The document discusses Endoca's CBD extraction and products. It describes Endoca's organic farming practices in Denmark and advanced extraction process. A variety of CBD products are described including oil drops, paste, capsules, and suppositories with different CBD concentrations. The document emphasizes Endoca's commitment to quality control, using ISO and GMP certifications. It warns that many CBD companies lack proper testing and quality standards.
Hacia marcos de gobernanza efectivos para el gobierno digital en PerĂş - OCDEOECD Governance
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PresentaciĂłn de Barbara Ubaldi, Gestora de Proyectos Senior, DirecciĂłn de la Gobernanza PĂşblica, OCDE, (Lima, PerĂş, 15 de Marzo del 2017) - Hacia marcos de gobernanza efectivos para el gobierno digital en PerĂş. www.oecd.org/gov/digital-government/
This is my senior thesis. My project focuses on the evaluation of antioxidant properties of different colors of asian rice against carbosulfan insecticide using mealworms.
Everything You Wanted to Know About LinkedIn, but Were Too Embarrassed to AskJonathan Rick
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PUNTOG - HEAD SHOP - VAPE SHOP - HEMP SHOP - GROW SHOP
VENDITA E ASSISTENZA ON LINE SU PRODOTTI AL CBD
www.puntog-shop.com
Mobile +39 345 889 3933
Email : info@puntog-shop.com
ORDINI TELEFONICI PER PRODOTTI NATURALI AL CBD
Spediamo la merce in tutta Italia con Consegna in pacco assolutamente robusto. Riceverai la merce entro tre giorni lavorativi dallâordine. Chiama Ora!
First Aid is the help given to a sick or injured person until full medical treatment is available.
The importance of First Aid is to preserve life, to prevent further harm/condition from worsening and to promote recovery.
Hacia marcos de gobernanza efectivos para el gobierno digital en PerĂş - OCDEOECD Governance
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PresentaciĂłn de Barbara Ubaldi, Gestora de Proyectos Senior, DirecciĂłn de la Gobernanza PĂşblica, OCDE, (Lima, PerĂş, 15 de Marzo del 2017) - Hacia marcos de gobernanza efectivos para el gobierno digital en PerĂş. www.oecd.org/gov/digital-government/
This is my senior thesis. My project focuses on the evaluation of antioxidant properties of different colors of asian rice against carbosulfan insecticide using mealworms.
Everything You Wanted to Know About LinkedIn, but Were Too Embarrassed to AskJonathan Rick
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If youâre reading this, you no doubt have a LinkedIn profile. What you may not have is a comprehensive understanding of LinkedInâs hidden powers â how it can transform your online presence from an afterthought into a model of thought leadership.
PUNTOG - HEAD SHOP - VAPE SHOP - HEMP SHOP - GROW SHOP
VENDITA E ASSISTENZA ON LINE SU PRODOTTI AL CBD
www.puntog-shop.com
Mobile +39 345 889 3933
Email : info@puntog-shop.com
ORDINI TELEFONICI PER PRODOTTI NATURALI AL CBD
Spediamo la merce in tutta Italia con Consegna in pacco assolutamente robusto. Riceverai la merce entro tre giorni lavorativi dallâordine. Chiama Ora!
First Aid is the help given to a sick or injured person until full medical treatment is available.
The importance of First Aid is to preserve life, to prevent further harm/condition from worsening and to promote recovery.
Buyers no longer use voicemails and emails from strangers to learn about products. This information is online, whenever buyers are interested. This SlideShare presentation show sellers how to connect in a meaningful way by starting conversations around the buyerâs plans, goals and challenges.
This presentation is one class in HubSpot Academy's free sales training course. You can enroll here: http://certification.hubspot.com/inbound-sales-certification
Modern Prospecting Techniques for Connecting with Prospects (from Sales Hacke...HubSpot
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Sales is a difficult world to be in because buyers aren't putting up with salespeople anymore. Instead of helping and building relationships, sales reps are still focused on closing prospects - even when they aren't ready to buy! So buyers ignore them. Because of that, even great sales reps would be lucky to get on the phone with someone.
While buyers have evolved and become more sophisticated, sales reps and training programs have been slow to adapt to that change.
Learn actionable modern prospecting techniques you can apply immediately from two best selling authors and sales experts: Max Altschuler CEO of Sales Hacker, and Mark Roberge CRO of HubSpot.
