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Objectives
• Explain the rationale of the use of metformin in
polycystic ovarian syndrome
• Activation of enzyme AMP-activated protein kinase
(AMPK)
-Reduce hepatic gluconeogenesis
• Increase uptake of glucose
• Reduce carbohydrate absorption
• Increase fatty acid oxidation
• In overweight women with PCOS,
Metformin treatment reduces
• hyperinsulinemia
• basal and stimulated LH levels
• free testosterone concentration
• Prevents further development of insulin
resistance
• Improves fertility
References
• Jeffcoate’s Principle of Gynaecology,8th edition, 2014,
Page no. 364
• Basic and clinical pharmacology, 12th edition, 2012
• Davidson’s Principles and Practise of Medicine,21st
edition,2010, Page no. 761
T hank you

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Explain the rationale of the use of metformin in polycystic ovarian syndrome

  • 1. Objectives • Explain the rationale of the use of metformin in polycystic ovarian syndrome
  • 2. • Activation of enzyme AMP-activated protein kinase (AMPK) -Reduce hepatic gluconeogenesis • Increase uptake of glucose • Reduce carbohydrate absorption • Increase fatty acid oxidation
  • 3. • In overweight women with PCOS, Metformin treatment reduces • hyperinsulinemia • basal and stimulated LH levels • free testosterone concentration • Prevents further development of insulin resistance • Improves fertility
  • 4. References • Jeffcoate’s Principle of Gynaecology,8th edition, 2014, Page no. 364 • Basic and clinical pharmacology, 12th edition, 2012 • Davidson’s Principles and Practise of Medicine,21st edition,2010, Page no. 761