This study experimentally analyzed the heat transfer characteristics of R744/R1270 refrigerant mixtures flowing in a horizontal smooth tube. Tests were conducted at varying mass fluxes (40-80 kg/m2s) and heat fluxes (15-24 kW/m2). The heat transfer coefficient, inner wall temperature, and Nusselt number were found to decrease along the length of the tube. Higher mass and heat fluxes resulted in higher heat transfer coefficients and inner wall temperatures. The mixture of R744/R1270 at a 25/75 ratio and mass flux of 80 kg/m2s provided maximum heat transfer.