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Le Bono Collection - 2015 Brand CatelogScott Larsen
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Le Bono Collection represents a curation of the best sustainable and wellness brands, products and services available in Asia. We hope you enjoy discovering them as much as we have.
Joy of Life is a unique concept based on two guiding objectives: Improving the human bodyâs natural resistance against physical, mental and spiritual problems, i.e. improving the human bodyâs aura. Improving the human bodyâs self healing power, i.e. balancing the Chakras.
A brief presentation from Benedetto Cerilli on a new CBD & hemp business set to develop in Puerto Rico. More content from Benedetto can be found on his website: BenedettoCerilli.net
Buyers no longer use voicemails and emails from strangers to learn about products. This information is online, whenever buyers are interested. This SlideShare presentation show sellers how to connect in a meaningful way by starting conversations around the buyerâs plans, goals and challenges.
This presentation is one class in HubSpot Academy's free sales training course. You can enroll here: http://certification.hubspot.com/inbound-sales-certification
Modern Prospecting Techniques for Connecting with Prospects (from Sales Hacke...HubSpot
Â
Sales is a difficult world to be in because buyers aren't putting up with salespeople anymore. Instead of helping and building relationships, sales reps are still focused on closing prospects - even when they aren't ready to buy! So buyers ignore them. Because of that, even great sales reps would be lucky to get on the phone with someone.
While buyers have evolved and become more sophisticated, sales reps and training programs have been slow to adapt to that change.
Learn actionable modern prospecting techniques you can apply immediately from two best selling authors and sales experts: Max Altschuler CEO of Sales Hacker, and Mark Roberge CRO of HubSpot.
Why People Block Ads (And What It Means for Marketers and Advertisers) [New R...HubSpot
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HubSpot Research shares new data on why people use ad blockers and what marketers and advertisers need to do to keep people from blocking out ads completely. Hint: it's stop using interruptive and annoying ads.
3 Proven Sales Email Templates Used by Successful CompaniesHubSpot
Â
76% of emails never get opened. That makes life for salespeople very difficult. So we've partnered up with Breakthrough Email to bring you email templates that are proven to engage prospects and close more deals. Start using them today and grow your revenue.
Sequoya provides an integrated provision of production, distribution & import/export services for supplying quality Hemp GMP extracts (full-spectrum CBD & pharmaceutical isolate), hemp biomass & medical cannabis (marijuana) products to European buyers and stakeholders.
AMA Herbal Laboratories Pvt. Ltd. is the recognized manufacturer of extract form of eco-friendly natural dyes. Our offered range of dyes is widely used for coloring hairs. Besides, these dyes are also used for dying clothes & carpets in textile factories. We offer various types of dyes under the brand name "Vegetal Bio Color" which are made of only herbs and natural ingredients thus providing long lasting and shiny colors to the hairs.
Le Bono Collection - 2015 Brand CatelogScott Larsen
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Le Bono Collection represents a curation of the best sustainable and wellness brands, products and services available in Asia. We hope you enjoy discovering them as much as we have.
Joy of Life is a unique concept based on two guiding objectives: Improving the human bodyâs natural resistance against physical, mental and spiritual problems, i.e. improving the human bodyâs aura. Improving the human bodyâs self healing power, i.e. balancing the Chakras.
A brief presentation from Benedetto Cerilli on a new CBD & hemp business set to develop in Puerto Rico. More content from Benedetto can be found on his website: BenedettoCerilli.net
PUNTOG - HEAD SHOP - VAPE SHOP - HEMP SHOP - GROW SHOP
VENDITA E ASSISTENZA ON LINE SU OLI, BALSAMI E GICCE AL CBD
www.puntog-shop.com
Mobile +39 345 889 3933
Email : info@puntog-shop.com
ORDINI TELEFONICI PER OLI, BALSAMI E GICCE AL CBD
Spediamo la merce in tutta Italia con Consegna in pacco assolutamente robusto. Riceverai la merce entro tre giorni lavorativi dallâordine. Chiama Ora!
CBDnew.ME - CBD Pure affiliates - Buy Cannabidiol OilLiz Evans
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CBDPure is a full-spectrum cannabidiol (CBD) oil derived from organic hemp grown in Colorado, without the use of harmful pesticides or herbicides. http://cbdnew.me
What are cannabis concentrates? Cannabis concentrates are products derived
from cannabis flowers intensively processed to extract the most desirable
compounds. The components collected are the psychoactive compounds
tetrahydrocannabinol (THC), cannabinoids and terpenes while removing
excess plant material and other impurities. Cannabis concentrates contain
a higher percentage of cannabinoids and terpenes compared to natural
cannabis flowers. Concentrates have higher absorption in the body, the
effects of which are felt and experienced almost immediately.
