that one in eight women, all over the wide, would develop breast cancer during her life. Breast cancer is considered one of the first-leading causes of cancer deaths among women. The early detection of breast cancer could save many women's life. Mammogram is one of the most imaging technology used for diagnosing breast cancer. Although mammogram has recorded a high detection and classification accuracy, it is difficult in imaging dense breast tissues, its performance is poor in younger women, it is harmful, and it couldn’t detect breast tumor that less than 2 mm. To overcome these limitations, it was found that there is a relation between the temperature and the presence of breast cancer. Utilizing this fact, infrared thermography could be a good source of breast images to study and detect cancer at the early stages which is crucial for cancer patients for increasing the rate of breast cancer survival.
This talk aims to give an overview of the thermal imaging technology, its possible applications in the medical field, focusing on its opportunities and challenges for the early detection of breast cancer and highlighting the state-of-the-art of this point.
New Developments in Breast Reconstruction Surgerybkling
Deborah Axelrod, MD, of NYU Langone Perlmutter Cancer Center, and Rachel Bluebond-Langner, MD, of NYU Langone Medical Center discuss the latest research in autologous breast reconstruction, fat injection, pre-pectoral implants, and oncoplastic surgery.
Disclaimer: Graphic medical imagery.
Breast conserving surgery followed by adjuvant radiotherapy is adopted in the early detected cases and mastectomy followed by radiotherapy or chemotherapy in the advanced cases are the general practices.
Shared Decision Making, Decision Support and Breast Conservation TherapyMatthew Katz
Shared Decision Making, Decision Support and Breast Conservation Therapy explores how breast cancer patients interpret decisions around making decisions about mastectomy vs. lumpectomy.
EBCTCG METAANALYSIS
INDICATION OF POST OP RADIOTHERAPY
Immobilization devices
Conventional planning
Alignment of the Tangential Beam with the Chest Wall Contour
Doses To Heart & Lung By Tangential Fields
Adrenal Mass in Pregnancy: Diagnostic Approach and DilemmasApollo Hospitals
An adrenal incidentaloma is a mass lesion greater than 1 cm in diameter, incidentally found during radiologic examination for other reasons.
1. Such “adrenal incidentalomas” are increasingly recognised in clinical practice.
2. This is attributed to routine use of sophisticated and sensitive imaging techniques, with a reported prevalence of 4.4%.
3. Incidental findings of such masses pose dilemmas in evaluation and management, as current recommendations based on expert opinion.
4. Are open to debate in terms of cost and clinical
benefits. The uncertainties in management multiply with
such adrenal incidentalomas in the context of pregnancy.
We report a rare case of a large adrenal incidentaloma
complicating second trimester of pregnancy. This case
outlines the huge decisional dilemmas, both for the patient
and healthcare provider.
Thermal Imaging: Opportunities and Challenges for Breast Cancer DetectionTarek Gaber
Thermal Imaging: Opportunities and Challenges for Breast Cancer Detection
Abstract:
Breast cancer is the most common cancer among women in the world. It is estimated that one in eight women, all over the wide, would develop breast cancer during her life. Breast cancer is considered one of the first-leading causes of cancer deaths among women. The early detection of breast cancer could save many women's life. Mammogram is one of the most imaging technology used for diagnosing breast cancer. Although mammogram has recorded a high detection and classification accuracy, it is difficult in imaging dense breast tissues, its performance is poor in younger women, it is harmful, and it couldn’t detect breast tumor that less than 2 mm. To overcome these limitations, it was found that there is a relation between the temperature and the presence of breast cancer. Utilizing this fact, infrared thermography could be a good source of breast images to study and detect cancer at the early stages which is crucial for cancer patients for increasing the rate of breast cancer survival.
This talk aims to give an overview of the thermal imaging technology, its possible applications in the medical field, focusing on its opportunities and challenges for the early detection of breast cancer and highlighting the state-of-the-art of this point.
New Developments in Breast Reconstruction Surgerybkling
Deborah Axelrod, MD, of NYU Langone Perlmutter Cancer Center, and Rachel Bluebond-Langner, MD, of NYU Langone Medical Center discuss the latest research in autologous breast reconstruction, fat injection, pre-pectoral implants, and oncoplastic surgery.
