Patients with Barrett's esophagus have a 40 times higher risk of developing esophageal cancer. Barrett's esophagus involves a change in the normal esophageal lining to an abnormal columnar epithelium and can progress from low-grade dysplasia to high-grade dysplasia (a pre-cancerous condition) and eventually invasive cancer. Whole body PET imaging of a patient who underwent radiation therapy 6 weeks prior showed intense uptake in the gastroesophageal junction measuring 5.9cm by 4.9cm, consistent with residual cancer. Focal uptake was also seen in the left adrenal gland and a lymph node, indicating metastatic disease.