Here you will get a basic info of Synthite Company
Synthite is the world's largest producer of Value added spice extracts and natural spice powder with ventures in the food flavouring, real estate and hospitality industry.
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The "ICH Guidelines for Pharmacovigilance" PDF provides a comprehensive overview of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines related to pharmacovigilance. These guidelines aim to ensure that drugs are safe and effective for patients by monitoring and assessing adverse effects, ensuring proper reporting systems, and improving risk management practices. The document is essential for professionals in the pharmaceutical industry, regulatory authorities, and healthcare providers, offering detailed procedures and standards for pharmacovigilance activities to enhance drug safety and protect public health.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
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Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.Â
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctorsâ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
 Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratoryÂ
 to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
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The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patientâs body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
How many patients does case series should have In comparison to case reports.pdfpubrica101
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Pubricaâs team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
3. 3
LETTER FROM âTHE FIELDSâ .........................................................................................................................5
OUR VISION ...........................................................................................................................................................7
OUR FIELDS ..........................................................................................................................................................9
CBD EXTRACTION ..............................................................................................................................................11
THE PRODUCTS .................................................................................................................................................13
CBD OIL DROPS ..................................................................................................................................................15
CBD PASTE ...........................................................................................................................................................17
CBD CAPSULES .................................................................................................................................................19
CBD SUPPOSITORIES .....................................................................................................................................21
CANNABIS CRYSTALS ....................................................................................................................................23
CBD SHISH ..........................................................................................................................................................25
CBD CHEWING GUM ........................................................................................................................................27
WHOLESALE .....................................................................................................................................................28
DO YOU REALLY KNOW WHAT IS IN YOUR CBD OIL? ........................................................................30
HEMP VS. CANNABIS .....................................................................................................................................32
ABOUT CBD & CBDA .......................................................................................................................................33
CBD THERAPEUTIC AREAS .........................................................................................................................34
MISSION ...............................................................................................................................................................37
ENDOCA VILLAGE ...........................................................................................................................................38
Table of contents
4.
5. âWhen I started working with cannabis in 2006 there
were no other companies producing CBD. Today there
are several companies manufacturing CBD but many
are compromising on quality to save costs. In addition
there are many online companies that sell CBD by re-
branding cheap, low quality CBD extracts to increase
their margins.This influx of newcomers attracted
by the high profit margins and lack of regulation has
made it difficult for consumers to find high quality CBD
products.
The amount of mis-information and pseudo scientific
jargon being thrown around has also angered the
existing medical community and caused concern
for the pharmaceutical industry who want the
government to regulate and stifle this emerging
market.
Itâs a great opportunity and a great challenge for
Endoca to continue innovating and pushing the
standards higher, setting the bar for others to follow.
As the leaders in cannabinoid production and research
we feel itâs our duty to educate and work together with
other companies and government regulatory bodies
while informing the consumer about CBD oil and itâs
revolutionary applications in medicine.â
Henry Vincenty
CEO Endoca
Letter from âthe fieldsâ
6.
7. 7
At Endoca we are leading the revolution in plant based
medicine, unlocking the secrets of nature and setting
the gold standard in the cannabis industry for natural,
pharmaceutical-grade products made from hemp.
(Cannabis Sativa L.)
Endoca has a long-standing family tradition of growing
and cultivating the finest hemp in the world. Henry
Vincenty, the founder of Endoca, discovered many
ways hemp plants could be used as native, holistic,
and natural health aids and using his training in organic
chemistry and botany, he developed Endoca CBD oil
extracts using the versatile and eco-friendly hemp
plant that his family had grown for generations.
Today our primary focus is to research and develop
innovative hemp extracts and to make them
accessible worldwide. We are dedicated to producing
the finest and purest quality CBD.
Our primary goal is to develop high quality hemp
extracts with a broad profile of cannabinoids and other
natural molecules found in hemp and to identify their
distinct properties.
In the near future Endoca
products will be high in
CBD but with 0% THC.
CBD products will be sold in
stores around the world,
just like typical vitamins
and supplements.
Our Vision
8.