Disclaimer: Graphic medical imagery.
Breast conserving surgery followed by adjuvant radiotherapy is adopted in the early detected cases and mastectomy followed by radiotherapy or chemotherapy in the advanced cases are the general practices.
MRI offers a great aid in diagnosis of abnormal placentation. This presentation describes the normal MRI appearance of the placenta and the MRI signs of placental adhesion disorders.
Abstract—3D ultrasound (3-dimensional sonography) when combined with sonosalpingography, it provides detailed information regarding internal and external contours of the uterus, without the need for radiation contrast material or surgical intervention. This study was done because of the need of such diagnostic modality that is highly accurate as well as least invasive. A descriptive study was conducted on 50 infertile females to assess the diagnostic value of 3-dimensional SHG in reference of diagnostic hystero-laproscopy (DHL) assuming as gold standard. It was found that sensitivity of 3-dimensional SHG reasons of tubal patency, ovarian pathology and uterine cavity was found 97.6%, 90.91% and 71.43% respectively. And diagnostic accuracy of 3-dimensional SHG in reference of DHL for tubal patency, ovarian pathology and for uterine cavity was found 96%, 92% and 96% respectively. So it can be concluded from present study that 3-Dimensional sonohysterography is an efficient tool to assess women with infertility. Its sensitivity, specificity, and diagnostic accuracy is comparable to hysterolaproscopy.
Chest sonography images in neonatal r.d.s. And proposed gradingiosrphr_editor
BACKGROUND : Lung sonography has been used to monitor the patients of R.D.S. in
N.I.C.U. in recent times.
AIMS : To Describe and Grade the changes of R.D.S. by lung sonography.
SETTING & DESIGN : Tertiary care institutional set up in a rural medical college.
STUDY DURATION : September 2014 to May 2015. Follow-up variable, upto 2 weeks.
PROSPECTIVE, ANALYTICAL STUDY.
MATERIALS AND METHODS -This was a single institute study approved by the institutional ethics
committee. Prior informed consent was obtained from the parents. 100 consecutive patients admitted in
N.I.C.U. WITH gestational age < 36 weeks with respiratory complaints were enrolled. Chest x-ray was
obtained within few hours of admission and lung sonography was performed within 24 hours. Follow – up
sonography was performed as and when necessary. Sonography image was graded and correlated with chest
xray and clinical picture
Subserosal leiomyomas rarely have any significant effect on a pregnant uterus, but very large ones may compress the uterine cavity in early pregnancy resulting in abortion. A 32 year old female presented with vagina bleeding for days. There was a 3 month history of amenorrhoea. Her last confinement was 3 years prior to presentation which ended with vaginal delivery with no complication. However, obstetric ultrasound scan done 3 years earlier during the first pregnancy showed a subserous leiomyoma at the fundus of the uterus. On examination, the uterine size was greater than the gestational age. Abdomino-pelvic ultrasound showed huge degenerating leiomyoma extending from the uterine fundus to the left lobe of the liver. The uterus was anteverted and harbours a 12 week non-viable foetus which appeared compressed in the upper aspect of the uterine cavity. The size of the myometrium was normal for the gestational age. An impression of missed abortion associated with a huge degenerating subserous leiomyoma was made.
The Prenatal Diagnostic Center of Villa Donatello is able to provide state of the art performance in prenatal diagnosis, combining operator expertise with
the use of the latest generation of ultrasonic devices equipped with 3D / 4D probes and validated genetic screening tests.
Congenital Agenesis Of The Corpus Callosum With Intracerebral Lipoma And Fron...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. 52 Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
Fetal MRI: A pictorial essay
Sapna Rathee, Priscilla Joshi, Abhimanyu Kelkar, Nagesh Seth
Department of Radiodiagnosis, Bharati Hospital, Pune, Maharashtra, India
Correspondence: Dr. Sapna Rathee, C/O SR Century Public School, Delhi Rohtak Road, Bahadurgarh ‑ 124 507, Jhajjar, Haryana, India.
