This study evaluates various methods for estimating reference evapotranspiration (ETO) in the Nagarjuna Sagar Reservoir area of Andhra Pradesh, comparing four climate-based methods against the FAO-56 Penman-Monteith method. The research found that artificial neural networks (ANNs) outperformed these methods in accuracy when estimating ETO from climatic variables. Additionally, it developed crop coefficient models for different crops, suggesting that locally calibrated parameters can lead to more accurate estimations of crop evapotranspiration.