This document discusses ferroptosis, a form of regulated cell death, in the context of ischemic stroke. It provides background on ferroptosis, describing it as iron-dependent lipid peroxide accumulation. The core and penumbra regions of the brain are described in ischemic stroke. Several studies exploring mechanisms of ferroptosis and its potential role in stroke pathology and outcomes are summarized. The conclusion suggests that inhibiting ferroptosis may help reduce ischemic brain injury, and further research is needed to better understand ferroptosis regulation and its interaction with other cell death pathways in stroke.