E‑mail: dr.sapnarathee@gmail.com
Abstract
Ultrasonography (USG) is the primary method for antenatal fetal evaluation. However, fetal magnetic resonance imaging (MRI)
has now become a valuable adjunct to USG in confirming/excluding suspected abnormalities and in the detection of additional
abnormalities, thus changing the outcome of pregnancy and optimizing perinatal management. With the development of ultrafast
sequences, fetal MRI has made remarkable progress in recent times. In this pictorial essay, we illustrate a spectrum of structural
abnormalities affecting the central nervous system, thorax, genitourinary and gastrointestinal tract, as well as miscellaneous
anomalies. Anomalies in twin gestations and placental abnormalities have also been included.
Key words: Anomalies; congenital; fetal magnetic resonance imaging; ultrasonography
Introduction
USG has routinely been used in the evaluation of obstetrical
andgynecological conditions since the late 1950s.However,
due to its limitations of a small field of view, operator
dependence, a need for an additional imaging modality
has emerged, especially in cases of oligohydramnios and
obese patients. As MRI does not involve radiation, is safe
for the fetus, and provides detailed structural anatomy, it
has emerged as a suitable adjunct to USG.
MRI was first performed in 1983 for evaluation of the
placenta and fetus.[1]
The main drawback of MRI was
fetal motion which was overcome in the 1990s with the
development of ultrafast sequences.[2]
According to the
Safety Committee of the Society for MRI, no known
biological risks have so far been proven to be associated
with MRI.Acoustic noise and biological effects are the main
safety concerns for fetal MRI. The noise intensity produced
by gradients in fetal MRI can reach 120 dB. Fetal hearing
damage, which is a potential hazard, has still not been
confirmed in practice.[3]
Fetal MRI is indicated in pregnant women when other
non‑ionizing diagnostic imaging methods are inadequate
or when the examination provides important information
that would otherwise require exposure to ionizing
radiation.[4]
The quality of fetal MRI is comparable to
postnatal MRI, facilitating discussion of surgical treatment
options. Relative advantages and disadvantages of antenatal
USG and MRI are described in Table 1.
Fetal MRI should be performed in the second or third
trimester. As the teratogenic effects of MRI in early
pregnancy are not confirmed and the multilayer structure
of the cerebral parenchyma is appreciable after 16 weeks
of gestation on a 1.5 T MR, MRI is best performed after
completion of organogenesis (16 weeks).[5]
The patients
are advised to fast for 4 h prior to the study, to reduce
bowel peristalsis artifacts and to prevent postprandial fetal
motion. Patients are asked to empty the urinary bladder
prior to the study and positioned feet first supine or in left
lateral decubitus position.Asingle-body matrix coil is often
used over the abdomen and pelvis to improve the spatial
resolution. No medication or sedation is required.
MR Protocol
MR studies are best performed on a MRI system with
field strength of 1.5 T. Imaging is performed during free
breathing with respiratory gating to avoid artifacts.
Initially, multiplanarT2-weighted (T2W) scout images are
often obtained using 5-7-mm-thick slices with a 1- to 2-mm
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2. Rathee, et al.: Fetal MRI: A pictorial essay
53Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
gap and a large field of view, followed by a T2W_TSE
sagittal sequence of the mother, to visualize the position of
the fetus, placenta, and cervix as well as assess the uterus.
Sequences should be performed in the coronal, sagittal, and
axial planes through the region of interest for confirming/
excluding the suspected fetal anomalies. This is followed
by sequences through the rest of the fetus to rule out/detect
associated anomalies. Ultrafast T2W sequences known
as single-shot rapid acquisition with refocused echoes
(i.e. single-shot fast spin-echo or half-Fourier acquired
single-shot turbo spin-echo) are often used. Single images
acquired in less than 1 s, decrease the artifacts from fetal
motion. In addition to the regular T2W_TSE and balanced
turbo field echo (BTFE) sequences for evaluating the fetus,
T1-weighted image (T1WI) sequences of the fetal abdomen
in the sagittal and coronal planes help to confirm the
presence of meconium (which appears bright on T1WI) in
the large bowel and rectum, up to the anal verge [Table 2]. It
should be noted that BTFE, being a heavily T2W sequence,
demonstrates fetal anatomy better at an early gestational
age, as compared to the regular T2W sequence.