9. 9
Endoca extracts CBD oils from hemp plants grown
and cultivated organically without herbicides or
pesticides.
Our hemp grows in Denmark, one of the top ten
countries in Europe for organic share of the total
cultivated area. The low lying and relatively flat land
in Denmark added to the existing fertile soils, and
partially favorable climate (winter frost + warm and
sunny summer with rainfall over the average) makes
Denmark ideal for hemp farming.
Denmarkâs many years of experience has created a
unique management/quality system in the country,
which is highly systematised and coordinated in itâs
efforts to handle soil and groundwater contamination.
Regulations in Denmark have long since made soil
quality an area of great consideration for hemp
production.
Endoca begins with the best seeds nature can create
for CBD production. Our non-GMO organically grown
hemp plants are gently harvested and dried under
the most optimal natural conditions. The hemp
harvest at Endoca employs the most dedicated staff
and advanced tools in the world, above and beyond
those commonly available in the hemp industry
and including custom made technologies especially
developed for optimal CBD hemp farming.
Our Fields
10.
11. 11
CBD extraction
Endoca capacity:
2015, 100ha cannabis
2016, 500ha cannabis
2017, 1000ha cannabis
Endocaâs factory is capable of producing many
different GMP certified cannabinoids, on industrial
scale.
Generally, there is a lack of consistent quality control
in the hemp industry. There are no standards or
objective, professional, appropriately trained third
parties regulating the cannabinoid industry, even
though many believe there are. Legislators are relying
on cannabis hobbyists or under-qualified scientists
often with no background in the botanical science of
the cannabis plant or in food safety â to determine
standards for this massive new industry.
Most laboratories have limitations and difficulties
conducting reliable quality testing on cannabis,
limitations that can only be remedied by significant
investment in both emerging high technology and
experienced organic chemists.
Unfortunately, many products on the market
contain residual pesticides, herbicides, mold, fungi,
heavy metals, and even dangerous and overlooked
mycotoxins. Yet few are willing to invest in cutting-
edge analytics because the public is largely unaware
of dangerous lapses in cannabis product quality
rampant in the industry today.
Understanding this sad fact of life in the cannabis
industry, we have invested enormous amounts of
time and resources into our extraction methods,
quality assurance and quality control. Constant
improvement is our goal to ensure precision, accuracy,
and repeatability in our extraction and product testing
approaches.
Quality control is central to Endocaâs quest to bring
our customers the very best CBD and hemp products
nature and science can offer. Itâs why we follow strict
pharmaceutical industry standards throughout our
entire production process.
Every batch of hemp oil created at Endoca is tested
thoroughly to ensure that our organic products are
free from pesticides, herbicides, molds, heavy metals,
and other common contaminants. We utilize HPLC,
an industry standard, as well as an advanced nuclear
magnetic resonance (NMR) technology to monitor the
oil composition at all points in the production process.
We go this extra mile to provide our customers
with peace of mind and confidence that they have
purchased the finest quality hemp products in the
world.
Our laboratory analysis is certified and
standardised according to the following
protocols:
ISO 14001: 2004 certified
ISO 9001: 2008 certified
HACCP certified
GMP certified
13. 13
Through a unique extraction process, Endoca
reproduces the natural, balanced phytochemical
profile of the original dry cannabis material. Endoca
believes that the biochemical equilibrium within the
herb must be maintained since this has proven to be
effective throughout the ages to heal the body and
promote good health.
To ensure the quality of our products we currently
screen for over 300 pesticides, heavy metals, and
mycotoxins. While we use equipment unavailable
to most, every batch of product is verified by
independent GMP certified labs that crosscheck our
results.
We do all of this because our mission at Endoca is
to lead the hemp and cannabis industry, becoming
the gold standard for hemp analytics and quality
assurance, so that more people will benefit from the
therapeutic properties of cannabinoids. We do this
knowing that when we raise the bar for quality, the
benefits of our mission are shared with all current and
future hemp and cannabis product users.
The products
14.
15. 15
Available as:
(3%) 300mg CBD (3%) 300mg CBD+CBDa (15%) 1500mg CBD (15%) 1500mg CBD+CBDa
SIMPLE AND EFFECTIVE
Our CBD Oil Drops are an
easy way to administer
and consume CBD.
The absorption rates are
much higher when hemp
oil is taken in a liquid
form. For this product
CBD is diluted in
organic hemp seed oil
rich in Omega 3 and 6.