For detailed neurological evaluation, multiplanar T2W
and BTFE sequences can be obtained. Ventricular atrial
measurements are typically in the axial plane. Cavum
septum pellucidum and corpus callosum (CC) must be
identified. Age‑appropriate sulcation and gyration is
evaluated next. The tegmento‑vermian angle [Figure 1] is
measured on the midline sagittal image of the fetal brain.
It is the angle formed by lines along the anterior surface
of the vermis and the dorsal surface of the brainstem. The
angle should be near zero. Large angles indicate elevation
of the vermis due to the developmental anomalies of vermis.
The cerebellar transverse diameter and cisterna magna are
measured in axial images.
Indications
The most important indications of fetal MRI are evaluation
of the fetus in suspected chromosomal syndromes/familial
genetic disorders where USG is normal, confirmation
of anomalies/findings detected on USG, and detecting/
excluding associated anomalies. Fetal MRI can also assist in
planning prenatal/postnatal intervention where necessary
[Table 3].
Spectrum of anomalies
CNS anomalies
The most common indication for CNS imaging was
ventriculomegaly, followed by suspected CC abnormalities,
cerebellar anomalies, congenital infections, malformations
of cortical development, and posterior fossa anomalies.
Ventriculomegaly is defined as atrial width equal to or more
than 10 mm on the sonogram. Figure 1 shows normal CC
and brain anatomy.
CC anomalies
The CC is a midline cerebral structure consisting of white
matter tracts connecting two cerebral hemispheres. Its
formation starts at the 10th
week of gestation with genu
formation and is completed by 18‑20th
weeks with the
formation of rostrum.[6]
It is seen as a C‑shaped, curved
hypointense structure on T2W images in the midsagittal
plane [Figure 1]. Cerebral ventriculomegaly raises the
suspicion of CC agenesis. MRI is superior to prenatal USG
for evaluation of CC at any gestational age as it actually
shows the CC, whereas ultrasonography (USG) relies on
indirect signs like absence of cavum septum pellucidum
for diagnosing CC anomalies. MR imaging features
suggestive of CC agenesis are parallelization of lateral
ventricles (Viking helmet sign), colpocephaly, and a high
riding third ventricle [Figure 2].
Holoprosencephaly
Itischaracterizedbylackofcleavageofprosencephalon.[7]
There
is incomplete separation of two cerebral hemispheres. MRI is
complementarytoUSGforconfirmationandfurtherevaluation
of the subtypes of holoprosencephy, i.e. alobar [Figure 3],
semilobar, and lobar, in order of severity. The spectrum of
findings in holoprosencephaly includes monoventricle,
fusion of thalami, and absence of falx, CC, and optic tracts.
Table 1: Advantages and disadvantages of fetal MRI and antenatal
ultrasound
Antenatal ultrasound Fetal MRI
Real‑time display and
noninvasive
No radiation, superior spatial and soft
tissue resolution
Operator dependent Relatively operator independent
Small FOV and difficulty in
obtaining multiplanar views
Large field of view FOV and multiplanar
capabilities
Poor image quality in
oligohydramnios, maternal
obesity
Better fetal anatomy delineation,
independent of fetal position and maternal
obesity
Reverberation artifacts,
maternal bowel gas are
problems
Poor visualization at <16 weeks gestation.
Poor bone visualization, disadvantage in
skeletal dysplasia and calcified lesions
Cost‑effective Expensive, time consuming, claustrophobia
Widely available Limited availability
MR: Magnetic resource imaging, FOV: Field of view
Table 2: Sequences for fetal MRI
Sequence Plane FOV
(mm)
Slice thickness
(mm)
Gap
(mm)
TR/TE
(ms)
Matrix
BFFE_Survey 3‑plane 450 15 10 7.7/4.6 224×256
T2W_TSE 3‑plane 180 4 0.4 520/80 340×266
SSh_MRCP 3‑plane 250 40 0 8000/900 296×238
BTFE_RT 3‑plane 375 4 0.5 4.6/2.3 312×247
T1_TSE Sagittal,
coronal
375 5 1 10/4.6 252×151
BTFE_RLT Sagittal 320 5 0 2.2/1.10 192×190
MRI: Magnetic resource imaging, BTEF: Balanced turbo field echo, T2W: T2-weighted,
BFFE: Balanced fast field echo, TSE: Turbo spin echo, MRCP: Magnetic resonance
cholangiopancreatoraphy, RT: Respiratory triggering, RLT: Real time, TR/TE - Time to repeat/
Tome to echo
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3. Rathee, et al.: Fetal MRI: A pictorial essay
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Associated anomalies include cleft lip, hypertelorism,
encephaloceles [Figure 4], andrenal and cardiac anomalies.
Neural tube defects
These are a group of anomalies due to incomplete closure of
the neural tube in early pregnancy. They include spina bifida,
meningocele,meningomyelocele,andlipomeningomyelocele.
Anencephaly
It is a type of neural defect comprising absence of cranial
vault and cortical tissue [Figure 5]. It can be associated with
spina bifida, congenital heart anomalies, skeletal anomalies,
gastrointestinal anomalies, and diaphragmatic hernias.
Iniencephaly
It is a neural tube defect, more common in females,
with an incidence of 10 in 10,000.[8]
It is characterized by
retroflexion of head, absence of occipital bones, spinal
deformities, fusion of cervicothoracic vertebrae, and
absence of neck causing upward turning of chin and
face[9]
[Figure 6].
Chiari malformations
These are a group of disorders associated with congenital
downward displacement of the cerebellum and brainstem,
showing peg‑like tonsillar herniation into the upper
cervical canal on T2W images with a small posterior fossa.
Four types are known. Chiari I is the commonest type with
tonsillar herniation. Type II is associated with lumbosacral
spinal myelomeningocele [Figure 7]. Type III is associated
with a cervical/occipital encephalocele, and type IV is a
variation of cerebellar hypoplasia.[10]
The limitation of USG
Figure 1 (A-F): Normal corpus callosum and brain anatomy. T2WI sagittal (A) image shows normal corpus callosum, (B) normal tegmento-vermian
angle, and (C) shows increased angle in case of vermian hypoplasia. T2W axial (D) image shownormal cerebellum, cavum septum pellucidum
(E and F) reveal normal ventricular size
Table 3: Fetal MRI indications
Fetal indications Other indications
Confirmation/further evaluation of
inconclusive/occult sonographic findings
Placental abnormalities like
placenta previa, placenta accreta
Intrauterine growth retardation Molar pregnancy
Oligohydramnios Uterine leiomyoma
Evaluation in high‑risk pregnancies with
bad obstetric history
To assist in prenatal/postnatal
intervention
MRI: Magnetic resource imaging
D
C
B
F
A
E
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4. Rathee, et al.: Fetal MRI: A pictorial essay
55Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
in visualizing the posterior fossa and detecting tonsillar
herniation has been overcome by fetal MRI.
Genitourinary tract anomalies
MRI scores over USG as fetal kidneys are well visualized
and can be evaluated in the early gestational period as
well as in the presence of scanty liquor. Oligohydramnios
limits the assessment of genitourinary anomalies on US
due to the poor sonic window, thus making MRI a useful
adjunct. Fetal ureters are not visualized on USG unless
dilated. Hydronephrosis is the most common genitourinary
abnormalitydetectedonprenatalUSG.[11]
Commonestcauses
of hydronephrosis are pelviureteric junction obstruction,
vesicoureteral reflux, megaureter, and posterior urethral
valves (PUVs).
Posterior urethral valves
It is the commonest cause of hydronephrosis and obstructive
uropathy in male infants. On antenatal USG, the urethra
shows a “keyhole” appearance with a distended urinary
bladder and urethra proximal to valve [Figure 8]. Three
types of PUVs were described in the past; however, at
present, only one type is accepted (type I).[12]
Fetal MRI
Figure 2 (A-D): Agenesis of corpus callosum at 22 weeks gestation.
USG revealed colpocephaly. BTFE coronal image (A) shows a “high
riding” third ventricle. T2W sagittal image (B) shows non-visualization
of corpus callosum. T2W axial image (C) reveals colpocephaly and
BTFE axial image (D) shows parallelization of lateral ventricles
DC
B
A
Figure 3 (A-D): Alobar holoprosencephaly in a fetus at 16 weeks.
T2WI sagittal, (A) coronal, (B) axial, (carrows) and (D) images show
central horseshoe-shaped monoventricle with fused thalami centrally.