CBD Oil Drops
16.
17. 17
CBD Paste
Available as:
(20%) 2000mg CBD (20%) 2000mg CBD+CBDa (30%) 3000mg CBD (30%) 3000mg CBD+CBDa
CONCENTRATE
CBD extract is the classic
way of consuming CBD.
Known for its great
paste consistency, our
CBD extract also has a
unique flavor and a very
high concentration of
CBD and other
Phytocannabinoids.
18.
19. 19
CBD Capsules
Available as:
300mg CBD 300mg CBD+CBDa 1500mg CBD 1500mg CBD+CBDa
BEST FOR
PRECISE DOSING
Capsules are ideal for
precise dosing of CBD.
Vegan gel caps, gluten-
free and completely ko-
sher. Theyâre extremely
easy to swallow due to
their smooth texture and
they are also odorless
and tasteless.
20.
21. 21
CBD Suppositories
For people suffering from nausea, vomiting or a gastrointestinal condition,
oral consumption may not be suitable. In that case, our CBD suppositories are a great
alternative administration method.
BEST ABSORPTION RATE
- 10 suppositories 50mg cbd per suppository
Ingredients: Organic Raw Cannabis Sativa Extract, Coconut oil.
22.
23. 23
Cannabis Crystals
Pure 98% CBD(Cannabidiol), 0%THC. The purest Cannabidiol extract ever created.
Extracted using Supercritical CO2, Solvent free and lab tested.
Mix it with your flower, dab it pure or add it to tinctures.
PUREST EXTRACT
- 1 jar: 500mg CBD
ingredients: Pure 98% CBD (Cannabidiol), 0%THC
24.
25. 25
CBD Shish
CBD Shish, ideal to mix with your herbs or dab it pure using a vaporizer.
CBD evaporates above 180°C (356°F)
NEW CBD TO VAPORIZE
- 1 jar: 2g of CBD Shish for a total of 140mg CBD.
ingredients: organic plant material,CBD (Cannabidiol)
26.
27. 27
CBD Chewing Gum
Chewing gum increases the bioavailability of CBD.
Old traditional recipe. Made with natural chicle gum from the rain forest and without
the use ofsynthetic ingredients.
HIGH BIOAVAILABILITY
- One box contains 10 pieces of gum (150mg CBD)
- 15mg CBD per gum
ingredients: Chicle gum base, xylitol, CBD extract,
peppermint, menthol, sunflower lecithin.
28. 28
Wholesale
The Cannabis extracts we create can be divided into
different categories depending on the process that it
went through. Depending on what product you want to
formulate different types of extracts have different
advantages.
CO2 EXTRACTION (First Extract)
We extract cannabis using CO2 and this results in an
extract thatâs solid like a paste. The extract from the
first extraction is a thick, golden-brown colored paste.
The extraction can vary in % of CBD and CBDa from
3%(CBD) to 30%(CBD).
As standard we provide you with: 7%(CBD) or 7%
Raw(CBD+CBDa) . The reason that we make 7% as
a standard is that the THC content is then is under
0.2% and itâs possible to make a standard product in
large quantities very easily. If you have special needs
for this type of product lets us know as there are
possibilities to make the % of CBD or CBDa higher.
The First extract can be divided in 2 groups according
to the viscosity:
COLD FILTERED EXTRACT
The extract contains many waxes that makes the
product like a paste. To remove the waxes we have
two different approaches we call filtration:
1.Cold filtration & 2.Hot filtration
In Cold filtration we work with low temperatures and
remove 1 type of waxes from the first extract, the
result from this is more loose extract with a lower
viscosity we call cold filtered cbd extract. Because
the viscosity is lower the product is more liquid and
makes it possible to mix it with other products easily
and keep the end product more liquid. The cold filtered
cbd extract can vary in % of CBD and CBDa from 10%
to 50%. As standard we provide you with: 20%(CBD)
or 20% Raw(CBD+CBDa) . If you have special needs
for this type of product lets us know as there are
possibilities to make the % of CBD or CBDa higher.