Absent falx/interhemispheric fissure as well as corpus callosum. A
normal posterior fossa is seen
DC
BA
Figure 4 (A-D): Holoprosencephaly with encephalocele in a fetus
at16weeks.T2WI sagittal (A-C) and coronal (D) images reveal dilated
lateral ventricles. A cranial vault defect is seen toward the vertex (arrow)
DC
B
A
Figure 5 (A and B): Anencephaly in a fetus at 22 weeks. T2WI axial (A)
and sagittal (B) images show absence of cranial vault and herniation
of cerebral hemispheres
BA
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5. Rathee, et al.: Fetal MRI: A pictorial essay
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helps in diagnosing PUVs with associated hydronephrosis
or renal dysplasia.
Congenital megaureter
An infantile ureter measuring more than 7 mm, visualized
as a hyperintense tubular structure posterior to the bladder
on T2W sequences is termed as a megaureter.[13]
It can
be further classified as obstructed primary megaureter,
refluxing primary megaureter (vesicoureteric reflux), and
non‑refluxing obstructed primary megaureter.[13]
Antenatally, this is seen as a dilated collecting system and
ureter [Figure 9], as was seen in a 25‑week pregnancy in our
series. Reflux maybe excluded postnatally.
Multicystic dysplatic kidney
In multicystic dysplastic kidneys [Figure 10], multiple
small non‑communicating cysts are seen dispersed
throughout the renal parenchyma. It usually affects
one kidney with associated renal abnormalities likes
vesicoureteric reflux, pelviureteric junction obstruction,
ureteral ectopia, and ureterocele in the contralateral
kidney.[14]
The non‑communication of the cysts helps
differentiating it from hydronephrosis.
Chest anomalies
Fetal lungs appear hyperintense on T2W and BTFE
images. Common fetal thoracic anomalies are congenital
diaphragmatic hernia (CDH), congenital pulmonary
airway malformations (CPAM), and bronchopulmonary
sequestration (BPS).[15]
Lung volume is calculated on USG by lung to head
ratio (LHR); if it is >1.6, survival is >83%. In MRI, total
fetal lung volumes (TFLV) can be calculated. Cannie
etal.[16]
conducteda studyin200fetuseswithoutabnormalities
at University Hospital Gasthuisberg (Belgium). Total lung
volume correlated best with fetal body volume (FBV) than
with all other biometric variables. The estimated lung
volume ELV is calculated by the equation: ELV= [(2.0 × 10‑9
)
x FBV3
] – [(1.19 × 10‑5
) x FBV2
] + (0.0508 × FBV) – 1.79.
All fetuses with values < 14.3% have a 100% mortality
rate and those with values >32.8 have a 100% survival
rate.[16]
Thus, MRI scores over USG in calculating the lung
Figure 6 (A-F): Iniencephaly in a fetus at 29 weeks. T2W sagittal image, (A) BTFE s image coronal, (B) BTFE sagittal (C) and postnatal image
(D) show fusion of head with the chest, occipital bone defect, total absence of cervico-thoracic vertebrae, and fixed fetal head retroflexion
D
CB
F
A
E
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6. Rathee, et al.: Fetal MRI: A pictorial essay
57Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
volume more accurately and, therefore, predicting the fetal
outcome.[16]
Congenital diaphragmatic hernia
In CDH, the diaphragm is incompletely formed resulting
in a defect through which the contents of the abdomen
can enter the thoracic cavity [Figure 11]. Left‑sided
diaphragmatic hernias are more common than right‑sided
ones, with omental fat, stomach, and small bowel loops
being the commonest structures to herniate.In addition to
more accurate evaluation of residual lung volume, MRI
assesses the contents of the hernia more accurately than
USG, hence determining the outcome.
Congenital pulmonary airway malformations
They are abnormal pulmonary solid/cystic masses
vascularized by the pulmonary artery and drained via
pulmonaryveins.Stockeret al.[17]
classifiedthemas:Type I (one
or more cysts >2 cm), type II (multiple cysts 2‑0.5 cm), and
type III (large microcystic lesion <0.5 cm). CPAMs appear
hyperintense on T2WI than the normal lung parenchyma.