First Extraction
(solid)
Cold Filtred Extract
(extra liquid)
Cold Filtred Extract
(liquid)
29. 29
The Cold filtered extract can be divided in 2 groups
according to the viscosity:
HOT FILTERED EXTRACT
âGolden CBD Oilâ
We work with higher temperatures and remove
another type of waxes from the cold filtered cbd
extract, the result from this is a more loose extract
with lower viscosity we call hot filtered cbd extract
or âthe golden oilâ. The viscosity is lower than the
first CBD extraction but higher than in the cold filtered
cbd extract. The texture is more like coconut oil as it
becomes liquid when the temperature is high and solid
when temperature is below 20°C. The hot filtered cbd
extract can vary in % of CBD and CBDa from 10% to
50%, as standard we provide you with: 20%( CBD)
or 20% Raw(CBD+CBDa) If you have special needs
for this type of product lets us know as there are
possibilities to make the % of CBD or CBDa higher.
99% CBD (Pure CBD)
By means of continuing the filtration process of our
extracts we produce our 99% pure CBD, which can be
used in various production applications. As an example
we normally mix our extracts with organic hemp seed
oil to loosen up the material. For vape products we
recommend that you use 99% CBD.
Hot Filtered Extract
(solid)
Hot Filtered Extract
(liquid)
Hot Filtered Extract
(extra liquid)
99% Pure CBD
30. 30
Unfortunately the majority of Cannabis extracts are
produced without access to the proper laboratory
equipment and many manufacturers use toxic
solvents in the extraction process that leave residues
in the product. Besides the leftover chemicals from
the extraction process, many products on the market
may contain toxins such as pesticides, heavy metals,
herbicides, e-coli, mold fungi and even dangerous but
overlooked mycotoxins.
You may get an upset stomach, find that your CBD oil is
ineffective or even poison yourself with carcinogens
over time when using uncertified CBD oil that has not
been produced with conscientious attention to itâs
quality.
It takes the right plant
There are many ways to improve production and yields
and among these is the use of chemical fertilizers and
pesticides. We all know that these methods are bad
for us, and we could even turn a blind eye if the hemp
is used for fiber production, but when you are going
to consume a plant as food or even more importantly,
use it as a medicine, this is simply unacceptable.
These chemicals will be concentrated in oil extracts
and when these are ingested, they could even be lethal.
Luckily, there are ethical companies such as Endoca,
who have chosen to produce their hemp oil organically
and use the cleanest and most advanced methods of
extraction available today.
Do I chose Synthetic CBD
or natural CBD?
How much CBD is in the bottle? This appears to be
a simple question, but in the absence of regulation,
supplement manufacturers can print any fiction they
want on the product label.
Do you really know what is
in your Cannabis extract?
Can CBD be
dangerous?
Choose only
organic hemp
Fake CBD
percentages %
31. 31
How do we know we can trust a
CBD manufacturer?
These are the most important points to look out for:
⢠Batches are tested internally, but also by an impartial
third party and these results are made public.
⢠Good Manufacturing Practices (GMP) certification.
⢠International Organization for Standardization
(ISO) certification.
⢠Accessible, contactable customer care service.
GMP certification
Good manufacturing practices (GMP) are the practices
required in order to conform to the guidelines
recommended by agencies that control authorization
and licensing for manufacture and sale of food, drug
products, and active pharmaceutical products. These
guidelines provide minimum requirements that a
pharmaceutical or a food product manufacturer must
meet to assure that the products are of high quality
and do not pose any risk to the consumer or public.
Ask the CBD oil producer for the GMP certificate
number if they have one!
Fake CBD
Synthetic production of CBD is easy and profitable.
Thereâs just one problem: it doesnât work! It may
seem chemically similar, but it wonât be helpful as a
treatment and could even be dangerous. Studies show
that whole plant CBD is the only effective form of CBD.
How can I choose a good CBD oil?
⢠The producer is GMP certified
⢠online batch test results
⢠Transparent information and 3rd party lab tests
are available
⢠The producer works from seed to shelf maintaining
100% control over the entire production process.
⢠Organic production methods have been employed.
⢠The brand has a trusted status among other
consumers.
tested by
3rd party labs
Endoca is
GMP certified
Choose only
a trusted CBD
source
32. 32
Whatâs The Difference
Both are actually Cannabis plants, however Hemp
or industrial Hemp is a commonly used term for
cannabis plant strains that contain very low levels
of Tetrahydrocannabinol (THC) and are used for itâs
fiber and seeds. Cannabis use was identified in ancient
villages from over 10.000 years ago in Asia placing it
as one of the first humanly cultivated plants
What molecules does
cannabis contain?