Bronchogenic cysts
These are congenital malformations of the bronchial
tree (type of bronchopulmonary foregut malformation)
appearing as large solitary cystic lesions. Most bronchogenic
cysts appear as single lesions typically located in the
mediastinum [Figure 12], in the carinal region, but can
also be found in the lung parenchyma or extend below the
diaphragm as dumbbell‑shaped cysts.[18]
Cystic hygromas
They are known as vasculolymphatic origin anomalies.[19]
Theycanariseanywherealongthelymphaticsystem;however,
Figure 7 (A-G): (A) Arnold ChiariII malformation at 18 weeks gestation. Axial USG image shows lemon shaped skull, T2WI axial (B) reveal dilated
ventricles, coronal T2WI, (C) and sagittal BTFE (D) images show colpocephaly and hydrocephalus. MRI revealed tonsillar herniation which could
not be detected on ultrasound. Axial BTFE, (E) sagittal T2WI, (F) and postnatal (G) images show protrusion of CSF and meninges through a
dorsal spinal defect into the subcutaneous plane in the lumbosacral region suggestive of meningocele
B
D
G
C
F
A
E
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7. Rathee, et al.: Fetal MRI: A pictorial essay
58 Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
Figure 9 (A-D): Left hydronephrosis and megaureter in a fetus at 25
weeks. Single-shot coronal, (A) T2WI coronal, (B) BTFE axial (C and D)
images show tortuous left megauretermeasuring 18.5 mm. Left UV
junction is narrowed with hydronephrotic left kidney and enlarged right
kidney. Urinary bladder is normal
in most cases, they are located in the head and neck
region. Cystic hygromas are multilobulated, thin‑walled,
lymph‑containing sacs [Figure 13].
Other anomalies
Amniotic band syndrome
These are a group of congenital anomalies affecting
the limbs and internal organs due to early rupture
of amnion leading to fibrous bands with entrapment
and herniation of the fetal parts[20]
[Figure 14]. Multiple
amniotic bands maybe associated with colpocephaly due
to CC dysgenesis.
Figure 8 (A-D): Bilateral hydronephrosis due to posterior urethral
valvesat 23 weeks gestation. Sagittal T2W, (A) coronal T2W, (B) single
shot T2W, (C) and T2W coronal (d) images show grossly distended
urinary bladder causing elevation of the diaphragm, occupying the
whole abdomen. Dilated posterior urethra and bilateral hydronephrosis
is seen
DC
B
A
DC
B
A
Figure 11 (A-E): Congenital diaphragmatic hernia and Dandy Walker
variant in a fetus at 33 weeks. T2WI coronal (A and B) images show
a diaphragmatic defect with herniation of bowel loops into the left
hemithorax. T2W axial image (C) shows a giant cisterna magna. Right
pleural effusion is also noted. T2WI axial images (D and E) show
diaphragmatic hernias
DC
BA
E
Figure 10 (A-C): Left multicysticdysplatic kidney with right
hydronephrosis and hydroureter in a fetus at 22 weeks.USG
suggestive of bulky left multicysticdysplatic kidney, non-visualized
right kidney, and urinary bladder with severe oligohydramnios.
T2W coronal, (A) BTFE coronal (B) and BTFE coronalimages,(C)
detected the presence of right kidney with hydronephrosis,
hydroureter, and normal urinary bladder, and confirmed dysplastic
left kidney
CBA
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8. Rathee, et al.: Fetal MRI: A pictorial essay
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Figure 12 (A-D): Intrathoracic cyst/Bronchogenic cyst/CPAM typeI or IV
in a fetus at 22 weeks. T2WI sagittal, (A) coronal, (B and C) and axial
(D) images showing 5.7 × 3 cm cystic mass occupying right hemithorax,
causing diaphragmatic inversion and lung compression with thoracic
scoliosis.Inadditiontoit,MRIrevealedascitesandbilateralpleuraleffusion
Figure 13 (A-G): Cystic hygroma in a fetus at 31 weeks. T2WI sagittal, (A) and BTFE coronal, (B and C) axial T2WI (D) images showing large
multiloculated cystic midline mediastinal mass compressing and displacing the great vessels. Prenatal USG (E and F) revealed multiple cystic
lesions in the anterior mediastinum. Postnatal X-ray (G) showed anterior mediastinal widening
Congenital vascular malformations
These are a group of congenital dysplasias affecting the
arterial, capillary, or venous system, presenting at birth.
Sturge Weber, Klippel–Trenaunay, Maffucci, and Proteus
syndromes are a few of these complex malformations.
Klippel–Trenaunay syndrome [Figure 15] comprises bony
or soft tissue hypertrophy (localized gigantism), venous
malformations, and port wine hemangiomas.[21]
Twin pregnancies
Miscellaneous conditions were seen in twin pregnancies
including conjoint twins, genitourinary anomalies (renal
agenesis) involving one twin [Figure 16], dilated PUVs
[Figure 17], and twin reversed arterial perfusion sequence
(TRAP) syndrome.
TRAP sequence
It is seen in multifetal monochorionic pregnancies. It
consists of abnormalities resulting from entrapment
of various fetal parts from a disrupted amnion.The
condition results in one normal (pump) twin and
abnormal (acardiac) co‑twin[22]
[Figure 18]. The acardiac
twin is further classified as acardiusanceps (when the
head is poorly formed), acardiusacephalus (if the head
DC
BA
D
C
G
B
F
A
E
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9. Rathee, et al.: Fetal MRI: A pictorial essay
60 Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
is absent), acardiusacormus (presence of head only), and
acardiusamorphous (unrecognizable amorphous mass).[23]
Placental anomalies
Placenta previa, accreta, increta, and hydatiform molar
pregnancy with live fetus [Figure 19] were few of the
placental indications for performing fetal MRI.
Conclusion
The main role of MRI was to confirm/exclude lesions
suspected on USG, as well as to define their extent and
demonstrate associated abnormalities.
Fetal MRI scored over USG due to its higher spatial
resolution, larger field of view, and ability to visualize
fetal anatomy well, despite scanty liquor. Maternal factors
such as echogenic abdominal wall and obesity are also not
deterrents.
Figure 15 (A-F): Venous/lymphatic malformation and Klippel-
Trenaunay-Weber syndrome at 28 weeks gestation. T2W coronal,
(A and B) Coronal USG, (C) T2W sagittal (D) images show hyperintense
subcutaneous soft tissues in right lower limb with extension into the
gluteal region and T2W coronal (F) image shows bulky kidneys
D
CB
F
A
E
Figure 16 (A and B): Diamnioticdichorionic twin pregnancy with renal
agenesis in presenting twin. T2W sagittal (A and B) images show
presence of kidneys with distended bladder in the more cranial twin
B. Distended bladder/both kidneys could not be demonstrated in the
“presenting” more caudally placed fetus, twin A
BA
Figure 14 (A-G):Amniotic band syndrome in a fetus at 18 weeks. Maternal T2WI sagittal, axial and oblique coronal images(A-D and E-G) show
multiple amniotic bands with fetus trapped in persistent hyperflexion. Herniation of abdominal contents limited by amniotic membrane. Additional
MRI findings:Dilated lateral ventricles (colpocephaly), absent corpus callosum. (H) Autopsy specimen
D
H
C
G
B
F
A
E
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10. Rathee, et al.: Fetal MRI: A pictorial essay
61Indian Journal of Radiology and Imaging / February 2016 / Vol 26 / Issue 1
Fetal MRI is increasingly used in clinical practice, partly
because of the increasing interest in fetal surgery and fetal
medicine.[24]
It allows simultaneous imaging of different
organ systems with reproducibility of images, producing
images akin to postnatal scans, thus facilitating surgical
planning and intervention. It helps predict postnatal
management and in genetic counseling.
Sequences such as DWI, Apparent Diffusion Coefficient,
MRI spectroscopy, functional imaging, and volumetric
data acquisition are still under research and show future
promise.
Declaration of patient consent
The authors certify that they have obtained all appropriate
patient consent forms. In the form the patient(s) has/have
given his/her/their consent for his/her/their images and
other clinical information to be reported in the journal. The
patients understand that their names and initials will not
be published and due efforts will be made to conceal their
identity, but anonymity cannot be guaranteed.
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Cite this article as: Rathee S, Joshi P, Kelkar A, Seth N. Fetal MRI: A pictorial
essay. Indian J Radiol Imaging 2016;26:52-62.
Source of Support: Nil, Conflict of Interest: None declared.
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