There are over 480 natural components found within
the Cannabis plant. The molecules that recently got
most attention are cannabinoids At least 85 different
cannabinoids have been isolated from the Cannabis
plant. However there are other molecules: Terpenes,
Chlorophyll, Alkanes, Nitrogenous compounds,
Amino acids, Sugars, Aldehydes, Alcohols, Ketones,
Flavonoids, Glycosides, Vitamins, Pigments.
Why are cannabinoids so
interesting?
Our bodies create cannabinoid like substances
and we call them endogenous cannabinoids or
endocannabinoids. Plants make similar cannabinoids
and they are called phytocannabinoids.
Hemp vs. Cannabis
33. 33
CBD
The cannabis plant contains many different
cannabinoids,We have seen over 80 different types
and it seems there are many more. Most people
have heard of a cannabinoid called THC, which is the
ingredient in cannabis that gets users high. Unlike
THC, CBD is a nonÂŹpsychoactive cannabinoid and does
not cause a high. CBD has antipsychotic effects which
means CBD works completely the opposite way of
THC. Numerous studies suggest that CBD also acts
to reduce the intoxicating effects of THC, such as
memory impairment and paranoia.
CBDa
In nature CBD and THC are found mostly in their acid
form: CBD as CBDa and THC as THCA.
The plants actually contain very little CBD or THC.
Whatâs most remarkable is that if you eat the plant
raw, as nature intended, you will not get the the
psychoactive side effect as THCa is non-psychoactive.
The reason is that you need to heat THCa in order to
turn it in to THC. Historically, dietary use of the entire
raw cannabis plant brings us back to the beginning of
the human race.
Oils containing different forms of CBD have been
found to work much better the CBD alone.
About CBD CBDa
34. 34
The endocannabinoid system (ECS) is a lipid-derived
signaling system discovered within the past decade.
Cannabinoids, which are homeostatic regulators,
circulate throughout human and animal systems
continuously, affecting all physiological processes.
The endocannabinoid system is comprised of CB1 and
CB2 receptors which bind directly or indirectly to
cannabinoids and phytocannabinoids, CB1 receptors
are excitatory and are located n the central nervous
system, lungs, liver, and kidney. CB2 receptors
regulate immunological responses and are located in
the immune and circulatory systems.
Endogenous compounds, such as anandamide and
arachidonylglerol (2-AG), are made by mammals from
lipids and bind directly to the CB1 and CB2 receptors,
serving as neurotransmitters for cannabinoids.
Cannabidiol (CBD oil), a non-psychotropic cannabinoid
naturally occurring in human and animal species,
itâs also a phytocannabiniod, derived from the
industrial hemp plant . While CBD does not bind
directly with receptors, it does affect stress genes,
such as Soat2 and Cyp27a1, which control sterol (i.e.,
cholesterol) metabolism. CBD increases the amount
of anandamide and other vital lipids, thereby indirectly
increasing the availability of circulating cannabinoids
to bind with CB1 and CB2
receptors. Research has shown that cannabidiol in the
form of CBD oil has therapeutic benefits
individually and adjunctively with other interventions,
Cannabidiol (CBD) made from legal, industrial hemp
contains less than 0,3% THC, rendering it
non-psychoactive. CBD oil has antiemetic, antioxylitic,
antitumoral, and immunologically inhibitory
properties.
Three categories differentiate the types of clinical
endocannabinoid deficiency (CECD) which are
associated with different disease processes
and disorders: genetic, acquired, and idiopathic
autoimmune. Many disorders have a combination of
CECD origins, and supplementation with cannabidiol
(CBD) requires ongoing assessment to facilitate
optimal benefit for the individual.The pandemic of
obesity is directly related to the dysregulation of the
endocannabinoid system among humans throughout
the world. Metabolic syndrome, obesity, insulin
resistence and the associated diseases have escalated
over the past two decades.
Visceral fat, which is an indicator of inflammatory
processes affecting the gastrointestinal system,
and endocannabinoid receptor dysfunction, and
associated endocannabinoid depleteion, accumulates
as substances foreign to the human gastrointestinal
system, are repetitively ingested, for example,
processed foods containing synthetic sugars increase
abdominal visceral fat as the body produces a rapid
inflammatory response via the immune system,
which is governed by the endocannabinoid
system. In the presence of adequate
endocannabinoids, the immune system response is
CBD - Therapeutic Areas
35. 35
modified, and excessive inflammation does not occur.
However, because synthetic food substances block
endocannabinoid production and therefore alter
CB1 and CB2 responses, the immune response is
excessive inflammation around the intestinal tract and
intrabdominal cavity becomes expansive.
This phenomenon, repeated on a daily basis, leads to
metabolic syndrome and obesity, directly associated
with insulin resistence, leading to diabetes mellitus.
In light of the recent research on the role of the
endocannabinoid system as the core center for
human and mammalian system regulation, education
becomes imperative to prevent and reverse behaviors
which contribute to metabolic dysregulation.
Exercise is essential for the function of physiological
systems in the human body. The effects are clearly
documented throughout countless studies. The
effects of exercise, however, even in the presence of
reduced caloric intake, do not correlate with weight
loss or, most importantly, the loss of visceral fat.
The endocannabinoid system requires the presence of
adequate cannabinoids for metabolic balance
and the reduction of visceral fat, associated with
gastrointestinal inflammation. Because dietary
intake of phytocannabinoids, which effectively balance
the endocannabinoid system, are severely
inadequate in the diets of developed countries
throughout the world, cannabidiol (CBD oil), as a
food, is suggested, in combination with the elimination
of synthetic food derivatives, as an adjunctive option
to manage obesity and associated disorders.
In a recent study, Cannabinoid Research Group (Reillo,
2015) established the correlation of the increased
measurement of salivary nitric oxide after use of
cannabidiol.
Nitric oxide levels in the human body are associated
with multiple cardiovascular, immunological,
metabolic, and neurological functions, with depletion
directly associated with endocannabinoid dysfunction.
Optimal levels are correlated with adequate
phytocannabinoid intake and endocannabinoid
system health.
The validation in human subjects of measuring the
effect of cannabidiol as an expression of nitric oxide is
significant as an assessment tool in the management
of an individual by the health care practitioner and
renders validation of the quality of the CBD
preparation recommended for use under the guidance
of the health care practitioner.
CBD interacts and modulates with the human
endocannabinoid system, their endogenous
activators (ligands), enzymes, and transporters. In
addition, cannabinoids interact with other important
neurotransmitter systems, along with the TRP
Channels.
CBD proves to be effective in diverse therapeutic
areas. Some of the major pharmacological effects
include :
⢠Anti inflammatory
⢠Increases drug uptake
⢠Biochemical pathways associated with diabetes
⢠Anti-psychotic
⢠Reduce anxiety and depression
⢠Regulate obesity
⢠Anti epileptic
â˘Anti neoplastic agent
36.
37. 37
Endoca vision - CBD hemp oil
opens to a new consciousness.
Here at Endoca, our mission is to prove that humanity
can survive without having to poison ourselves and the
world around us. The plants that we extract out CBD
hemp oils from are grown and cultivated organically
without herbicides or pesticides. Our extraction
methods are also clean and do not require the use
of chemicals or solvents. This allows us to attain an
exceptionally high level of purity in our hemp oils.
Your health and the health of the environment are our
first priorities.
 We are currently developing our own packaging using
hemp fibers to reduce pollution caused by paper and
plastic production processes. The inks and dyes we
use will also be completely natural products.
Our next big step will be the use of hemp seed oil to
run our tractors and the use of solar energy as a
sustainable source of electricity for our facility. We
want to prove that 100% sustainable practices work,
and we want you to join us in our quest to make the
world a healthy place.
Mission
38. 38
Our vision includes the establishment of a village
surrounding our manufacturing site thatâs 100%
sustainable and independent, a place where organic
food is grown and everything we need is produced in
the village. Weâll go further than just being âorganicâ â
real permaculture principles will be implemented to
ensure maximum sustainability.
Raw Food Cannabis Hospital
In addition to being a home, we want to build a Raw
food hospital in our village, to be a place that people
visit and stay to learn more about and adopt healthier
lifestyle practices so that they can achieve healing
equilibrium and attain maximum wellness.
The reason we want to create a food hospital is that
we want to show people that you can often simply
eat your way to health. Eating organic raw food has
many health benefits. We also seek to use the profits
generated from the sales of our products to help
those in need, especially children.
We hope to build free accommodation and shelters for
the needy using hemp technologies, and even provide
them with work. We also hope to found an orphanage
where children will receive education and healthcare.
We have poured all profits from our sales into this
vision, and we have achieved excellent progress
towards its realization.
The Endoca Village